CA2578073C - Mass spectrometer - Google Patents

Mass spectrometer Download PDF

Info

Publication number
CA2578073C
CA2578073C CA2578073A CA2578073A CA2578073C CA 2578073 C CA2578073 C CA 2578073C CA 2578073 A CA2578073 A CA 2578073A CA 2578073 A CA2578073 A CA 2578073A CA 2578073 C CA2578073 C CA 2578073C
Authority
CA
Canada
Prior art keywords
ions
fragmentation device
separator
mass
ion mobility
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2578073A
Other languages
English (en)
French (fr)
Other versions
CA2578073A1 (en
Inventor
Jason Lee Wildgoose
Steven Derek Pringle
Kevin Giles
Robert Harold Bateman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micromass UK Ltd
Original Assignee
Micromass UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Publication of CA2578073A1 publication Critical patent/CA2578073A1/en
Application granted granted Critical
Publication of CA2578073C publication Critical patent/CA2578073C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/005—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by collision with gas, e.g. by introducing gas or by accelerating ions with an electric field

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
CA2578073A 2004-09-14 2005-09-14 Mass spectrometer Expired - Lifetime CA2578073C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB0420408.7A GB0420408D0 (en) 2004-09-14 2004-09-14 Mass spectrometer
GB0420408.7 2004-09-14
US61163604P 2004-09-21 2004-09-21
US60/611,636 2004-09-21
PCT/GB2005/003543 WO2006030205A2 (en) 2004-09-14 2005-09-14 Mass spectrometer

Publications (2)

Publication Number Publication Date
CA2578073A1 CA2578073A1 (en) 2006-03-23
CA2578073C true CA2578073C (en) 2015-02-10

Family

ID=33306533

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2578073A Expired - Lifetime CA2578073C (en) 2004-09-14 2005-09-14 Mass spectrometer

Country Status (6)

Country Link
US (1) US7622711B2 (https=)
EP (3) EP3644345A1 (https=)
JP (1) JP5166031B2 (https=)
CA (1) CA2578073C (https=)
GB (2) GB0420408D0 (https=)
WO (1) WO2006030205A2 (https=)

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US20020115056A1 (en) * 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
GB0305796D0 (en) 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
GB0514964D0 (en) 2005-07-21 2005-08-24 Ms Horizons Ltd Mass spectrometer devices & methods of performing mass spectrometry
WO2008007069A2 (en) * 2006-07-10 2008-01-17 Micromass Uk Limited Mass spectrometer
GB0424426D0 (en) 2004-11-04 2004-12-08 Micromass Ltd Mass spectrometer
GB2432043B (en) * 2004-12-07 2009-06-24 Micromass Ltd Mass spectrometer
US7544933B2 (en) * 2006-01-17 2009-06-09 Purdue Research Foundation Method and system for desorption atmospheric pressure chemical ionization
US8026477B2 (en) * 2006-03-03 2011-09-27 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
GB0608470D0 (en) * 2006-04-28 2006-06-07 Micromass Ltd Mass spectrometer
GB0609253D0 (en) * 2006-05-10 2006-06-21 Micromass Ltd Mass spectrometer
GB0612503D0 (en) 2006-06-23 2006-08-02 Micromass Ltd Mass spectrometer
US7479629B2 (en) * 2006-08-24 2009-01-20 Agilent Technologies, Inc. Multichannel rapid sampling of chromatographic peaks by tandem mass spectrometer
DE102007017055B4 (de) * 2007-04-11 2011-06-22 Bruker Daltonik GmbH, 28359 Messung der Mobilität massenselektierter Ionen
US8598517B2 (en) * 2007-12-20 2013-12-03 Purdue Research Foundation Method and apparatus for activation of cation transmission mode ion/ion reactions
GB0801309D0 (en) * 2008-01-24 2008-03-05 Micromass Ltd Mass spectrometer
GB0915474D0 (en) * 2009-09-04 2009-10-07 Micromass Ltd Multiple reaction monitoring with a time-of-flight based mass spectrometer
WO2011073794A2 (en) * 2009-12-18 2011-06-23 Dh Technologies Development Pte. Ltd. Method of processing ions
US8809772B2 (en) 2010-09-08 2014-08-19 Dh Technologies Development Pte. Ltd. Systems and methods for using variable mass selection window widths in tandem mass spectrometry
WO2012175978A1 (en) * 2011-06-24 2012-12-27 Micromass Uk Limited Method and apparatus for generating spectral data
GB201304536D0 (en) * 2013-03-13 2013-04-24 Micromass Ltd Charge state determination and optimum collision energy selection based upon the IMS drift time in a DDA experiment to reduce processing
US9697996B2 (en) 2013-03-13 2017-07-04 Micromass Uk Limited DDA experiment with reduced data processing
EP3069374A1 (en) 2013-11-12 2016-09-21 Micromass UK Limited Data dependent ms/ms analysis
WO2015071649A2 (en) * 2013-11-12 2015-05-21 Micromass Uk Limited Method of associating precursor and product ions
DE112015002567B4 (de) 2014-05-30 2023-09-07 Micromass Uk Limited Hybridmassenspektrometer
US10371665B2 (en) * 2014-06-06 2019-08-06 Micromass Uk Limited Mobility selective attenuation
WO2015189545A1 (en) * 2014-06-11 2015-12-17 Micromass Uk Limited Ion mobility spectrometry data directed acquisition
DE102015117635B4 (de) * 2015-10-16 2018-01-11 Bruker Daltonik Gmbh Strukturaufklärung von intakten schweren Molekülen und Molekülkomplexen in Massenspektrometern
CN109075012B (zh) 2016-04-14 2021-01-26 英国质谱公司 二维msms
GB2562690B (en) 2016-09-27 2022-11-02 Micromass Ltd Post-separation mobility analyser
GB201808890D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
GB201808912D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
GB201808893D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
GB201808892D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Mass spectrometer
GB201808932D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
GB201808894D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Mass spectrometer
GB201808936D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
GB201808949D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
US11373849B2 (en) 2018-05-31 2022-06-28 Micromass Uk Limited Mass spectrometer having fragmentation region
GB2602188B (en) 2018-05-31 2023-01-11 Micromass Ltd Mass spectrometer
EP3977628A4 (en) 2019-05-31 2023-06-28 DH Technologies Development Pte. Ltd. Method for real time encoding of scanning swath data and probabilistic framework for precursor inference
WO2023209553A1 (en) * 2022-04-25 2023-11-02 Dh Technologies Development Pte. Ltd. Data independent acquisition mass spectrometry with charge state reduction by proton transfer reactions

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4214160A (en) * 1976-03-04 1980-07-22 Finnigan Corporation Mass spectrometer system and method for control of ion energy for different masses
US4234791A (en) * 1978-11-13 1980-11-18 Research Corporation Tandem quadrupole mass spectrometer for selected ion fragmentation studies and low energy collision induced dissociator therefor
US6323482B1 (en) * 1997-06-02 2001-11-27 Advanced Research And Technology Institute, Inc. Ion mobility and mass spectrometer
CA2312754C (en) * 1997-12-04 2007-10-09 University Of Manitoba Method of and apparatus for selective collision-induced dissociation of ions in a quadrupole ion guide
CA2227806C (en) * 1998-01-23 2006-07-18 University Of Manitoba Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
US6534764B1 (en) * 1999-06-11 2003-03-18 Perseptive Biosystems Tandem time-of-flight mass spectrometer with damping in collision cell and method for use
US20020195555A1 (en) * 2000-10-11 2002-12-26 Weinberger Scot R. Apparatus and methods for affinity capture tandem mass spectrometry
US6441369B1 (en) * 2000-11-15 2002-08-27 Perseptive Biosystems, Inc. Tandem time-of-flight mass spectrometer with improved mass resolution
US6586732B2 (en) * 2001-02-20 2003-07-01 Brigham Young University Atmospheric pressure ionization ion mobility spectrometry
EP1402561A4 (en) * 2001-05-25 2007-06-06 Analytica Of Branford Inc ATMOSPHERIC MALDI IONS SOURCE AND UNDER LOW
CA2448990C (en) * 2001-05-25 2011-04-26 Ionwerks, Inc. A time-of-flight mass spectrometer for monitoring of fast processes
CA2391060C (en) * 2001-06-21 2011-08-09 Micromass Limited Mass spectrometer
US7586088B2 (en) * 2001-06-21 2009-09-08 Micromass Uk Limited Mass spectrometer and method of mass spectrometry
US6630662B1 (en) * 2002-04-24 2003-10-07 Mds Inc. Setup for mobility separation of ions implementing an ion guide with an axial field and counterflow of gas
GB2389704B (en) 2002-05-17 2004-06-02 * Micromass Limited Mass Spectrometer
US6791078B2 (en) * 2002-06-27 2004-09-14 Micromass Uk Limited Mass spectrometer
GB2392006B (en) 2002-07-03 2005-10-12 Micromass Ltd Mass spectrometer
GB0305796D0 (en) 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
DE10392952B4 (de) * 2002-09-03 2012-04-19 Micromass Uk Ltd. Verfahren zur Massenspektrometrie
JP3791479B2 (ja) * 2002-09-17 2006-06-28 株式会社島津製作所 イオンガイド
GB0313054D0 (en) 2003-06-06 2003-07-09 Micromass Ltd Mass spectrometer

Also Published As

Publication number Publication date
CA2578073A1 (en) 2006-03-23
EP2660850A1 (en) 2013-11-06
WO2006030205A3 (en) 2007-06-07
EP1789989A2 (en) 2007-05-30
GB0518778D0 (en) 2005-10-26
US20080135746A1 (en) 2008-06-12
EP1789989B1 (en) 2017-12-27
EP3644345A1 (en) 2020-04-29
WO2006030205A2 (en) 2006-03-23
JP5166031B2 (ja) 2013-03-21
GB2421839B (en) 2007-09-12
US7622711B2 (en) 2009-11-24
GB2421839A (en) 2006-07-05
JP2008513941A (ja) 2008-05-01
GB0420408D0 (en) 2004-10-20
EP2660850B1 (en) 2019-11-20

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