CA2581606A1 - Composition sans excipient pour le traitement de l'onychomycose - Google Patents
Composition sans excipient pour le traitement de l'onychomycose Download PDFInfo
- Publication number
- CA2581606A1 CA2581606A1 CA002581606A CA2581606A CA2581606A1 CA 2581606 A1 CA2581606 A1 CA 2581606A1 CA 002581606 A CA002581606 A CA 002581606A CA 2581606 A CA2581606 A CA 2581606A CA 2581606 A1 CA2581606 A1 CA 2581606A1
- Authority
- CA
- Canada
- Prior art keywords
- composition
- ingredients
- carrier
- mixture
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 40
- 208000010195 Onychomycosis Diseases 0.000 title abstract description 5
- 201000005882 tinea unguium Diseases 0.000 title abstract description 5
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000004615 ingredient Substances 0.000 claims abstract description 21
- 239000007788 liquid Substances 0.000 claims abstract description 14
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 13
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims abstract description 13
- 241000723346 Cinnamomum camphora Species 0.000 claims abstract description 13
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000005844 Thymol Substances 0.000 claims abstract description 13
- 229960000846 camphor Drugs 0.000 claims abstract description 13
- 229930008380 camphor Natural products 0.000 claims abstract description 13
- 229940041616 menthol Drugs 0.000 claims abstract description 13
- 229960000790 thymol Drugs 0.000 claims abstract description 13
- 244000166124 Eucalyptus globulus Species 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims description 13
- 239000003921 oil Substances 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 210000004906 toe nail Anatomy 0.000 claims description 3
- 206010017533 Fungal infection Diseases 0.000 claims description 2
- 208000031888 Mycoses Diseases 0.000 claims description 2
- 239000012230 colorless oil Substances 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 230000002538 fungal effect Effects 0.000 abstract description 2
- 208000026721 nail disease Diseases 0.000 abstract description 2
- 239000002904 solvent Substances 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 description 4
- 239000002609 medium Substances 0.000 description 3
- 210000000282 nail Anatomy 0.000 description 3
- 241001353193 Agromyces terreus Species 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 2
- 241000222173 Candida parapsilosis Species 0.000 description 2
- 241000223221 Fusarium oxysporum Species 0.000 description 2
- 241000690372 Fusarium proliferatum Species 0.000 description 2
- 241000893980 Microsporum canis Species 0.000 description 2
- 241000509463 Neoscytalidium hyalinum Species 0.000 description 2
- 241000228417 Sarocladium strictum Species 0.000 description 2
- 241000825258 Scopulariopsis brevicaulis Species 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical compound CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 1
- 241001019659 Acremonium <Plectosphaerellaceae> Species 0.000 description 1
- 241000228431 Acremonium chrysogenum Species 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241000228197 Aspergillus flavus Species 0.000 description 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241001480036 Epidermophyton floccosum Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 244000165852 Eucalyptus citriodora Species 0.000 description 1
- 235000004722 Eucalyptus citriodora Nutrition 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000223218 Fusarium Species 0.000 description 1
- 241001547451 Neoscytalidium dimidiatum Species 0.000 description 1
- 239000006159 Sabouraud's agar Substances 0.000 description 1
- 241000223255 Scytalidium Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000223238 Trichophyton Species 0.000 description 1
- 241001045770 Trichophyton mentagrophytes Species 0.000 description 1
- 241000223229 Trichophyton rubrum Species 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 238000002802 antimicrobial activity assay Methods 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- ZYVSOIYQKUDENJ-WKSBCEQHSA-N chromomycin A3 Chemical compound O([C@@H]1C[C@@H](O[C@H](C)[C@@H]1OC(C)=O)OC=1C=C2C=C3C[C@H]([C@@H](C(=O)C3=C(O)C2=C(O)C=1C)O[C@@H]1O[C@H](C)[C@@H](O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](O[C@@H]3O[C@@H](C)[C@H](OC(C)=O)[C@@](C)(O)C3)C2)C1)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O)[C@@H]1C[C@@H](O)[C@@H](OC)[C@@H](C)O1 ZYVSOIYQKUDENJ-WKSBCEQHSA-N 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000009629 microbiological culture Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Botany (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2004/031630 WO2006036144A1 (fr) | 2004-09-24 | 2004-09-24 | Composition sans excipient pour le traitement de l'onychomycose |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2581606A1 true CA2581606A1 (fr) | 2006-04-06 |
Family
ID=36119190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002581606A Abandoned CA2581606A1 (fr) | 2004-09-24 | 2004-09-24 | Composition sans excipient pour le traitement de l'onychomycose |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1796703A4 (fr) |
| JP (1) | JP2008514596A (fr) |
| CA (1) | CA2581606A1 (fr) |
| WO (1) | WO2006036144A1 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL1036661C2 (en) | 2009-03-04 | 2010-09-07 | Serrix B V | Anti-fungal compounds & compositions. |
| DE202010012041U1 (de) | 2010-08-31 | 2010-11-18 | Sanderstrothmann Gmbh | Zubereitung zur Nagelpflege |
| CN103893599A (zh) * | 2014-04-12 | 2014-07-02 | 张军 | 一种治疗灰指甲的外用中药洗剂 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04154719A (ja) * | 1990-10-19 | 1992-05-27 | Hiroshi Kikuchi | 水虫薬 |
| WO1998054279A1 (fr) * | 1997-05-30 | 1998-12-03 | The Procter & Gamble Company | Compositions desinfectantes et procedes de desinfection de surfaces |
| JP2000128800A (ja) * | 1998-10-16 | 2000-05-09 | Hideyo Yamaguchi | 水虫の感染予防および／又は治療法およびその器材 |
| US6344190B1 (en) * | 1999-02-08 | 2002-02-05 | Board Of Trustees Of Michigan State University | Method and compositions for treatment of fungal nail disease |
| US6436424B1 (en) * | 2000-03-20 | 2002-08-20 | Biosphere Medical, Inc. | Injectable and swellable microspheres for dermal augmentation |
| JP2003073290A (ja) * | 2001-08-31 | 2003-03-12 | Kao Corp | 外用剤組成物 |
-
2004
- 2004-09-24 JP JP2007533444A patent/JP2008514596A/ja active Pending
- 2004-09-24 WO PCT/US2004/031630 patent/WO2006036144A1/fr active Application Filing
- 2004-09-24 EP EP04789085A patent/EP1796703A4/fr not_active Withdrawn
- 2004-09-24 CA CA002581606A patent/CA2581606A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006036144A1 (fr) | 2006-04-06 |
| EP1796703A1 (fr) | 2007-06-20 |
| JP2008514596A (ja) | 2008-05-08 |
| AU2004323577A1 (en) | 2006-04-06 |
| EP1796703A4 (fr) | 2009-07-01 |
| WO2006036144A8 (fr) | 2007-06-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |