CA2647655C - Nouveaux analogues substitues en c-1 de la pancratistatine et de la 7-desoxypancratistatine et leurs procedes de preparation - Google Patents
Nouveaux analogues substitues en c-1 de la pancratistatine et de la 7-desoxypancratistatine et leurs procedes de preparation Download PDFInfo
- Publication number
- CA2647655C CA2647655C CA2647655A CA2647655A CA2647655C CA 2647655 C CA2647655 C CA 2647655C CA 2647655 A CA2647655 A CA 2647655A CA 2647655 A CA2647655 A CA 2647655A CA 2647655 C CA2647655 C CA 2647655C
- Authority
- CA
- Canada
- Prior art keywords
- compound
- formula
- nr2r3
- groups
- defined above
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne des composés de la formule I : (voir la formule I) à des compositions pharmaceutiques contenant ces composés et à lutilisation de ces composés dans le traitement du cancer. Lapplication concerne également des procédés pour la préparation de ces composés et la préparation dintermédiaires dans cette préparation.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2647655A CA2647655C (fr) | 2008-12-23 | 2008-12-23 | Nouveaux analogues substitues en c-1 de la pancratistatine et de la 7-desoxypancratistatine et leurs procedes de preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2647655A CA2647655C (fr) | 2008-12-23 | 2008-12-23 | Nouveaux analogues substitues en c-1 de la pancratistatine et de la 7-desoxypancratistatine et leurs procedes de preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2647655A1 CA2647655A1 (fr) | 2010-06-23 |
CA2647655C true CA2647655C (fr) | 2016-12-20 |
Family
ID=42283103
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2647655A Active CA2647655C (fr) | 2008-12-23 | 2008-12-23 | Nouveaux analogues substitues en c-1 de la pancratistatine et de la 7-desoxypancratistatine et leurs procedes de preparation |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2647655C (fr) |
-
2008
- 2008-12-23 CA CA2647655A patent/CA2647655C/fr active Active
Also Published As
Publication number | Publication date |
---|---|
CA2647655A1 (fr) | 2010-06-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2003260002B2 (en) | Synthesis of epothilones, intermediates thereto, analogues and uses thereof | |
EP0918776B1 (fr) | Synthese totale d'acylfulvenes antitumoraux | |
EP1040119B1 (fr) | Analogues d'hemiasterline | |
JP2009512662A (ja) | 中間体、並びにかかる中間体を用いたエクチナサイジン583、597などのエクチナサイジン類の調製方法 | |
US20030176368A1 (en) | Synthesis of epothilones, intermediates thereto and analogues thereof | |
CA2647655C (fr) | Nouveaux analogues substitues en c-1 de la pancratistatine et de la 7-desoxypancratistatine et leurs procedes de preparation | |
US10000527B2 (en) | 11-substituted bile acid derivatives, process for the preparation thereof and use of these compounds as medicaments | |
US8703792B2 (en) | C-1 analogs of pancratistatin and 7-deoxypancratistatin and processes for their preparation | |
EP0154185B1 (fr) | Dérivés du calciférol | |
EP1904485A2 (fr) | Synthese et attribution stereochimique complete de psymberine/irciniastatine pour une application anti-tumorale | |
Jackova et al. | Total Synthesis and Bioactivity of ent-homospisulosine and N, O-diacetylhomoclavaminol A | |
EP0758316B1 (fr) | Derives de borneol influant sur la polymerisation et la depolymerisation de la tubuline | |
Gruszecka-Kowalik et al. | Free-radical reactions of retronecine and heliotridine derivatives. The synthesis of (-)-supinidine | |
WO2004028452A2 (fr) | Procede de preparation d'intermediaires acides a squelette crambescidine et leur utilisation dans la preparation d'analogues d'alcaloides de crambescidine en tant qu'agents therapeutiques | |
WO2014100367A1 (fr) | Synthèse de fr901464 et de ses analogues à activité antitumorale | |
US9771325B2 (en) | Tricyclic compounds and preparation thereof | |
JP2020533374A (ja) | 環状ペプチド抗生物質 | |
TWI842251B (zh) | 抗瘧疾藥劑 | |
Vlad et al. | Asymmetric dihydroxylation of drim-7-en-11-ol: synthesis of diastereomerically pure driman-7α, 8α, 11-triol and its elaboration into novel chlorinated norlabdanic compounds | |
US20160002193A1 (en) | Anticancer compounds and process for the preparation thereof | |
JP2000229977A (ja) | トリデカノリド誘導体及び抗癌剤 | |
JP2004315373A (ja) | 抗腫瘍活性および血管新生阻害活性を有する化合物、ならびにその製造方法 | |
EP2493885B1 (fr) | Molecules polyketides comme agents anticancereux | |
CN115698018A (zh) | 美亚霉素类似物和使用方法 | |
US20040235939A1 (en) | Synthesis of peloruside a and analogs thereof for use as antitumor agents |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |
Effective date: 20141030 |