CA2626691A1 - Dispositif medicaux pour la detection, la prevention et/ou le traitement de troubles neurologiques, et procedes associes - Google Patents
Dispositif medicaux pour la detection, la prevention et/ou le traitement de troubles neurologiques, et procedes associes Download PDFInfo
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- CA2626691A1 CA2626691A1 CA002626691A CA2626691A CA2626691A1 CA 2626691 A1 CA2626691 A1 CA 2626691A1 CA 002626691 A CA002626691 A CA 002626691A CA 2626691 A CA2626691 A CA 2626691A CA 2626691 A1 CA2626691 A1 CA 2626691A1
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- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Surgery (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Neurosurgery (AREA)
- Social Psychology (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Developmental Disabilities (AREA)
- Child & Adolescent Psychology (AREA)
- Physiology (AREA)
- Electrotherapy Devices (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96789104A | 2004-10-18 | 2004-10-18 | |
| US10/967,891 | 2004-10-18 | ||
| PCT/US2005/037246 WO2006044793A2 (fr) | 2004-10-18 | 2005-10-17 | Dispositif medicaux pour la detection, la prevention et/ou le traitement de troubles neurologiques, et procedes associes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2626691A1 true CA2626691A1 (fr) | 2006-04-27 |
Family
ID=36203623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002626691A Abandoned CA2626691A1 (fr) | 2004-10-18 | 2005-10-17 | Dispositif medicaux pour la detection, la prevention et/ou le traitement de troubles neurologiques, et procedes associes |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1809369A4 (fr) |
| JP (1) | JP2008516696A (fr) |
| CA (1) | CA2626691A1 (fr) |
| WO (1) | WO2006044793A2 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110392592A (zh) * | 2016-12-23 | 2019-10-29 | 西奈山伊坎医学院 | 评价全身麻醉的患者的喉返神经与迷走神经完整性的方法和系统 |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060058853A1 (en) | 2004-09-13 | 2006-03-16 | Jonathan Bentwich | Integrated system and method for treating disease using cognitive-training and brain stimulation and computerized magnetic photo-electric stimulator (cmpes) |
| US8095209B2 (en) | 2005-01-06 | 2012-01-10 | Braingate Co., Llc | Biological interface system with gated control signal |
| WO2006074029A2 (fr) | 2005-01-06 | 2006-07-13 | Cyberkinetics Neurotechnology Systems, Inc. | Systemes ambulatoires de patients a dispositifs multiples et a commande neurale et procedes associes |
| WO2006073915A2 (fr) | 2005-01-06 | 2006-07-13 | Cyberkinetics Neurotechnology Systems, Inc. | Routine d'entrainement d'un patient destinee a un systeme d'interface biologique |
| US20060189901A1 (en) | 2005-01-10 | 2006-08-24 | Flaherty J C | Biological interface system with surrogate controlled device |
| US7881780B2 (en) | 2005-01-18 | 2011-02-01 | Braingate Co., Llc | Biological interface system with thresholded configuration |
| WO2008005478A2 (fr) * | 2006-07-05 | 2008-01-10 | Brainvital Corporation | Traitement de troubles neurologiques par stimulation électrique et procédés correspondants |
| US8103341B2 (en) | 2006-08-25 | 2012-01-24 | Cardiac Pacemakers, Inc. | System for abating neural stimulation side effects |
| JP4992034B2 (ja) * | 2006-10-13 | 2012-08-08 | 岡山県 | 生体計測装置及び生体刺激装置 |
| CN101687097B (zh) * | 2007-07-10 | 2014-02-26 | 沙皮恩斯脑部刺激控制有限公司 | 神经刺激系统 |
| JP2011517962A (ja) * | 2007-10-04 | 2011-06-23 | ニューロニクス エルティーディー． | 中枢神経系に関連する医学的状態の治療のための、および認知機能の向上のためのシステムならびに方法 |
| WO2009044270A2 (fr) * | 2007-10-04 | 2009-04-09 | Neuronix Ltd. | Systèmes et procédés permettant d'évaluer et traiter des états médicaux liés au système nerveux central et d'améliorer les fonctions cognitives |
| KR101152282B1 (ko) | 2007-10-24 | 2012-06-08 | 연세대학교 산학협력단 | 신경 소자 |
| WO2009122485A1 (fr) | 2008-03-31 | 2009-10-08 | 岡山県 | Système de mesure biologique et système de stimulation biologique |
| DE102008043973B4 (de) * | 2008-11-21 | 2011-12-01 | Burkhard Brocke | Vorrichtung zur transkraniellen Neurostimulation |
| KR101749607B1 (ko) | 2009-10-05 | 2017-06-21 | 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 | 신경정신병학적 장애들의 치료를 위한 시스템, 장치 및 방법 |
| US8665101B2 (en) | 2009-11-16 | 2014-03-04 | Aquarius Spectrum Ltd. | System method and device for leak detection and localization in a pipe network |
| US9364674B2 (en) | 2010-11-30 | 2016-06-14 | Ian A. Cook | Pulse generator for cranial nerve stimulation |
| KR20140037803A (ko) * | 2010-12-14 | 2014-03-27 | 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 | 의료 질환 치료용 장치, 시스템 및 방법 |
| EP2651497B1 (fr) | 2010-12-14 | 2019-02-20 | The Regents of The University of California | Systèmes implantables extra-crâniens destinés au traitement de troubles médicaux |
| JP5780432B2 (ja) * | 2012-03-12 | 2015-09-16 | 医療法人社団ブックス | 脳疲労及び／又はうつ治療装置の作動方法 |
| WO2013163594A1 (fr) * | 2012-04-27 | 2013-10-31 | Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations | Systèmes de commande électrique automatisés non invasifs et procédés de surveillance des conditions d'un animal |
| AU2013256232B2 (en) | 2012-05-03 | 2018-02-15 | Ioannis Mihail Skaribas | External, head-worn electrical stimulator for treating headache conditions |
| FR2990137B1 (fr) * | 2012-05-07 | 2019-12-20 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Dispositifs de stimulation electrique d'un tissu biologique et son procede de calibrage. |
| AU2013282405B2 (en) * | 2012-06-29 | 2015-12-24 | Boston Scientific Neuromodulation Corporation | High frequency neuromodulation system for reducing energy requirements |
| CA2959332C (fr) * | 2014-08-26 | 2023-03-21 | Avent, Inc. | Procede et systeme d'identification de source de douleur chronique, et traitement |
| WO2018191310A1 (fr) | 2017-04-11 | 2018-10-18 | Peaklogic, Inc. | Stimulation magnétique transcrânienne à seuil minimal d'activation neuronale à fréquence de résonance personnalisée |
| US20210361967A1 (en) * | 2018-05-01 | 2021-11-25 | Brainsway Ltd. | Device and method for real-time closed-loop brain stimulation |
| EP3639883A1 (fr) * | 2018-10-18 | 2020-04-22 | CEFALY Technology Sprl | Stimulation e-tns kilohertz |
| CN110487996B (zh) * | 2019-08-05 | 2020-11-24 | 汕头大学医学院 | 神经干单-双相动作电位同时记录研究实验方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3809502A (en) | 1973-04-06 | 1974-05-07 | Bertea Corp | Pressure transformer |
| US3850161A (en) * | 1973-04-09 | 1974-11-26 | S Liss | Method and apparatus for monitoring and counteracting excess brain electrical energy to prevent epileptic seizures and the like |
| US5683422A (en) * | 1996-04-25 | 1997-11-04 | Medtronic, Inc. | Method and apparatus for treating neurodegenerative disorders by electrical brain stimulation |
| US5873898A (en) * | 1997-04-29 | 1999-02-23 | Medtronic, Inc. | Microprocessor capture detection circuit and method |
| US6248080B1 (en) * | 1997-09-03 | 2001-06-19 | Medtronic, Inc. | Intracranial monitoring and therapy delivery control device, system and method |
| CA2396334C (fr) * | 2000-01-07 | 2008-08-12 | Biowave Corporation | Procedes et dispositifs d'electrotherapie |
| JP2001271203A (ja) * | 2000-03-24 | 2001-10-02 | Ya Man Ltd | パルス健康器 |
| US7305268B2 (en) * | 2000-07-13 | 2007-12-04 | Northstar Neurscience, Inc. | Systems and methods for automatically optimizing stimulus parameters and electrode configurations for neuro-stimulators |
| US7010351B2 (en) * | 2000-07-13 | 2006-03-07 | Northstar Neuroscience, Inc. | Methods and apparatus for effectuating a lasting change in a neural-function of a patient |
| GB2380677B (en) * | 2001-09-07 | 2006-02-01 | Desmond Bryan Mills | Contact electrode |
| US7221981B2 (en) * | 2002-03-28 | 2007-05-22 | Northstar Neuroscience, Inc. | Electrode geometries for efficient neural stimulation |
| US6882882B2 (en) * | 2002-04-22 | 2005-04-19 | Medtronic, Inc. | Atrioventricular delay adjustment |
| US7302298B2 (en) * | 2002-11-27 | 2007-11-27 | Northstar Neuroscience, Inc | Methods and systems employing intracranial electrodes for neurostimulation and/or electroencephalography |
| EP3327957B1 (fr) | 2009-07-27 | 2020-10-21 | Huawei Technologies Co., Ltd. | Procédé de traitement de transmission de signal et appareil et station de base répartie |
-
2005
- 2005-10-17 EP EP05808963A patent/EP1809369A4/fr not_active Withdrawn
- 2005-10-17 JP JP2007536997A patent/JP2008516696A/ja active Pending
- 2005-10-17 WO PCT/US2005/037246 patent/WO2006044793A2/fr active Application Filing
- 2005-10-17 CA CA002626691A patent/CA2626691A1/fr not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110392592A (zh) * | 2016-12-23 | 2019-10-29 | 西奈山伊坎医学院 | 评价全身麻醉的患者的喉返神经与迷走神经完整性的方法和系统 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006044793A3 (fr) | 2007-08-23 |
| JP2008516696A (ja) | 2008-05-22 |
| EP1809369A4 (fr) | 2010-06-09 |
| EP1809369A2 (fr) | 2007-07-25 |
| WO2006044793A2 (fr) | 2006-04-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20131017 |