CA2641254A1 - Pyrrolo(3,2-c) pyridines useful as inhibitors of protein kinases - Google Patents

Pyrrolo(3,2-c) pyridines useful as inhibitors of protein kinases Download PDF

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Publication number
CA2641254A1
CA2641254A1 CA002641254A CA2641254A CA2641254A1 CA 2641254 A1 CA2641254 A1 CA 2641254A1 CA 002641254 A CA002641254 A CA 002641254A CA 2641254 A CA2641254 A CA 2641254A CA 2641254 A1 CA2641254 A1 CA 2641254A1
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Canada
Prior art keywords
aliphatic
disease
ring
compound according
compound
Prior art date
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Abandoned
Application number
CA002641254A
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English (en)
French (fr)
Inventor
Juan-Miguel Jimenez
Philip Collier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
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Individual
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Filing date
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Publication of CA2641254A1 publication Critical patent/CA2641254A1/en
Abandoned legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/12Drugs for disorders of the urinary system of the kidneys
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    • A61P3/04Anorexiants; Antiobesity agents
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    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
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    • A61P31/12Antivirals
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    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
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    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
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    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • AIDS & HIV (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Tropical Medicine & Parasitology (AREA)
CA002641254A 2006-02-14 2007-02-12 Pyrrolo(3,2-c) pyridines useful as inhibitors of protein kinases Abandoned CA2641254A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77314306P 2006-02-14 2006-02-14
US60/773,143 2006-02-14
PCT/US2007/003767 WO2007095223A2 (en) 2006-02-14 2007-02-12 Pyrrolo(3,2-c) pyridines useful as inhibitors of protein kinases

Publications (1)

Publication Number Publication Date
CA2641254A1 true CA2641254A1 (en) 2007-08-23

Family

ID=38180574

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002641254A Abandoned CA2641254A1 (en) 2006-02-14 2007-02-12 Pyrrolo(3,2-c) pyridines useful as inhibitors of protein kinases

Country Status (7)

Country Link
US (1) US7659283B2 (de)
EP (1) EP2004645A2 (de)
JP (1) JP2009528991A (de)
CN (1) CN101848909A (de)
AU (1) AU2007215161A1 (de)
CA (1) CA2641254A1 (de)
WO (1) WO2007095223A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9512125B2 (en) 2004-11-19 2016-12-06 The Regents Of The University Of California Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents
TW201412738A (zh) 2006-01-17 2014-04-01 Vertex Pharma 適合作為傑納斯激酶(janus kinase)抑制劑之氮雜吲哚
PT2004654E (pt) 2006-04-04 2013-08-27 Univ California Derivados de pirazolopirimidina para utilização como antagonistas da quinase
US8247421B2 (en) 2006-12-21 2012-08-21 Vertex Pharmaceuticals Incorporated 5-cyano-4-(pyrrolo [2,3B] pyridine-3-yl)-pyrimidine derivatives useful as protein kinase inhibitors
WO2009046448A1 (en) 2007-10-04 2009-04-09 Intellikine, Inc. Chemical entities and therapeutic uses thereof
JP2011513483A (ja) * 2008-03-10 2011-04-28 バーテックス ファーマシューティカルズ インコーポレイテッド タンパク質キナーゼの阻害剤として有用なピリミジンおよびピリジン
WO2009114874A2 (en) 2008-03-14 2009-09-17 Intellikine, Inc. Benzothiazole kinase inhibitors and methods of use
WO2009114870A2 (en) 2008-03-14 2009-09-17 Intellikine, Inc. Kinase inhibitors and methods of use
KR20110039326A (ko) 2008-07-08 2011-04-15 인텔리카인, 인크. 키나제 억제제 및 사용 방법
US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
NZ597059A (en) 2009-06-17 2014-01-31 Vertex Pharma Inhibitors of influenza viruses replication
US8980899B2 (en) 2009-10-16 2015-03-17 The Regents Of The University Of California Methods of inhibiting Ire1
KR101173678B1 (ko) 2010-10-20 2012-08-13 한국과학기술연구원 피롤로[3,2-c]피리딘 유도체 및 그의 제조 방법
CN103492381A (zh) 2010-12-16 2014-01-01 沃泰克斯药物股份有限公司 流感病毒复制的抑制剂
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
CA2846496C (en) 2011-09-02 2020-07-14 The Regents Of The University Of California Substituted pyrazolo[3,4-d]pyrimidines and uses thereof
CA2886240A1 (en) 2012-09-26 2014-04-03 The Regents Of The University Of California Modulation of ire1
JP6084291B2 (ja) 2013-07-18 2017-02-22 大鵬薬品工業株式会社 Fgfr阻害剤の間歇投与用抗腫瘍剤
JP6084292B2 (ja) 2013-07-18 2017-02-22 大鵬薬品工業株式会社 Fgfr阻害剤耐性癌の治療薬
EP3068776B1 (de) 2013-11-13 2019-05-29 Vertex Pharmaceuticals Incorporated Hemmer der influenzavirenreplikation
RU2019104421A (ru) 2013-11-13 2019-04-17 Вертекс Фармасьютикалз Инкорпорейтед Способы получения ингибиторов репликации вирусов гриппа
AU2015296210B2 (en) 2014-07-31 2019-08-15 Merck Patent Gmbh Indolizine derivatives which are applicable to neurodegenerative diseases
WO2016183116A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
WO2016183120A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
PL3426637T3 (pl) * 2016-03-11 2022-05-30 Angel Pharmaceutical Co., Ltd. Związki i sposoby modulowania kinazy tyrozynowej brutona

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
PT888353E (pt) * 1996-03-15 2003-11-28 Novartis Ag Novas n-7-heterociclil-pirrolo¬2,3-d|pirimidinas e sua aplicacao
IL135302A0 (en) * 1997-10-20 2001-05-20 Hoffmann La Roche Bicyclic kinase inhibitors
WO2000017203A1 (en) * 1998-09-18 2000-03-30 Basf Aktiengesellschaft Pyrrolopyrimidines as protein kinase inhibitors
PL347138A1 (en) * 1998-09-18 2002-03-25 Basf Ag 4-aminopyrrolopyrimidines as kinase inhibitors
EP1058549A4 (de) * 1998-12-23 2003-11-12 Bristol Myers Squibb Pharma Co THROMBIN- ODER FAKTOR-Xa HEMMER
WO2003009852A1 (en) * 2001-07-24 2003-02-06 Merck & Co., Inc. Tyrosine kinase inhibitors
US20050026944A1 (en) * 2003-07-24 2005-02-03 Patrick Betschmann Thienopyridine and furopyridine kinase inhibitors
TW200538453A (en) * 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
CA2572058A1 (en) * 2004-06-30 2006-01-12 Vertex Pharmaceuticals Incorporated Azaindoles useful as inhibitors of protein kinases
JP5033119B2 (ja) * 2005-04-25 2012-09-26 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング キナーゼ阻害剤としての新規アザ複素環化合物

Also Published As

Publication number Publication date
JP2009528991A (ja) 2009-08-13
CN101848909A (zh) 2010-09-29
EP2004645A2 (de) 2008-12-24
AU2007215161A1 (en) 2007-08-23
US7659283B2 (en) 2010-02-09
US20070213327A1 (en) 2007-09-13
WO2007095223A3 (en) 2010-06-24
WO2007095223A2 (en) 2007-08-23

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FZDE Discontinued

Effective date: 20140212