CA2587669A1 - Novel 2h-chromene derivatives as selective estrogen receptor modulators - Google Patents
Novel 2h-chromene derivatives as selective estrogen receptor modulators Download PDFInfo
- Publication number
- CA2587669A1 CA2587669A1 CA002587669A CA2587669A CA2587669A1 CA 2587669 A1 CA2587669 A1 CA 2587669A1 CA 002587669 A CA002587669 A CA 002587669A CA 2587669 A CA2587669 A CA 2587669A CA 2587669 A1 CA2587669 A1 CA 2587669A1
- Authority
- CA
- Canada
- Prior art keywords
- group
- chromen
- ethoxy
- compound
- 4alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000333 selective estrogen receptor modulator Substances 0.000 title description 7
- 229940095743 selective estrogen receptor modulator Drugs 0.000 title description 6
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 15
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 15
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 13
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- BCAHYKSCCYDNLZ-UHFFFAOYSA-N 3-(hydroxymethyl)-4-methyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2h-chromen-7-ol Chemical compound O1C2=CC(O)=CC=C2C(C)=C(CO)C1C(C=C1)=CC=C1OCCN1CCCCC1 BCAHYKSCCYDNLZ-UHFFFAOYSA-N 0.000 claims description 2
- FANGYSXRPPSHRV-UHFFFAOYSA-N 4-(2-hydroxyethyl)-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2h-chromen-7-ol Chemical compound O1C2=CC(O)=CC=C2C(CCO)=CC1C(C=C1)=CC=C1OCCN1CCCCC1 FANGYSXRPPSHRV-UHFFFAOYSA-N 0.000 claims description 2
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- QYHKGMAAOCANDP-UHFFFAOYSA-N 6-[4-[2-(dimethylamino)ethoxy]phenyl]-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-ol Chemical compound C1=CC(OCCN(C)C)=CC=C1C1C(CCCCC2)=C2C2=CC=C(O)C=C2O1 QYHKGMAAOCANDP-UHFFFAOYSA-N 0.000 claims description 2
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- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
- PAUMCYOKUFGQRG-LJAQVGFWSA-N (2s)-4-methyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-3-(2-trimethylsilylethoxymethyl)-2h-chromen-7-ol Chemical compound C1=CC([C@H]2C(COCC[Si](C)(C)C)=C(C3=CC=C(O)C=C3O2)C)=CC=C1OCCN1CCCCC1 PAUMCYOKUFGQRG-LJAQVGFWSA-N 0.000 claims 2
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Classifications
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- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
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- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
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- Obesity (AREA)
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- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62898704P | 2004-11-18 | 2004-11-18 | |
| US60/628,987 | 2004-11-18 | ||
| PCT/US2005/041648 WO2006055694A1 (en) | 2004-11-18 | 2005-11-17 | Novel 2h-chromene derivatives as selective estrogen receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2587669A1 true CA2587669A1 (en) | 2006-05-26 |
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|---|---|---|---|
| CA002587669A Abandoned CA2587669A1 (en) | 2004-11-18 | 2005-11-17 | Novel 2h-chromene derivatives as selective estrogen receptor modulators |
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|---|---|
| US (1) | US20060166933A1 (enExample) |
| EP (1) | EP1812417B1 (enExample) |
| JP (1) | JP2008520688A (enExample) |
| CN (1) | CN101103011A (enExample) |
| AT (1) | ATE412643T1 (enExample) |
| AU (1) | AU2005307704A1 (enExample) |
| CA (1) | CA2587669A1 (enExample) |
| DE (1) | DE602005010735D1 (enExample) |
| DK (1) | DK1812417T3 (enExample) |
| ES (1) | ES2314747T3 (enExample) |
| PL (1) | PL1812417T3 (enExample) |
| PT (1) | PT1812417E (enExample) |
| SI (1) | SI1812417T1 (enExample) |
| WO (1) | WO2006055694A1 (enExample) |
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| JP6768711B2 (ja) * | 2015-05-26 | 2020-10-14 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 複素環式エストロゲン受容体モジュレーター及びその使用 |
| WO2020024977A1 (zh) * | 2018-08-01 | 2020-02-06 | 陕西麦科奥特科技有限公司 | 用于治疗神经系统疾病的化合物及其应用 |
| CN119176799B (zh) * | 2024-09-19 | 2025-10-03 | 晨伫(杭州)生物科技有限责任公司 | 色烯衍生物及其应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6060503A (en) * | 1991-12-02 | 2000-05-09 | Endorecherche, Inc. | Benzopyran-containing compounds and method for their use |
| DE10013782A1 (de) * | 2000-03-15 | 2001-10-18 | Schering Ag | 4-Fluoralkyl-2H-benzopyrane mit antiestrogener Wirksamkeit, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, die diese enthalten sowie deren Verwendung zur Herstellung von Arzneimitteln |
| DE60220179T2 (de) * | 2001-11-19 | 2008-02-07 | Eli Lilly And Co., Indianapolis | Substituierte benzopyrane als selektive agonisten am östrogenrezeptor-beta |
| US7329654B2 (en) * | 2001-12-19 | 2008-02-12 | Janssen Pharmaceutica N.V. | Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators |
-
2005
- 2005-11-17 US US11/281,074 patent/US20060166933A1/en not_active Abandoned
- 2005-11-17 CA CA002587669A patent/CA2587669A1/en not_active Abandoned
- 2005-11-17 DE DE602005010735T patent/DE602005010735D1/de not_active Expired - Fee Related
- 2005-11-17 PL PL05824228T patent/PL1812417T3/pl unknown
- 2005-11-17 ES ES05824228T patent/ES2314747T3/es not_active Expired - Lifetime
- 2005-11-17 DK DK05824228T patent/DK1812417T3/da active
- 2005-11-17 EP EP05824228A patent/EP1812417B1/en not_active Expired - Lifetime
- 2005-11-17 PT PT05824228T patent/PT1812417E/pt unknown
- 2005-11-17 JP JP2007543221A patent/JP2008520688A/ja not_active Withdrawn
- 2005-11-17 AT AT05824228T patent/ATE412643T1/de not_active IP Right Cessation
- 2005-11-17 SI SI200530558T patent/SI1812417T1/sl unknown
- 2005-11-17 AU AU2005307704A patent/AU2005307704A1/en not_active Abandoned
- 2005-11-17 CN CNA2005800468519A patent/CN101103011A/zh active Pending
- 2005-11-17 WO PCT/US2005/041648 patent/WO2006055694A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN101103011A (zh) | 2008-01-09 |
| US20060166933A1 (en) | 2006-07-27 |
| PT1812417E (pt) | 2008-12-05 |
| ATE412643T1 (de) | 2008-11-15 |
| WO2006055694A1 (en) | 2006-05-26 |
| EP1812417B1 (en) | 2008-10-29 |
| AU2005307704A1 (en) | 2006-05-26 |
| DK1812417T3 (da) | 2009-02-16 |
| PL1812417T3 (pl) | 2009-04-30 |
| ES2314747T3 (es) | 2009-03-16 |
| SI1812417T1 (sl) | 2009-04-30 |
| JP2008520688A (ja) | 2008-06-19 |
| EP1812417A1 (en) | 2007-08-01 |
| DE602005010735D1 (de) | 2008-12-11 |
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| FZDE | Discontinued |