CA2632774C - Inhaler with breath actuated dose counter - Google Patents
Inhaler with breath actuated dose counter Download PDFInfo
- Publication number
- CA2632774C CA2632774C CA2632774A CA2632774A CA2632774C CA 2632774 C CA2632774 C CA 2632774C CA 2632774 A CA2632774 A CA 2632774A CA 2632774 A CA2632774 A CA 2632774A CA 2632774 C CA2632774 C CA 2632774C
- Authority
- CA
- Canada
- Prior art keywords
- inhaler
- link member
- restraining
- container
- link
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000008878 coupling Effects 0.000 claims abstract description 7
- 238000010168 coupling process Methods 0.000 claims abstract description 7
- 238000005859 coupling reaction Methods 0.000 claims abstract description 7
- 239000003814 drug Substances 0.000 claims description 59
- 230000000452 restraining effect Effects 0.000 claims description 53
- 230000004044 response Effects 0.000 claims description 19
- 239000012530 fluid Substances 0.000 abstract description 124
- 230000002401 inhibitory effect Effects 0.000 abstract description 3
- 238000007599 discharging Methods 0.000 abstract description 2
- 230000007246 mechanism Effects 0.000 description 39
- 239000000428 dust Substances 0.000 description 27
- 229940071648 metered dose inhaler Drugs 0.000 description 9
- 230000000717 retained effect Effects 0.000 description 9
- 210000000629 knee joint Anatomy 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 230000013011 mating Effects 0.000 description 4
- 230000006835 compression Effects 0.000 description 3
- 238000007906 compression Methods 0.000 description 3
- 210000003127 knee Anatomy 0.000 description 3
- 239000003380 propellant Substances 0.000 description 3
- 238000004891 communication Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000003414 extremity Anatomy 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 241000237983 Trochidae Species 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000036316 preload Effects 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0091—Inhalators mechanically breath-triggered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/007—Mechanical counters
- A61M15/0071—Mechanical counters having a display or indicator
- A61M15/0073—Mechanical counters having a display or indicator on a ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/007—Mechanical counters
- A61M15/0071—Mechanical counters having a display or indicator
- A61M15/0075—Mechanical counters having a display or indicator on a disc
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/008—Electronic counters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0091—Inhalators mechanically breath-triggered
- A61M15/0093—Inhalators mechanically breath-triggered without arming or cocking, e.g. acting directly on the delivery valve
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0091—Inhalators mechanically breath-triggered
- A61M15/0095—Preventing manual activation in absence of inhalation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0091—Inhalators mechanically breath-triggered
- A61M15/0096—Hindering inhalation before activation of the dispenser
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/299,307 US7600512B2 (en) | 2003-07-14 | 2005-12-09 | Inhaler with breath actuated dose counter |
| US11/299,307 | 2005-12-09 | ||
| PCT/GB2006/004624 WO2007066140A1 (en) | 2005-12-09 | 2006-12-08 | Inhaler with breath actuated dose counter |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2632774A1 CA2632774A1 (en) | 2007-06-14 |
| CA2632774C true CA2632774C (en) | 2016-01-12 |
Family
ID=37722119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2632774A Active CA2632774C (en) | 2005-12-09 | 2006-12-08 | Inhaler with breath actuated dose counter |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7600512B2 (enExample) |
| EP (1) | EP1962933B1 (enExample) |
| JP (1) | JP2009518095A (enExample) |
| AU (1) | AU2006323446A1 (enExample) |
| CA (1) | CA2632774C (enExample) |
| CY (1) | CY1116619T1 (enExample) |
| DK (1) | DK1962933T3 (enExample) |
| ES (1) | ES2543961T3 (enExample) |
| HU (1) | HUE025128T2 (enExample) |
| NZ (1) | NZ569721A (enExample) |
| PL (1) | PL1962933T3 (enExample) |
| PT (1) | PT1962933E (enExample) |
| SI (1) | SI1962933T1 (enExample) |
| WO (1) | WO2007066140A1 (enExample) |
| ZA (1) | ZA200805953B (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0425518D0 (en) | 2004-11-19 | 2004-12-22 | Clinical Designs Ltd | Substance source |
| GB0518400D0 (en) | 2005-09-09 | 2005-10-19 | Clinical Designs Ltd | Dispenser |
| JP4765526B2 (ja) * | 2005-10-04 | 2011-09-07 | オムロンヘルスケア株式会社 | 吸入器および吸入器用マウスピース |
| DE102006029753A1 (de) * | 2006-03-10 | 2007-09-13 | Alfred Von Schuckmann | Inhalator für pulverförmige Substanzen |
| US20110030700A1 (en) * | 2006-08-30 | 2011-02-10 | Wilson John K | Snoring Treatment and Associated Apparatus, System and Method |
| US7775211B2 (en) * | 2006-08-30 | 2010-08-17 | Wilson John K | Snoring treatment and associated apparatus, system and method |
| FR2924351B1 (fr) * | 2007-12-03 | 2011-09-30 | Valois Sas | Dispositif de distribution de produit fluide |
| EP2077132A1 (en) | 2008-01-02 | 2009-07-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device, storage device and method for dispensing a formulation |
| GB2461752B (en) * | 2008-07-14 | 2013-04-17 | Neo Inhalation Products Ltd | Metered dose inhaler |
| WO2010067240A1 (en) * | 2008-12-11 | 2010-06-17 | Koninklijke Philips Electronics, N.V. | System and method for monitoring a metered dose inhaler |
| GB0904059D0 (en) | 2009-03-10 | 2009-04-22 | Euro Celtique Sa | Counter |
| GB0904040D0 (en) | 2009-03-10 | 2009-04-22 | Euro Celtique Sa | Counter |
| US10011906B2 (en) | 2009-03-31 | 2018-07-03 | Beohringer Ingelheim International Gmbh | Method for coating a surface of a component |
| EP3508239B1 (de) | 2009-05-18 | 2020-12-23 | Boehringer Ingelheim International GmbH | Adapter, inhalationseinrichtung und zerstäuber |
| JP5658268B2 (ja) | 2009-11-25 | 2015-01-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ネブライザ |
| EA026241B1 (ru) * | 2009-11-25 | 2017-03-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Распылитель |
| US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
| US9545488B2 (en) | 2010-01-12 | 2017-01-17 | Dance Biopharm Inc. | Preservative-free single dose inhaler systems |
| US20130269684A1 (en) | 2012-04-16 | 2013-10-17 | Dance Pharmaceuticals, Inc. | Methods and systems for supplying aerosolization devices with liquid medicaments |
| US8950394B2 (en) | 2010-01-12 | 2015-02-10 | Dance Biopharm Inc. | Preservative-free single dose inhaler systems |
| JP5874724B2 (ja) | 2010-06-24 | 2016-03-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ネブライザ |
| US9757528B2 (en) | 2010-08-23 | 2017-09-12 | Darren Rubin | Nebulizer having different negative pressure threshold settings |
| WO2012026963A2 (en) | 2010-08-23 | 2012-03-01 | Darren Rubin | Systems and methods of aerosol delivery with airflow regulation |
| EP2694220B1 (de) | 2011-04-01 | 2020-05-06 | Boehringer Ingelheim International GmbH | Medizinisches gerät mit behälter |
| US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
| US9202164B2 (en) | 2011-09-26 | 2015-12-01 | Trudell Medical International | Dose counter and medication delivery device |
| WO2013152894A1 (de) | 2012-04-13 | 2013-10-17 | Boehringer Ingelheim International Gmbh | Zerstäuber mit kodiermitteln |
| GB201304784D0 (en) * | 2013-03-15 | 2013-05-01 | Euro Celtique Sa | Dispenser |
| EP3030298B1 (en) | 2013-08-09 | 2017-10-11 | Boehringer Ingelheim International GmbH | Nebulizer |
| ES2836977T3 (es) | 2013-08-09 | 2021-06-28 | Boehringer Ingelheim Int | Nebulizador |
| USD771800S1 (en) * | 2013-08-28 | 2016-11-15 | Gecko Health Innovations, Inc. | Inhaler cap |
| PL3116570T3 (pl) * | 2014-03-29 | 2020-07-13 | Cipla (Eu) Limited | Urządzenie inhalatora |
| WO2015169732A1 (en) | 2014-05-07 | 2015-11-12 | Boehringer Ingelheim International Gmbh | Container, nebulizer and use |
| ES2874029T3 (es) | 2014-05-07 | 2021-11-04 | Boehringer Ingelheim Int | Nebulizador |
| AU2015258107B2 (en) | 2014-05-07 | 2019-12-19 | Boehringer Ingelheim International Gmbh | Nebulizer |
| US10307550B2 (en) | 2014-06-09 | 2019-06-04 | Dance Biopharm Inc. | Liquid drug cartridges and associated dispenser |
| GB2528068B (en) * | 2014-07-08 | 2017-02-15 | Kind Consumer Ltd | An inhaler |
| SG11201610399VA (en) | 2014-06-30 | 2017-01-27 | Chiesi Farma Spa | Dry powder inhaler and inhalation actuated mechanism thereof |
| US10857313B2 (en) | 2014-07-01 | 2020-12-08 | Aerami Therapeutics, Inc. | Liquid nebulization systems and methods |
| US11273271B2 (en) | 2014-07-01 | 2022-03-15 | Aerami Therapeutics, Inc. | Aerosolization system with flow restrictor and feedback device |
| US10471222B2 (en) | 2014-07-01 | 2019-11-12 | Dance Biopharm Inc. | Aerosolization system with flow restrictor and feedback device |
| USD798438S1 (en) | 2014-08-27 | 2017-09-26 | Gecko Health Innovations, Inc. | Inhaler cap |
| US20170361036A1 (en) * | 2016-06-15 | 2017-12-21 | Virgilant Technologies Limited | Electronic inhaling device |
| GB2553534A (en) | 2016-09-07 | 2018-03-14 | 3M Innovative Properties Co | Trigger mechanism for an inhaler |
| GB2553535A (en) * | 2016-09-07 | 2018-03-14 | 3M Innovative Properties Co | Trigger mechansim for an inhaler |
| GB201706505D0 (en) | 2017-04-25 | 2017-06-07 | 3M Innovative Properties Co | Medicinal inhaler drive mechanism |
| FR3068894B1 (fr) * | 2017-07-11 | 2019-08-09 | Aptar France Sas | Dispositif de distribution de produit fluide. |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3565070A (en) * | 1969-02-28 | 1971-02-23 | Riker Laboratories Inc | Inhalation actuable aerosol dispenser |
| US3636949A (en) | 1969-08-08 | 1972-01-25 | Armstrong Kropp Dev Corp | Inhalation-initiated aerosol dispenser |
| US4972830A (en) * | 1985-07-31 | 1990-11-27 | Vortran Medical Technology, Inc. | Inhalation device and method |
| US5119806A (en) * | 1987-05-12 | 1992-06-09 | Glaxo Inc. | Inhalation device |
| DE3751272T2 (de) | 1987-09-22 | 1995-09-28 | Vortran Medical Technology Inc | Inhalationsvorrichtung und Methode. |
| GB8919131D0 (en) * | 1989-08-23 | 1989-10-04 | Riker Laboratories Inc | Inhaler |
| GB9025654D0 (en) | 1990-11-26 | 1991-01-09 | Riker Laboratories Inc | Device |
| GB9026191D0 (en) | 1990-12-01 | 1991-01-16 | Harris Pharma Ltd | Breath actuated dispensing device |
| GB9211436D0 (en) | 1992-05-29 | 1992-07-15 | Norton Healthcare Ltd | Dose indicating device |
| GB9217545D0 (en) | 1992-08-18 | 1992-09-30 | Minnesota Mining & Mfg | Inhalation device |
| CA2165961C (en) | 1993-06-29 | 2005-08-30 | Robert Martin Voges | Dispenser |
| US5564414A (en) * | 1994-05-26 | 1996-10-15 | Walker; William F. | Pressurized and metered medication dose counter on removable sleeve |
| GB2292891A (en) | 1994-09-07 | 1996-03-13 | Norton Healthcare Ltd | Actuator for breath-actuated medicament dispenser |
| US5544647A (en) | 1994-11-29 | 1996-08-13 | Iep Group, Inc. | Metered dose inhalator |
| FR2750780B1 (fr) * | 1996-07-05 | 1998-10-30 | Valois | Compteur de doses |
| AU729716B2 (en) | 1997-05-23 | 2001-02-08 | Pa Knowledge Limited | Inhaler mechanism |
| TW533865U (en) | 1997-06-10 | 2003-05-21 | Glaxo Group Ltd | Dispenser for dispensing medicament and actuation indicating device |
| GB9807558D0 (en) * | 1998-04-09 | 1998-06-10 | Bason Neil P | An indicator device |
| BR9913921A (pt) | 1998-09-24 | 2001-06-19 | Astrazeneca Ab | Inalador para aporte de medicamento por inalação |
| GB0121568D0 (en) * | 2001-09-06 | 2001-10-24 | Optinose As | Nasal delivery device |
| US7171965B2 (en) * | 2000-02-01 | 2007-02-06 | Valois S.A.S. | Breath actuated dry powder inhaler and tape dose strip |
| GB2360218A (en) | 2000-03-18 | 2001-09-19 | Astrazeneca Uk Ltd | Inhaler |
| TWI224513B (en) | 2000-06-23 | 2004-12-01 | Norton Healthcare Ltd | Dose counter for medicament inhaler |
| SE517228C2 (sv) * | 2000-09-25 | 2002-05-14 | Microdrug Ag | Inhalator för torrt pulver med andningsaktivering |
| DK1357965T3 (en) | 2001-01-25 | 2014-12-15 | Clinical Designs Ltd | Dispenser for drug |
| GB0101944D0 (en) | 2001-01-25 | 2001-03-07 | Bacon Raymond J | Dispenser |
| GB2372541B (en) * | 2001-02-23 | 2003-08-20 | Bespak Plc | Dosage counting devices |
| GB0222295D0 (en) * | 2002-09-25 | 2002-10-30 | 3M Innovative Properties Co | Breath actuated medicament dispensing devices |
| US20060231093A1 (en) * | 2002-11-04 | 2006-10-19 | Simon Burge | Pressurised inhalers |
-
2005
- 2005-12-09 US US11/299,307 patent/US7600512B2/en active Active
-
2006
- 2006-12-08 PL PL06820487T patent/PL1962933T3/pl unknown
- 2006-12-08 DK DK06820487.4T patent/DK1962933T3/en active
- 2006-12-08 HU HUE06820487A patent/HUE025128T2/en unknown
- 2006-12-08 ZA ZA200805953A patent/ZA200805953B/xx unknown
- 2006-12-08 SI SI200631963T patent/SI1962933T1/sl unknown
- 2006-12-08 AU AU2006323446A patent/AU2006323446A1/en not_active Abandoned
- 2006-12-08 EP EP06820487.4A patent/EP1962933B1/en active Active
- 2006-12-08 PT PT68204874T patent/PT1962933E/pt unknown
- 2006-12-08 NZ NZ569721A patent/NZ569721A/en unknown
- 2006-12-08 JP JP2008543913A patent/JP2009518095A/ja not_active Withdrawn
- 2006-12-08 ES ES06820487.4T patent/ES2543961T3/es active Active
- 2006-12-08 CA CA2632774A patent/CA2632774C/en active Active
- 2006-12-08 WO PCT/GB2006/004624 patent/WO2007066140A1/en not_active Ceased
-
2015
- 2015-08-13 CY CY20151100712T patent/CY1116619T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL1962933T3 (pl) | 2015-10-30 |
| HUE025128T2 (en) | 2016-01-28 |
| CA2632774A1 (en) | 2007-06-14 |
| AU2006323446A1 (en) | 2007-06-14 |
| US7600512B2 (en) | 2009-10-13 |
| PT1962933E (pt) | 2015-10-12 |
| EP1962933A1 (en) | 2008-09-03 |
| DK1962933T3 (en) | 2015-08-17 |
| ES2543961T3 (es) | 2015-08-26 |
| NZ569721A (en) | 2011-06-30 |
| US20060150971A1 (en) | 2006-07-13 |
| ZA200805953B (en) | 2009-10-28 |
| JP2009518095A (ja) | 2009-05-07 |
| HK1119608A1 (en) | 2009-03-13 |
| SI1962933T1 (sl) | 2015-10-30 |
| CY1116619T1 (el) | 2017-03-15 |
| WO2007066140A1 (en) | 2007-06-14 |
| EP1962933B1 (en) | 2015-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |