CA2566213A1 - 2-{[2-(2-methylamino-pyrimidine-4-yl)-1h-indole-5-carbonyle]-amine}-3-(phenylpyridine-2-yl-amine)-acide propionique substantiellement pur comme inhibiteur de kinase ikb - Google Patents
2-{[2-(2-methylamino-pyrimidine-4-yl)-1h-indole-5-carbonyle]-amine}-3-(phenylpyridine-2-yl-amine)-acide propionique substantiellement pur comme inhibiteur de kinase ikb Download PDFInfo
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- CA2566213A1 CA2566213A1 CA002566213A CA2566213A CA2566213A1 CA 2566213 A1 CA2566213 A1 CA 2566213A1 CA 002566213 A CA002566213 A CA 002566213A CA 2566213 A CA2566213 A CA 2566213A CA 2566213 A1 CA2566213 A1 CA 2566213A1
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- compound
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- UGZADUVQMDAIAO-UHFFFAOYSA-L zinc hydroxide Chemical compound [OH-].[OH-].[Zn+2] UGZADUVQMDAIAO-UHFFFAOYSA-L 0.000 description 1
- 229940007718 zinc hydroxide Drugs 0.000 description 1
- 229910021511 zinc hydroxide Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La présente invention est destinée au composé substantiellement pur de formule (A) ou à un sel pharmaceutiquement acceptable ou un solvat dudit composé ; à une composition pharmaceutique comprenant la quantité pharmaceutiquement efficace du composé de formule (A) et un vecteur pharmaceutiquement acceptable ; l'utilisation d'un composé de formule (A) ayant une activité d'inhibiteur, de préférence un inhibiteur sélectif, de IkB (IKK), en particulier IKK-2 et les méthodes liées à cela.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57014604P | 2004-05-12 | 2004-05-12 | |
| US60/570,146 | 2004-05-12 | ||
| PCT/US2005/016381 WO2005113544A1 (fr) | 2004-05-12 | 2005-05-11 | 2-{[2-(2-méthylamino-pyrimidine-4-yl)-1h-indole-5-carbonyle]-aminé}-3-(phénylpyridine-2-yl-aminé)-acide propionique substantiellement pur comme inhibiteur de kinase ikb |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2566213A1 true CA2566213A1 (fr) | 2005-12-11 |
Family
ID=34969825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002566213A Abandoned CA2566213A1 (fr) | 2004-05-12 | 2005-05-11 | 2-{[2-(2-methylamino-pyrimidine-4-yl)-1h-indole-5-carbonyle]-amine}-3-(phenylpyridine-2-yl-amine)-acide propionique substantiellement pur comme inhibiteur de kinase ikb |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1747215A1 (fr) |
| JP (1) | JP2007537266A (fr) |
| KR (1) | KR20070011483A (fr) |
| CN (1) | CN1950359A (fr) |
| AR (1) | AR049274A1 (fr) |
| AU (1) | AU2005245834A1 (fr) |
| BR (1) | BRPI0511029A (fr) |
| CA (1) | CA2566213A1 (fr) |
| EC (1) | ECSP066992A (fr) |
| GT (1) | GT200500111A (fr) |
| IL (1) | IL178992A0 (fr) |
| MA (1) | MA28553B1 (fr) |
| MX (1) | MXPA06012870A (fr) |
| NO (1) | NO20065719L (fr) |
| PA (1) | PA8633101A1 (fr) |
| PE (1) | PE20060269A1 (fr) |
| RU (1) | RU2006143758A (fr) |
| SV (1) | SV2006002111A (fr) |
| TN (1) | TNSN06338A1 (fr) |
| TW (1) | TW200605881A (fr) |
| UY (1) | UY28897A1 (fr) |
| WO (1) | WO2005113544A1 (fr) |
| ZA (1) | ZA200608712B (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19951360A1 (de) | 1999-10-26 | 2001-05-03 | Aventis Pharma Gmbh | Substituierte Indole |
| DE102004033406A1 (de) * | 2004-07-10 | 2006-02-16 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung der enantiomeren Formen von 2,3-Diaminopropionsäurederivaten |
| EP2025674A1 (fr) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament |
| CA2721927C (fr) | 2008-04-21 | 2014-01-28 | Otonomy, Inc. | Preparations auriculaires de traitement de maladies et etats otiques |
| US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
| WO2011107494A1 (fr) | 2010-03-03 | 2011-09-09 | Sanofi | Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation |
| EP2563774B1 (fr) * | 2010-04-27 | 2014-03-12 | Hutchison Medipharma Limited | Pyrimidinylindoles |
| EP2582709B1 (fr) | 2010-06-18 | 2018-01-24 | Sanofi | Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| EP2766349B1 (fr) | 2011-03-08 | 2016-06-01 | Sanofi | Dérivés d'oxathiazine substitués par des carbocycles ou des hétérocycles, leur procédé de préparation, médicaments contenant ces composés et leur utilisation |
| US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| EP2760862B1 (fr) | 2011-09-27 | 2015-10-21 | Sanofi | Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique utilisés comme inhibiteurs de kinase |
| CA3029281A1 (fr) | 2016-06-29 | 2018-01-04 | Otonomy, Inc. | Formulations otiques a base de triglycerides et leurs utilisations |
| CN106588803A (zh) * | 2016-11-16 | 2017-04-26 | 西南科技大学 | 一种制备5‑乙酰基异噁唑的新方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10237722A1 (de) * | 2002-08-17 | 2004-08-19 | Aventis Pharma Deutschland Gmbh | Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase |
-
2005
- 2005-05-11 RU RU2006143758/04A patent/RU2006143758A/ru not_active Application Discontinuation
- 2005-05-11 AU AU2005245834A patent/AU2005245834A1/en not_active Abandoned
- 2005-05-11 BR BRPI0511029-7A patent/BRPI0511029A/pt not_active IP Right Cessation
- 2005-05-11 MX MXPA06012870A patent/MXPA06012870A/es not_active Application Discontinuation
- 2005-05-11 GT GT200500111A patent/GT200500111A/es unknown
- 2005-05-11 CA CA002566213A patent/CA2566213A1/fr not_active Abandoned
- 2005-05-11 JP JP2007513292A patent/JP2007537266A/ja not_active Abandoned
- 2005-05-11 WO PCT/US2005/016381 patent/WO2005113544A1/fr active Application Filing
- 2005-05-11 CN CNA200580015046XA patent/CN1950359A/zh active Pending
- 2005-05-11 AR ARP050101914A patent/AR049274A1/es not_active Application Discontinuation
- 2005-05-11 KR KR1020067023661A patent/KR20070011483A/ko not_active Application Discontinuation
- 2005-05-11 EP EP05749733A patent/EP1747215A1/fr not_active Withdrawn
- 2005-05-11 PE PE2005000524A patent/PE20060269A1/es not_active Application Discontinuation
- 2005-05-12 TW TW094115316A patent/TW200605881A/zh unknown
- 2005-05-12 SV SV2005002111A patent/SV2006002111A/es not_active Application Discontinuation
- 2005-05-12 PA PA20058633101A patent/PA8633101A1/es unknown
- 2005-05-12 UY UY28897A patent/UY28897A1/es unknown
-
2006
- 2006-10-18 TN TNP2006000338A patent/TNSN06338A1/en unknown
- 2006-10-18 ZA ZA200608712A patent/ZA200608712B/en unknown
- 2006-10-27 MA MA29415A patent/MA28553B1/fr unknown
- 2006-11-01 IL IL178992A patent/IL178992A0/en unknown
- 2006-11-10 EC EC2006006992A patent/ECSP066992A/es unknown
- 2006-12-12 NO NO20065719A patent/NO20065719L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PA8633101A1 (es) | 2006-01-23 |
| IL178992A0 (en) | 2007-03-08 |
| RU2006143758A (ru) | 2008-06-27 |
| WO2005113544A1 (fr) | 2005-12-01 |
| ZA200608712B (en) | 2008-06-25 |
| BRPI0511029A (pt) | 2007-11-27 |
| UY28897A1 (es) | 2005-12-30 |
| PE20060269A1 (es) | 2006-05-11 |
| AU2005245834A1 (en) | 2005-12-01 |
| ECSP066992A (es) | 2006-12-29 |
| TW200605881A (en) | 2006-02-16 |
| AR049274A1 (es) | 2006-07-12 |
| KR20070011483A (ko) | 2007-01-24 |
| MXPA06012870A (es) | 2007-02-15 |
| NO20065719L (no) | 2006-12-12 |
| JP2007537266A (ja) | 2007-12-20 |
| GT200500111A (es) | 2006-05-09 |
| EP1747215A1 (fr) | 2007-01-31 |
| SV2006002111A (es) | 2006-01-30 |
| MA28553B1 (fr) | 2007-04-03 |
| CN1950359A (zh) | 2007-04-18 |
| TNSN06338A1 (en) | 2008-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |