CA2576006A1 - Device for separating the epithelial layer from the surface of the cornea of an eye - Google Patents
Device for separating the epithelial layer from the surface of the cornea of an eye Download PDFInfo
- Publication number
- CA2576006A1 CA2576006A1 CA002576006A CA2576006A CA2576006A1 CA 2576006 A1 CA2576006 A1 CA 2576006A1 CA 002576006 A CA002576006 A CA 002576006A CA 2576006 A CA2576006 A CA 2576006A CA 2576006 A1 CA2576006 A1 CA 2576006A1
- Authority
- CA
- Canada
- Prior art keywords
- separator
- eye
- edge
- epithelial layer
- planar surface
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 210000005081 epithelial layer Anatomy 0.000 title claims abstract description 196
- 210000004087 cornea Anatomy 0.000 title claims description 65
- 238000000034 method Methods 0.000 claims abstract description 82
- 238000012545 processing Methods 0.000 claims abstract description 10
- 230000000149 penetrating effect Effects 0.000 claims abstract description 8
- 210000003683 corneal stroma Anatomy 0.000 claims description 49
- 230000010355 oscillation Effects 0.000 claims description 40
- 239000000758 substrate Substances 0.000 claims description 39
- 230000007246 mechanism Effects 0.000 claims description 6
- 210000004709 eyebrow Anatomy 0.000 claims description 4
- 238000000926 separation method Methods 0.000 description 48
- 210000000981 epithelium Anatomy 0.000 description 44
- 238000010586 diagram Methods 0.000 description 38
- 239000000463 material Substances 0.000 description 29
- 210000002919 epithelial cell Anatomy 0.000 description 23
- 210000004379 membrane Anatomy 0.000 description 23
- 239000012528 membrane Substances 0.000 description 23
- 210000001519 tissue Anatomy 0.000 description 20
- 230000008569 process Effects 0.000 description 15
- 238000000608 laser ablation Methods 0.000 description 12
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- 230000035876 healing Effects 0.000 description 9
- 229910052751 metal Inorganic materials 0.000 description 9
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- 238000001356 surgical procedure Methods 0.000 description 7
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- 230000000887 hydrating effect Effects 0.000 description 4
- 230000000007 visual effect Effects 0.000 description 4
- 208000004550 Postoperative Pain Diseases 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 238000004873 anchoring Methods 0.000 description 3
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- 238000013532 laser treatment Methods 0.000 description 3
- 150000002739 metals Chemical class 0.000 description 3
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 3
- 229920000052 poly(p-xylylene) Polymers 0.000 description 3
- 239000004926 polymethyl methacrylate Substances 0.000 description 3
- 230000007017 scission Effects 0.000 description 3
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- 238000011282 treatment Methods 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 2
- 241000408521 Lucida Species 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- 229910045601 alloy Inorganic materials 0.000 description 2
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- 239000010936 titanium Substances 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229940044192 2-hydroxyethyl methacrylate Drugs 0.000 description 1
- 229910000851 Alloy steel Inorganic materials 0.000 description 1
- 229920000049 Carbon (fiber) Polymers 0.000 description 1
- 102000002734 Collagen Type VI Human genes 0.000 description 1
- 108010043741 Collagen Type VI Proteins 0.000 description 1
- 102000004510 Collagen Type VII Human genes 0.000 description 1
- 108010017377 Collagen Type VII Proteins 0.000 description 1
- 229920002306 Glycocalyx Polymers 0.000 description 1
- -1 LASEK Chemical compound 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 230000009471 action Effects 0.000 description 1
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- 239000004917 carbon fiber Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 210000000795 conjunctiva Anatomy 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003560 epithelium corneal Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 210000004517 glycocalyx Anatomy 0.000 description 1
- 210000000301 hemidesmosome Anatomy 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000004410 intraocular pressure Effects 0.000 description 1
- 210000000110 microvilli Anatomy 0.000 description 1
- 230000000394 mitotic effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
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- 239000003223 protective agent Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000012858 resilient material Substances 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 239000003104 tissue culture media Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 210000000216 zygoma Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/013—Instruments for compensation of ocular refraction ; Instruments for use in cornea removal, for reshaping or performing incisions in the cornea
- A61F9/0133—Knives or scalpels specially adapted therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/013—Instruments for compensation of ocular refraction ; Instruments for use in cornea removal, for reshaping or performing incisions in the cornea
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Surgery (AREA)
- Prostheses (AREA)
- Eye Examination Apparatus (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59936804P | 2004-08-06 | 2004-08-06 | |
| US60/599,368 | 2004-08-06 | ||
| US10/971,727 US20050288696A1 (en) | 2001-07-23 | 2004-10-22 | Device for separating the epithelial layer from the surface of the cornea of an eye |
| US10/971,727 | 2004-10-22 | ||
| PCT/US2005/028188 WO2006017835A2 (en) | 2004-08-06 | 2005-08-08 | Device for separating the epithelial layer from the surface of the cornea of eye |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2576006A1 true CA2576006A1 (en) | 2006-02-16 |
Family
ID=35839979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002576006A Abandoned CA2576006A1 (en) | 2004-08-06 | 2005-08-08 | Device for separating the epithelial layer from the surface of the cornea of an eye |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1784148A2 (de) |
| JP (1) | JP2008508957A (de) |
| KR (1) | KR20070065313A (de) |
| CA (1) | CA2576006A1 (de) |
| WO (1) | WO2006017835A2 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070265650A1 (en) * | 2001-07-23 | 2007-11-15 | Ioannis Pallikaris | Device for separating the epithelial layer from the surface of the cornea of an eye |
| EP2035062A4 (de) * | 2006-07-05 | 2013-01-16 | Jms North America Corp | Nadelabdeckung mit standortvorbereitungsspitze |
| WO2015069189A1 (en) * | 2013-11-07 | 2015-05-14 | Nanyang Technological University | An ocular surgical device |
| WO2016157324A1 (ja) * | 2015-03-27 | 2016-10-06 | 株式会社日立製作所 | 細胞コロニーの分割・剥離方法 |
| WO2016157326A1 (ja) * | 2015-03-27 | 2016-10-06 | 株式会社日立製作所 | 分割・剥離部材、培養容器、及び装置 |
| KR101679510B1 (ko) | 2015-04-22 | 2016-12-12 | 아이리움헬스케어 (주) | 라섹용 안구 상피 제거 브러시 장치 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4731079A (en) * | 1986-11-26 | 1988-03-15 | Kingston Technologies, Inc. | Intraocular lenses |
| US4834750A (en) * | 1987-09-17 | 1989-05-30 | Ioptex Research, Inc. | Deformable-elastic intraocular lens |
| US5376099A (en) * | 1992-09-17 | 1994-12-27 | Kmi, Inc. | Undercut diamond surgical blade and method of using the same |
| US5817115A (en) * | 1995-12-04 | 1998-10-06 | Chiron Vision Corporation | Apparatus for resecting corneal tissue |
| EP1408901A1 (de) * | 2001-07-23 | 2004-04-21 | FOS Holding S.A. | Vorrichtung zum abtrennen der epithelschicht von der oberfläche der hornhaut eines auges |
| JP3977070B2 (ja) * | 2001-12-12 | 2007-09-19 | 株式会社ニデック | 角膜手術器具 |
-
2005
- 2005-08-08 WO PCT/US2005/028188 patent/WO2006017835A2/en active Application Filing
- 2005-08-08 EP EP05789836A patent/EP1784148A2/de not_active Withdrawn
- 2005-08-08 JP JP2007525073A patent/JP2008508957A/ja active Pending
- 2005-08-08 KR KR1020077005178A patent/KR20070065313A/ko not_active Application Discontinuation
- 2005-08-08 CA CA002576006A patent/CA2576006A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006017835A3 (en) | 2007-11-08 |
| JP2008508957A (ja) | 2008-03-27 |
| EP1784148A2 (de) | 2007-05-16 |
| WO2006017835A2 (en) | 2006-02-16 |
| KR20070065313A (ko) | 2007-06-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |