CA2582403A1 - Compositions pharmaceutiques comprenant du fenofibrate et de l'atorvastatine - Google Patents
Compositions pharmaceutiques comprenant du fenofibrate et de l'atorvastatine Download PDFInfo
- Publication number
- CA2582403A1 CA2582403A1 CA002582403A CA2582403A CA2582403A1 CA 2582403 A1 CA2582403 A1 CA 2582403A1 CA 002582403 A CA002582403 A CA 002582403A CA 2582403 A CA2582403 A CA 2582403A CA 2582403 A1 CA2582403 A1 CA 2582403A1
- Authority
- CA
- Canada
- Prior art keywords
- fenofibrate
- atorvastatin
- dosage form
- vehicle
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- YMTINGFKWWXKFG-UHFFFAOYSA-N fenofibrate Chemical compound C1=CC(OC(C)(C)C(=O)OC(C)C)=CC=C1C(=O)C1=CC=C(Cl)C=C1 YMTINGFKWWXKFG-UHFFFAOYSA-N 0.000 title claims abstract description 337
- 229960002297 fenofibrate Drugs 0.000 title claims abstract description 274
- 229960005370 atorvastatin Drugs 0.000 title claims abstract description 200
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 title claims abstract description 195
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 title claims abstract description 192
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 86
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200401506 | 2004-10-01 | ||
DKPA200401506 | 2004-10-01 | ||
DKPA200401761 | 2004-11-15 | ||
DKPA200401761 | 2004-11-15 | ||
DKPA200402004 | 2004-12-23 | ||
DKPA200402004 | 2004-12-23 | ||
DKPA200500196 | 2005-02-09 | ||
DKPA200500196 | 2005-02-09 | ||
DKPA200500534 | 2005-04-13 | ||
DKPA200500534 | 2005-04-13 | ||
PCT/DK2005/050001 WO2006037344A1 (fr) | 2004-10-01 | 2005-10-03 | Compositions pharmaceutiques comprenant du fenofibrate et de l'atorvastatine |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2582403A1 true CA2582403A1 (fr) | 2006-04-13 |
Family
ID=35726678
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002582403A Abandoned CA2582403A1 (fr) | 2004-10-01 | 2005-10-03 | Compositions pharmaceutiques comprenant du fenofibrate et de l'atorvastatine |
CA002582405A Abandoned CA2582405A1 (fr) | 2004-10-01 | 2005-10-03 | Compositions pharmaceutiques contenant du fenofibrate et de l'atorvastatine |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002582405A Abandoned CA2582405A1 (fr) | 2004-10-01 | 2005-10-03 | Compositions pharmaceutiques contenant du fenofibrate et de l'atorvastatine |
Country Status (3)
Country | Link |
---|---|
EP (2) | EP1804769A1 (fr) |
CA (2) | CA2582403A1 (fr) |
WO (2) | WO2006037347A1 (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20070104447A (ko) * | 2005-02-10 | 2007-10-25 | 라이프사이클 파마 에이/에스 | 페노피브레이트 및 HMG-CoA 리덕타제 억제제의 고정용량 배합물을 포함하는 안정한 약학 조성물 |
US7915247B1 (en) | 2006-08-21 | 2011-03-29 | Mutual Pharmaceutical Company, Inc. | Methods of use of fenofibric acid |
WO2008075320A2 (fr) * | 2006-12-21 | 2008-06-26 | Ranbaxy Laboratories Limited | Compositions pharmaceutiques antilipidémiques et leur procédé de préparation |
US20110097414A1 (en) * | 2007-02-26 | 2011-04-28 | Sandal Roshan Lal | Pharmaceutical compositions comprising adsorbate of fenofibrate |
WO2008117154A2 (fr) * | 2007-03-26 | 2008-10-02 | Torrent Pharmaceuticals Limited | Compositions pharmaceutiques stables d'inhibiteur de hmg-coa réductase et leur procédé de préparation |
JP2011521992A (ja) * | 2008-06-06 | 2011-07-28 | ニコックス エス エイ | アトルバスタチン4−(ニトロキシ)ブチルエステルおよび脂質低下剤を含む組成物 |
JP5758899B2 (ja) * | 2009-09-17 | 2015-08-05 | ビーエーエスエフ ソシエタス・ヨーロピアBasf Se | 活性物質を含有するコーティングにより被覆されたペレット |
CN102781429A (zh) * | 2010-03-05 | 2012-11-14 | 巴斯夫欧洲公司 | 经熔体涂覆的药物剂型 |
US20110217289A1 (en) * | 2010-03-05 | 2011-09-08 | Basf Se | Melt-Coated Dosage Forms |
CN102525942A (zh) * | 2012-01-05 | 2012-07-04 | 金陵药业股份有限公司 | 一种阿托伐他汀钙肠溶微丸及其制备方法 |
KR20230079187A (ko) | 2020-09-29 | 2023-06-05 | 라보라토리오스 실레인즈, 에스.에이. 드 씨.브이. | 고지혈증 및 심혈관 질환의 치료 및 예방을 위한 스타틴 및 피브레이트의 약학적 병용 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6294501A (en) * | 2000-09-20 | 2002-04-02 | Rtp Pharma Inc | Spray drying process and compositions of fenofibrate |
US7217431B2 (en) * | 2001-07-06 | 2007-05-15 | Lifecycle Pharma A/S | Controlled agglomeration |
US20030162827A1 (en) * | 2002-01-30 | 2003-08-28 | Suresh Venkataram | HMG CoA reductase inhibiting composition, method of preparation thereof and method for competitively inhibiting HMG CoA reductase using such composition |
US20060115524A1 (en) * | 2003-02-19 | 2006-06-01 | H. Lundbeck A/S | Method for preparation of an agglomerate using melt agglomeration |
MXPA06003813A (es) * | 2003-10-10 | 2006-06-14 | Lifecycle Pharma As | Forma solida de dosificacion que comprende un fibrato y una estatina. |
-
2005
- 2005-10-03 EP EP05789004A patent/EP1804769A1/fr not_active Withdrawn
- 2005-10-03 CA CA002582403A patent/CA2582403A1/fr not_active Abandoned
- 2005-10-03 WO PCT/DK2005/050004 patent/WO2006037347A1/fr active Application Filing
- 2005-10-03 EP EP05789000A patent/EP1804768A1/fr not_active Withdrawn
- 2005-10-03 CA CA002582405A patent/CA2582405A1/fr not_active Abandoned
- 2005-10-03 WO PCT/DK2005/050001 patent/WO2006037344A1/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
CA2582405A1 (fr) | 2006-04-13 |
EP1804768A1 (fr) | 2007-07-11 |
WO2006037347A1 (fr) | 2006-04-13 |
WO2006037344A1 (fr) | 2006-04-13 |
EP1804769A1 (fr) | 2007-07-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Dead |