CA2542033C - Method for identifying a subject at risk of developing heart failure by determining the level of galectin-3 or thrombospondin-2 - Google Patents

Method for identifying a subject at risk of developing heart failure by determining the level of galectin-3 or thrombospondin-2 Download PDF

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Publication number
CA2542033C
CA2542033C CA2542033A CA2542033A CA2542033C CA 2542033 C CA2542033 C CA 2542033C CA 2542033 A CA2542033 A CA 2542033A CA 2542033 A CA2542033 A CA 2542033A CA 2542033 C CA2542033 C CA 2542033C
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Prior art keywords
galectin
rats
heart failure
cardiac
level
Prior art date
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Expired - Lifetime
Application number
CA2542033A
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English (en)
French (fr)
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CA2542033A1 (en
Inventor
Yigal M. Pinto
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Universiteit Maastricht
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Universiteit Maastricht
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Priority to CA2842308A priority Critical patent/CA2842308A1/en
Publication of CA2542033A1 publication Critical patent/CA2542033A1/en
Application granted granted Critical
Publication of CA2542033C publication Critical patent/CA2542033C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9453Cardioregulators, e.g. antihypotensives, antiarrhythmics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4703Regulators; Modulating activity
    • G01N2333/4704Inhibitors; Supressors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4724Lectins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4728Details alpha-Glycoproteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/32Cardiovascular disorders
    • G01N2800/321Arterial hypertension
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/32Cardiovascular disorders
    • G01N2800/325Heart failure or cardiac arrest, e.g. cardiomyopathy, congestive heart failure
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/50Determining the risk of developing a disease
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/811Test for named disease, body condition or organ function

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrotherapy Devices (AREA)
CA2542033A 2003-10-09 2004-09-27 Method for identifying a subject at risk of developing heart failure by determining the level of galectin-3 or thrombospondin-2 Expired - Lifetime CA2542033C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2842308A CA2842308A1 (en) 2003-10-09 2004-09-27 Method for identifying a subject at risk of developing heart failure by determining the level of thrombospondin-2

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03078161A EP1522857A1 (en) 2003-10-09 2003-10-09 Method for identifying a subject at risk of developing heart failure by determining the level of galectin-3 or thrombospondin-2
EP03078161.1 2003-10-09
PCT/EP2004/010879 WO2005040817A1 (en) 2003-10-09 2004-09-27 Method for identifying a subject at risk of developing heart failure by determining the level of galectin-3 or thrombospondin-2

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2842308A Division CA2842308A1 (en) 2003-10-09 2004-09-27 Method for identifying a subject at risk of developing heart failure by determining the level of thrombospondin-2

Publications (2)

Publication Number Publication Date
CA2542033A1 CA2542033A1 (en) 2005-05-06
CA2542033C true CA2542033C (en) 2014-04-29

Family

ID=34306912

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2542033A Expired - Lifetime CA2542033C (en) 2003-10-09 2004-09-27 Method for identifying a subject at risk of developing heart failure by determining the level of galectin-3 or thrombospondin-2
CA2842308A Abandoned CA2842308A1 (en) 2003-10-09 2004-09-27 Method for identifying a subject at risk of developing heart failure by determining the level of thrombospondin-2

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2842308A Abandoned CA2842308A1 (en) 2003-10-09 2004-09-27 Method for identifying a subject at risk of developing heart failure by determining the level of thrombospondin-2

Country Status (14)

Country Link
US (5) US7888137B2 (enExample)
EP (4) EP1522857A1 (enExample)
JP (5) JP4840744B2 (enExample)
CN (2) CN102998458B (enExample)
AT (1) ATE532073T1 (enExample)
AU (2) AU2004284496C1 (enExample)
CA (2) CA2542033C (enExample)
CY (2) CY1112359T1 (enExample)
DK (2) DK1682907T3 (enExample)
ES (2) ES2377012T3 (enExample)
PL (2) PL2317324T3 (enExample)
PT (2) PT1682907E (enExample)
SI (2) SI1682907T1 (enExample)
WO (1) WO2005040817A1 (enExample)

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Publication number Publication date
SI2317324T1 (sl) 2015-11-30
CN1879022B (zh) 2012-10-17
US20110104722A1 (en) 2011-05-05
CN102998458A (zh) 2013-03-27
ES2377012T3 (es) 2012-03-21
CA2542033A1 (en) 2005-05-06
PL2317324T3 (pl) 2015-10-30
CY1116147T1 (el) 2017-02-08
US20080193954A1 (en) 2008-08-14
EP2317324B1 (en) 2014-11-12
ES2530567T3 (es) 2015-03-03
JP2015171365A (ja) 2015-10-01
JP5580774B2 (ja) 2014-08-27
AU2009227844A1 (en) 2009-11-26
US20150037353A1 (en) 2015-02-05
US8084276B2 (en) 2011-12-27
CY1112359T1 (el) 2015-12-09
PT1682907E (pt) 2012-02-03
JP2011177184A (ja) 2011-09-15
EP2317324A1 (en) 2011-05-04
AU2004284496B2 (en) 2009-08-06
CA2842308A1 (en) 2005-05-06
PT2317324E (pt) 2015-02-17
SI1682907T1 (sl) 2012-03-30
AU2009227844B2 (en) 2012-07-19
EP1682907B1 (en) 2011-11-02
WO2005040817A1 (en) 2005-05-06
ATE532073T1 (de) 2011-11-15
DK1682907T3 (da) 2012-08-13
JP5789009B2 (ja) 2015-10-07
HK1101426A1 (en) 2007-10-18
JP4840744B2 (ja) 2011-12-21
CN1879022A (zh) 2006-12-13
CN102998458B (zh) 2015-07-22
JP2007508527A (ja) 2007-04-05
AU2004284496A1 (en) 2005-05-06
EP1682907A1 (en) 2006-07-26
HK1184534A1 (zh) 2014-01-24
JP2014115297A (ja) 2014-06-26
US20130189716A1 (en) 2013-07-25
JP2010279378A (ja) 2010-12-16
EP1522857A1 (en) 2005-04-13
DK2317324T3 (en) 2015-02-16
PL1682907T3 (pl) 2012-03-30
US7888137B2 (en) 2011-02-15
AU2004284496C1 (en) 2010-03-04
US20120220532A1 (en) 2012-08-30
EP2919012A1 (en) 2015-09-16

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