CA2594602A1 - Derives de 8-aza-bicyclo (3.2.1) octane possedant une activite de recepteurs de chimiokines ccr5 - Google Patents

Derives de 8-aza-bicyclo (3.2.1) octane possedant une activite de recepteurs de chimiokines ccr5 Download PDF

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Publication number
CA2594602A1
CA2594602A1 CA002594602A CA2594602A CA2594602A1 CA 2594602 A1 CA2594602 A1 CA 2594602A1 CA 002594602 A CA002594602 A CA 002594602A CA 2594602 A CA2594602 A CA 2594602A CA 2594602 A1 CA2594602 A1 CA 2594602A1
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Canada
Prior art keywords
alkyl
compound
formula
atoms
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002594602A
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English (en)
Inventor
David Cameron Pryde
Paul Anthony Stupple
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd
Original Assignee
Pfizer Limited
David Cameron Pryde
Paul Anthony Stupple
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0428267A external-priority patent/GB0428267D0/en
Application filed by Pfizer Limited, David Cameron Pryde, Paul Anthony Stupple filed Critical Pfizer Limited
Publication of CA2594602A1 publication Critical patent/CA2594602A1/fr
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
CA002594602A 2004-12-23 2005-12-12 Derives de 8-aza-bicyclo (3.2.1) octane possedant une activite de recepteurs de chimiokines ccr5 Abandoned CA2594602A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0428267.9 2004-12-23
GB0428267A GB0428267D0 (en) 2004-12-23 2004-12-23 Chemical compounds
US65664805P 2005-02-24 2005-02-24
US60/656,648 2005-02-24
PCT/IB2005/003822 WO2006067584A1 (fr) 2004-12-23 2005-12-12 Derives de 8-aza-bicyclo (3.2.1) octane possedant une activite de recepteurs de chimiokines ccr5

Publications (1)

Publication Number Publication Date
CA2594602A1 true CA2594602A1 (fr) 2006-06-29

Family

ID=35954064

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002594602A Abandoned CA2594602A1 (fr) 2004-12-23 2005-12-12 Derives de 8-aza-bicyclo (3.2.1) octane possedant une activite de recepteurs de chimiokines ccr5

Country Status (4)

Country Link
EP (1) EP1831210A1 (fr)
JP (1) JP2008525418A (fr)
CA (1) CA2594602A1 (fr)
WO (1) WO2006067584A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5898196B2 (ja) * 2010-08-05 2016-04-13 シガ・テクノロジーズ・インコーポレーテッド Ｓｔ−２４６液体製剤および方法
BR112013023050A8 (pt) 2011-03-09 2018-09-25 G Pestell Richard antagonista de ccr5, método para determinar se um indivíduo humano tendo câncer de próstata está sofrendo de ou sob o risco de desenvolver metástase, para identificar um antagonista de ccr5, método para determinar se um indivíduo humano tendo câncer de próstata está sofrendo de ou sob o risco de desenvolver metástase, para identificar um composto candidato, para produzir in vitro células epiteliais primárias, para diagnosticar câncer de próstata, para selecionar um tratamento para um indivíduo tendo um câncer/tumor de próstata, linhagem de célula, e, modelo animal
CA2873743C (fr) * 2012-05-14 2022-12-06 Prostagene, Llc Utilisation de modulateurs de ccr5 dans le traitement du cancer
GB201321748D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
US10676428B2 (en) 2015-12-17 2020-06-09 Ramot At Tel-Aviv University Ltd. Antiviral agents for amantadine-resistant influenza A

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6531484B2 (en) * 2000-10-11 2003-03-11 Merck & Co., Inc. Pyrrolidine modulators of CCR5 chemokine receptor activity

Also Published As

Publication number Publication date
EP1831210A1 (fr) 2007-09-12
WO2006067584A1 (fr) 2006-06-29
JP2008525418A (ja) 2008-07-17

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