CA2656910C - Anti-cancer therapy comprising an h2-blocker, at least one antiinflammatory agent and a cytotoxic agent - Google Patents
Anti-cancer therapy comprising an h2-blocker, at least one antiinflammatory agent and a cytotoxic agent Download PDFInfo
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- CA2656910C CA2656910C CA2656910A CA2656910A CA2656910C CA 2656910 C CA2656910 C CA 2656910C CA 2656910 A CA2656910 A CA 2656910A CA 2656910 A CA2656910 A CA 2656910A CA 2656910 C CA2656910 C CA 2656910C
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81916406P | 2006-07-07 | 2006-07-07 | |
| US60/819,164 | 2006-07-07 | ||
| US88010707P | 2007-01-12 | 2007-01-12 | |
| US60/880,107 | 2007-01-12 | ||
| PCT/IL2007/000836 WO2008004231A1 (en) | 2006-07-07 | 2007-07-04 | Anti-cancer therapy comprising an h2-blocker, at least one antiinflammatory agent and a cytotoxic agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2656910A1 CA2656910A1 (en) | 2008-01-10 |
| CA2656910C true CA2656910C (en) | 2012-08-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| CA2656910A Expired - Fee Related CA2656910C (en) | 2006-07-07 | 2007-07-04 | Anti-cancer therapy comprising an h2-blocker, at least one antiinflammatory agent and a cytotoxic agent |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7838513B2 (https=) |
| EP (1) | EP2043659B1 (https=) |
| JP (1) | JP2009542623A (https=) |
| CN (1) | CN101511372B (https=) |
| AU (1) | AU2007270686B2 (https=) |
| CA (1) | CA2656910C (https=) |
| ES (1) | ES2414708T3 (https=) |
| WO (1) | WO2008004231A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7595378B2 (en) | 2001-06-13 | 2009-09-29 | Genmab A/S | Human monoclonal antibodies to epidermal growth factor receptor (EGFR) |
| KR101332869B1 (ko) | 2005-04-15 | 2013-11-25 | 알버트 아인슈타인 컬리지 오브 메디신 오브 예쉬바 유니버시티 | 항-ｅｇｆｒ 치료법에 속발된 피부 발진의 예방 및 치료를위한 비타민 ｋ |
| EP2043685B1 (en) | 2006-07-03 | 2015-12-23 | Genmab A/S | Prevention of rash in patients undergoing anti-egfr therapy |
| US8815953B2 (en) | 2008-03-13 | 2014-08-26 | Spectrum Pharmaceuticals, Inc. | Formulations of vitamin K analogs for topical use |
| EA201100863A1 (ru) * | 2008-11-28 | 2011-12-30 | Эдванс Холдингз Лимитед | Фармацевтическая композиция, включающая диклофенак и сложный эфир гидроксижирной кислоты и полиоксиалкилена |
| WO2012125724A1 (en) | 2011-03-14 | 2012-09-20 | Beth Israel Deaconess Medical Center | Methods and compositions for the treatment of proliferative disorders |
| WO2012167099A1 (en) * | 2011-06-01 | 2012-12-06 | Baylor College Of Medicine | Biomarkers and therapy for cancer |
| AU2013208649B2 (en) * | 2012-01-09 | 2017-04-06 | Tiltan Pharma Ltd. | Combination therapy for the treatment of cancer |
| KR102271848B1 (ko) * | 2013-11-01 | 2021-07-01 | 피트니 파마슈티컬스 피티와이 리미티드 | 암 치료용 약학적 배합물 |
| WO2016011268A1 (en) | 2014-07-17 | 2016-01-21 | Beth Israel Deaconess Medical Center, Inc. | Atra for modulating pin1 activity and stability |
| WO2016166761A1 (en) * | 2015-04-14 | 2016-10-20 | Tiltan Pharma Ltd. | Combination therapies and uses thereof in the treatment of cancer |
| WO2018069924A1 (en) | 2016-10-10 | 2018-04-19 | Tiltan Pharma Ltd. | Non-cytotoxic combination therapies and uses thereof in the treatment of cancer |
| TR201717134A2 (tr) * | 2016-12-07 | 2018-07-23 | Imuneks Farma Ilac Sanayi Ve Ticaret Anonim Sirketi | Ağrı Ve Enflamasyonun Hızlı Tedavisi İçin Diklofenak Ve H2 Reseptör Antagonistlerinin Çabuk Salımlı Oral Kombinasyonları |
| TR201718099A2 (tr) * | 2017-11-16 | 2019-06-21 | Mehmet Nevzat Pisak | Ağri ve enflamasyonun tedavi̇si̇ i̇çi̇n di̇klofenak, h2 reseptör antagoni̇stleri̇ ve alkali̇ metal bi̇karbonatlarindan olusan kombi̇nasyonlar |
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| WO1993013751A1 (en) * | 1992-01-16 | 1993-07-22 | Board Of Regents, The University Of Texas System | Formulation and use of carotenoids in treatment of cancer |
| CA2086874E (en) * | 1992-08-03 | 2000-01-04 | Renzo Mauro Canetta | Methods for administration of taxol |
| JPH11228409A (ja) * | 1997-09-23 | 1999-08-24 | Smith Kline Beecham Seiyaku Kk | 新規癌治療 |
| US7182942B2 (en) * | 2000-10-27 | 2007-02-27 | Irx Therapeutics, Inc. | Vaccine immunotherapy for immune suppressed patients |
| US20030158118A1 (en) | 2001-11-26 | 2003-08-21 | Weidner Morten Sloth | Combination of cimetidine and cysteine derivatives for treating cancer |
| JP4502641B2 (ja) | 2002-01-24 | 2010-07-14 | ティルタン ファーマ リミテッド | 抗癌組み合わせおよびその使用方法 |
| EP1718303A4 (en) * | 2004-02-10 | 2010-09-01 | Santarus Inc | COMBINATION OF INHIBITOR OF PROTON PUMP, BUFFER AND NON-STEROIDAL ANTI-INFLAMMATORY DRUG |
| CA2583315A1 (en) * | 2004-10-06 | 2006-06-01 | Tiltan Pharma Ltd. | Method and composition for enhancing anti-angiogenic therapy |
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2007
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- 2007-07-04 EP EP07766866A patent/EP2043659B1/en not_active Not-in-force
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- 2007-07-04 ES ES07766866T patent/ES2414708T3/es active Active
- 2007-07-04 CN CN2007800324155A patent/CN101511372B/zh not_active Expired - Fee Related
- 2007-07-04 CA CA2656910A patent/CA2656910C/en not_active Expired - Fee Related
- 2007-07-04 JP JP2009517608A patent/JP2009542623A/ja active Pending
- 2007-07-04 AU AU2007270686A patent/AU2007270686B2/en not_active Ceased
Also Published As
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| ES2414708T3 (es) | 2013-07-22 |
| EP2043659B1 (en) | 2013-04-03 |
| US7838513B2 (en) | 2010-11-23 |
| EP2043659A1 (en) | 2009-04-08 |
| JP2009542623A (ja) | 2009-12-03 |
| AU2007270686B2 (en) | 2011-05-26 |
| WO2008004231A1 (en) | 2008-01-10 |
| AU2007270686A1 (en) | 2008-01-10 |
| CA2656910A1 (en) | 2008-01-10 |
| CN101511372A (zh) | 2009-08-19 |
| US20090318391A1 (en) | 2009-12-24 |
| CN101511372B (zh) | 2011-11-16 |
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| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20180704 |