CA2628927C - Mass spectrometer - Google Patents
Mass spectrometer Download PDFInfo
- Publication number
- CA2628927C CA2628927C CA2628927A CA2628927A CA2628927C CA 2628927 C CA2628927 C CA 2628927C CA 2628927 A CA2628927 A CA 2628927A CA 2628927 A CA2628927 A CA 2628927A CA 2628927 C CA2628927 C CA 2628927C
- Authority
- CA
- Canada
- Prior art keywords
- parent
- ions
- precursor ions
- mass
- ion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000002500 ions Chemical class 0.000 claims abstract description 1243
- 238000013467 fragmentation Methods 0.000 claims abstract description 426
- 238000006062 fragmentation reaction Methods 0.000 claims abstract description 426
- 238000000034 method Methods 0.000 claims abstract description 45
- 238000001077 electron transfer detection Methods 0.000 claims abstract description 38
- 238000004949 mass spectrometry Methods 0.000 claims abstract description 20
- 239000002243 precursor Substances 0.000 claims description 567
- 238000006243 chemical reaction Methods 0.000 claims description 278
- 239000012634 fragment Substances 0.000 claims description 253
- 238000001211 electron capture detection Methods 0.000 claims description 38
- 238000005040 ion trap Methods 0.000 claims description 33
- 239000003153 chemical reaction reagent Substances 0.000 claims description 18
- 238000011144 upstream manufacturing Methods 0.000 claims description 12
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 claims description 8
- 238000003795 desorption Methods 0.000 claims description 7
- 230000001133 acceleration Effects 0.000 claims description 6
- 238000010265 fast atom bombardment Methods 0.000 claims description 6
- 238000009616 inductively coupled plasma Methods 0.000 claims description 6
- 238000001698 laser desorption ionisation Methods 0.000 claims description 6
- 238000004992 fast atom bombardment mass spectroscopy Methods 0.000 claims description 5
- 230000005405 multipole Effects 0.000 claims description 5
- 238000000688 desorption electrospray ionisation Methods 0.000 claims description 4
- 238000000132 electrospray ionisation Methods 0.000 claims description 4
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims description 3
- 238000004252 FT/ICR mass spectrometry Methods 0.000 claims description 3
- 101000823051 Homo sapiens Amyloid-beta precursor protein Proteins 0.000 claims description 3
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims description 3
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims description 3
- 208000035699 Distal ileal obstruction syndrome Diseases 0.000 claims description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 2
- 238000000451 chemical ionisation Methods 0.000 claims description 2
- PXHVJJICTQNCMI-RNFDNDRNSA-N nickel-63 Chemical compound [63Ni] PXHVJJICTQNCMI-RNFDNDRNSA-N 0.000 claims description 2
- 238000004150 penning trap Methods 0.000 claims description 2
- 230000002285 radioactive effect Effects 0.000 claims description 2
- 229910052710 silicon Inorganic materials 0.000 claims description 2
- 239000010703 silicon Substances 0.000 claims description 2
- 238000001819 mass spectrum Methods 0.000 abstract description 84
- 238000010494 dissociation reaction Methods 0.000 abstract description 70
- 230000005593 dissociations Effects 0.000 abstract description 69
- 238000004458 analytical method Methods 0.000 abstract description 25
- 108090000765 processed proteins & peptides Proteins 0.000 description 91
- 238000010828 elution Methods 0.000 description 55
- 102000004169 proteins and genes Human genes 0.000 description 46
- 108090000623 proteins and genes Proteins 0.000 description 46
- 235000018102 proteins Nutrition 0.000 description 45
- 102000004196 processed proteins & peptides Human genes 0.000 description 26
- 238000001228 spectrum Methods 0.000 description 21
- 230000005855 radiation Effects 0.000 description 18
- 239000005018 casein Substances 0.000 description 17
- 102000011632 Caseins Human genes 0.000 description 16
- 108010076119 Caseins Proteins 0.000 description 16
- 238000001360 collision-induced dissociation Methods 0.000 description 16
- 239000007789 gas Substances 0.000 description 16
- 238000005259 measurement Methods 0.000 description 16
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 15
- 235000021240 caseins Nutrition 0.000 description 15
- 239000012491 analyte Substances 0.000 description 14
- 239000000203 mixture Substances 0.000 description 14
- 101000693922 Bos taurus Albumin Proteins 0.000 description 11
- 210000004027 cell Anatomy 0.000 description 11
- 102000004190 Enzymes Human genes 0.000 description 10
- 108090000790 Enzymes Proteins 0.000 description 10
- 230000015556 catabolic process Effects 0.000 description 9
- 238000006731 degradation reaction Methods 0.000 description 9
- 230000005684 electric field Effects 0.000 description 9
- 238000001976 enzyme digestion Methods 0.000 description 9
- 239000007788 liquid Substances 0.000 description 9
- 230000014759 maintenance of location Effects 0.000 description 9
- 229920001184 polypeptide Polymers 0.000 description 9
- 238000004587 chromatography analysis Methods 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 101100476210 Caenorhabditis elegans rnt-1 gene Proteins 0.000 description 6
- 239000003480 eluent Substances 0.000 description 6
- 238000004128 high performance liquid chromatography Methods 0.000 description 6
- 238000000926 separation method Methods 0.000 description 6
- -1 daughter Substances 0.000 description 5
- 230000007935 neutral effect Effects 0.000 description 5
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
- 102100040094 Glycogen phosphorylase, brain form Human genes 0.000 description 4
- 101000748183 Homo sapiens Glycogen phosphorylase, brain form Proteins 0.000 description 4
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 4
- 239000002356 single layer Substances 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- 230000001052 transient effect Effects 0.000 description 4
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 3
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 3
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 3
- 239000004215 Carbon black (E152) Substances 0.000 description 3
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 229940024606 amino acid Drugs 0.000 description 3
- 150000001413 amino acids Chemical group 0.000 description 3
- 229960001230 asparagine Drugs 0.000 description 3
- 235000009582 asparagine Nutrition 0.000 description 3
- 230000004323 axial length Effects 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 238000005251 capillar electrophoresis Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 3
- 238000004817 gas chromatography Methods 0.000 description 3
- 229930195733 hydrocarbon Natural products 0.000 description 3
- 150000002430 hydrocarbons Chemical class 0.000 description 3
- 238000004811 liquid chromatography Methods 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 230000004481 post-translational protein modification Effects 0.000 description 3
- 239000002094 self assembled monolayer Substances 0.000 description 3
- 239000013545 self-assembled monolayer Substances 0.000 description 3
- 230000003595 spectral effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 229920002527 Glycogen Polymers 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000003570 air Substances 0.000 description 2
- 125000000539 amino acid group Chemical group 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 229910052786 argon Inorganic materials 0.000 description 2
- 210000004899 c-terminal region Anatomy 0.000 description 2
- 238000001962 electrophoresis Methods 0.000 description 2
- 229940096919 glycogen Drugs 0.000 description 2
- 239000001307 helium Substances 0.000 description 2
- 229910052734 helium Inorganic materials 0.000 description 2
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000002545 neutral loss scan Methods 0.000 description 2
- 238000002542 parent ion scan Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 235000011007 phosphoric acid Nutrition 0.000 description 2
- 230000026731 phosphorylation Effects 0.000 description 2
- 238000006366 phosphorylation reaction Methods 0.000 description 2
- 238000002541 precursor ion scan Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 239000003643 water by type Substances 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 108010000675 CEI12 peptide Proteins 0.000 description 1
- 102000002068 Glycopeptides Human genes 0.000 description 1
- 108010015899 Glycopeptides Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- ILZZTQYNTRWQSJ-UHFFFAOYSA-N Phe-Phe-Val-Ala-Pro-Phe-Pro-Glu-Val-Phe-Gly-Lys Natural products CC(C)C(NC(=O)C(Cc1ccccc1)NC(=O)C(N)Cc2ccccc2)C(=O)NC(C)C(=O)N3CCCC3C(=O)NC(Cc4ccccc4)C(=O)N5CCCC5C(=O)NC(CCC(=O)O)C(=O)NC(C(C)C)C(=O)NC(Cc6ccccc6)C(=O)NCC(=O)NC(CCCCN)C(=O)O ILZZTQYNTRWQSJ-UHFFFAOYSA-N 0.000 description 1
- 108010065081 Phosphorylase b Proteins 0.000 description 1
- 102000006382 Ribonucleases Human genes 0.000 description 1
- 108010083644 Ribonucleases Proteins 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 238000005349 anion exchange Methods 0.000 description 1
- 238000005571 anion exchange chromatography Methods 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 238000005341 cation exchange Methods 0.000 description 1
- 238000005277 cation exchange chromatography Methods 0.000 description 1
- 230000004637 cellular stress Effects 0.000 description 1
- 150000001793 charged compounds Chemical class 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000011033 desalting Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000000766 differential mobility spectroscopy Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000012489 doughnuts Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000004232 ion pair reversed phase chromatography Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000002705 metabolomic analysis Methods 0.000 description 1
- 230000001431 metabolomic effect Effects 0.000 description 1
- 238000001844 multi-dimensional electrophoresis Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 238000012510 peptide mapping method Methods 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 108091005981 phosphorylated proteins Proteins 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
- H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0027—Methods for using particle spectrometers
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nanotechnology (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Composite Materials (AREA)
- General Physics & Mathematics (AREA)
- Materials Engineering (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physics & Mathematics (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2835042A CA2835042A1 (en) | 2005-11-23 | 2006-11-23 | Mass spectrometer |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/286,262 US20060138320A1 (en) | 2002-07-24 | 2005-11-23 | Mass spectrometer |
| GB0523811.8 | 2005-11-23 | ||
| GBGB0523811.8A GB0523811D0 (en) | 2005-11-23 | 2005-11-23 | Mass stectrometer |
| US11/286,262 | 2005-11-23 | ||
| PCT/GB2006/004387 WO2007060437A2 (en) | 2005-11-23 | 2006-11-23 | Mass spectrometer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2835042A Division CA2835042A1 (en) | 2005-11-23 | 2006-11-23 | Mass spectrometer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2628927A1 CA2628927A1 (en) | 2007-05-31 |
| CA2628927C true CA2628927C (en) | 2017-09-05 |
Family
ID=35601031
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2835042A Abandoned CA2835042A1 (en) | 2005-11-23 | 2006-11-23 | Mass spectrometer |
| CA2628927A Expired - Fee Related CA2628927C (en) | 2005-11-23 | 2006-11-23 | Mass spectrometer |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2835042A Abandoned CA2835042A1 (en) | 2005-11-23 | 2006-11-23 | Mass spectrometer |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1952425A2 (ja) |
| JP (1) | JP4959713B2 (ja) |
| CA (2) | CA2835042A1 (ja) |
| GB (4) | GB0523811D0 (ja) |
| WO (1) | WO2007060437A2 (ja) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0806725D0 (en) * | 2008-04-14 | 2008-05-14 | Micromass Ltd | Mass spectrometer |
| GB0810125D0 (en) | 2008-06-03 | 2008-07-09 | Thermo Fisher Scient Bremen | Collosion cell |
| US8604419B2 (en) | 2010-02-04 | 2013-12-10 | Thermo Fisher Scientific (Bremen) Gmbh | Dual ion trapping for ion/ion reactions in a linear RF multipole trap with an additional DC gradient |
| GB201019337D0 (en) * | 2010-11-16 | 2010-12-29 | Micromass Ltd | Controlling hydrogen-deuterium exchange on a spectrum by spectrum basis |
| WO2013171494A2 (en) * | 2012-05-18 | 2013-11-21 | Micromass Uk Limited | IMPROVED METHOD OF MSe MASS SPECTROMETRY |
| RU2673551C2 (ru) * | 2012-11-12 | 2018-11-28 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт биомедицинской химии им. В.Н. Ореховича" Российской академии медицинских наук (ФГБУ "ИБМХ" РАМН) | Протеотипический пептид q9y4w6-02 и способ масс-спектрометрического анализа содержания afg3-подобного белка человека на его основе |
| EP2924425B1 (en) | 2012-11-22 | 2019-09-11 | Shimadzu Corporation | Tandem quadrupole mass spectrometer |
| GB201406981D0 (en) * | 2014-04-17 | 2014-06-04 | Micromass Ltd | Hybrid acquisition method incorporating electron transfer dissociation triggered from fast sequential 2D MS/MS collision induced dissociation |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3300602B2 (ja) * | 1996-06-20 | 2002-07-08 | 株式会社日立製作所 | 大気圧イオン化イオントラップ質量分析方法及び装置 |
| US6323482B1 (en) * | 1997-06-02 | 2001-11-27 | Advanced Research And Technology Institute, Inc. | Ion mobility and mass spectrometer |
| JP2000241390A (ja) * | 1999-02-17 | 2000-09-08 | Japan Atom Energy Res Inst | 中性種の解離を用いる電荷逆転質量分析法 |
| US6545268B1 (en) * | 2000-04-10 | 2003-04-08 | Perseptive Biosystems | Preparation of ion pulse for time-of-flight and for tandem time-of-flight mass analysis |
| CA2340150C (en) * | 2000-06-09 | 2005-11-22 | Micromass Limited | Methods and apparatus for mass spectrometry |
| DE60210056T2 (de) * | 2001-03-22 | 2006-11-16 | Syddansk Universitet | Massenspektrometrisches Verfahren mit Elektroneneinfang durch Ionen und Massenspektrometer zum Durchführen des Verfahrens |
| US6744040B2 (en) * | 2001-06-13 | 2004-06-01 | Bruker Daltonics, Inc. | Means and method for a quadrupole surface induced dissociation quadrupole time-of-flight mass spectrometer |
| GB0121172D0 (en) * | 2001-08-31 | 2001-10-24 | Shimadzu Res Lab Europe Ltd | A method for dissociating ions using a quadrupole ion trap device |
| JP4161125B2 (ja) * | 2002-04-24 | 2008-10-08 | 滋雄 早川 | 質量分析法および質量分析装置 |
| CA2643534C (en) * | 2002-05-31 | 2011-08-02 | Analytica Of Branford, Inc. | Fragmentation methods for mass spectrometry |
| GB2390935A (en) * | 2002-07-16 | 2004-01-21 | Anatoli Nicolai Verentchikov | Time-nested mass analysis using a TOF-TOF tandem mass spectrometer |
| GB0305796D0 (en) * | 2002-07-24 | 2003-04-16 | Micromass Ltd | Method of mass spectrometry and a mass spectrometer |
| AU2002952747A0 (en) * | 2002-11-18 | 2002-12-05 | Ludwig Institute For Cancer Research | Method for analysing peptides |
| EP1597749A2 (en) * | 2003-02-21 | 2005-11-23 | The Johns Hopkins University School Of Medicine | Tandem time-of-flight mass spectrometer |
| GB2402260B (en) * | 2003-05-30 | 2006-05-24 | Thermo Finnigan Llc | All mass MS/MS method and apparatus |
| JP4275545B2 (ja) * | 2004-02-17 | 2009-06-10 | 株式会社日立ハイテクノロジーズ | 質量分析装置 |
| CA2559260C (en) * | 2004-03-12 | 2015-05-12 | University Of Virginia Patent Foundation | Electron transfer dissociation for biopolymer sequence analysis |
-
2005
- 2005-11-23 GB GBGB0523811.8A patent/GB0523811D0/en not_active Ceased
-
2006
- 2006-11-23 CA CA2835042A patent/CA2835042A1/en not_active Abandoned
- 2006-11-23 GB GB0801092A patent/GB2443570B/en active Active
- 2006-11-23 GB GB0816196A patent/GB2451963B/en active Active
- 2006-11-23 JP JP2008541822A patent/JP4959713B2/ja not_active Expired - Fee Related
- 2006-11-23 GB GB0623377A patent/GB2435714B/en active Active
- 2006-11-23 EP EP06808660A patent/EP1952425A2/en not_active Withdrawn
- 2006-11-23 WO PCT/GB2006/004387 patent/WO2007060437A2/en active Application Filing
- 2006-11-23 CA CA2628927A patent/CA2628927C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP4959713B2 (ja) | 2012-06-27 |
| GB0816196D0 (en) | 2008-10-15 |
| GB0801092D0 (en) | 2008-02-27 |
| WO2007060437A3 (en) | 2008-05-08 |
| CA2835042A1 (en) | 2007-05-31 |
| EP1952425A2 (en) | 2008-08-06 |
| GB2443570A (en) | 2008-05-07 |
| JP2009516843A (ja) | 2009-04-23 |
| CA2628927A1 (en) | 2007-05-31 |
| GB0623377D0 (en) | 2007-01-03 |
| GB2435714A (en) | 2007-09-05 |
| GB2435714B (en) | 2010-06-23 |
| GB2451963A (en) | 2009-02-18 |
| GB2443570B (en) | 2010-06-23 |
| GB2451963B (en) | 2010-06-16 |
| GB0523811D0 (en) | 2006-01-04 |
| WO2007060437A2 (en) | 2007-05-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10083825B2 (en) | Mass spectrometer with bypass of a fragmentation device | |
| US7928363B2 (en) | Mass spectrometer | |
| CA2628924C (en) | Mass spectrometer | |
| CA2628927C (en) | Mass spectrometer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20201123 |