CA2567686A1 - Use of vegf inhibitors for the treatment of human cancer - Google Patents
Use of vegf inhibitors for the treatment of human cancer Download PDFInfo
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- CA2567686A1 CA2567686A1 CA002567686A CA2567686A CA2567686A1 CA 2567686 A1 CA2567686 A1 CA 2567686A1 CA 002567686 A CA002567686 A CA 002567686A CA 2567686 A CA2567686 A CA 2567686A CA 2567686 A1 CA2567686 A1 CA 2567686A1
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- cancer
- vegf
- subsequent doses
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- CILBMBUYJCWATM-PYGJLNRPSA-N vinorelbine ditartrate Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC CILBMBUYJCWATM-PYGJLNRPSA-N 0.000 description 1
- 201000005102 vulva cancer Diseases 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229940053867 xeloda Drugs 0.000 description 1
- 229950009268 zinostatin Drugs 0.000 description 1
- 229960000641 zorubicin Drugs 0.000 description 1
- FBTUMDXHSRTGRV-ALTNURHMSA-N zorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(\C)=N\NC(=O)C=1C=CC=CC=1)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 FBTUMDXHSRTGRV-ALTNURHMSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57849904P | 2004-06-10 | 2004-06-10 | |
| US60/578,499 | 2004-06-10 | ||
| PCT/US2005/020762 WO2005123104A2 (en) | 2004-06-10 | 2005-06-10 | Use of vegf inhibitors for the treatment of human cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2567686A1 true CA2567686A1 (en) | 2005-12-29 |
Family
ID=35510259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002567686A Abandoned CA2567686A1 (en) | 2004-06-10 | 2005-06-10 | Use of vegf inhibitors for the treatment of human cancer |
Country Status (9)
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2568534A1 (en) * | 2004-06-18 | 2006-01-26 | Regeneron Pharmaceuticals, Inc. | Vegf inhibitors for the treatment of malignant pleural effusion |
| CN102614134B (zh) * | 2005-03-25 | 2016-09-07 | 瑞泽恩制药公司 | Vegf拮抗剂制剂 |
| CN101237880B (zh) | 2005-08-12 | 2011-09-21 | 瑞泽恩制药公司 | 通过vegf拮抗剂的皮下给药治疗疾病 |
| JP2009537606A (ja) * | 2006-05-25 | 2009-10-29 | ノバルティス アクチエンゲゼルシャフト | チロシンキナーゼ阻害剤 |
| EP3753548A1 (en) | 2006-06-16 | 2020-12-23 | Regeneron Pharmaceuticals, Inc. | Vegf antagonist formulations suitable for intravitreal administration |
| GB0612721D0 (en) | 2006-06-27 | 2006-08-09 | Novartis Ag | Organic compounds |
| ME02371B (me) | 2006-09-29 | 2016-06-20 | Oncomed Pharm Inc | Sastojci i postupci za dijagnstikovanje i tretman raka |
| AU2014201795B2 (en) * | 2006-12-19 | 2016-05-19 | Genentech, Inc. | VEGF-specific antagonists for adjuvant and neoadjuvant therapy and the treatment of early stage tumors |
| KR20140148491A (ko) * | 2006-12-19 | 2014-12-31 | 제넨테크, 인크. | 조기 종양의 치료 및 아주반트 및 네오아주반트 요법을 위한 ｖｅｇｆ－특이적 길항제 |
| TWI580694B (zh) | 2007-11-30 | 2017-05-01 | 建南德克公司 | 抗-ｖｅｇｆ抗體 |
| AU2009329994B2 (en) * | 2008-12-23 | 2014-04-03 | Genentech, Inc. | Methods and compositions for diagnostic use in cancer patients |
| MX373926B (es) | 2009-05-27 | 2020-07-10 | Ptc Therapeutics Inc | Metodos para tratar cancer y estados no neoplasicos. |
| EP3485908B1 (en) | 2009-10-16 | 2021-08-18 | Mereo BioPharma 5, Inc. | Therapeutic combination and use of dll4 antagonist antibodies and anti-hypertensive agents |
| EP2596364B1 (en) * | 2010-07-19 | 2015-12-16 | F.Hoffmann-La Roche Ag | Blood plasma biomarkers for bevacizumab combination therapies for treatment of pancreatic cancer |
| US8551479B2 (en) | 2010-09-10 | 2013-10-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating melanoma |
| CA2824422A1 (en) | 2011-01-13 | 2012-07-19 | Regeneron Pharmaceuticals, Inc. | Use of a vegf antagonist to treat angiogenic eye disorders |
| JO3283B1 (ar) | 2011-04-26 | 2018-09-16 | Sanofi Sa | تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI) |
| EP2546268A1 (en) | 2011-07-13 | 2013-01-16 | F-Star Biotechnologische Forschungs - und Entwicklungsges. M.B.H. | Internalising immunoglobulin |
| EP3485903B1 (en) | 2011-09-23 | 2022-11-16 | Mereo BioPharma 5, Inc. | Vegf/dll4 binding agents and uses thereof |
| US20140227252A1 (en) | 2012-10-31 | 2014-08-14 | Oncomed Pharmaceuticals , Inc. | Methods and Monitoring of Treatment with a DLL4 Antagonist |
| LT2956476T (lt) | 2013-02-18 | 2020-02-25 | Vegenics Pty Limited | Ligandą surišančios molekulės ir jų panaudojimas |
| AU2015208482B2 (en) * | 2014-01-25 | 2017-02-02 | Chengdu Kanghong Biotechnologies Co., Ltd. | Fusion protein inhibiting angiogenesis or growth and use thereof |
| CN104004058B (zh) * | 2014-06-23 | 2016-06-08 | 栾晓鹏 | 有关白介素-33抑制剂多肽及其应用 |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| HRP20191145T1 (hr) | 2014-07-18 | 2019-10-04 | Sanofi | Postupak predviđanja ishoda liječenja s afliberceptom kod pacijenta za kojeg se sumnja da ima rak |
| DK3212233T3 (da) | 2014-10-31 | 2020-07-27 | Oncomed Pharm Inc | Kombinationsterapi til behandling af sygdom |
| MX2017006201A (es) * | 2014-11-14 | 2017-07-31 | Genentech Inc | Respuesta de prediccion a un antagonista de vegf. |
| AU2016326609B2 (en) | 2015-09-23 | 2023-03-09 | Mereo Biopharma 5, Inc. | Methods and compositions for treatment of cancer |
| KR20250057128A (ko) | 2015-12-30 | 2025-04-28 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
| MX2018009112A (es) * | 2016-01-25 | 2018-08-28 | Sanofi Sa | Metodo para predecir el resultado de un tratamiento con aflibercept de un paciente que se sospecha que padece un cancer mediante la medicion del nivel de un biomarcador plasmatico. |
| CA3014888A1 (en) | 2016-02-18 | 2017-08-24 | University Of Massachusetts | Combination therapy |
| KR101685532B1 (ko) * | 2016-04-26 | 2016-12-13 | 한국프라임제약주식회사 | 혈관내피성장인자 수용체 융합단백질 |
| WO2018178363A1 (en) * | 2017-03-30 | 2018-10-04 | Progastrine Et Cancers S.À R.L. | Compositions and methods for detecting and treating prostate cancer using progastrin binding molecule |
| WO2019028171A1 (en) * | 2017-08-01 | 2019-02-07 | Ptc Therapeutics, Inc. | DHODH INHIBITOR FOR USE IN THE TREATMENT OF HEMATOLOGICAL CANCERS |
| CN111343984A (zh) * | 2017-10-24 | 2020-06-26 | Md Bio有限公司 | 包含链黑菌素及雷帕霉素作为有效成分的癌症预防或治疗用药学组合物 |
| RS63703B1 (sr) | 2017-11-30 | 2022-11-30 | Regeneron Pharma | Upotreba antagonista vegf za lečenje angiogenih očnih poremećaja |
| IL310376A (en) | 2018-01-26 | 2024-03-01 | Univ California | Methods and compositions for treatment of angiogenic disorders using anti-vegf agents |
| JP2021514656A (ja) | 2018-03-02 | 2021-06-17 | コディアック サイエンシーズ インコーポレイテッドＫｏｄｉａｋ Ｓｃｉｅｎｃｅｓ Ｉｎｃ． | Ｉｌ−６抗体ならびにその融合構築物およびコンジュゲート |
| WO2020106051A2 (ko) * | 2018-11-20 | 2020-05-28 | (주)엠디바이오랩 | 스트렙토니그린 및 항암제를 모두 포함하는 암 예방 또는 치료에 사용하기 위한 약학적 조성물 |
| KR20200094110A (ko) * | 2019-01-29 | 2020-08-06 | (주)엠디바이오랩 | 스트렙토니그린 및 항암제를 포함하는 뇌종양 예방 또는 치료용 조성물 |
| KR102358632B1 (ko) * | 2019-02-01 | 2022-02-04 | (주)엠디바이오랩 | 스트렙토니그린 및 항암제를 포함하는 대장암 예방 또는 치료용 약학적 조성물 |
| AU2020364071A1 (en) | 2019-10-10 | 2022-05-26 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| KR20220104756A (ko) | 2019-11-25 | 2022-07-26 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 안구내 신생혈관형성을 위한 장기지속형 vegf 억제제 |
| MX2022013812A (es) | 2020-05-08 | 2022-12-15 | Regeneron Pharma | Trampas y mini-trampas de vegf y metodos para el tratamiento de trastornos oculares y cancer. |
| US20220196166A1 (en) * | 2020-12-18 | 2022-06-23 | Nibco Inc. | L-ball union drain valve |
| US11898643B1 (en) | 2022-12-28 | 2024-02-13 | Nibco Inc. | Dual union ball drain valve with T-flow adjustability |
| US12140236B2 (en) | 2023-02-08 | 2024-11-12 | Nibco Inc. | Dual union drain valve with reversible check inserts |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6100071A (en) * | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
| US7264801B2 (en) * | 1998-08-11 | 2007-09-04 | Genentech, Inc. | EG-VEGF nucleic acids and polypeptides and method of use |
| US7087411B2 (en) * | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| US6833349B2 (en) * | 1999-06-08 | 2004-12-21 | Regeneron Pharmaceuticals, Inc. | Methods of treating inflammatory skin diseases |
| WO2000075319A1 (en) * | 1999-06-08 | 2000-12-14 | Regeneron Pharmaceuticals, Inc. | Modified chimeric polypeptides with improved pharmacokinetic properties |
| US7300653B2 (en) * | 2003-05-28 | 2007-11-27 | Regeneron Pharmaceuticals, Inc. | Method of treating corneal transplant rejection |
| US7186699B2 (en) * | 2003-06-03 | 2007-03-06 | Cell Genesys, Inc. | Method for treating cancer by vector-mediated delivery of one or more anti-angiogenic or pro-apoptotic genes |
| CA2519875C (en) | 2003-06-06 | 2014-01-14 | Regeneron Pharmaceuticals, Inc. | Method of tumor regression with vegf inhibitors |
-
2005
- 2005-06-10 MX MXPA06014421A patent/MXPA06014421A/es not_active Application Discontinuation
- 2005-06-10 AU AU2005254058A patent/AU2005254058A1/en not_active Abandoned
- 2005-06-10 CN CNA2005800189582A patent/CN101102786A/zh active Pending
- 2005-06-10 US US11/149,738 patent/US7354580B2/en active Active
- 2005-06-10 JP JP2007527795A patent/JP2008502738A/ja not_active Withdrawn
- 2005-06-10 EP EP05750079A patent/EP1753442A2/en not_active Ceased
- 2005-06-10 EP EP12176929.3A patent/EP2583685A1/en not_active Withdrawn
- 2005-06-10 CA CA002567686A patent/CA2567686A1/en not_active Abandoned
- 2005-06-10 WO PCT/US2005/020762 patent/WO2005123104A2/en not_active Application Discontinuation
-
2006
- 2006-11-23 IL IL179515A patent/IL179515A0/en unknown
-
2008
- 2008-02-29 US US12/072,965 patent/US7482001B2/en not_active Expired - Lifetime
- 2008-02-29 US US12/074,140 patent/US7479275B2/en not_active Expired - Lifetime
- 2008-02-29 US US12/074,104 patent/US7479274B2/en not_active Expired - Lifetime
- 2008-02-29 US US12/072,966 patent/US7482002B2/en not_active Expired - Lifetime
- 2008-02-29 US US12/072,967 patent/US7479272B2/en not_active Expired - Lifetime
- 2008-02-29 US US12/074,096 patent/US7479273B2/en not_active Expired - Lifetime
-
2011
- 2011-11-10 JP JP2011246211A patent/JP2012067116A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US20080171703A1 (en) | 2008-07-17 |
| US7479275B2 (en) | 2009-01-20 |
| JP2008502738A (ja) | 2008-01-31 |
| AU2005254058A1 (en) | 2005-12-29 |
| US7479273B2 (en) | 2009-01-20 |
| US7479274B2 (en) | 2009-01-20 |
| US7482001B2 (en) | 2009-01-27 |
| US7354580B2 (en) | 2008-04-08 |
| US20080188420A1 (en) | 2008-08-07 |
| IL179515A0 (en) | 2007-05-15 |
| US20080188419A1 (en) | 2008-08-07 |
| US7479272B2 (en) | 2009-01-20 |
| US20080188418A1 (en) | 2008-08-07 |
| WO2005123104A2 (en) | 2005-12-29 |
| US20080214466A1 (en) | 2008-09-04 |
| EP1753442A2 (en) | 2007-02-21 |
| CN101102786A (zh) | 2008-01-09 |
| US20080214465A1 (en) | 2008-09-04 |
| EP2583685A1 (en) | 2013-04-24 |
| MXPA06014421A (es) | 2007-05-04 |
| US7482002B2 (en) | 2009-01-27 |
| JP2012067116A (ja) | 2012-04-05 |
| WO2005123104A3 (en) | 2006-04-27 |
| US20050276808A1 (en) | 2005-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20161114 |