CA2643663C - Body fluid analysis system with priming structures integrated in test elements - Google Patents
Body fluid analysis system with priming structures integrated in test elements Download PDFInfo
- Publication number
- CA2643663C CA2643663C CA2643663A CA2643663A CA2643663C CA 2643663 C CA2643663 C CA 2643663C CA 2643663 A CA2643663 A CA 2643663A CA 2643663 A CA2643663 A CA 2643663A CA 2643663 C CA2643663 C CA 2643663C
- Authority
- CA
- Canada
- Prior art keywords
- flushing liquid
- sample
- channel
- analysis
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000004458 analytical method Methods 0.000 title claims abstract description 138
- 238000012360 testing method Methods 0.000 title claims abstract description 135
- 210000001124 body fluid Anatomy 0.000 title claims abstract description 25
- 239000010839 body fluid Substances 0.000 title claims abstract description 25
- 230000037452 priming Effects 0.000 title description 18
- 239000007788 liquid Substances 0.000 claims abstract description 209
- 238000011010 flushing procedure Methods 0.000 claims abstract description 151
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 39
- 238000005259 measurement Methods 0.000 claims abstract description 28
- 239000012530 fluid Substances 0.000 claims abstract description 18
- 238000004891 communication Methods 0.000 claims abstract description 14
- 238000006243 chemical reaction Methods 0.000 claims abstract description 13
- 230000008859 change Effects 0.000 claims abstract description 10
- 239000012491 analyte Substances 0.000 claims abstract description 9
- 238000005406 washing Methods 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 14
- 239000002699 waste material Substances 0.000 claims description 12
- 239000011159 matrix material Substances 0.000 claims description 7
- 239000002250 absorbent Substances 0.000 claims description 4
- 230000002745 absorbent Effects 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 3
- 239000000523 sample Substances 0.000 description 93
- 239000000243 solution Substances 0.000 description 18
- 238000000926 separation method Methods 0.000 description 6
- 230000003287 optical effect Effects 0.000 description 5
- 230000009471 action Effects 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 238000012544 monitoring process Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 238000003541 multi-stage reaction Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000013461 design Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000009870 specific binding Effects 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 238000009423 ventilation Methods 0.000 description 2
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- 206010034719 Personality change Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
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- 230000032683 aging Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000013024 dilution buffer Substances 0.000 description 1
- 238000004141 dimensional analysis Methods 0.000 description 1
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- 230000001900 immune effect Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 230000000984 immunochemical effect Effects 0.000 description 1
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- 238000000159 protein binding assay Methods 0.000 description 1
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- 150000003839 salts Chemical class 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N35/00069—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/021—Adjust spacings in an array of wells, pipettes or holders, format transfer between arrays of different size or geometry
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/025—Align devices or objects to ensure defined positions relative to each other
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/16—Reagents, handling or storing thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0803—Disc shape
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07022814.3 | 2007-11-24 | ||
| EP07022814A EP2062643B1 (de) | 2007-11-24 | 2007-11-24 | Analysesystem und Verfahren zur Analyse einer Körperflüssigkeitsprobe auf einen darin enthaltenen Analyten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2643663A1 CA2643663A1 (en) | 2009-05-24 |
| CA2643663C true CA2643663C (en) | 2011-09-20 |
Family
ID=39284231
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2643663A Expired - Fee Related CA2643663C (en) | 2007-11-24 | 2008-11-12 | Body fluid analysis system with priming structures integrated in test elements |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8114351B2 (enExample) |
| EP (1) | EP2062643B1 (enExample) |
| JP (1) | JP2009128367A (enExample) |
| CN (1) | CN101446593A (enExample) |
| AT (1) | ATE541639T1 (enExample) |
| CA (1) | CA2643663C (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050249641A1 (en) * | 2004-04-08 | 2005-11-10 | Boehringer Ingelheim Microparts Gmbh | Microstructured platform and method for manipulating a liquid |
| EP2163901A1 (de) * | 2008-09-10 | 2010-03-17 | Roche Diagnostics GmbH | Verfahren und Dosiereinrichtung zum Dosieren einer Flüssigkeit in einen Aufnahmekanal eines Testelementes zur Analyse von Körperflüssigkeiten |
| GB2472236A (en) * | 2009-07-29 | 2011-02-02 | Iti Scotland Ltd | Apparatus for analysing microfluidic devices |
| KR101722548B1 (ko) | 2010-01-29 | 2017-04-03 | 삼성전자주식회사 | 원심력기반의 미세유동장치 및 이를 이용한 유체시료 내 분석대상물질 검출방법 |
| MX368123B (es) * | 2011-11-07 | 2019-09-19 | Rapid Micro Biosystems Inc | Cassette para pruebas de esterilidad. |
| CN102430549B (zh) * | 2011-12-15 | 2013-10-23 | 深圳市尚荣医疗股份有限公司 | 一种全自动生化分析仪的清洗装置及其清洗方法 |
| JP6155591B2 (ja) * | 2012-09-28 | 2017-07-05 | 凸版印刷株式会社 | 複数試料を分析するための試料分析チップとその分析方法 |
| CN107966576B (zh) | 2013-03-15 | 2021-08-03 | 雅培制药有限公司 | 具有后面可进入轨道系统的自动化诊断分析仪及相关方法 |
| US9400285B2 (en) | 2013-03-15 | 2016-07-26 | Abbot Laboratories | Automated diagnostic analyzers having vertically arranged carousels and related methods |
| EP4354149B1 (en) | 2013-03-15 | 2025-07-02 | Abbott Laboratories | Diagnostic analyzers with pretreatment carousels and related methods |
| CA3005826C (en) | 2013-04-15 | 2021-11-23 | Becton, Dickinson And Company | Biological fluid collection device and biological fluid separation and testing system |
| US9517026B2 (en) | 2013-04-15 | 2016-12-13 | Becton, Dickinson And Company | Biological fluid collection device and biological fluid separation and testing system |
| EP2944965A1 (en) * | 2014-05-13 | 2015-11-18 | Roche Diagnostics GmbH | Rotatable cartridge for measuring a property of a biological sample |
| EP2952258A1 (en) | 2014-06-06 | 2015-12-09 | Roche Diagnostics GmbH | Rotatable cartridge for analyzing a biological sample |
| EP2952257A1 (en) | 2014-06-06 | 2015-12-09 | Roche Diagnostics GmbH | Rotatable cartridge for processing and analyzing a biological sample |
| CN106489072B (zh) | 2014-06-06 | 2019-05-14 | 豪夫迈·罗氏有限公司 | 具有计量室的用于分析生物样品的旋转筒 |
| EP2957890A1 (en) | 2014-06-16 | 2015-12-23 | Roche Diagnostics GmbH | Cartridge with a rotatable lid |
| JP6030676B2 (ja) * | 2015-01-30 | 2016-11-24 | シャープ株式会社 | 試料分析装置及び試料分析方法 |
| JP5932077B1 (ja) * | 2015-02-24 | 2016-06-08 | シャープ株式会社 | 成分分析用容器 |
| EP3173149A1 (en) | 2015-11-26 | 2017-05-31 | Roche Diagnostics GmbH | Determining a quantity of an analyte in a blood sample |
| EP3184158B1 (en) | 2015-12-21 | 2019-01-16 | Roche Diagniostics GmbH | Blood collector with capillary structure |
| EP3231513B1 (en) | 2016-04-14 | 2022-03-02 | Roche Diagnostics GmbH | Cartridge and optical measurement of an analyte with said cartridge |
| US10639635B2 (en) | 2016-10-07 | 2020-05-05 | Biosurfit, SA | Device and method for handling liquid |
| ES2857735T3 (es) | 2016-11-16 | 2021-09-29 | Hoffmann La Roche | Cartucho giratorio con múltiples cámaras medidoras |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3044372A1 (de) | 1980-11-25 | 1982-07-08 | Boehringer Mannheim Gmbh, 6800 Mannheim | Rotoreinheit mit einsatzelementen fuer einen zentrifugalanalysator |
| US4580896A (en) | 1983-11-07 | 1986-04-08 | Allied Corporation | Multicuvette centrifugal analyzer rotor with annular recessed optical window channel |
| US4713974A (en) | 1986-04-18 | 1987-12-22 | Varian Associates, Inc./Scientific Systems, Inc. | Autosampler |
| US5746982A (en) * | 1996-02-29 | 1998-05-05 | Advanced Chemtech, Inc. | Apparatus for automated synthesis of chemical compounds |
| EE9900377A (et) | 1997-02-28 | 2000-04-17 | Burstein Laboratories, Inc. | Labor laserkettas |
| US7261859B2 (en) * | 1998-12-30 | 2007-08-28 | Gyros Ab | Microanalysis device |
| US6720187B2 (en) * | 2000-06-28 | 2004-04-13 | 3M Innovative Properties Company | Multi-format sample processing devices |
| US20040265172A1 (en) * | 2003-06-27 | 2004-12-30 | Pugia Michael J. | Method and apparatus for entry and storage of specimens into a microfluidic device |
| US20040265171A1 (en) | 2003-06-27 | 2004-12-30 | Pugia Michael J. | Method for uniform application of fluid into a reactive reagent area |
| US7527763B2 (en) * | 2005-07-05 | 2009-05-05 | 3M Innovative Properties Company | Valve control system for a rotating multiplex fluorescence detection device |
| JP2009530606A (ja) * | 2006-03-13 | 2009-08-27 | ギロス パテント アーべー | 増強型磁気粒子ステアリング |
-
2007
- 2007-11-24 AT AT07022814T patent/ATE541639T1/de active
- 2007-11-24 EP EP07022814A patent/EP2062643B1/de active Active
-
2008
- 2008-11-12 CA CA2643663A patent/CA2643663C/en not_active Expired - Fee Related
- 2008-11-21 US US12/275,707 patent/US8114351B2/en active Active
- 2008-11-21 JP JP2008298682A patent/JP2009128367A/ja not_active Withdrawn
- 2008-11-24 CN CN200810181598.3A patent/CN101446593A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20090137062A1 (en) | 2009-05-28 |
| US8114351B2 (en) | 2012-02-14 |
| EP2062643B1 (de) | 2012-01-18 |
| EP2062643A1 (de) | 2009-05-27 |
| CN101446593A (zh) | 2009-06-03 |
| CA2643663A1 (en) | 2009-05-24 |
| JP2009128367A (ja) | 2009-06-11 |
| ATE541639T1 (de) | 2012-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20131113 |