CA2561717A1 - Combination of organic compounds - Google Patents
Combination of organic compounds Download PDFInfo
- Publication number
- CA2561717A1 CA2561717A1 CA002561717A CA2561717A CA2561717A1 CA 2561717 A1 CA2561717 A1 CA 2561717A1 CA 002561717 A CA002561717 A CA 002561717A CA 2561717 A CA2561717 A CA 2561717A CA 2561717 A1 CA2561717 A1 CA 2561717A1
- Authority
- CA
- Canada
- Prior art keywords
- arthritis
- rapamycin
- renal
- disease
- diabetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000002894 organic compounds Chemical class 0.000 title 1
- 229960002930 sirolimus Drugs 0.000 claims abstract description 63
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims abstract description 53
- 150000003839 salts Chemical class 0.000 claims abstract description 38
- 239000000400 angiotensin II type 1 receptor blocker Substances 0.000 claims abstract description 36
- 102000013530 TOR Serine-Threonine Kinases Human genes 0.000 claims abstract description 33
- 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 claims abstract description 33
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 31
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 29
- 239000003937 drug carrier Substances 0.000 claims abstract description 27
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims abstract description 27
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- QFMKPDZCOKCBAQ-NFCVMBANSA-N sar943-nxa Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)CC1 QFMKPDZCOKCBAQ-NFCVMBANSA-N 0.000 claims description 14
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- CGTADGCBEXYWNE-JUKNQOCSSA-N zotarolimus Chemical compound N1([C@H]2CC[C@@H](C[C@@H](C)[C@H]3OC(=O)[C@@H]4CCCCN4C(=O)C(=O)[C@@]4(O)[C@H](C)CC[C@H](O4)C[C@@H](/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C3)OC)C[C@H]2OC)C=NN=N1 CGTADGCBEXYWNE-JUKNQOCSSA-N 0.000 claims description 6
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- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 claims 1
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- 239000000203 mixture Substances 0.000 description 58
- ACWBQPMHZXGDFX-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=NN1 ACWBQPMHZXGDFX-QFIPXVFZSA-N 0.000 description 50
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 32
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 32
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- 235000019359 magnesium stearate Nutrition 0.000 description 16
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 14
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- 239000002775 capsule Substances 0.000 description 12
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US57172904P | 2004-05-17 | 2004-05-17 | |
| US60/571,729 | 2004-05-17 | ||
| US60056704P | 2004-08-11 | 2004-08-11 | |
| US60/600,567 | 2004-08-11 | ||
| PCT/EP2005/005286 WO2005110480A2 (en) | 2004-05-17 | 2005-05-13 | Combination of organic compounds |
Publications (1)
| Publication Number | Publication Date |
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| CA2561717A1 true CA2561717A1 (en) | 2005-11-24 |
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| CA002561717A Abandoned CA2561717A1 (en) | 2004-05-17 | 2005-05-13 | Combination of organic compounds |
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| BR (1) | BRPI0511262A (https=) |
| CA (1) | CA2561717A1 (https=) |
| MX (1) | MXPA06013294A (https=) |
| RU (1) | RU2006144809A (https=) |
| WO (1) | WO2005110480A2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1859274A2 (en) * | 2005-03-07 | 2007-11-28 | Novartis AG | Genes involved in neurodegenerative conditions |
| US20080207671A1 (en) * | 2006-07-31 | 2008-08-28 | The Regents Of The University Of Michigan | Diagnosis and treatment of diseases arising from defects in the tuberous sclerosis pathway |
| AU2007287809A1 (en) * | 2006-08-22 | 2008-02-28 | Novartis Ag | Rapamycin and its derivatives for the treatment of liver-associated fibrosing disorders |
| EP2131821B1 (en) | 2007-03-07 | 2018-05-09 | Abraxis BioScience, LLC | Nanoparticle comprising rapamycin and albumin as anticancer agent |
| US20100166869A1 (en) * | 2007-05-03 | 2010-07-01 | Desai Neil P | Methods and compositions for treating pulmonary hypertension |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0306858A (pt) * | 2002-01-10 | 2004-11-03 | Novartis Ag | Sistemas de liberação de drogas para a prevenção e tratamento de doenças vasculares compreendendo rapamicina e derivados da mesma |
| PT1478648E (pt) * | 2002-02-01 | 2014-07-15 | Ariad Pharma Inc | Compostos contendo fósforo e suas utilizações |
-
2005
- 2005-05-13 BR BRPI0511262-1A patent/BRPI0511262A/pt not_active IP Right Cessation
- 2005-05-13 RU RU2006144809/15A patent/RU2006144809A/ru unknown
- 2005-05-13 AU AU2005244437A patent/AU2005244437A1/en not_active Abandoned
- 2005-05-13 US US11/596,943 patent/US20080280939A1/en not_active Abandoned
- 2005-05-13 MX MXPA06013294A patent/MXPA06013294A/es not_active Application Discontinuation
- 2005-05-13 KR KR1020067023980A patent/KR20070012486A/ko not_active Withdrawn
- 2005-05-13 EP EP05744586A patent/EP1755681A2/en not_active Withdrawn
- 2005-05-13 CA CA002561717A patent/CA2561717A1/en not_active Abandoned
- 2005-05-13 WO PCT/EP2005/005286 patent/WO2005110480A2/en not_active Ceased
- 2005-05-13 JP JP2007517056A patent/JP2007538030A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070012486A (ko) | 2007-01-25 |
| WO2005110480A3 (en) | 2006-07-27 |
| AU2005244437A1 (en) | 2005-11-24 |
| EP1755681A2 (en) | 2007-02-28 |
| RU2006144809A (ru) | 2008-06-27 |
| US20080280939A1 (en) | 2008-11-13 |
| BRPI0511262A (pt) | 2007-11-27 |
| MXPA06013294A (es) | 2007-02-02 |
| WO2005110480A2 (en) | 2005-11-24 |
| JP2007538030A (ja) | 2007-12-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20130313 |