CA2642097C - Improved preparation of molecular imprinted polymers - Google Patents

Improved preparation of molecular imprinted polymers Download PDF

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Publication number
CA2642097C
CA2642097C CA2642097A CA2642097A CA2642097C CA 2642097 C CA2642097 C CA 2642097C CA 2642097 A CA2642097 A CA 2642097A CA 2642097 A CA2642097 A CA 2642097A CA 2642097 C CA2642097 C CA 2642097C
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Canada
Prior art keywords
mips
mip
template
particles
binding
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CA2642097A
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English (en)
French (fr)
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CA2642097A1 (en
Inventor
Jesper Svenning Kristensen
Klaus Gregorius Nielsen
Nicolas Otto Krogh
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Mipsalus ApS
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Mipsalus ApS
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Publication of CA2642097A1 publication Critical patent/CA2642097A1/en
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/268—Polymers created by use of a template, e.g. molecularly imprinted polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/305—Addition of material, later completely removed, e.g. as result of heat treatment, leaching or washing, e.g. for forming pores
    • B01J20/3057—Use of a templating or imprinting material ; filling pores of a substrate or matrix followed by the removal of the substrate or matrix
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Materials Engineering (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Polymers & Plastics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2642097A 2006-02-21 2007-02-21 Improved preparation of molecular imprinted polymers Active CA2642097C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US74333006P 2006-02-21 2006-02-21
DKPA200600248 2006-02-21
US60/743,330 2006-02-21
DKPA200600248 2006-02-21
PCT/DK2007/000083 WO2007095949A2 (en) 2006-02-21 2007-02-21 Improved preparation of molecular imprinted polymers

Publications (2)

Publication Number Publication Date
CA2642097A1 CA2642097A1 (en) 2007-08-30
CA2642097C true CA2642097C (en) 2016-08-02

Family

ID=38038548

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2642097A Active CA2642097C (en) 2006-02-21 2007-02-21 Improved preparation of molecular imprinted polymers

Country Status (11)

Country Link
US (1) US8287908B2 (cg-RX-API-DMAC7.html)
EP (1) EP1988993B1 (cg-RX-API-DMAC7.html)
JP (1) JP2009527471A (cg-RX-API-DMAC7.html)
KR (1) KR101475528B1 (cg-RX-API-DMAC7.html)
AU (1) AU2007218396C1 (cg-RX-API-DMAC7.html)
CA (1) CA2642097C (cg-RX-API-DMAC7.html)
DK (1) DK1988993T3 (cg-RX-API-DMAC7.html)
ES (1) ES2736148T3 (cg-RX-API-DMAC7.html)
IL (1) IL193416A (cg-RX-API-DMAC7.html)
RU (1) RU2437665C2 (cg-RX-API-DMAC7.html)
WO (1) WO2007095949A2 (cg-RX-API-DMAC7.html)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
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GB201200878D0 (en) * 2012-01-19 2012-02-29 British American Tobacco Co Polymer compositions
RU2605924C2 (ru) * 2009-09-16 2016-12-27 Мипсалус Апс Усовершенствованная очистка полиспецифичных рецепторов
CN101942062B (zh) * 2010-08-09 2013-07-17 南开大学 一种用于催化有机磷农药降解的表面印迹聚合物及制备方法
WO2012031128A2 (en) * 2010-09-01 2012-03-08 The Research Foundation Of State University Of New York Microorganism imprinted polymers with integrated emission sites, and methods of making and using same
US9060938B2 (en) * 2011-05-10 2015-06-23 Bend Research, Inc. Pharmaceutical compositions of active agents and cationic dextran polymer derivatives
HK1205712A1 (en) 2012-02-28 2015-12-24 Mipsalus Aps Preparation of molecular imprinted polymers by cross-linking
US9557250B2 (en) 2012-05-17 2017-01-31 The Board Of Trustees Of The Leland Stanford Junior University Devices and methods for separating particles
RU2515455C2 (ru) * 2012-07-29 2014-05-10 Закрытое Акционерное Общество "Аксион-Редкие И Драгоценные Металлы" Способ получения адаптивно-селективного к редкоземельным металлам ионообменного материала
US11051529B2 (en) 2015-01-13 2021-07-06 The Decaf Company, Llc Programmable polymer caffeine extraction
WO2017111692A1 (en) * 2015-12-21 2017-06-29 Stockholm University A solid form sampling tablet and its use for determining the amount of a specific analyte in a liquid sample.
CA3017412A1 (en) 2016-03-15 2017-09-21 Mipsalus Aps A method for qualitative or quantitative determination of the presence of an analyte in a sample
AT518590A3 (de) * 2016-04-29 2022-09-15 Mosbach Klaus Speicherung von binärkodes in molekular geprägten polymeren
AU2018294520B2 (en) 2017-06-29 2023-10-19 Mipsalus Aps Molecular imprinted polymers targeting phenylalanine
CN111151227A (zh) * 2019-10-21 2020-05-15 深圳市易瑞生物技术股份有限公司 半分子印迹材料及其制备方法和应用
US10828322B1 (en) 2019-11-29 2020-11-10 Claves Life Sciences Limited Molecularly imprinted polymers for sequestering acetate and other molecules
RU2765188C1 (ru) * 2020-11-03 2022-01-26 Федеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ получения селективного сорбента для твердофазной экстракции
CN113231034A (zh) * 2021-04-21 2021-08-10 华南师范大学 一种dgt结合相及其制备方法和应用
WO2025153614A1 (en) 2024-01-16 2025-07-24 Mipsalus Aps Cross-linked polymers and their use in methods of binding cations

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SE9203435D0 (sv) * 1992-11-11 1992-11-11 Georg Vlatakis Fondation For R Framstaellande av artificiella antikroppar med molekylavtrycksmetoden samt deras anvaendning vid analys
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US5994110A (en) * 1995-02-10 1999-11-30 Mosbach; Klaus Methods for direct synthesis of compounds having complementary structure to a desired molecular entity and use thereof
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US6379599B1 (en) * 2000-01-10 2002-04-30 Council Of Scientific And Industrial Research Process for the preparation of molecularly imprinted polymers useful for separation of enzymes
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WO2002059184A2 (en) * 2001-01-24 2002-08-01 Virginia Commonwealth University Molecular imprinting of small particles, and production of small particles from solid state reactants
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GB0511116D0 (en) * 2005-06-01 2005-07-06 Univ Cranfield Preparation of soluble and collodial imprinted polymers by living polymerization

Also Published As

Publication number Publication date
EP1988993A2 (en) 2008-11-12
JP2009527471A (ja) 2009-07-30
AU2007218396A1 (en) 2007-08-30
KR20080096834A (ko) 2008-11-03
RU2437665C2 (ru) 2011-12-27
IL193416A0 (en) 2009-05-04
IL193416A (en) 2013-02-28
WO2007095949A2 (en) 2007-08-30
CA2642097A1 (en) 2007-08-30
DK1988993T3 (da) 2019-07-01
WO2007095949A3 (en) 2008-01-10
KR101475528B1 (ko) 2014-12-22
ES2736148T3 (es) 2019-12-26
RU2008134011A (ru) 2010-03-27
US20090104277A1 (en) 2009-04-23
AU2007218396B2 (en) 2011-07-28
EP1988993B1 (en) 2019-04-17
US8287908B2 (en) 2012-10-16
AU2007218396C1 (en) 2013-01-17

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