CA2582095A1 - Inhibitors of hepatitis c virus - Google Patents
Inhibitors of hepatitis c virus Download PDFInfo
- Publication number
- CA2582095A1 CA2582095A1 CA002582095A CA2582095A CA2582095A1 CA 2582095 A1 CA2582095 A1 CA 2582095A1 CA 002582095 A CA002582095 A CA 002582095A CA 2582095 A CA2582095 A CA 2582095A CA 2582095 A1 CA2582095 A1 CA 2582095A1
- Authority
- CA
- Canada
- Prior art keywords
- seq
- leu
- peptide
- group
- thr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 239000003094 microcapsule Substances 0.000 description 1
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- 238000002887 multiple sequence alignment Methods 0.000 description 1
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- 230000004044 response Effects 0.000 description 1
- NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61428004P | 2004-09-29 | 2004-09-29 | |
| US60/614,280 | 2004-09-29 | ||
| PCT/US2005/034777 WO2006039326A2 (en) | 2004-09-29 | 2005-09-26 | Inhibitors of hepatitits c virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2582095A1 true CA2582095A1 (en) | 2006-04-13 |
Family
ID=36143015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002582095A Abandoned CA2582095A1 (en) | 2004-09-29 | 2005-09-26 | Inhibitors of hepatitis c virus |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7381705B2 (https=) |
| EP (1) | EP1797112B1 (https=) |
| JP (1) | JP4980915B2 (https=) |
| AT (1) | ATE474587T1 (https=) |
| AU (1) | AU2005292135B2 (https=) |
| CA (1) | CA2582095A1 (https=) |
| DE (1) | DE602005022463D1 (https=) |
| ES (1) | ES2349153T3 (https=) |
| PL (1) | PL1797112T3 (https=) |
| PT (1) | PT1797112E (https=) |
| WO (1) | WO2006039326A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2009510122A (ja) * | 2005-09-29 | 2009-03-12 | ザ スクリプス リサーチ インスティテュート | ウイルスペプチドおよびフラビウイルス科のウイルスに対してウイルス感染を阻害するためのその使用 |
| WO2008124176A2 (en) | 2007-04-10 | 2008-10-16 | The Administrators Of The Tulane Educational Fund | Soluble and membrane-anchored forms of lassa virus subunit proteins |
| WO2009021063A2 (en) * | 2007-08-06 | 2009-02-12 | The Regents Of The University Of California | Composition and method of use for hcv immunization |
| WO2009030872A1 (en) * | 2007-09-07 | 2009-03-12 | Mats Axel Atterdag Persson | Materials and methods for the treatment of hepatitis c |
| CA2698666A1 (en) * | 2007-09-11 | 2009-03-19 | Mondobiotech Laboratories Ag | Use of a peptide as a therapeutic agent |
| US20100104555A1 (en) * | 2008-10-24 | 2010-04-29 | The Scripps Research Institute | HCV neutralizing epitopes |
| CA2658714A1 (en) | 2009-03-17 | 2010-09-17 | Thomas Krey | Hcv-derived polypeptides and uses thereof |
| WO2013050048A2 (en) | 2011-10-07 | 2013-04-11 | Skau Aps | Identification and attenuation of the immunosuppressive domains in fusion proteins of enveloped rna viruses |
| CN104324361A (zh) * | 2014-05-16 | 2015-02-04 | 中国疾病预防控制中心病毒病预防控制所 | 丙型肝炎病毒(hcv)细胞进入抑制肽zte2序列及应用 |
| CN109232721B (zh) * | 2018-09-26 | 2021-06-29 | 广州市第八人民医院 | Hcv包膜蛋白高度保守区域的肽段418-429及其用途 |
| AU2020323462A1 (en) * | 2019-07-26 | 2022-03-10 | The Scripps Research Institute | Engineered HCV E2 immunogens and related vaccine compositions |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0185373B1 (ko) * | 1989-03-17 | 1999-05-01 | 로버트 피. 블랙버언 | Hcv 폴리단백질에서 유래되는 hcv 아미노산 서열 부분을 포함하는 폴리펩티드 및 그 사용 |
| US5747239A (en) * | 1990-02-16 | 1998-05-05 | United Biomedical, Inc. | Synthetic peptides specific for the detection of antibodies to HCV, diagnosis of HCV infection and preventions thereof as vaccines |
| EP0992580B1 (en) * | 1993-11-04 | 2005-03-09 | Innogenetics N.V. | Immunodominant human T-cell epitopes of Hepatitis C virus |
| US6127116A (en) * | 1995-08-29 | 2000-10-03 | Washington University | Functional DNA clone for hepatitis C virus (HCV) and uses thereof |
| SE9503380D0 (sv) * | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
| US6037348A (en) * | 1996-02-09 | 2000-03-14 | Eli Lilly And Company | Inhibition of viral replication |
| JP2001514508A (ja) * | 1997-03-05 | 2001-09-11 | ユニバーシティー オブ ワシントン | C型肝炎ウイルスの複製を選択的に抑制する薬剤を同定するための新規なスクリーニング法 |
| US6153421A (en) * | 1997-07-18 | 2000-11-28 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Cloned genomes of infectious hepatitis C viruses and uses thereof |
| US6127166A (en) * | 1997-11-03 | 2000-10-03 | Bayley; Hagan | Molluscan ligament polypeptides and genes encoding them |
| US7091324B2 (en) * | 1998-11-05 | 2006-08-15 | Board Of Trustees Of Leland Stanford Junior University | Prevention and treatment of HCV infection employing antibodies directed against conformational epitopes |
| EP1178116A1 (en) | 2000-08-03 | 2002-02-06 | Hybrigenics S.A. | Sid nucleic acids and polypeptides selected from a pathogenic strain of hepatitis C virus and applications thereof |
| JP5175417B2 (ja) * | 2000-08-17 | 2013-04-03 | トリペップ アクチ ボラゲット | リバビリンを含むワクチンおよびその使用方法 |
| US20030232745A1 (en) * | 2001-06-26 | 2003-12-18 | Olson William C. | Uses of DC-sign and DC-Signr for inhibiting hepatitis C virus infection |
| US7022323B2 (en) * | 2001-06-26 | 2006-04-04 | Progenics Pharmaceuticals, Inc. | Uses of DC-SIGN and DC-SIGNR for inhibiting hepatitis C virus infection |
| DK1558276T3 (da) | 2002-11-08 | 2012-10-22 | Univ Tulane | Flavivirus-fusionsinhibitorer |
| EP1638993A4 (en) * | 2003-06-10 | 2007-05-09 | Univ Melbourne | IMMUNOMODULATING COMPOSITIONS, APPLICATIONS THEREOF AND METHOD FOR THE PRODUCTION THEREOF |
-
2005
- 2005-09-26 AT AT05814026T patent/ATE474587T1/de not_active IP Right Cessation
- 2005-09-26 JP JP2007534728A patent/JP4980915B2/ja not_active Expired - Fee Related
- 2005-09-26 WO PCT/US2005/034777 patent/WO2006039326A2/en not_active Ceased
- 2005-09-26 ES ES05814026T patent/ES2349153T3/es active Active
- 2005-09-26 CA CA002582095A patent/CA2582095A1/en not_active Abandoned
- 2005-09-26 DE DE602005022463T patent/DE602005022463D1/de active Active
- 2005-09-26 EP EP05814026A patent/EP1797112B1/en not_active Not-in-force
- 2005-09-26 AU AU2005292135A patent/AU2005292135B2/en not_active Ceased
- 2005-09-26 PL PL05814026T patent/PL1797112T3/pl unknown
- 2005-09-26 US US11/235,672 patent/US7381705B2/en not_active Expired - Fee Related
- 2005-09-26 PT PT05814026T patent/PT1797112E/pt unknown
-
2008
- 2008-05-19 US US12/152,964 patent/US20080241156A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20060069027A1 (en) | 2006-03-30 |
| JP2008514717A (ja) | 2008-05-08 |
| AU2005292135B2 (en) | 2011-09-29 |
| EP1797112A4 (en) | 2009-04-01 |
| EP1797112B1 (en) | 2010-07-21 |
| ATE474587T1 (de) | 2010-08-15 |
| AU2005292135A1 (en) | 2006-04-13 |
| US7381705B2 (en) | 2008-06-03 |
| US20080241156A1 (en) | 2008-10-02 |
| PL1797112T3 (pl) | 2011-04-29 |
| EP1797112A2 (en) | 2007-06-20 |
| WO2006039326A3 (en) | 2007-05-10 |
| DE602005022463D1 (de) | 2010-09-02 |
| PT1797112E (pt) | 2010-10-25 |
| JP4980915B2 (ja) | 2012-07-18 |
| ES2349153T3 (es) | 2010-12-28 |
| WO2006039326A2 (en) | 2006-04-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20160323 |