CA2650390C - Mass spectrometer - Google Patents
Mass spectrometer Download PDFInfo
- Publication number
- CA2650390C CA2650390C CA2650390A CA2650390A CA2650390C CA 2650390 C CA2650390 C CA 2650390C CA 2650390 A CA2650390 A CA 2650390A CA 2650390 A CA2650390 A CA 2650390A CA 2650390 C CA2650390 C CA 2650390C
- Authority
- CA
- Canada
- Prior art keywords
- electrodes
- ion guide
- ions
- amplitude
- voltage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 150000002500 ions Chemical class 0.000 claims abstract description 706
- 238000005036 potential barrier Methods 0.000 claims abstract description 145
- 230000001052 transient effect Effects 0.000 claims abstract description 58
- 230000007423 decrease Effects 0.000 claims description 80
- 230000004323 axial length Effects 0.000 claims description 60
- 230000000750 progressive effect Effects 0.000 claims description 52
- 238000011144 upstream manufacturing Methods 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 14
- 230000003247 decreasing effect Effects 0.000 claims description 13
- 230000002441 reversible effect Effects 0.000 abstract description 3
- 238000005040 ion trap Methods 0.000 description 28
- 238000013467 fragmentation Methods 0.000 description 26
- 238000006062 fragmentation reaction Methods 0.000 description 26
- 230000004888 barrier function Effects 0.000 description 18
- 238000006243 chemical reaction Methods 0.000 description 15
- 230000005684 electric field Effects 0.000 description 14
- 230000005540 biological transmission Effects 0.000 description 13
- 230000001133 acceleration Effects 0.000 description 11
- 238000001819 mass spectrum Methods 0.000 description 11
- 238000000926 separation method Methods 0.000 description 11
- 230000001419 dependent effect Effects 0.000 description 9
- 239000007789 gas Substances 0.000 description 8
- 238000006073 displacement reaction Methods 0.000 description 7
- 238000010494 dissociation reaction Methods 0.000 description 6
- 230000005593 dissociations Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 230000003068 static effect Effects 0.000 description 5
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
- 230000005405 multipole Effects 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 238000001360 collision-induced dissociation Methods 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 description 3
- 230000001360 synchronised effect Effects 0.000 description 3
- 229910052786 argon Inorganic materials 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000003795 desorption Methods 0.000 description 2
- 238000000688 desorption electrospray ionisation Methods 0.000 description 2
- 238000000132 electrospray ionisation Methods 0.000 description 2
- 238000010265 fast atom bombardment Methods 0.000 description 2
- 238000004992 fast atom bombardment mass spectroscopy Methods 0.000 description 2
- 238000009616 inductively coupled plasma Methods 0.000 description 2
- 238000001698 laser desorption ionisation Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000005192 partition Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 description 1
- 208000035699 Distal ileal obstruction syndrome Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 238000004252 FT/ICR mass spectrometry Methods 0.000 description 1
- 101000823051 Homo sapiens Amyloid-beta precursor protein Proteins 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000000451 chemical ionisation Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000005094 computer simulation Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000000112 cooling gas Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000001211 electron capture detection Methods 0.000 description 1
- 238000001077 electron transfer detection Methods 0.000 description 1
- 238000001976 enzyme digestion Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000010304 firing Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000012886 linear function Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- PXHVJJICTQNCMI-RNFDNDRNSA-N nickel-63 Chemical compound [63Ni] PXHVJJICTQNCMI-RNFDNDRNSA-N 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 238000004150 penning trap Methods 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/422—Two-dimensional RF ion traps
- H01J49/4235—Stacked rings or stacked plates
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
- H01J49/065—Ion guides having stacked electrodes, e.g. ring stack, plate stack
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0608470.1A GB0608470D0 (en) | 2006-04-28 | 2006-04-28 | Mass spectrometer |
| GB0608470.1 | 2006-04-28 | ||
| US80177206P | 2006-05-19 | 2006-05-19 | |
| US60/801,772 | 2006-05-19 | ||
| PCT/GB2007/001589 WO2007125354A2 (en) | 2006-04-28 | 2007-04-30 | Mass spectrometer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2650390A1 CA2650390A1 (en) | 2007-11-08 |
| CA2650390C true CA2650390C (en) | 2017-05-16 |
Family
ID=38573479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2650390A Active CA2650390C (en) | 2006-04-28 | 2007-04-30 | Mass spectrometer |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP2013895B8 (xx) |
| JP (1) | JP5290960B2 (xx) |
| CA (1) | CA2650390C (xx) |
| HK (1) | HK1132839A1 (xx) |
| WO (1) | WO2007125354A2 (xx) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0514964D0 (en) | 2005-07-21 | 2005-08-24 | Ms Horizons Ltd | Mass spectrometer devices & methods of performing mass spectrometry |
| JP5341753B2 (ja) * | 2006-07-10 | 2013-11-13 | マイクロマス ユーケー リミテッド | 質量分析計 |
| GB0622780D0 (en) | 2006-11-15 | 2006-12-27 | Micromass Ltd | Mass spectrometer |
| GB0718468D0 (en) | 2007-09-21 | 2007-10-31 | Micromass Ltd | Mass spectrometer |
| GB0820308D0 (en) * | 2008-11-06 | 2008-12-17 | Micromass Ltd | Mass spectrometer |
| GB201000852D0 (en) * | 2010-01-19 | 2010-03-03 | Micromass Ltd | Mass spectrometer |
| KR20140020152A (ko) * | 2012-08-08 | 2014-02-18 | (주)영린기기 | 질량 분석기용 ｒｆ／ｄｃ 이온 가이드 |
| DE112014005915T5 (de) | 2013-12-19 | 2016-09-08 | Micromass Uk Limited | Massenauflösende Hochdruck-Ionenführung mit axialem Feld |
| DE112014005868T5 (de) | 2013-12-24 | 2016-09-15 | Micromass Uk Limited | Wanderwellen-IMS mit Gegenstrom von Gas |
| GB201323004D0 (en) * | 2013-12-24 | 2014-02-12 | Micromass Ltd | Travelling wave IMS with counterflow of gas |
| GB2541346B (en) * | 2014-06-25 | 2022-05-11 | Hitachi High Tech Corp | Mass spectrometer |
| CN107665806B (zh) | 2016-07-28 | 2019-11-26 | 株式会社岛津制作所 | 质谱仪、离子光学装置及对质谱仪中离子操作的方法 |
| CN113066713A (zh) | 2020-01-02 | 2021-07-02 | 株式会社岛津制作所 | 离子光学装置、质谱仪以及离子操作方法 |
| US11600480B2 (en) * | 2020-09-22 | 2023-03-07 | Thermo Finnigan Llc | Methods and apparatus for ion transfer by ion bunching |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5206506A (en) * | 1991-02-12 | 1993-04-27 | Kirchner Nicholas J | Ion processing: control and analysis |
| EP0843887A1 (en) * | 1995-08-11 | 1998-05-27 | Mds Health Group Limited | Spectrometer with axial field |
| EP1212778A2 (en) * | 1999-08-26 | 2002-06-12 | University Of New Hampshire | Multiple stage mass spectrometer |
| JP2002184347A (ja) * | 2000-12-12 | 2002-06-28 | Shimadzu Corp | 質量分析装置 |
| JP3791479B2 (ja) * | 2002-09-17 | 2006-06-28 | 株式会社島津製作所 | イオンガイド |
| US6838662B2 (en) * | 2002-11-08 | 2005-01-04 | Micromass Uk Limited | Mass spectrometer |
| DE602005027656D1 (de) * | 2004-01-09 | 2011-06-09 | Micromass Ltd | Ionenextraktionseinrichtungen und verfahren zur selektiven extraktion von ionen |
| JP4193734B2 (ja) * | 2004-03-11 | 2008-12-10 | 株式会社島津製作所 | 質量分析装置 |
| GB0522327D0 (en) * | 2005-11-01 | 2005-12-07 | Micromass Ltd | Mass spectrometer |
| EP1956635B1 (en) * | 2005-11-28 | 2013-05-15 | Hitachi, Ltd. | Ion guide device, ion reactor, and mass analyzer |
-
2007
- 2007-04-30 EP EP07732622.1A patent/EP2013895B8/en active Active
- 2007-04-30 CA CA2650390A patent/CA2650390C/en active Active
- 2007-04-30 WO PCT/GB2007/001589 patent/WO2007125354A2/en active Application Filing
- 2007-04-30 JP JP2009507174A patent/JP5290960B2/ja active Active
-
2009
- 2009-12-22 HK HK09112043.3A patent/HK1132839A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP2013895B8 (en) | 2019-07-17 |
| WO2007125354A3 (en) | 2008-10-02 |
| WO2007125354A2 (en) | 2007-11-08 |
| JP5290960B2 (ja) | 2013-09-18 |
| EP2013895B1 (en) | 2018-09-12 |
| JP2009535761A (ja) | 2009-10-01 |
| CA2650390A1 (en) | 2007-11-08 |
| HK1132839A1 (en) | 2010-03-05 |
| EP2013895A2 (en) | 2009-01-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |