CA2584209A1 - Reversible inhibitors of s-adenosyl-l-homocysteine hydrolase and uses thereof - Google Patents
Reversible inhibitors of s-adenosyl-l-homocysteine hydrolase and uses thereof Download PDFInfo
- Publication number
- CA2584209A1 CA2584209A1 CA002584209A CA2584209A CA2584209A1 CA 2584209 A1 CA2584209 A1 CA 2584209A1 CA 002584209 A CA002584209 A CA 002584209A CA 2584209 A CA2584209 A CA 2584209A CA 2584209 A1 CA2584209 A1 CA 2584209A1
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- alkenyl
- heteroaryl
- aryl
- alkyl
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Classifications
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- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
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- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/964,236 US7517887B2 (en) | 2003-04-09 | 2004-10-13 | Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof |
| US10/964,236 | 2004-10-13 | ||
| PCT/US2005/036890 WO2006044573A2 (en) | 2004-10-13 | 2005-10-13 | Reversible inhibitors of s-adenosyl-l-homocysteine hydrolase and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2584209A1 true CA2584209A1 (en) | 2006-04-27 |
Family
ID=36203526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002584209A Abandoned CA2584209A1 (en) | 2004-10-13 | 2005-10-13 | Reversible inhibitors of s-adenosyl-l-homocysteine hydrolase and uses thereof |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7517887B2 (enExample) |
| EP (1) | EP1799682B1 (enExample) |
| JP (2) | JP5270163B2 (enExample) |
| AU (1) | AU2005295704A1 (enExample) |
| CA (1) | CA2584209A1 (enExample) |
| WO (1) | WO2006044573A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011156889A1 (en) * | 2010-06-14 | 2011-12-22 | Trt Pharma Inc. | Novel modulators of nrf2 and uses thereof |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7517887B2 (en) | 2003-04-09 | 2009-04-14 | General Atomics | Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof |
| US7868011B2 (en) * | 2003-04-09 | 2011-01-11 | General Atomics | Use of reversible inhibitors of S-adenosyl-L-homocysteine hydrolase for treating lupus |
| US7196093B2 (en) * | 2003-04-09 | 2007-03-27 | General Atomics | Reversible inhibitors of SAH hydrolase and uses thereof |
| TW200523262A (en) * | 2003-07-29 | 2005-07-16 | Smithkline Beecham Corp | Inhibitors of AKT activity |
| BRPI0615250A2 (pt) * | 2005-09-02 | 2011-05-10 | Pfizer | 1h-imidazopiridinas substituÍdas por hidràxi, composiÇço farmacÊutica contendo as mesmas, bem como seus usos |
| US7625890B2 (en) | 2005-11-10 | 2009-12-01 | Smithkline Beecham Corp. | Substituted imidazo[4,5-c]pyridine compounds as Akt inhibitors |
| UY30892A1 (es) | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | Inhibidores de la actividad akt |
| WO2008145159A1 (de) * | 2007-05-30 | 2008-12-04 | Sarstedt Aktiengesellschaft & Co. | Eine blutentnahmevorrichtung umfassend komponenten zur stabilisierung des homocysteinspiegels und/oder zur hemmung der fortlaufenden bildung von homocystein in blutproben, serumproben oder blutplasmaproben |
| CN101456860B (zh) | 2007-12-10 | 2011-02-16 | 中国科学院上海药物研究所 | 4-[9-(6-氨基嘌呤基)]-2(s)-羟基丁酸甲酯的制备方法 |
| TWI386204B (zh) * | 2008-04-10 | 2013-02-21 | Mitsubishi Tanabe Pharma Corp | 高半胱胺酸合成酶抑制劑 |
| MY161598A (en) * | 2009-01-30 | 2017-04-28 | Glaxosmithkline Llc | Crystalline n-{ (1s)-2-amino-1-[(3-fluorophenyl)methyl]ethyl} -5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride |
| WO2011043480A1 (ja) * | 2009-10-09 | 2011-04-14 | 田辺三菱製薬株式会社 | ホモシステイン合成酵素阻害薬 |
| CN117045661B (zh) * | 2023-10-11 | 2024-01-30 | 广东医科大学附属医院 | Sahh可逆型抑制剂的应用、药物组合物及其应用 |
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| SE8404768L (sv) * | 1983-09-27 | 1985-03-28 | Ceskoslovenska Akademie Ved | 9-(aminoalkyl)-8-hydroxiadeniner och sett for deras framstellning |
| SE463851B (sv) | 1988-09-02 | 1991-02-04 | Amsu Ltd | Komposition foer behandling av erektil dysfunktion via uretra |
| JPH0374330A (ja) * | 1989-08-11 | 1991-03-28 | Snow Brand Milk Prod Co Ltd | 脱髄疾患治療剤 |
| DE4221256C2 (de) | 1992-06-26 | 1997-07-10 | Lancaster Group Ag | Galenische Zusammensetzung für die topische Anwendung |
| US5804584A (en) * | 1992-11-16 | 1998-09-08 | Cell Therapeutics, Inc. | Therapeutic compounds containing a monocyclic five- to six- membered ring structure having one to two nitrogen atoms |
| US5869305A (en) | 1992-12-04 | 1999-02-09 | The University Of Pittsburgh | Recombinant viral vector system |
| US5629327A (en) | 1993-03-01 | 1997-05-13 | Childrens Hospital Medical Center Corp. | Methods and compositions for inhibition of angiogenesis |
| US5641783A (en) * | 1993-11-12 | 1997-06-24 | Cell Therapeutics, Inc. | Substituted amino alcohol compounds |
| US6020337A (en) * | 1993-04-05 | 2000-02-01 | Cell Therapeutics, Inc. | Electronegative-substituted long chain xanthine compounds |
| DE69402548T2 (de) | 1993-06-21 | 1997-07-17 | Merrell Pharma Inc | Carbocyclische nucleoside mittel nützlich als selektive inhibitoren von proinflammatorischen cytokinen |
| US5756466A (en) | 1994-06-17 | 1998-05-26 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
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| US5888767A (en) | 1996-11-27 | 1999-03-30 | The Johns Hopkins University School Of Medicine | Method of using a conditionally replicating viral vector to express a gene |
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| US5668173A (en) | 1996-02-23 | 1997-09-16 | The Board Of Trustees Of The University Of Illinois Corp. | Method of increasing the conversion of homocysteine to methionine and uses thereof |
| US5736154A (en) | 1996-03-11 | 1998-04-07 | Fuisz Technologies Ltd. | Transdermal delivery system |
| US6429212B1 (en) * | 1996-08-16 | 2002-08-06 | Ishihara Sangyo Kaisha Ltd. | Medicinal composition |
| EP1019501A1 (en) * | 1997-03-14 | 2000-07-19 | Otsuka Pharmaceutical Co., Ltd. | Novel pyrimidine derivative |
| EP0969743B1 (en) | 1997-03-20 | 2004-09-15 | Coventry Group, Ltd. | Nutritional supplement for cardiovascular health |
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| SE9703226D0 (sv) | 1997-09-08 | 1997-09-08 | Astra Ab | New pharmaceutical composition |
| EP1029851B1 (en) * | 1997-10-14 | 2005-04-20 | Mitsubishi Pharma Corporation | Piperazine compounds and medicinal use thereof |
| GB9724838D0 (en) * | 1997-11-26 | 1998-01-21 | Franks Christopher R | Compositions |
| US6197801B1 (en) | 1998-01-14 | 2001-03-06 | Usa Doctors Products, Inc. | Injectable pharmaceutical composition for treatment and reversal of erectile dysfunction |
| US5962274A (en) | 1998-03-13 | 1999-10-05 | Wake Forest University | Viral vector directed to predetermined target cells |
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| EP1076649A4 (en) * | 1998-04-28 | 2010-06-02 | Trega Biosciences Inc | ISOQUINOLINE-BASED COMPOUNDS IN PLACE OF MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USE |
| US6353003B1 (en) | 1998-06-17 | 2002-03-05 | Eli Lilly And Company | Method for reducing levels of homocysteine and C-reactive protein |
| US6323188B1 (en) | 1998-07-01 | 2001-11-27 | Donald L. Weissman | Treatment and prevention of cardiovascular diseases, heart attack, and stroke, primary and subsequent, with help of aspirin and certain vitamins |
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| US6274170B1 (en) | 1999-02-18 | 2001-08-14 | Richard Heibel | Compounds for cardiovascular treatment comprising multi-vitamin and anti-platelet aggregating agents and methods for making and using the same |
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| US6811788B2 (en) | 2000-01-19 | 2004-11-02 | Baofa Yu | Combinations and methods for treating neoplasms |
| US6361800B1 (en) | 2000-04-13 | 2002-03-26 | Cooper Concepts, Inc. | Multi-vitamin and mineral supplement |
| US6337317B1 (en) * | 2000-06-27 | 2002-01-08 | The University Of British Columbia | Antimicrobial peptides and methods of use thereof |
| CA2488801A1 (en) * | 2002-06-07 | 2003-12-18 | 3M Innovative Properties Company | Ether substituted imidazopyridines |
| US7517887B2 (en) | 2003-04-09 | 2009-04-14 | General Atomics | Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof |
| US7868011B2 (en) | 2003-04-09 | 2011-01-11 | General Atomics | Use of reversible inhibitors of S-adenosyl-L-homocysteine hydrolase for treating lupus |
| US7196093B2 (en) * | 2003-04-09 | 2007-03-27 | General Atomics | Reversible inhibitors of SAH hydrolase and uses thereof |
-
2004
- 2004-10-13 US US10/964,236 patent/US7517887B2/en not_active Expired - Lifetime
-
2005
- 2005-10-13 EP EP05814804A patent/EP1799682B1/en not_active Expired - Lifetime
- 2005-10-13 CA CA002584209A patent/CA2584209A1/en not_active Abandoned
- 2005-10-13 WO PCT/US2005/036890 patent/WO2006044573A2/en not_active Ceased
- 2005-10-13 AU AU2005295704A patent/AU2005295704A1/en not_active Abandoned
- 2005-10-13 JP JP2007536899A patent/JP5270163B2/ja not_active Expired - Fee Related
-
2012
- 2012-07-09 JP JP2012153898A patent/JP2012197314A/ja not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011156889A1 (en) * | 2010-06-14 | 2011-12-22 | Trt Pharma Inc. | Novel modulators of nrf2 and uses thereof |
| US9139592B2 (en) | 2010-06-14 | 2015-09-22 | Trt Pharma Inc. | Modulators of Nrf2 and uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1799682A2 (en) | 2007-06-27 |
| WO2006044573A3 (en) | 2006-06-15 |
| EP1799682B1 (en) | 2012-12-05 |
| US7517887B2 (en) | 2009-04-14 |
| WO2006044573A2 (en) | 2006-04-27 |
| EP1799682A4 (en) | 2009-11-04 |
| US20050182075A1 (en) | 2005-08-18 |
| JP2008515994A (ja) | 2008-05-15 |
| JP2012197314A (ja) | 2012-10-18 |
| JP5270163B2 (ja) | 2013-08-21 |
| AU2005295704A1 (en) | 2006-04-27 |
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