CA2576059A1 - Dispositifs et procedes d'interfacage de dispositifs microfluidiques avec des dispositifs de manipulation de fluides - Google Patents
Dispositifs et procedes d'interfacage de dispositifs microfluidiques avec des dispositifs de manipulation de fluides Download PDFInfo
- Publication number
- CA2576059A1 CA2576059A1 CA002576059A CA2576059A CA2576059A1 CA 2576059 A1 CA2576059 A1 CA 2576059A1 CA 002576059 A CA002576059 A CA 002576059A CA 2576059 A CA2576059 A CA 2576059A CA 2576059 A1 CA2576059 A1 CA 2576059A1
- Authority
- CA
- Canada
- Prior art keywords
- tile
- microfluidic
- tiles
- fluidic
- input port
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000012530 fluid Substances 0.000 title claims abstract description 136
- 238000000034 method Methods 0.000 title claims abstract description 73
- 239000011449 brick Substances 0.000 claims description 111
- 239000000758 substrate Substances 0.000 claims description 89
- 239000003153 chemical reaction reagent Substances 0.000 claims description 45
- 238000003556 assay Methods 0.000 claims description 42
- 239000007788 liquid Substances 0.000 claims description 37
- 208000029152 Small face Diseases 0.000 claims description 26
- 239000010410 layer Substances 0.000 claims description 26
- 238000004891 communication Methods 0.000 claims description 20
- 238000007789 sealing Methods 0.000 claims description 20
- 239000000463 material Substances 0.000 claims description 17
- 230000003287 optical effect Effects 0.000 claims description 16
- 238000012545 processing Methods 0.000 claims description 16
- 238000000605 extraction Methods 0.000 claims description 15
- 150000001875 compounds Chemical class 0.000 claims description 14
- 238000001746 injection moulding Methods 0.000 claims description 14
- -1 polyethylene Polymers 0.000 claims description 10
- 238000001514 detection method Methods 0.000 claims description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 8
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 8
- 230000007246 mechanism Effects 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 239000010703 silicon Substances 0.000 claims description 7
- 229910052710 silicon Inorganic materials 0.000 claims description 7
- 238000004049 embossing Methods 0.000 claims description 6
- 239000004417 polycarbonate Substances 0.000 claims description 6
- 238000003780 insertion Methods 0.000 claims description 5
- 230000037431 insertion Effects 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 229920000515 polycarbonate Polymers 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 239000004698 Polyethylene Substances 0.000 claims description 4
- 229920000573 polyethylene Polymers 0.000 claims description 4
- 239000004743 Polypropylene Substances 0.000 claims description 3
- 239000004793 Polystyrene Substances 0.000 claims description 3
- 239000012790 adhesive layer Substances 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000000608 laser ablation Methods 0.000 claims description 3
- 238000000465 moulding Methods 0.000 claims description 3
- 229920001155 polypropylene Polymers 0.000 claims description 3
- 239000000377 silicon dioxide Substances 0.000 claims description 3
- 125000006850 spacer group Chemical group 0.000 claims description 3
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical class COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims description 2
- 239000004809 Teflon Substances 0.000 claims description 2
- 229920006362 Teflon® Polymers 0.000 claims description 2
- HABJPZIXZYFQGT-UHFFFAOYSA-N acetonitrile;buta-1,3-diene;styrene Chemical compound CC#N.C=CC=C.C=CC1=CC=CC=C1 HABJPZIXZYFQGT-UHFFFAOYSA-N 0.000 claims description 2
- 238000003486 chemical etching Methods 0.000 claims description 2
- 239000013078 crystal Substances 0.000 claims description 2
- 230000002255 enzymatic effect Effects 0.000 claims description 2
- 238000003475 lamination Methods 0.000 claims description 2
- 229920000098 polyolefin Polymers 0.000 claims description 2
- 229920002223 polystyrene Polymers 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 238000012360 testing method Methods 0.000 claims description 2
- 239000012491 analyte Substances 0.000 claims 3
- 238000010256 biochemical assay Methods 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 238000000423 cell based assay Methods 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 238000013461 design Methods 0.000 abstract description 15
- 238000004519 manufacturing process Methods 0.000 description 53
- 238000011068 loading method Methods 0.000 description 52
- 238000005516 engineering process Methods 0.000 description 31
- 230000008569 process Effects 0.000 description 23
- 238000013459 approach Methods 0.000 description 17
- 230000008901 benefit Effects 0.000 description 17
- 239000000243 solution Substances 0.000 description 17
- 238000003860 storage Methods 0.000 description 12
- 238000001704 evaporation Methods 0.000 description 11
- 238000011109 contamination Methods 0.000 description 10
- 239000000523 sample Substances 0.000 description 10
- 230000008020 evaporation Effects 0.000 description 9
- 230000033001 locomotion Effects 0.000 description 9
- 238000012986 modification Methods 0.000 description 9
- 230000004048 modification Effects 0.000 description 9
- 229920000642 polymer Polymers 0.000 description 9
- 239000007789 gas Substances 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 7
- 239000000428 dust Substances 0.000 description 7
- 239000011159 matrix material Substances 0.000 description 7
- 230000001133 acceleration Effects 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 238000012546 transfer Methods 0.000 description 6
- 230000001070 adhesive effect Effects 0.000 description 5
- 238000004140 cleaning Methods 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 238000005530 etching Methods 0.000 description 5
- 238000011049 filling Methods 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 230000009467 reduction Effects 0.000 description 5
- 238000012216 screening Methods 0.000 description 5
- 239000000853 adhesive Substances 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 238000005304 joining Methods 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 229920003023 plastic Polymers 0.000 description 4
- 230000010076 replication Effects 0.000 description 4
- 230000032258 transport Effects 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 238000005553 drilling Methods 0.000 description 3
- 238000007876 drug discovery Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 238000012856 packing Methods 0.000 description 3
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 3
- 239000004926 polymethyl methacrylate Substances 0.000 description 3
- 230000003362 replicative effect Effects 0.000 description 3
- 108091000080 Phosphotransferase Proteins 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 239000002998 adhesive polymer Substances 0.000 description 2
- 230000031018 biological processes and functions Effects 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 238000001962 electrophoresis Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 238000003801 milling Methods 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 102000020233 phosphotransferase Human genes 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 229920006254 polymer film Polymers 0.000 description 2
- 238000012805 post-processing Methods 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 238000003908 quality control method Methods 0.000 description 2
- 239000010453 quartz Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 230000011218 segmentation Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000009987 spinning Methods 0.000 description 2
- 230000009897 systematic effect Effects 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 244000043261 Hevea brasiliensis Species 0.000 description 1
- 241000233855 Orchidaceae Species 0.000 description 1
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000538 analytical sample Substances 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003851 biochemical process Effects 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 150000005829 chemical entities Chemical class 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 230000005574 cross-species transmission Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000010017 direct printing Methods 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000011038 discontinuous diafiltration by volume reduction Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 235000012489 doughnuts Nutrition 0.000 description 1
- 238000009713 electroplating Methods 0.000 description 1
- 238000007824 enzymatic assay Methods 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000012252 genetic analysis Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000007641 inkjet printing Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 238000005468 ion implantation Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 229940043355 kinase inhibitor Drugs 0.000 description 1
- 238000001459 lithography Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002493 microarray Methods 0.000 description 1
- 238000001393 microlithography Methods 0.000 description 1
- 229920003052 natural elastomer Polymers 0.000 description 1
- 229920001194 natural rubber Polymers 0.000 description 1
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000002974 pharmacogenomic effect Effects 0.000 description 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 description 1
- 239000012994 photoredox catalyst Substances 0.000 description 1
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 239000013047 polymeric layer Substances 0.000 description 1
- 229940124606 potential therapeutic agent Drugs 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 239000005297 pyrex Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000002444 silanisation Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000012289 standard assay Methods 0.000 description 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 210000001138 tear Anatomy 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
- B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00801—Means to assemble
- B01J2219/0081—Plurality of modules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00891—Feeding or evacuation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/028—Modular arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/02—Identification, exchange or storage of information
- B01L2300/021—Identification, e.g. bar codes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0829—Multi-well plates; Microtitration plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00326—Analysers with modular structure
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0418—Plate elements with several rows of samples
- G01N2035/0425—Stacks, magazines or elevators for plates
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59859804P | 2004-08-04 | 2004-08-04 | |
US60/598,598 | 2004-08-04 | ||
PCT/IB2005/003985 WO2006043181A2 (fr) | 2004-08-04 | 2005-08-04 | Dispositifs et procedes d'interfacage de dispositifs microfluidiques avec des dispositifs de manipulation de fluides |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2576059A1 true CA2576059A1 (fr) | 2006-04-27 |
Family
ID=36143272
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002576059A Abandoned CA2576059A1 (fr) | 2004-08-04 | 2005-08-04 | Dispositifs et procedes d'interfacage de dispositifs microfluidiques avec des dispositifs de manipulation de fluides |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1799348A2 (fr) |
JP (1) | JP2008509387A (fr) |
CN (1) | CN101094722A (fr) |
CA (1) | CA2576059A1 (fr) |
WO (1) | WO2006043181A2 (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7867763B2 (en) | 2004-01-25 | 2011-01-11 | Fluidigm Corporation | Integrated chip carriers with thermocycler interfaces and methods of using the same |
US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
WO2007147074A2 (fr) | 2006-06-14 | 2007-12-21 | Living Microsystems, Inc. | Utilisation de génotypage snp fortement parallèle pour diagnostic fœtal |
EP2589668A1 (fr) | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Analyse de cellules rares utilisant la division d'échantillons et les marqueurs d'ADN |
US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
ES2277573B1 (es) * | 2006-10-31 | 2008-05-16 | Grifols, S.A. | Dispositivo para la carga de tarjetas de reactivos para analizadores clinicos. |
WO2008137213A1 (fr) | 2007-05-02 | 2008-11-13 | Siemens Healthcare Diagnostics Inc. | Distribution piézoélectrique d'un liquide diagnostique sur une surface de réactifs |
US8361782B2 (en) | 2007-05-02 | 2013-01-29 | Siemens Healthcare Diagnostics, Inc. | Piezo dispensing of a diagnostic liquid into microfluidic devices |
WO2009150549A2 (fr) * | 2008-06-13 | 2009-12-17 | Spinx, Inc. | Dispositifs microfluides et procédés de cristallisation de protéines et de diffraction de rayons x in situ |
EP3378951B1 (fr) | 2008-09-20 | 2020-05-13 | The Board of Trustees of the Leland Stanford Junior University | Diagnostic non invasif d'une aneuploïdie par séquençage |
US11092977B1 (en) | 2017-10-30 | 2021-08-17 | Zane Coleman | Fluid transfer component comprising a film with fluid channels |
FR2984508A1 (fr) * | 2011-12-16 | 2013-06-21 | Francois Couillard | Dispositif permettant de collecter des liquides provenant d'instruments de separation traversant un tube dont l'extremite se deplace au dessus des recipients, de collecte sans perte de liquide |
DE102013220427A1 (de) * | 2013-10-10 | 2015-04-16 | Hamilton Bonaduz Ag | Bewegungsvorrichtung mit kombiniertem Individual- und Blockbewegungsantrieb für mehrere gemeinsam geführte Bewegungseinheiten |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040053290A1 (en) * | 2000-01-11 | 2004-03-18 | Terbrueggen Robert Henry | Devices and methods for biochip multiplexing |
WO2001021310A2 (fr) * | 1999-09-21 | 2001-03-29 | Genome Therapeutics Corporation | Dispositif de traitement rapide d'echantillons d'adn a manipulation des liquides, thermocyclage, et purification integres |
FR2806646A1 (fr) * | 2000-03-22 | 2001-09-28 | Francois Geli | Micro-arrays ou macro-arrays multiblocs avec laboratoires sur puces integres |
CA2427669A1 (fr) * | 2000-11-03 | 2002-06-06 | Clinical Micro Sensors, Inc. | Dispositifs et procedes de multiplexage de puces a adn |
US20050112033A1 (en) * | 2003-09-08 | 2005-05-26 | Irm, Llc | Multi-well containers, systems, and methods of using the same |
-
2005
- 2005-08-04 EP EP05846425A patent/EP1799348A2/fr not_active Withdrawn
- 2005-08-04 WO PCT/IB2005/003985 patent/WO2006043181A2/fr active Application Filing
- 2005-08-04 CA CA002576059A patent/CA2576059A1/fr not_active Abandoned
- 2005-08-04 CN CNA2005800336420A patent/CN101094722A/zh active Pending
- 2005-08-04 JP JP2007524427A patent/JP2008509387A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN101094722A (zh) | 2007-12-26 |
JP2008509387A (ja) | 2008-03-27 |
WO2006043181A2 (fr) | 2006-04-27 |
EP1799348A2 (fr) | 2007-06-27 |
WO2006043181A3 (fr) | 2006-06-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20070031282A1 (en) | Devices and methods for interfacing microfluidic devices with fluid handling devices | |
CA2576059A1 (fr) | Dispositifs et procedes d'interfacage de dispositifs microfluidiques avec des dispositifs de manipulation de fluides | |
US6582662B1 (en) | Devices and methods for the performance of miniaturized homogeneous assays | |
US8226908B2 (en) | Dosimeter for programmable microscale manipulation of fluids | |
US20120230887A1 (en) | Devices and methods for interfacing microfluidic devices with macrofluidic devices | |
EP1756586B1 (fr) | Système automatique de manipulation de dispositifs microfluidiques | |
US6485690B1 (en) | Multiple fluid sample processor and system | |
US7476361B2 (en) | Microfluidics devices and methods of diluting samples and reagents | |
US20020151078A1 (en) | Microfluidics devices and methods for high throughput screening | |
WO2001087485A2 (fr) | Dispositifs microfluidiques et procedes de criblage a haut debit | |
EP1730489A2 (fr) | Dispositifs de formation de cristaux et systemes et procedes de fabrication et d'utilisation de ceux-ci | |
JP2009168824A (ja) | 微小流体素子の並列処理 | |
US20050136545A1 (en) | Microfluidics devices and methods for performing based assays | |
US11485968B2 (en) | Microfluidic cartridge for processing and detecting nucleic acids | |
CN110437992A (zh) | 一种液相样品大规模、快速数字化分解芯片及其使用方法 | |
US20020137199A1 (en) | Micro storage, reaction and detection cells and method and apparatus for use thereof | |
US20130042888A1 (en) | Siphoning as a washing method and apparatus for heterogeneous assays |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued |
Effective date: 20130521 |