WO2007125354A2 - Spectromètre de masse - Google Patents
Spectromètre de masse Download PDFInfo
- Publication number
- WO2007125354A2 WO2007125354A2 PCT/GB2007/001589 GB2007001589W WO2007125354A2 WO 2007125354 A2 WO2007125354 A2 WO 2007125354A2 GB 2007001589 W GB2007001589 W GB 2007001589W WO 2007125354 A2 WO2007125354 A2 WO 2007125354A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- peak
- electrodes
- mass analyser
- mhz
- ion guide
- Prior art date
Links
- 150000002500 ions Chemical class 0.000 claims abstract description 867
- 238000005036 potential barrier Methods 0.000 claims abstract description 179
- 230000001052 transient effect Effects 0.000 claims abstract description 63
- 230000002441 reversible effect Effects 0.000 claims abstract description 4
- 230000007423 decrease Effects 0.000 claims description 153
- 230000000750 progressive effect Effects 0.000 claims description 100
- 230000004323 axial length Effects 0.000 claims description 86
- 238000005040 ion trap Methods 0.000 claims description 49
- 238000013467 fragmentation Methods 0.000 claims description 48
- 238000006062 fragmentation reaction Methods 0.000 claims description 48
- 238000006243 chemical reaction Methods 0.000 claims description 30
- 230000004888 barrier function Effects 0.000 claims description 25
- 238000011144 upstream manufacturing Methods 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 19
- 238000000926 separation method Methods 0.000 claims description 17
- 230000005684 electric field Effects 0.000 claims description 15
- 230000005540 biological transmission Effects 0.000 claims description 14
- 230000003247 decreasing effect Effects 0.000 claims description 14
- 230000001133 acceleration Effects 0.000 claims description 13
- 238000006073 displacement reaction Methods 0.000 claims description 13
- 238000010494 dissociation reaction Methods 0.000 claims description 12
- 230000005593 dissociations Effects 0.000 claims description 12
- 230000005405 multipole Effects 0.000 claims description 6
- 238000001360 collision-induced dissociation Methods 0.000 claims description 5
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 claims description 5
- 238000003795 desorption Methods 0.000 claims description 4
- 238000000688 desorption electrospray ionisation Methods 0.000 claims description 4
- 238000010265 fast atom bombardment Methods 0.000 claims description 4
- 238000004992 fast atom bombardment mass spectroscopy Methods 0.000 claims description 4
- 238000009616 inductively coupled plasma Methods 0.000 claims description 4
- 238000001698 laser desorption ionisation Methods 0.000 claims description 4
- 230000005855 radiation Effects 0.000 claims description 4
- 230000008859 change Effects 0.000 claims description 3
- 238000000132 electrospray ionisation Methods 0.000 claims description 3
- 238000005192 partition Methods 0.000 claims description 3
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 238000004252 FT/ICR mass spectrometry Methods 0.000 claims description 2
- 101000823051 Homo sapiens Amyloid-beta precursor protein Proteins 0.000 claims description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 2
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims description 2
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims description 2
- 230000015556 catabolic process Effects 0.000 claims description 2
- 238000000451 chemical ionisation Methods 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims description 2
- 238000006731 degradation reaction Methods 0.000 claims description 2
- 238000001211 electron capture detection Methods 0.000 claims description 2
- 238000001077 electron transfer detection Methods 0.000 claims description 2
- 238000001976 enzyme digestion Methods 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- PXHVJJICTQNCMI-RNFDNDRNSA-N nickel-63 Chemical compound [63Ni] PXHVJJICTQNCMI-RNFDNDRNSA-N 0.000 claims description 2
- 238000004150 penning trap Methods 0.000 claims description 2
- 230000002285 radioactive effect Effects 0.000 claims description 2
- 229910052710 silicon Inorganic materials 0.000 claims description 2
- 239000010703 silicon Substances 0.000 claims description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- 239000008186 active pharmaceutical agent Substances 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 238000001819 mass spectrum Methods 0.000 description 11
- 230000001419 dependent effect Effects 0.000 description 9
- 239000007789 gas Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 5
- 230000003068 static effect Effects 0.000 description 5
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 230000001360 synchronised effect Effects 0.000 description 3
- 229910052786 argon Inorganic materials 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- 208000035699 Distal ileal obstruction syndrome Diseases 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000005094 computer simulation Methods 0.000 description 1
- 239000000112 cooling gas Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000010304 firing Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000012886 linear function Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/422—Two-dimensional RF ion traps
- H01J49/4235—Stacked rings or stacked plates
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
- H01J49/065—Ion guides having stacked electrodes, e.g. ring stack, plate stack
Abstract
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07732622.1A EP2013895B8 (fr) | 2006-04-28 | 2007-04-30 | Spectrometre de masse |
US12/297,481 US7919747B2 (en) | 2006-04-28 | 2007-04-30 | Mass spectrometer |
CA2650390A CA2650390C (fr) | 2006-04-28 | 2007-04-30 | Spectrometre de masse |
JP2009507174A JP5290960B2 (ja) | 2006-04-28 | 2007-04-30 | 質量分析計 |
CN200780024103XA CN101479828B (zh) | 2006-04-28 | 2007-04-30 | 质谱仪 |
HK09112043.3A HK1132839A1 (en) | 2006-04-28 | 2009-12-22 | Mass to charge ratio selective barrier |
US13/078,198 US8455819B2 (en) | 2006-04-28 | 2011-04-01 | Mass spectrometer device and method using scanned phase applied potentials in ion guidance |
US13/908,568 US8586917B2 (en) | 2006-04-28 | 2013-06-03 | Mass spectrometer device and method using scanned phase applied potentials in ion guidance |
US14/081,201 US9269549B2 (en) | 2006-04-28 | 2013-11-15 | Mass spectrometer device and method using scanned phase applied potentials in ion guidance |
US15/042,245 US9786479B2 (en) | 2006-04-28 | 2016-02-12 | Mass spectrometer device and method using scanned phase applied potentials in ion guidance |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0608470.1A GB0608470D0 (en) | 2006-04-28 | 2006-04-28 | Mass spectrometer |
GB0608470.1 | 2006-04-28 | ||
US80177206P | 2006-05-19 | 2006-05-19 | |
US60/801,772 | 2006-05-19 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/297,481 A-371-Of-International US7919747B2 (en) | 2006-04-28 | 2007-04-30 | Mass spectrometer |
US13/078,198 Continuation US8455819B2 (en) | 2006-04-28 | 2011-04-01 | Mass spectrometer device and method using scanned phase applied potentials in ion guidance |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007125354A2 true WO2007125354A2 (fr) | 2007-11-08 |
WO2007125354A3 WO2007125354A3 (fr) | 2008-10-02 |
Family
ID=38573479
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2007/001589 WO2007125354A2 (fr) | 2006-04-28 | 2007-04-30 | Spectromètre de masse |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP2013895B8 (fr) |
JP (1) | JP5290960B2 (fr) |
CA (1) | CA2650390C (fr) |
HK (1) | HK1132839A1 (fr) |
WO (1) | WO2007125354A2 (fr) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2450939A1 (fr) * | 2008-06-05 | 2012-05-09 | Micromass UK Limited | Procédé de réduction de charge d'ions de produits de dissociation par transfert d'électrons |
US20130099110A1 (en) * | 2010-01-19 | 2013-04-25 | Micromass Uk Limited | Mass to Charge Ratio Selective Ejection from Ion Guide Having Supplemental RF Voltage Applied Thereto |
US8581181B2 (en) | 2007-09-21 | 2013-11-12 | Micromass Uk Limited | Ion guiding device |
EP2038913B1 (fr) * | 2006-07-10 | 2015-07-08 | Micromass UK Limited | Spectrometre de masse |
EP2082415B1 (fr) * | 2006-11-15 | 2015-07-29 | Micromass UK Limited | Spectromètre de masse |
GB2525275A (en) * | 2013-12-24 | 2015-10-21 | Micromass Ltd | Travelling wave IMS with counterflow of gas |
WO2018020712A1 (fr) | 2016-07-28 | 2018-02-01 | Shimadzu Corporation | Spectromètre de masse, dispositif optique ionique et procédé de manipulation d'ions dans un spectromètre de masse |
US9929002B2 (en) | 2013-12-19 | 2018-03-27 | Miromass Uk Limited | High pressure mass resolving ion guide with axial field |
US9939408B2 (en) | 2013-12-24 | 2018-04-10 | Micromass Uk Limited | Travelling wave IMS with counterflow of gas |
US10388500B2 (en) | 2005-07-21 | 2019-08-20 | Micromass Uk Limited | Mass spectrometer |
WO2021137293A1 (fr) | 2020-01-02 | 2021-07-08 | Shimadzu Corporation | Dispositif optique ionique, spectromètre de masse et procédé de fonctionnement ionique |
CN114256053A (zh) * | 2020-09-22 | 2022-03-29 | 萨默费尼根有限公司 | 用于通过离子聚束进行离子转移的方法和设备 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20140020152A (ko) * | 2012-08-08 | 2014-02-18 | (주)영린기기 | 질량 분석기용 rf/dc 이온 가이드 |
WO2015198721A1 (fr) * | 2014-06-25 | 2015-12-30 | 株式会社 日立ハイテクノロジーズ | Spectromètre de masse |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5206506A (en) * | 1991-02-12 | 1993-04-27 | Kirchner Nicholas J | Ion processing: control and analysis |
WO1997007530A1 (fr) * | 1995-08-11 | 1997-02-27 | Mds Health Group Limited | Spectrometre a champ axial |
US6483109B1 (en) * | 1999-08-26 | 2002-11-19 | University Of New Hampshire | Multiple stage mass spectrometer |
JP2002184347A (ja) * | 2000-12-12 | 2002-06-28 | Shimadzu Corp | 質量分析装置 |
JP3791479B2 (ja) * | 2002-09-17 | 2006-06-28 | 株式会社島津製作所 | イオンガイド |
US6838662B2 (en) * | 2002-11-08 | 2005-01-04 | Micromass Uk Limited | Mass spectrometer |
ATE507576T1 (de) * | 2004-01-09 | 2011-05-15 | Micromass Ltd | Ionenextraktionseinrichtungen und verfahren zur selektiven extraktion von ionen |
JP4193734B2 (ja) * | 2004-03-11 | 2008-12-10 | 株式会社島津製作所 | 質量分析装置 |
GB0522327D0 (en) * | 2005-11-01 | 2005-12-07 | Micromass Ltd | Mass spectrometer |
JP4621744B2 (ja) * | 2005-11-28 | 2011-01-26 | 株式会社日立製作所 | イオンガイド装置、イオン反応装置、及び質量分析装置 |
-
2007
- 2007-04-30 CA CA2650390A patent/CA2650390C/fr active Active
- 2007-04-30 JP JP2009507174A patent/JP5290960B2/ja active Active
- 2007-04-30 WO PCT/GB2007/001589 patent/WO2007125354A2/fr active Application Filing
- 2007-04-30 EP EP07732622.1A patent/EP2013895B8/fr active Active
-
2009
- 2009-12-22 HK HK09112043.3A patent/HK1132839A1/xx not_active IP Right Cessation
Non-Patent Citations (1)
Title |
---|
None |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10388500B2 (en) | 2005-07-21 | 2019-08-20 | Micromass Uk Limited | Mass spectrometer |
EP2038913B1 (fr) * | 2006-07-10 | 2015-07-08 | Micromass UK Limited | Spectrometre de masse |
EP2082415B1 (fr) * | 2006-11-15 | 2015-07-29 | Micromass UK Limited | Spectromètre de masse |
US8581181B2 (en) | 2007-09-21 | 2013-11-12 | Micromass Uk Limited | Ion guiding device |
EP2450939A1 (fr) * | 2008-06-05 | 2012-05-09 | Micromass UK Limited | Procédé de réduction de charge d'ions de produits de dissociation par transfert d'électrons |
US20130099110A1 (en) * | 2010-01-19 | 2013-04-25 | Micromass Uk Limited | Mass to Charge Ratio Selective Ejection from Ion Guide Having Supplemental RF Voltage Applied Thereto |
US9177776B2 (en) * | 2010-01-19 | 2015-11-03 | Micromass Uk Limited | Mass to charge ratio selective ejection from ion guide having supplemental RF voltage applied thereto |
US9929002B2 (en) | 2013-12-19 | 2018-03-27 | Miromass Uk Limited | High pressure mass resolving ion guide with axial field |
US9939408B2 (en) | 2013-12-24 | 2018-04-10 | Micromass Uk Limited | Travelling wave IMS with counterflow of gas |
GB2557524A (en) * | 2013-12-24 | 2018-06-20 | Micromass Ltd | Travelling wave IMS with counterflow of gas |
GB2525275B (en) * | 2013-12-24 | 2018-07-18 | Micromass Ltd | Travelling wave IMS with counterflow of gas |
GB2557524B (en) * | 2013-12-24 | 2018-09-05 | Micromass Ltd | Travelling wave IMS with counterflow of gas |
GB2525275A (en) * | 2013-12-24 | 2015-10-21 | Micromass Ltd | Travelling wave IMS with counterflow of gas |
WO2018020712A1 (fr) | 2016-07-28 | 2018-02-01 | Shimadzu Corporation | Spectromètre de masse, dispositif optique ionique et procédé de manipulation d'ions dans un spectromètre de masse |
US10741379B2 (en) | 2016-07-28 | 2020-08-11 | Shimadzu Corporation | Mass spectrometer, ion optical device, and method for ion manipulation in mass spectrometer using trap with concentric ring electrodes |
WO2021137293A1 (fr) | 2020-01-02 | 2021-07-08 | Shimadzu Corporation | Dispositif optique ionique, spectromètre de masse et procédé de fonctionnement ionique |
CN114256053A (zh) * | 2020-09-22 | 2022-03-29 | 萨默费尼根有限公司 | 用于通过离子聚束进行离子转移的方法和设备 |
Also Published As
Publication number | Publication date |
---|---|
JP5290960B2 (ja) | 2013-09-18 |
EP2013895A2 (fr) | 2009-01-14 |
EP2013895B1 (fr) | 2018-09-12 |
WO2007125354A3 (fr) | 2008-10-02 |
EP2013895B8 (fr) | 2019-07-17 |
CA2650390C (fr) | 2017-05-16 |
JP2009535761A (ja) | 2009-10-01 |
CA2650390A1 (fr) | 2007-11-08 |
HK1132839A1 (en) | 2010-03-05 |
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