CA2603873A1 - Abuse-resistant amphetamine prodrugs - Google Patents
Abuse-resistant amphetamine prodrugs Download PDFInfo
- Publication number
- CA2603873A1 CA2603873A1 CA002603873A CA2603873A CA2603873A1 CA 2603873 A1 CA2603873 A1 CA 2603873A1 CA 002603873 A CA002603873 A CA 002603873A CA 2603873 A CA2603873 A CA 2603873A CA 2603873 A1 CA2603873 A1 CA 2603873A1
- Authority
- CA
- Canada
- Prior art keywords
- amphetamine
- lysine
- pharmaceutical composition
- auc
- bioavailability
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- WEAPVABOECTMGR-UHFFFAOYSA-N triethyl 2-acetyloxypropane-1,2,3-tricarboxylate Chemical compound CCOC(=O)CC(C(=O)OCC)(OC(C)=O)CC(=O)OCC WEAPVABOECTMGR-UHFFFAOYSA-N 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
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- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66938505P | 2005-04-08 | 2005-04-08 | |
| US66938605P | 2005-04-08 | 2005-04-08 | |
| US60/669,386 | 2005-04-08 | ||
| US60/669,385 | 2005-04-08 | ||
| US68117005P | 2005-05-16 | 2005-05-16 | |
| US60/681,170 | 2005-05-16 | ||
| US75654806P | 2006-01-06 | 2006-01-06 | |
| US60/756,548 | 2006-01-06 | ||
| US75995806P | 2006-01-19 | 2006-01-19 | |
| US60/759,958 | 2006-01-19 | ||
| PCT/US2006/013221 WO2006121552A2 (en) | 2005-04-08 | 2006-04-10 | Abuse-resistant amphetamine prodrugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2603873A1 true CA2603873A1 (en) | 2006-11-16 |
Family
ID=37397039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002603873A Abandoned CA2603873A1 (en) | 2005-04-08 | 2006-04-10 | Abuse-resistant amphetamine prodrugs |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1865980A4 (enExample) |
| JP (1) | JP2008535860A (enExample) |
| BR (1) | BRPI0612440A2 (enExample) |
| CA (1) | CA2603873A1 (enExample) |
| MX (1) | MX2007012507A (enExample) |
| WO (1) | WO2006121552A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8318813B2 (en) | 2007-09-13 | 2012-11-27 | Lcs Group, Llc | Method of treating binge eating disorder |
| US8487134B2 (en) | 2008-10-09 | 2013-07-16 | Archimica, Inc. | Process for the synthesis of amphetamine derivatives |
| GB201002612D0 (en) * | 2010-02-16 | 2010-03-31 | Jagotec Ag | Improvements in or relating to organic compounds |
| US20140073589A1 (en) * | 2012-06-27 | 2014-03-13 | Shire Ag | Amphetamine Prodrugs |
| WO2018118902A1 (en) | 2016-12-19 | 2018-06-28 | The Regents Of The University Of California | Dual-enzyme responsive peptides |
| EP3554548A4 (en) | 2016-12-19 | 2020-08-19 | The Regents of The University of California | NON-CRUSHABLE PILL FORMULATIONS |
| EP3459538B1 (en) | 2017-09-20 | 2020-05-06 | Sandoz AG | Crystalline salts of a dextroamphetamine prodrug |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| AU2020258086A1 (en) | 2019-04-17 | 2021-11-11 | Compass Pathfinder Limited | Methods of treating neurocognitive disorders, chronic pain and reducing inflammation |
| HUE059869T2 (hu) * | 2019-12-30 | 2023-01-28 | Labomed Pharmaceutical Company S A | Lizdexamfetamin-sókat tartalmazó orális oldatok |
| JP2023549405A (ja) | 2020-11-18 | 2023-11-24 | マインド メディシン， インコーポレイテッド | 心理療法を補助するためのｍｄｍａプロドラッグ |
| US20250064759A1 (en) | 2021-12-16 | 2025-02-27 | Labomed Pharmaceutical Company S.A. | Container comprising a lisdexamfetamine containing oral solution |
| EP4561528A1 (en) | 2022-07-29 | 2025-06-04 | Labomed Pharmaceutical Company S.A. | Lisdexamfetamine containing oral solution |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3878187A (en) * | 1972-09-11 | 1975-04-15 | Syva Co | Polypeptide derivatives of amphetamine and analogs for immunoassays |
| US6384020B1 (en) * | 1999-07-14 | 2002-05-07 | Shire Laboratories, Inc. | Rapid immediate release oral dosage form |
| KR100911779B1 (ko) * | 2001-05-25 | 2009-08-12 | 세파론, 인코포레이티드 | 모다피닐을 포함하는 고형 제약 제제 |
| US7105486B2 (en) * | 2002-02-22 | 2006-09-12 | New River Pharmaceuticals Inc. | Abuse-resistant amphetamine compounds |
| NZ546226A (en) * | 2003-09-30 | 2009-03-31 | Shire Llc | Oxycodone conjugates for prevention of overdose or abuse |
-
2006
- 2006-04-10 JP JP2008505617A patent/JP2008535860A/ja active Pending
- 2006-04-10 MX MX2007012507A patent/MX2007012507A/es unknown
- 2006-04-10 CA CA002603873A patent/CA2603873A1/en not_active Abandoned
- 2006-04-10 WO PCT/US2006/013221 patent/WO2006121552A2/en not_active Ceased
- 2006-04-10 EP EP06769808A patent/EP1865980A4/en not_active Withdrawn
- 2006-04-10 BR BRPI0612440-2A patent/BRPI0612440A2/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006121552A9 (en) | 2007-03-08 |
| WO2006121552A3 (en) | 2007-07-05 |
| EP1865980A4 (en) | 2009-11-11 |
| EP1865980A2 (en) | 2007-12-19 |
| WO2006121552A2 (en) | 2006-11-16 |
| BRPI0612440A2 (pt) | 2010-11-23 |
| JP2008535860A (ja) | 2008-09-04 |
| MX2007012507A (es) | 2008-03-11 |
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| Publication | Publication Date | Title |
|---|---|---|
| US7678771B2 (en) | Abuse-resistant amphetamine prodrugs | |
| US7678770B2 (en) | Abuse-resistant amphetamine prodrugs | |
| CA2603873A1 (en) | Abuse-resistant amphetamine prodrugs |
Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Dead |
Effective date: 20130314 |