CA2603863A1 - Gammaretrovirus associated with cancer - Google Patents

Gammaretrovirus associated with cancer Download PDF

Info

Publication number
CA2603863A1
CA2603863A1 CA002603863A CA2603863A CA2603863A1 CA 2603863 A1 CA2603863 A1 CA 2603863A1 CA 002603863 A CA002603863 A CA 002603863A CA 2603863 A CA2603863 A CA 2603863A CA 2603863 A1 CA2603863 A1 CA 2603863A1
Authority
CA
Canada
Prior art keywords
xmrv
nucleic acid
seq
virus
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002603863A
Other languages
English (en)
French (fr)
Inventor
Robert H. Silverman
Eric A. Klein
Joseph Derisi
Don Ganem
Graham Casey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cleveland Clinic Foundation
University of California, San Diego
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2603863A1 publication Critical patent/CA2603863A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/112—Retroviridae (F), e.g. leukemia viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA002603863A 2005-04-07 2006-04-07 Gammaretrovirus associated with cancer Abandoned CA2603863A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US66947305P 2005-04-07 2005-04-07
US60/669,473 2005-04-07
US75180905P 2005-12-19 2005-12-19
US60/751,809 2005-12-19
PCT/US2006/013167 WO2006110589A2 (en) 2005-04-07 2006-04-07 Gammaretrovirus associated with cancer

Publications (1)

Publication Number Publication Date
CA2603863A1 true CA2603863A1 (en) 2006-10-19

Family

ID=37024999

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002603863A Abandoned CA2603863A1 (en) 2005-04-07 2006-04-07 Gammaretrovirus associated with cancer

Country Status (8)

Country Link
US (2) US8263085B2 (enExample)
EP (1) EP1882032A2 (enExample)
JP (2) JP2008538494A (enExample)
AU (1) AU2006235266B2 (enExample)
CA (1) CA2603863A1 (enExample)
MX (1) MX2007012361A (enExample)
NZ (1) NZ562221A (enExample)
WO (1) WO2006110589A2 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2603863A1 (en) 2005-04-07 2006-10-19 The Cleveland Clinic Foundation Gammaretrovirus associated with cancer
JP5564499B2 (ja) * 2008-07-31 2014-07-30 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ 前立腺癌の進行を予防または減退させるのに有効な組成物
WO2010075414A2 (en) 2008-12-23 2010-07-01 The Cleveland Clinic Foundation Method for detection of xmrv
EP2628803A3 (en) * 2009-02-25 2014-01-01 Cepheid Methods of detecting lung cancer
WO2010132886A1 (en) * 2009-05-15 2010-11-18 The University Of Utah Research Foundation Compositions and methods relating to xmrv-related diseases and conditions
WO2010148323A2 (en) * 2009-06-18 2010-12-23 Whittemore Peterson Institute For Neuro-Immune Disease Diagnosis and treatment of diseases or disorders associated with xenotropic murine leukemia virus
EP2449381A1 (en) * 2009-06-30 2012-05-09 Abbott Laboratories Markers of xmrv infection and uses thereof
WO2011041350A2 (en) * 2009-10-02 2011-04-07 Emory University Xenotropic mulv-related virus (xmrv) compositions and methods of use
WO2011091395A1 (en) * 2010-01-25 2011-07-28 Functional Genetics, Inc. Antibodies for diagnosis and therapeutic treatment of prostate cancer
WO2011092199A1 (en) 2010-01-26 2011-08-04 Institut Gustave Roussy Mutated xmrv env proteins in the immunosuppressive domain
US20110311484A1 (en) * 2010-04-06 2011-12-22 Whittemore Peterson Institute For Neuro-Immune Disease Strains of xenotropic murine leukemia-related virus and methods for detection thereof
EP2913402B1 (en) * 2010-07-16 2017-10-18 Tocagen Inc. Retrovirus detection
WO2012024513A2 (en) * 2010-08-18 2012-02-23 Abbott Laboratories Molecular detection of xmrv infection
WO2012024518A1 (en) * 2010-08-18 2012-02-23 Abbott Laboratories Molecular detection of xmrv infection
WO2012030856A2 (en) * 2010-08-30 2012-03-08 Gen-Probe Incorporated Compositions, methods and reaction mixtures for the detection of xenotropic murine leukemia virus-related virus
US9107892B2 (en) * 2010-10-28 2015-08-18 University of Pittsburgh—of the Commonwealth System of Higher Education Identification of a novel retrovirus in patients with benign prostatic hyperplasia
GB201019043D0 (en) 2010-11-10 2010-12-22 Protea Biopharma N V Use of 2',5'-oligoadenylate derivative compounds
WO2012103355A2 (en) 2011-01-26 2012-08-02 Cepheid Methods of detecting lung cancer
EP2561879A1 (en) 2011-08-23 2013-02-27 Protea Biopharma N.V. Macrophage activating factor for use in the treatment of chronic fatigue syndrome (CFS) and CFS-related diseases and disorders
US20130065222A1 (en) * 2011-08-30 2013-03-14 Gen-Probe Incorporated Compositions, methods and reaction mixtures for the detection of murine leukemia virus-related virus
US20140272993A1 (en) * 2013-03-15 2014-09-18 The Translational Genomics Research Institute Method of sequencing a full microrna profile from cerebrospinal fluid
US20140303025A1 (en) * 2013-03-15 2014-10-09 The Translational Genomics Research Institute Methods for the diagnosis and prognosis of neurodegenerative diseases
WO2016143226A1 (ja) * 2015-03-10 2016-09-15 株式会社島津製作所 反応場を制限したプロテアーゼ分解反応による抗体からペプチド断片を得る方法
CN114898802B (zh) * 2022-07-14 2022-09-30 臻和(北京)生物科技有限公司 基于血浆游离dna甲基化测序数据的末端序列频率分布特征确定方法、评价方法及装置

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0464533B1 (de) 1990-06-28 1998-07-29 Hoechst Aktiengesellschaft Fusionsproteine mit immunglobulinanteilen, ihre Herstellung und Verwendung
CA2468903A1 (en) * 2001-12-07 2004-05-06 Chiron Corporation Endogenous retrovirus up-regulated in prostate cancer
CA2603863A1 (en) 2005-04-07 2006-10-19 The Cleveland Clinic Foundation Gammaretrovirus associated with cancer
WO2010075414A2 (en) 2008-12-23 2010-07-01 The Cleveland Clinic Foundation Method for detection of xmrv
US20110151431A1 (en) 2009-06-18 2011-06-23 Whittemore Peterson Institute For Neuro-Immune Disease Detection of xenotropic murine leukemia virus
WO2010148323A2 (en) 2009-06-18 2010-12-23 Whittemore Peterson Institute For Neuro-Immune Disease Diagnosis and treatment of diseases or disorders associated with xenotropic murine leukemia virus
EP2449381A1 (en) 2009-06-30 2012-05-09 Abbott Laboratories Markers of xmrv infection and uses thereof

Also Published As

Publication number Publication date
EP1882032A2 (en) 2008-01-30
MX2007012361A (es) 2008-02-11
US8263085B2 (en) 2012-09-11
AU2006235266A1 (en) 2006-10-19
US20130040369A1 (en) 2013-02-14
WO2006110589A8 (en) 2007-03-01
NZ562221A (en) 2011-06-30
JP2013046619A (ja) 2013-03-07
WO2006110589A2 (en) 2006-10-19
WO2006110589A3 (en) 2007-01-11
JP2008538494A (ja) 2008-10-30
AU2006235266B2 (en) 2010-12-23
AU2006235266A2 (en) 2006-10-19
US20100166797A1 (en) 2010-07-01

Similar Documents

Publication Publication Date Title
US8263085B2 (en) Gammaretrovirus associated with cancer
Löchelt et al. The human foamy virus pol gene is expressed as a Pro-Pol polyprotein and not as a Gag-Pol fusion protein
Winkler et al. Characterization of the genome of feline foamy virus and its proteins shows distinct features different from those of primate spumaviruses
Cannon et al. Conserved sequences in the carboxyl terminus of integrase that are essential for human immunodeficiency virus type 1 replication
Tsang et al. Evidence of avian leukosis virus subgroup E and endogenous avian virus in measles and mumps vaccines derived from chicken cells: investigation of transmission to vaccine recipients
EP0942987B1 (en) Viral material and nucleotide fragments associated with multiple sclerosis, for diagnostic, prophylactic and therapeutic purposes
EP1578919A2 (en) Endogenous retrovirus up-regulated in prostate cancer
Bacharach et al. The carboxy-terminal fragment of nucleolin interacts with the nucleocapsid domain of retroviral gag proteins and inhibits virion assembly
Ruggieri et al. Human endogenous retrovirus HERV-K (HML-2) encodes a stable signal peptide with biological properties distinct from Rec
HERCHENRÖDER et al. Infectious proviral clones of chimpanzee foamy virus (SFVcpz) generated by long PCR reveal close functional relatedness to human foamy virus
US20120021403A1 (en) Human Endogenous Retrovirus with Foamy-Like Properties and Uses Thereof
Merregaert et al. Nucleotide sequence of a radiation leukemia virus genome
Afonso et al. Absence of accessory genes in a divergent simian T-lymphotropic virus type 1 isolated from a bonnet macaque (Macaca radiata)
Schneiderman et al. The Japanese feral mouse Pit1 and Pit2 homologs lack an acidic residue at position 550 but still function as gibbon ape leukemia virus receptors: implications for virus binding motif
Delviks-Frankenberry et al. Generation of multiple replication-competent retroviruses through recombination between PreXMRV-1 and PreXMRV-2
Stewart et al. trans-Acting viral protease is necessary and sufficient for activation of avian leukosis virus reverse transcriptase
AU5829201A (en) An infective endogenous retrovirus and its association with demyelinating diseases and other diseases
Hunter et al. Isolation and characterization of irradiation fusion hybrids from mouse chromosome 1 for mapping Rmc-1, a gene encoding a cellular receptor for MCF class murine retroviruses
Molinaro RNA activators of the RNase L system in prostate cancer
Yoshikawa et al. Suppression of production of baboon endogenous virus by dominant negative mutants of cellular factors involved in multivesicular body sorting pathway
EP1176193B1 (en) Inhibitors for viral infection targeting integrase n-terminal region
Subgroup Evidence of Avian Leukosis Virus
George Identification and Analysis of Cleavage Sites and Subdomains in the Group Specific Antigen (Gag) of the Human Endogenous Retrovirus-K (HML-2)
Kolokithas Interactions Between the Glycosylated Gag Protein of a Murine Leukemia Virus and Murine Apobec3: Novel Insights Into how a Murine Leukemia Virus Counteracts a Restriction Factor
WO2006133795A2 (en) A new human t-cell lymphotropic virus (htlv-3): nucleic acid and peptidic sequences thereof and method for detecting htlv-3

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20141125