CA2566655C

CA2566655C - Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them

Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them Download PDF

Info

Publication number: CA2566655C
Authority: CA; Canada
Prior art keywords: pharmaceutical formulation; proton pump; meq; pump inhibitor; formulation according
Prior art date: 2004-05-25
Legal status : Expired - Fee Related

Application number

CA2566655A

Other languages

English (en)

French (fr)

Other versions

CA2566655A1 (en

Inventor

Kay Olmstead

Warren Hall

Gerald T. Proehl

Current Assignee

Santarus Inc

Original Assignee

Santarus Inc

Priority date

2004-05-25

Filing date

2005-05-25

Publication date

2013-04-16

2005-05-25 Application filed by Santarus Inc filed Critical Santarus Inc

2005-12-08 Publication of CA2566655A1 publication Critical patent/CA2566655A1/en

2013-04-16 Application granted granted Critical

2013-04-16 Publication of CA2566655C publication Critical patent/CA2566655C/en

2025-05-25 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 193
230000002401 inhibitory effect Effects 0.000 title claims abstract description 48
238000000034 method Methods 0.000 title abstract description 45
230000009858 acid secretion Effects 0.000 title description 8
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 220
229940069428 antacid Drugs 0.000 claims abstract description 217
239000003159 antacid agent Substances 0.000 claims abstract description 217
239000000203 mixture Substances 0.000 claims abstract description 193
230000001458 anti-acid effect Effects 0.000 claims abstract description 188
239000003795 chemical substances by application Substances 0.000 claims abstract description 57
102100021904 Potassium-transporting ATPase alpha chain 1 Human genes 0.000 claims abstract description 45
108010083204 Proton Pumps Proteins 0.000 claims abstract description 45
229940126409 proton pump inhibitor Drugs 0.000 claims description 331
239000000612 proton pump inhibitor Substances 0.000 claims description 255
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 225
239000002775 capsule Substances 0.000 claims description 114
229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 114
235000017557 sodium bicarbonate Nutrition 0.000 claims description 113
239000007884 disintegrant Substances 0.000 claims description 105
SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 claims description 102
210000002966 serum Anatomy 0.000 claims description 100
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VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims description 77
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239000002253 acid Substances 0.000 claims description 73
239000003814 drug Substances 0.000 claims description 55
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MJIHNNLFOKEZEW-UHFFFAOYSA-N lansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-UHFFFAOYSA-N 0.000 claims description 39
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SUBDBMMJDZJVOS-DEOSSOPVSA-N esomeprazole Chemical group C([S@](=O)C1=NC2=CC=C(C=C2N1)OC)C1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-DEOSSOPVSA-N 0.000 claims description 9
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AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims description 7
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