CA2646309C - Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents - Google Patents

Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents Download PDF

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Publication number
CA2646309C
CA2646309C CA2646309A CA2646309A CA2646309C CA 2646309 C CA2646309 C CA 2646309C CA 2646309 A CA2646309 A CA 2646309A CA 2646309 A CA2646309 A CA 2646309A CA 2646309 C CA2646309 C CA 2646309C
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polymerase
target enzyme
dna
drug
substrate
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CA2646309A
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English (en)
French (fr)
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CA2646309A1 (en
Inventor
Anita Goel
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Nanobiosym Inc
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Nanobiosym Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
    • G01N2333/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
    • G01N2333/16—HIV-1, HIV-2
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/91245—Nucleotidyltransferases (2.7.7)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2646309A 2006-04-21 2007-04-23 Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents Active CA2646309C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79372006P 2006-04-21 2006-04-21
US60/793,720 2006-04-21
PCT/US2007/009747 WO2007124105A2 (en) 2006-04-21 2007-04-23 Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents

Publications (2)

Publication Number Publication Date
CA2646309A1 CA2646309A1 (en) 2007-11-01
CA2646309C true CA2646309C (en) 2016-07-26

Family

ID=38625640

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2646309A Active CA2646309C (en) 2006-04-21 2007-04-23 Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents

Country Status (6)

Country Link
US (5) US9862984B2 (cg-RX-API-DMAC7.html)
EP (1) EP2016415B1 (cg-RX-API-DMAC7.html)
JP (1) JP2009534033A (cg-RX-API-DMAC7.html)
CN (1) CN101479605A (cg-RX-API-DMAC7.html)
CA (1) CA2646309C (cg-RX-API-DMAC7.html)
WO (1) WO2007124105A2 (cg-RX-API-DMAC7.html)

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JP2009545330A (ja) * 2006-08-04 2009-12-24 ザ トラスティーズ オブ ザ ユニバーシティー オブ ぺンシルべニア Ｉｇｅ依存性疾患を治療するための方法および組成物
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Also Published As

Publication number Publication date
WO2007124105A2 (en) 2007-11-01
US12435351B2 (en) 2025-10-07
WO2007124105A4 (en) 2009-02-19
JP2009534033A (ja) 2009-09-24
EP2016415B1 (en) 2013-08-14
US20180195104A1 (en) 2018-07-12
US11807892B2 (en) 2023-11-07
CA2646309A1 (en) 2007-11-01
US20250382654A1 (en) 2025-12-18
US20070254279A1 (en) 2007-11-01
WO2007124105A3 (en) 2008-11-27
US20240309420A1 (en) 2024-09-19
US9862984B2 (en) 2018-01-09
US20200308618A1 (en) 2020-10-01
CN101479605A (zh) 2009-07-08
EP2016415A4 (en) 2009-12-16
EP2016415A2 (en) 2009-01-21

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