CA2562267C - Alkylamine as an antimicrobial agent in ophthalmic compositions - Google Patents
Alkylamine as an antimicrobial agent in ophthalmic compositions Download PDFInfo
- Publication number
- CA2562267C CA2562267C CA2562267A CA2562267A CA2562267C CA 2562267 C CA2562267 C CA 2562267C CA 2562267 A CA2562267 A CA 2562267A CA 2562267 A CA2562267 A CA 2562267A CA 2562267 C CA2562267 C CA 2562267C
- Authority
- CA
- Canada
- Prior art keywords
- solution
- component
- contact lens
- alkylamine
- antimicrobial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000017 hydrogel Substances 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
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- 208000006443 lactic acidosis Diseases 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L magnesium chloride Substances [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
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- 229920000609 methyl cellulose Polymers 0.000 description 1
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- 239000000693 micelle Substances 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- IFYDWYVPVAMGRO-UHFFFAOYSA-N n-[3-(dimethylamino)propyl]tetradecanamide Chemical compound CCCCCCCCCCCCCC(=O)NCCCN(C)C IFYDWYVPVAMGRO-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229940085991 phosphate ion Drugs 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229920001993 poloxamer 188 Polymers 0.000 description 1
- 229940044519 poloxamer 188 Drugs 0.000 description 1
- 229920001992 poloxamer 407 Polymers 0.000 description 1
- 229940044476 poloxamer 407 Drugs 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229940068965 polysorbates Drugs 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 230000003134 recirculating effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 229930187593 rose bengal Natural products 0.000 description 1
- AZJPTIGZZTZIDR-UHFFFAOYSA-L rose bengal Chemical compound [K+].[K+].[O-]C(=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1C1=C2C=C(I)C(=O)C(I)=C2OC2=C(I)C([O-])=C(I)C=C21 AZJPTIGZZTZIDR-UHFFFAOYSA-L 0.000 description 1
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- 238000013207 serial dilution Methods 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- UKLNMMHNWFDKNT-UHFFFAOYSA-M sodium chlorite Chemical compound [Na+].[O-]Cl=O UKLNMMHNWFDKNT-UHFFFAOYSA-M 0.000 description 1
- 229960002218 sodium chlorite Drugs 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 108010019783 tear proteins Proteins 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
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- 229960001295 tocopherol Drugs 0.000 description 1
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- 239000011732 tocopherol Substances 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- 229940073585 tromethamine hydrochloride Drugs 0.000 description 1
- 229920001664 tyloxapol Polymers 0.000 description 1
- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 description 1
- 229960004224 tyloxapol Drugs 0.000 description 1
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- 239000000080 wetting agent Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/131—Amines acyclic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/04—Nitrogen directly attached to aliphatic or cycloaliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Organic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Eyeglasses (AREA)
- Detergent Compositions (AREA)
- Medicinal Preparation (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/820,354 | 2004-04-07 | ||
| US10/820,354 US7157412B2 (en) | 2004-04-07 | 2004-04-07 | Alkylamine as an antimicrobial agent in ophthalmic compositions |
| PCT/US2005/010698 WO2005099779A1 (en) | 2004-04-07 | 2005-03-30 | Alkylamine as an antimicrobial agent in ophthalmic compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2562267A1 CA2562267A1 (en) | 2005-10-27 |
| CA2562267C true CA2562267C (en) | 2013-03-12 |
Family
ID=34965139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2562267A Expired - Fee Related CA2562267C (en) | 2004-04-07 | 2005-03-30 | Alkylamine as an antimicrobial agent in ophthalmic compositions |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7157412B2 (enExample) |
| EP (1) | EP1732617B1 (enExample) |
| JP (1) | JP4989459B2 (enExample) |
| CN (1) | CN100512884C (enExample) |
| AU (1) | AU2005232566C1 (enExample) |
| BR (1) | BRPI0509651A (enExample) |
| CA (1) | CA2562267C (enExample) |
| ES (1) | ES2304864B1 (enExample) |
| WO (1) | WO2005099779A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0609711B8 (pt) | 2005-03-23 | 2021-05-25 | Oculus Innovative Sciences Inc | uso de uma solução aquosa com potencial redutivo oxidativo (orp) |
| AU2007205861B2 (en) | 2006-01-20 | 2013-05-09 | Oculus Innovative Sciences, Inc. | Methods of treating or preventing sinusitis with oxidative reductive potential water solution |
| US20070264226A1 (en) * | 2006-05-10 | 2007-11-15 | Karagoezian Hampar L | Synergistically enhanced disinfecting solutions |
| US20080214421A1 (en) * | 2007-02-19 | 2008-09-04 | Fang Zhao | Contact lens care composition |
| TWI607705B (zh) * | 2008-05-26 | 2017-12-11 | 大幸藥品股份有限公司 | 忌避劑、刺咬忌避劑及節肢動物媒介病預防劑 |
| US10342825B2 (en) | 2009-06-15 | 2019-07-09 | Sonoma Pharmaceuticals, Inc. | Solution containing hypochlorous acid and methods of using same |
| US8335127B2 (en) * | 2009-08-12 | 2012-12-18 | Pgs Geophysical As | Method for generating spread spectrum driver signals for a seismic vibrator array using multiple biphase modulation operations in each driver signal chip |
| CN103719142B (zh) * | 2012-10-10 | 2015-09-16 | 俞致健 | 一种消毒剂及其制备方法与应用 |
| JP2019509516A (ja) * | 2016-02-22 | 2019-04-04 | クーパーヴィジョン インターナショナル ホウルディング カンパニー リミテッド パートナーシップ | 改良された潤滑性を有するシリコーンヒドロゲルコンタクトレンズ |
| EP3618613A4 (en) * | 2017-05-05 | 2021-01-20 | Pamel, Gregory J. | COMPOSITION CONTAINING CHLORINE DIOXIDE AND ITS METHODS OF USE |
| GB201813229D0 (en) | 2018-08-14 | 2018-09-26 | Ocutec Ltd | Formulation |
| CN115282349A (zh) * | 2022-07-05 | 2022-11-04 | 复旦大学附属眼耳鼻喉科医院 | 一种有利于改善孟加拉玫瑰红-绿光角膜胶原交联技术中cct降低的角膜交联试剂 |
| US20240166971A1 (en) * | 2022-10-26 | 2024-05-23 | Bausch + Lomb Ireland Limited | Contact lens treating solution |
| CN117230437B (zh) * | 2023-08-09 | 2025-12-02 | 山东科技大学 | 镁合金基材表面edta辅助低温水浴mao/ldh杂化涂层的制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3542970A1 (de) * | 1985-12-05 | 1987-06-11 | Benckiser Gmbh Joh A | Fluessige sanitaerreinigungs- und entkalkungsmittel und verfahren zu deren herstellung |
| AU6667894A (en) * | 1993-04-28 | 1994-11-21 | Alcon Laboratories, Inc. | Diamines as antimicrobial agents and use thereof in ophthalmic composition |
| US5935518A (en) | 1996-01-29 | 1999-08-10 | Bausch & Lomb Incorporated | Swimming pool treatment |
| JP3706216B2 (ja) * | 1996-12-05 | 2005-10-12 | 株式会社トーメー | コンタクトレンズ用剤 |
| AU718199B2 (en) * | 1996-12-13 | 2000-04-06 | Alcon Laboratories, Inc. | Use of low molecular weight amino alcohols in ophthalmic compositions |
| US6063745A (en) * | 1997-11-26 | 2000-05-16 | Allergan | Mutli-purpose contact lens care compositions |
| US6162371A (en) * | 1997-12-22 | 2000-12-19 | S. C. Johnson & Son, Inc. | Stabilized acidic chlorine bleach composition and method of use |
| JPH11281937A (ja) * | 1998-03-27 | 1999-10-15 | Menicon Co Ltd | コンタクトレンズ用剤 |
| EP0982394A1 (en) * | 1998-08-27 | 2000-03-01 | The Procter & Gamble Company | Liquid neutral or alkaline hard-surface cleaning composition |
| WO2001020997A1 (en) * | 1999-09-20 | 2001-03-29 | Menicon Co., Ltd. | Liquid preparation for contact lenses |
| AU2001258644B2 (en) | 2000-06-02 | 2005-06-02 | Arch Chemicals, Inc | Treatment of circulating water systems |
| US20030153475A1 (en) | 2001-12-20 | 2003-08-14 | Zhenze Hu | Composition for treating contact lenses |
| US20040120916A1 (en) | 2002-12-23 | 2004-06-24 | Advanced Medical Optics, Inc. | Contact lens care compositions, methods of use and preparation which protect ocular tissue membrane integrity |
| US20050095215A1 (en) * | 2003-11-03 | 2005-05-05 | Popp Karl F. | Antimicrobial shampoo compositions |
-
2004
- 2004-04-07 US US10/820,354 patent/US7157412B2/en not_active Expired - Lifetime
-
2005
- 2005-03-30 WO PCT/US2005/010698 patent/WO2005099779A1/en not_active Ceased
- 2005-03-30 JP JP2007507367A patent/JP4989459B2/ja not_active Expired - Fee Related
- 2005-03-30 CN CNB2005800096802A patent/CN100512884C/zh not_active Expired - Fee Related
- 2005-03-30 EP EP05733007.8A patent/EP1732617B1/en not_active Expired - Lifetime
- 2005-03-30 BR BRPI0509651-0A patent/BRPI0509651A/pt not_active Application Discontinuation
- 2005-03-30 CA CA2562267A patent/CA2562267C/en not_active Expired - Fee Related
- 2005-03-30 AU AU2005232566A patent/AU2005232566C1/en not_active Ceased
- 2005-03-31 ES ES200650069A patent/ES2304864B1/es not_active Expired - Fee Related
-
2006
- 2006-09-25 US US11/534,990 patent/US7488706B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0509651A (pt) | 2007-10-09 |
| WO2005099779A1 (en) | 2005-10-27 |
| US20050228046A1 (en) | 2005-10-13 |
| US7157412B2 (en) | 2007-01-02 |
| CA2562267A1 (en) | 2005-10-27 |
| CN100512884C (zh) | 2009-07-15 |
| JP2007532544A (ja) | 2007-11-15 |
| US7488706B2 (en) | 2009-02-10 |
| JP4989459B2 (ja) | 2012-08-01 |
| AU2005232566C1 (en) | 2010-04-01 |
| AU2005232566A1 (en) | 2005-10-27 |
| ES2304864B1 (es) | 2009-10-02 |
| ES2304864A1 (es) | 2008-10-16 |
| EP1732617B1 (en) | 2015-03-25 |
| CN1938053A (zh) | 2007-03-28 |
| US20080125494A1 (en) | 2008-05-29 |
| AU2005232566B2 (en) | 2009-10-08 |
| EP1732617A1 (en) | 2006-12-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20220301 |
|
| MKLA | Lapsed |
Effective date: 20200831 |