CA2571030A1 - Compositions and methods for the prevention and control of insulin-induced hypoglycemia - Google Patents
Compositions and methods for the prevention and control of insulin-induced hypoglycemia Download PDFInfo
- Publication number
- CA2571030A1 CA2571030A1 CA002571030A CA2571030A CA2571030A1 CA 2571030 A1 CA2571030 A1 CA 2571030A1 CA 002571030 A CA002571030 A CA 002571030A CA 2571030 A CA2571030 A CA 2571030A CA 2571030 A1 CA2571030 A1 CA 2571030A1
- Authority
- CA
- Canada
- Prior art keywords
- glucagon
- insulin
- administered
- hypoglycemia
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 208000035824 paresthesia Diseases 0.000 description 1
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- 230000002572 peristaltic effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 description 1
- HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
- 108010029667 pramlintide Proteins 0.000 description 1
- 229960004457 pramlintide acetate Drugs 0.000 description 1
- 229940071643 prefilled syringe Drugs 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 229950008679 protamine sulfate Drugs 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000003801 protein tyrosine phosphatase 1B inhibitor Substances 0.000 description 1
- 201000001474 proteinuria Diseases 0.000 description 1
- 210000003456 pulmonary alveoli Anatomy 0.000 description 1
- 230000000541 pulsatile effect Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 206010038464 renal hypertension Diseases 0.000 description 1
- 229960002354 repaglinide Drugs 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- SUFUKZSWUHZXAV-BTJKTKAUSA-N rosiglitazone maleate Chemical compound [H+].[H+].[O-]C(=O)\C=C/C([O-])=O.C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O SUFUKZSWUHZXAV-BTJKTKAUSA-N 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000001235 sensitizing effect Effects 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
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- 210000002784 stomach Anatomy 0.000 description 1
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- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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- GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58444904P | 2004-06-29 | 2004-06-29 | |
| US60/584,449 | 2004-06-29 | ||
| PCT/US2005/022812 WO2006004696A2 (en) | 2004-06-29 | 2005-06-27 | Compositions and methods for the prevention and control of insulin-induced hypoglycemia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2571030A1 true CA2571030A1 (en) | 2006-01-12 |
Family
ID=35783298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002571030A Abandoned CA2571030A1 (en) | 2004-06-29 | 2005-06-27 | Compositions and methods for the prevention and control of insulin-induced hypoglycemia |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1778266A4 (enExample) |
| JP (1) | JP2008505087A (enExample) |
| KR (1) | KR20070029276A (enExample) |
| CN (1) | CN101001638A (enExample) |
| AU (1) | AU2005260025A1 (enExample) |
| CA (1) | CA2571030A1 (enExample) |
| IL (1) | IL180361A0 (enExample) |
| MX (1) | MXPA06014970A (enExample) |
| NO (1) | NO20070174L (enExample) |
| WO (1) | WO2006004696A2 (enExample) |
| ZA (1) | ZA200700708B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012059764A1 (en) | 2010-11-03 | 2012-05-10 | Arecor Limited | Novel composition comprising glucagon |
| EP3344231B1 (en) * | 2015-09-04 | 2022-04-13 | Latitude Pharmaceuticals, Inc. | Stabilized glucagon solutions |
| GB201611077D0 (en) | 2016-06-24 | 2016-08-10 | Arecor Ltd | Novel composition |
| US11357829B2 (en) | 2017-02-03 | 2022-06-14 | Vanderbilt University | Systems, compositions and methods for treating diabetes |
| BR112020000447A2 (pt) * | 2017-07-14 | 2020-07-21 | Xeris Pharmaceuticals, Inc. | métodos de tratamento de hiperinsulinismo congênito |
| WO2019108640A1 (en) * | 2017-11-28 | 2019-06-06 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Methods and kits for evaluating metabolism |
| EP4171509A1 (en) * | 2020-06-26 | 2023-05-03 | Xeris Pharmaceuticals, Inc. | Stable sustained release therapeutic compositions in aprotic polar solvents and methods of manufacturing the same |
| GB202109087D0 (en) * | 2021-06-24 | 2021-08-11 | Norwegian Univ Sci & Tech Ntnu | Therapeutic methods and devices |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3897551A (en) * | 1971-04-05 | 1975-07-29 | Lilly Co Eli | Iodoglucagons and process for prolonging the biological activity of glucagon |
| US5321008A (en) * | 1991-01-10 | 1994-06-14 | Amylin Pharmaceuticals, Inc. | Methods and compositions for treatment of diabetes mellitus, hypoglycemia, and other conditions |
| JP2006508975A (ja) * | 2002-11-18 | 2006-03-16 | ファイザー・プロダクツ・インク | ジペプチジルペプチダーゼｉｖを阻害するフッ素化環状アミド |
| NZ541365A (en) * | 2002-12-27 | 2009-09-25 | Diobex Inc | Compositions and methods for the prevention and control of insulin-induced hypoglycemia |
-
2005
- 2005-06-27 ZA ZA200700708A patent/ZA200700708B/xx unknown
- 2005-06-27 AU AU2005260025A patent/AU2005260025A1/en not_active Abandoned
- 2005-06-27 CN CNA2005800270476A patent/CN101001638A/zh active Pending
- 2005-06-27 JP JP2007519344A patent/JP2008505087A/ja active Pending
- 2005-06-27 MX MXPA06014970A patent/MXPA06014970A/es not_active Application Discontinuation
- 2005-06-27 EP EP05787795A patent/EP1778266A4/en not_active Withdrawn
- 2005-06-27 CA CA002571030A patent/CA2571030A1/en not_active Abandoned
- 2005-06-27 WO PCT/US2005/022812 patent/WO2006004696A2/en not_active Ceased
- 2005-06-27 KR KR1020077002164A patent/KR20070029276A/ko not_active Withdrawn
-
2006
- 2006-12-26 IL IL180361A patent/IL180361A0/en unknown
-
2007
- 2007-01-10 NO NO20070174A patent/NO20070174L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20070174L (no) | 2007-03-13 |
| ZA200700708B (en) | 2009-03-25 |
| AU2005260025A1 (en) | 2006-01-12 |
| IL180361A0 (en) | 2007-06-03 |
| EP1778266A4 (en) | 2009-09-09 |
| WO2006004696A2 (en) | 2006-01-12 |
| JP2008505087A (ja) | 2008-02-21 |
| EP1778266A2 (en) | 2007-05-02 |
| MXPA06014970A (es) | 2007-03-07 |
| CN101001638A (zh) | 2007-07-18 |
| WO2006004696A3 (en) | 2006-10-26 |
| KR20070029276A (ko) | 2007-03-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |