CA2650390A1 - Spectrometre de masse - Google Patents
Spectrometre de masse Download PDFInfo
- Publication number
- CA2650390A1 CA2650390A1 CA002650390A CA2650390A CA2650390A1 CA 2650390 A1 CA2650390 A1 CA 2650390A1 CA 002650390 A CA002650390 A CA 002650390A CA 2650390 A CA2650390 A CA 2650390A CA 2650390 A1 CA2650390 A1 CA 2650390A1
- Authority
- CA
- Canada
- Prior art keywords
- peak
- electrodes
- mass analyser
- mhz
- ion guide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000002500 ions Chemical class 0.000 claims abstract description 866
- 238000005036 potential barrier Methods 0.000 claims abstract description 179
- 230000001052 transient effect Effects 0.000 claims abstract description 63
- 230000002441 reversible effect Effects 0.000 claims abstract description 4
- 230000007423 decrease Effects 0.000 claims description 153
- 230000000750 progressive effect Effects 0.000 claims description 100
- 230000004323 axial length Effects 0.000 claims description 87
- 238000005040 ion trap Methods 0.000 claims description 49
- 238000013467 fragmentation Methods 0.000 claims description 48
- 238000006062 fragmentation reaction Methods 0.000 claims description 48
- 238000006243 chemical reaction Methods 0.000 claims description 30
- 238000011144 upstream manufacturing Methods 0.000 claims description 25
- 230000004888 barrier function Effects 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 19
- 238000000926 separation method Methods 0.000 claims description 17
- 230000005684 electric field Effects 0.000 claims description 15
- 230000005540 biological transmission Effects 0.000 claims description 14
- 230000003247 decreasing effect Effects 0.000 claims description 14
- 230000001133 acceleration Effects 0.000 claims description 13
- 238000006073 displacement reaction Methods 0.000 claims description 13
- 238000010494 dissociation reaction Methods 0.000 claims description 12
- 230000005593 dissociations Effects 0.000 claims description 12
- 238000001360 collision-induced dissociation Methods 0.000 claims description 5
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 claims description 5
- 230000005405 multipole Effects 0.000 claims description 5
- 238000003795 desorption Methods 0.000 claims description 4
- 238000000688 desorption electrospray ionisation Methods 0.000 claims description 4
- 238000010265 fast atom bombardment Methods 0.000 claims description 4
- 238000009616 inductively coupled plasma Methods 0.000 claims description 4
- 238000001698 laser desorption ionisation Methods 0.000 claims description 4
- 230000005855 radiation Effects 0.000 claims description 4
- 230000008859 change Effects 0.000 claims description 3
- 238000000132 electrospray ionisation Methods 0.000 claims description 3
- 238000004992 fast atom bombardment mass spectroscopy Methods 0.000 claims description 3
- 238000005192 partition Methods 0.000 claims description 3
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims description 2
- 208000035699 Distal ileal obstruction syndrome Diseases 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 238000004252 FT/ICR mass spectrometry Methods 0.000 claims description 2
- 101000823051 Homo sapiens Amyloid-beta precursor protein Proteins 0.000 claims description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 2
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims description 2
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims description 2
- 230000015556 catabolic process Effects 0.000 claims description 2
- 238000000451 chemical ionisation Methods 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims description 2
- 238000006731 degradation reaction Methods 0.000 claims description 2
- 238000001211 electron capture detection Methods 0.000 claims description 2
- 238000001077 electron transfer detection Methods 0.000 claims description 2
- 238000001976 enzyme digestion Methods 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- PXHVJJICTQNCMI-RNFDNDRNSA-N nickel-63 Chemical compound [63Ni] PXHVJJICTQNCMI-RNFDNDRNSA-N 0.000 claims description 2
- 238000004150 penning trap Methods 0.000 claims description 2
- 230000002285 radioactive effect Effects 0.000 claims description 2
- 229910052710 silicon Inorganic materials 0.000 claims description 2
- 239000010703 silicon Substances 0.000 claims description 2
- 238000001819 mass spectrum Methods 0.000 description 11
- 230000001419 dependent effect Effects 0.000 description 9
- 239000007789 gas Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 5
- 230000003068 static effect Effects 0.000 description 5
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 230000001360 synchronised effect Effects 0.000 description 3
- 229910052786 argon Inorganic materials 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000005094 computer simulation Methods 0.000 description 1
- 239000000112 cooling gas Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000010304 firing Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000012886 linear function Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000001004 secondary ion mass spectrometry Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/422—Two-dimensional RF ion traps
- H01J49/4235—Stacked rings or stacked plates
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
- H01J49/065—Ion guides having stacked electrodes, e.g. ring stack, plate stack
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Abstract
L'invention concerne un guide d'ions ou un analyseur de masse (2) comprenant une pluralité d'électrodes (2a) possédant des ouvertures au travers desquelles des ions sont émis en cours de fonctionnement. Une pseudo-barrière de potentiel est créée à la sortie du guide d'ions ou de l'analyseur de masse (2). L'amplitude ou la profondeur de la pseudo-barrière de potentiel est inversement proportionnelle au rapport masse/charge d'un ion. Une ou plusieurs tensions continues transitoires (4) sont appliquées aux électrodes (2a) du guide d'ions ou de l'analyseur de masse (2) afin d'accélérer les ions le long du guide d'ions ou de l'analyseur de masse (2). L'amplitude des tensions continues transitoires (4) appliquées à l'électrode (2a) peut être augmentée en fonction du temps de telle sorte que les ions soient émis depuis le guide d'ions ou l'analyseur de masse (2) dans l'ordre inverse de leur rapport masse/charge.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0608470.1 | 2006-04-28 | ||
| GBGB0608470.1A GB0608470D0 (en) | 2006-04-28 | 2006-04-28 | Mass spectrometer |
| US80177206P | 2006-05-19 | 2006-05-19 | |
| US60/801,772 | 2006-05-19 | ||
| PCT/GB2007/001589 WO2007125354A2 (fr) | 2006-04-28 | 2007-04-30 | Spectromètre de masse |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2650390A1 true CA2650390A1 (fr) | 2007-11-08 |
| CA2650390C CA2650390C (fr) | 2017-05-16 |
Family
ID=38573479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2650390A Active CA2650390C (fr) | 2006-04-28 | 2007-04-30 | Spectrometre de masse |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP2013895B8 (fr) |
| JP (1) | JP5290960B2 (fr) |
| CA (1) | CA2650390C (fr) |
| HK (1) | HK1132839A1 (fr) |
| WO (1) | WO2007125354A2 (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0514964D0 (en) | 2005-07-21 | 2005-08-24 | Ms Horizons Ltd | Mass spectrometer devices & methods of performing mass spectrometry |
| JP5341753B2 (ja) * | 2006-07-10 | 2013-11-13 | マイクロマス ユーケー リミテッド | 質量分析計 |
| GB0622780D0 (en) | 2006-11-15 | 2006-12-27 | Micromass Ltd | Mass spectrometer |
| GB0718468D0 (en) | 2007-09-21 | 2007-10-31 | Micromass Ltd | Mass spectrometer |
| GB0820308D0 (en) * | 2008-11-06 | 2008-12-17 | Micromass Ltd | Mass spectrometer |
| GB201000852D0 (en) * | 2010-01-19 | 2010-03-03 | Micromass Ltd | Mass spectrometer |
| KR20140020152A (ko) * | 2012-08-08 | 2014-02-18 | (주)영린기기 | 질량 분석기용 ｒｆ／ｄｃ 이온 가이드 |
| US9929002B2 (en) | 2013-12-19 | 2018-03-27 | Miromass Uk Limited | High pressure mass resolving ion guide with axial field |
| WO2015097462A1 (fr) | 2013-12-24 | 2015-07-02 | Micromass Uk Limited | Ims à onde progressive à contre-courant de gaz |
| GB201323004D0 (en) * | 2013-12-24 | 2014-02-12 | Micromass Ltd | Travelling wave IMS with counterflow of gas |
| WO2015198721A1 (fr) * | 2014-06-25 | 2015-12-30 | 株式会社 日立ハイテクノロジーズ | Spectromètre de masse |
| CN107665806B (zh) | 2016-07-28 | 2019-11-26 | 株式会社岛津制作所 | 质谱仪、离子光学装置及对质谱仪中离子操作的方法 |
| CN113066713A (zh) | 2020-01-02 | 2021-07-02 | 株式会社岛津制作所 | 离子光学装置、质谱仪以及离子操作方法 |
| US11600480B2 (en) * | 2020-09-22 | 2023-03-07 | Thermo Finnigan Llc | Methods and apparatus for ion transfer by ion bunching |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5206506A (en) * | 1991-02-12 | 1993-04-27 | Kirchner Nicholas J | Ion processing: control and analysis |
| EP0843887A1 (fr) * | 1995-08-11 | 1998-05-27 | Mds Health Group Limited | Spectrometre a champ axial |
| JP2003507874A (ja) * | 1999-08-26 | 2003-02-25 | ユニバーシティ オブ ニュー ハンプシャー | 多段型の質量分析計 |
| JP2002184347A (ja) * | 2000-12-12 | 2002-06-28 | Shimadzu Corp | 質量分析装置 |
| JP3791479B2 (ja) * | 2002-09-17 | 2006-06-28 | 株式会社島津製作所 | イオンガイド |
| US6838662B2 (en) * | 2002-11-08 | 2005-01-04 | Micromass Uk Limited | Mass spectrometer |
| WO2005067000A2 (fr) * | 2004-01-09 | 2005-07-21 | Ms Horizons Limited | Dispositifs d'extraction d'ions et procedes d'extraction selective d'ions |
| JP4193734B2 (ja) * | 2004-03-11 | 2008-12-10 | 株式会社島津製作所 | 質量分析装置 |
| GB0522327D0 (en) * | 2005-11-01 | 2005-12-07 | Micromass Ltd | Mass spectrometer |
| JP4621744B2 (ja) * | 2005-11-28 | 2011-01-26 | 株式会社日立製作所 | イオンガイド装置、イオン反応装置、及び質量分析装置 |
-
2007
- 2007-04-30 WO PCT/GB2007/001589 patent/WO2007125354A2/fr active Application Filing
- 2007-04-30 CA CA2650390A patent/CA2650390C/fr active Active
- 2007-04-30 JP JP2009507174A patent/JP5290960B2/ja active Active
- 2007-04-30 EP EP07732622.1A patent/EP2013895B8/fr active Active
-
2009
- 2009-12-22 HK HK09112043.3A patent/HK1132839A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007125354A3 (fr) | 2008-10-02 |
| EP2013895B1 (fr) | 2018-09-12 |
| JP2009535761A (ja) | 2009-10-01 |
| HK1132839A1 (en) | 2010-03-05 |
| EP2013895A2 (fr) | 2009-01-14 |
| WO2007125354A2 (fr) | 2007-11-08 |
| JP5290960B2 (ja) | 2013-09-18 |
| CA2650390C (fr) | 2017-05-16 |
| EP2013895B8 (fr) | 2019-07-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9786479B2 (en) | Mass spectrometer device and method using scanned phase applied potentials in ion guidance | |
| CA2650390C (fr) | Spectrometre de masse | |
| EP3640970B1 (fr) | Dispositif de guidage ionique | |
| US8598518B2 (en) | Mass spectrometer | |
| EP2084732B1 (fr) | Spectromètre de masse | |
| US8969799B2 (en) | Mass spectrometer | |
| US20160163526A1 (en) | Mass Spectrometer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |