CA2599657A1 - Microfluidic valve for liquids - Google Patents

Microfluidic valve for liquids Download PDF

Info

Publication number
CA2599657A1
CA2599657A1 CA 2599657 CA2599657A CA2599657A1 CA 2599657 A1 CA2599657 A1 CA 2599657A1 CA 2599657 CA2599657 CA 2599657 CA 2599657 A CA2599657 A CA 2599657A CA 2599657 A1 CA2599657 A1 CA 2599657A1
Authority
CA
Canada
Prior art keywords
vent hole
chamber
substrate
microfluidic device
chambers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2599657
Other languages
English (en)
French (fr)
Inventor
Horacio Kido
Marc J. Madou
Jim V. Zoval
Jitae Kim
Guangyao Jia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
The Regents Of The University Of California
Horacio Kido
Marc J. Madou
Jim V. Zoval
Jitae Kim
Guangyao Jia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of California, Horacio Kido, Marc J. Madou, Jim V. Zoval, Jitae Kim, Guangyao Jia filed Critical The Regents Of The University Of California
Publication of CA2599657A1 publication Critical patent/CA2599657A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0028—Valves having multiple inlets or outlets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B01L2300/0806—Standardised forms, e.g. compact disc [CD] format
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0694—Valves, specific forms thereof vents used to stop and induce flow, backpressure valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0082—Microvalves adapted for a particular use
    • F16K2099/0084—Chemistry or biology, e.g. "lab-on-a-chip" technology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
    • G01N2035/00247—Microvalves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N35/00069—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/0318—Processes
    • Y10T137/0324—With control of flow by a condition or characteristic of a fluid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/0318—Processes
    • Y10T137/0324—With control of flow by a condition or characteristic of a fluid
    • Y10T137/0357—For producing uniform flow
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/206—Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
    • Y10T137/218—Means to regulate or vary operation of device
    • Y10T137/2202—By movable element

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
CA 2599657 2005-03-09 2006-03-08 Microfluidic valve for liquids Abandoned CA2599657A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66006005P 2005-03-09 2005-03-09
US60/660,060 2005-03-09
PCT/US2006/008411 WO2006099042A2 (en) 2005-03-09 2006-03-08 Microfluidic valve for liquids

Publications (1)

Publication Number Publication Date
CA2599657A1 true CA2599657A1 (en) 2006-09-21

Family

ID=36992226

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2599657 Abandoned CA2599657A1 (en) 2005-03-09 2006-03-08 Microfluidic valve for liquids

Country Status (5)

Country Link
US (1) US20080110500A1 (ja)
EP (1) EP1856405A4 (ja)
JP (1) JP2008532748A (ja)
CA (1) CA2599657A1 (ja)
WO (1) WO2006099042A2 (ja)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4963437B2 (ja) * 2007-03-30 2012-06-27 京セラ株式会社 流路体、配線基板、流路形成配線基板、流路形成方法、流路体の製造方法、ならびに流路体キット
KR20100009482A (ko) * 2008-07-18 2010-01-27 삼성전자주식회사 공기 출구 및 밸브가 구비된 구조물을 포함하는 미세 유동 장치, 및 이를 이용한 액체 이송 방법
US8303911B2 (en) * 2009-10-19 2012-11-06 The Regents Of The University Of California Centrifugal microfluidic system for nucleic acid sample preparation, amplification, and detection
DE102009050979B4 (de) 2009-10-28 2011-09-22 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Vorrichtung und Verfahren zum Steuern eines Flüssigkeitsflusses und Vorrichtung zum Verschließen eines Entlüftungskanals
PE20130172A1 (es) * 2009-11-24 2013-03-03 Opko Diagnostics Llc Mezclado y entrega de fluidos en sistemas microfluidicos
TWI427280B (zh) * 2010-08-13 2014-02-21 Univ Nat Taiwan 碟片型流體收集裝置
EP2691178B1 (en) * 2011-03-28 2020-02-05 Biosurfit, S.A. Liquid switching, dosing and pumping
US9186672B2 (en) 2011-04-18 2015-11-17 The Regents Of The Univeristy Of California Microfluidic device for whole blood sample preparation
JP5951219B2 (ja) * 2011-10-24 2016-07-13 ローム株式会社 液体試薬内蔵型マイクロチップ
JP5912582B2 (ja) * 2012-01-27 2016-04-27 ローム株式会社 包材入り液体試薬内蔵型マイクロチップおよびその使用方法
EP2682753A1 (en) * 2012-05-08 2014-01-08 Roche Diagniostics GmbH Cartridge for Dispensing a Fluid Comprising a Reagent
US8734734B2 (en) 2012-09-12 2014-05-27 LaMotte Chemical Products Company Liquid analysis cartridge
DE102013203293B4 (de) 2013-02-27 2016-01-21 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Vorrichtung und Verfahren zum Leiten einer Flüssigkeit durch einen ersten oder zweiten Auslasskanal
US10166541B2 (en) 2014-12-10 2019-01-01 The Regents Of The University Of California Centrifugal microfluidic platform for automated media exchange
WO2016092333A2 (en) * 2014-12-12 2016-06-16 Bio Amd Holdings Limited Assay apparatus
JPWO2017056748A1 (ja) * 2015-09-28 2018-07-19 Ｐｈｃホールディングス株式会社 アナライトを分析するセンサ及びアナライトの分析方法
CA3016582A1 (en) * 2016-03-04 2017-09-08 Alere San Diego, Inc. Automated nested recombinase polymerase amplification
WO2017212031A1 (en) 2016-06-09 2017-12-14 Biosurfit, S.A. Liquid handling device for rotationally driving liquid flow and method of using device
US20210331182A1 (en) * 2020-04-24 2021-10-28 Quommni Technologies Limited Fluidics device, apparatus, and method for partitioning fluid
US20220080416A1 (en) * 2020-09-17 2022-03-17 Citrogene Inc. Microfluidic device and method for rapid high throughput identification of microorganisms

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3931833A (en) * 1974-10-02 1976-01-13 Bell Telephone Laboratories, Incorporated Fluidic device
US5242606A (en) * 1990-06-04 1993-09-07 Abaxis, Incorporated Sample metering port for analytical rotor having overflow chamber
AU3233193A (en) * 1991-12-18 1993-07-19 Icu Medical, Inc. Medical valve
AU4047493A (en) * 1992-04-02 1993-11-08 Abaxis, Inc. Analytical rotor with dye mixing chamber
US6153148A (en) * 1998-06-15 2000-11-28 Becton, Dickinson And Company Centrifugal hematology disposable
US6615856B2 (en) * 2000-08-04 2003-09-09 Biomicro Systems, Inc. Remote valving for microfluidic flow control
US6743632B2 (en) * 2001-03-14 2004-06-01 Universities Space Research Association Directional acceleration vector-driven displacement of fluids (DAVD-DOF)
WO2002097422A1 (en) * 2001-05-31 2002-12-05 Electron-Bio, Inc. A micro valve apparatus using micro bead and method for controlling the same
US6729599B2 (en) * 2001-06-26 2004-05-04 Tini Alloy Company Liquid microvalve
EP1500937B1 (en) * 2002-04-30 2017-06-28 ARKRAY, Inc. Analyzing article, analyzer and method of analyzing a sample using the analyzing article
EP1419818B1 (de) * 2002-11-14 2013-10-30 Boehringer Ingelheim microParts GmbH Vorrichtung zum schrittweisen Transport von Flüssigkeit unter Ausnutzung von Kapillarkräften
US7238269B2 (en) * 2003-07-01 2007-07-03 3M Innovative Properties Company Sample processing device with unvented channel
US7418977B2 (en) * 2004-10-04 2008-09-02 Albert-Ludwigs-Universitaet Liquid-handling apparatus having a liquid switch and method for handling liquids

Also Published As

Publication number Publication date
WO2006099042A3 (en) 2007-04-12
JP2008532748A (ja) 2008-08-21
WO2006099042A2 (en) 2006-09-21
EP1856405A2 (en) 2007-11-21
EP1856405A4 (en) 2010-08-04
US20080110500A1 (en) 2008-05-15

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Legal Events

Date Code Title Description
FZDE Discontinued