CA2591069A1 - Benzisothiazole-1, 1-dioxide acting as antagonists to the vanilloid receptor subtype 1 (vr1) and uses thereof - Google Patents

Benzisothiazole-1, 1-dioxide acting as antagonists to the vanilloid receptor subtype 1 (vr1) and uses thereof Download PDF

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Publication number
CA2591069A1
CA2591069A1 CA002591069A CA2591069A CA2591069A1 CA 2591069 A1 CA2591069 A1 CA 2591069A1 CA 002591069 A CA002591069 A CA 002591069A CA 2591069 A CA2591069 A CA 2591069A CA 2591069 A1 CA2591069 A1 CA 2591069A1
Authority
CA
Canada
Prior art keywords
alkyl
compound
benzisothiazol
dioxide
trifluoromethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002591069A
Other languages
English (en)
French (fr)
Inventor
Brian S. Brown
Ryan G. Keddy
Chih-Hung Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2591069A1 publication Critical patent/CA2591069A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002591069A 2004-12-13 2005-12-07 Benzisothiazole-1, 1-dioxide acting as antagonists to the vanilloid receptor subtype 1 (vr1) and uses thereof Abandoned CA2591069A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63549104P 2004-12-13 2004-12-13
US60/635,491 2004-12-13
PCT/US2005/044613 WO2006065646A1 (en) 2004-12-13 2005-12-07 Benzisothiazole-1, 1-dioxide acting as antagonists to the vanilloid receptor subtype 1 (vr1) and uses thereof

Publications (1)

Publication Number Publication Date
CA2591069A1 true CA2591069A1 (en) 2006-06-22

Family

ID=36129676

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002591069A Abandoned CA2591069A1 (en) 2004-12-13 2005-12-07 Benzisothiazole-1, 1-dioxide acting as antagonists to the vanilloid receptor subtype 1 (vr1) and uses thereof

Country Status (6)

Country Link
US (1) US7615570B2 (enExample)
EP (1) EP1836200B1 (enExample)
JP (2) JP4960254B2 (enExample)
CA (1) CA2591069A1 (enExample)
MX (1) MX2007007100A (enExample)
WO (1) WO2006065646A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7615570B2 (en) * 2004-12-13 2009-11-10 Abbott Laboratories Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof
WO2007024651A2 (en) * 2005-08-19 2007-03-01 Elan Pharmaceuticals, Inc. Bridged n-bicyclic sulfonamido inhibitors of gamma secretase
CN101426498A (zh) * 2006-04-18 2009-05-06 艾博特公司 香草素受体亚型1（vr1）的拮抗剂及其用途
CN101589030A (zh) * 2007-01-26 2009-11-25 巴斯夫欧洲公司 用于对抗动物害虫的3-氨基-1,2-苯并异噻唑化合物ⅱ
UA104601C2 (uk) 2008-10-23 2014-02-25 Вертекс Фармасьютікалз, Інкорпорейтед Модулятори регулятора трансмембранної провідності при муковісцидозі
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
AR080056A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de ciclohexil-amida como antagonistas de los receptores de crf
EP2531510B1 (en) 2010-02-01 2014-07-23 Novartis AG Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists
US8835444B2 (en) 2010-02-02 2014-09-16 Novartis Ag Cyclohexyl amide derivatives as CRF receptor antagonists
CN102718701B (zh) 2011-03-30 2014-05-07 中国中化股份有限公司 芳氧基二卤丙烯醚类化合物与应用
SG11201509194SA (en) 2013-05-07 2015-12-30 Univ California Radiomitigating pharmaceutical formulations
CN105707076B (zh) * 2014-12-05 2018-12-14 沈阳中化农药化工研发有限公司 除草组合物及应用
WO2019185413A1 (en) 2018-03-27 2019-10-03 Basf Se Pesticidal substituted cyclopropyl derivatives
CN113264900B (zh) * 2021-06-07 2023-05-26 南京中医药大学 一种苯并异噻唑和苯并噻吩的制备方法及其医药用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US473692A (en) * 1892-04-26 Rington
US4147698A (en) 1978-07-13 1979-04-03 E. R. Squibb & Sons, Inc. 3-(Heterocyclicalkylamino)benzisothiazole-1,1-dioxides
US4166910A (en) 1978-07-13 1979-09-04 E. R. Squibb & Sons, Inc. 3-(Nitrogen containing heterocyclic)amino) benzisothiazole-1,1-dioxide
US4743692A (en) 1986-09-30 1988-05-10 American Home Products Corporation N-(pyridinylalkyl)-thieno-or benzo-isothiazol-3-amine derivatives
EP1628661A2 (en) 2003-06-05 2006-03-01 Vertex Pharmaceuticals Incorporated Modulators of vr1 receptor
CA2531515A1 (en) 2003-07-10 2005-02-03 Neurogen Corporation Aryl-substituted benzo[d]isothiazol-3-ylamine analogues as capsaicin receptor modulators
US7615570B2 (en) * 2004-12-13 2009-11-10 Abbott Laboratories Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof

Also Published As

Publication number Publication date
EP1836200A1 (en) 2007-09-26
JP2012121887A (ja) 2012-06-28
EP1836200B1 (en) 2012-05-16
JP4960254B2 (ja) 2012-06-27
WO2006065646A1 (en) 2006-06-22
MX2007007100A (es) 2007-06-22
US20060148867A1 (en) 2006-07-06
US7615570B2 (en) 2009-11-10
JP2008523091A (ja) 2008-07-03

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20131015