CA2541536A1 - Methods and devices for concentration and purification of analytes for chemical analysis including matrix-assisted laser desorption/ionization (maldi) mass spectrometry (ms) - Google Patents

Methods and devices for concentration and purification of analytes for chemical analysis including matrix-assisted laser desorption/ionization (maldi) mass spectrometry (ms) Download PDF

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Publication number
CA2541536A1
CA2541536A1 CA002541536A CA2541536A CA2541536A1 CA 2541536 A1 CA2541536 A1 CA 2541536A1 CA 002541536 A CA002541536 A CA 002541536A CA 2541536 A CA2541536 A CA 2541536A CA 2541536 A1 CA2541536 A1 CA 2541536A1
Authority
CA
Canada
Prior art keywords
layer
capture
concentrator
membrane
porous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002541536A
Other languages
English (en)
French (fr)
Inventor
Dean G. Hafeman
Kilian Dill
James B. Harkins, Iv
Richard M. Caprioli
Jeremy Norris
Nathan S. Lewis
Daniel Kuban
Charles E. Ii Witkowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Protein Discovery Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2541536A1 publication Critical patent/CA2541536A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255—Multi-well filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Electrochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
CA002541536A 2003-10-10 2004-10-12 Methods and devices for concentration and purification of analytes for chemical analysis including matrix-assisted laser desorption/ionization (maldi) mass spectrometry (ms) Abandoned CA2541536A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US51161503P 2003-10-10 2003-10-10
US60/511,615 2003-10-10
US58184304P 2004-06-22 2004-06-22
US60/581,843 2004-06-22
US58609904P 2004-07-07 2004-07-07
US60/586,099 2004-07-07
PCT/US2004/033471 WO2005036132A2 (en) 2003-10-10 2004-10-12 Methods and devices for concentration and purification of analytes for chemical analysis including matrix-assisted laser desorption/ionization (maldi) mass spectrometry (ms)

Publications (1)

Publication Number Publication Date
CA2541536A1 true CA2541536A1 (en) 2005-04-21

Family

ID=34437675

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002541536A Abandoned CA2541536A1 (en) 2003-10-10 2004-10-12 Methods and devices for concentration and purification of analytes for chemical analysis including matrix-assisted laser desorption/ionization (maldi) mass spectrometry (ms)

Country Status (5)

Country Link
US (2) US7534338B2 (enExample)
EP (1) EP1676292A4 (enExample)
JP (1) JP2007508552A (enExample)
CA (1) CA2541536A1 (enExample)
WO (1) WO2005036132A2 (enExample)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7095018B2 (en) * 2004-12-29 2006-08-22 Wisconsin Alumni Research Foundation Deposition of samples and sample matrix for enhancing the sensitivity of matrix assisted laser desorption/ionization mass spectrometry
US7829291B2 (en) * 2005-02-17 2010-11-09 Vanderbilt University In situ analysis of tissues
US8153435B1 (en) 2005-03-30 2012-04-10 Tracer Detection Technology Corp. Methods and articles for identifying objects using encapsulated perfluorocarbon tracers
US7109481B1 (en) * 2005-04-28 2006-09-19 Thermo Finnigan Llc Matrix-assisted laser desorption and ionization (MALDI) sample plate releasably coupled to a sample plate adapter
EP1898799A1 (en) * 2005-07-06 2008-03-19 Medizinische Universität Graz Device for and method of delivery and removal of substances in and from a tissue or vessel
US8237114B2 (en) * 2005-10-20 2012-08-07 Japan Science & Technology Agency Sample target used in mass spectrometry, method for producing the same, and mass spectrometer using the sample target
AU2006321772A1 (en) * 2005-12-08 2007-06-14 Protein Discovery, Inc. Methods and devices for concentration and fractionation of analytes for chemical analysis
JP2007192673A (ja) * 2006-01-19 2007-08-02 Shimadzu Corp サンプルプレート
WO2007127011A2 (en) * 2006-03-29 2007-11-08 Cangen Biotechnologies, Inc. Apparatus and method for filtration to enhance the detection of peaks
US7858928B2 (en) * 2006-09-20 2010-12-28 The United States of America Department of Health and Human Services Nanostructured surfaces as a dual ionization LDI-DESI platform for increased peptide coverage in proteomic analysis
US20090071834A1 (en) * 2007-06-08 2009-03-19 Protein Discovery, Inc. Methods and Devices for Concentration and Fractionation of Analytes for Chemical Analysis Including Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry (MS)
WO2010095677A1 (ja) * 2009-02-18 2010-08-26 日本電気株式会社 ターゲットプレートおよびその製造方法
EP2425216B1 (en) * 2009-04-27 2019-10-23 Expedeon Holdings Ltd. Programmable electrophoretic notch filter systems and methods
US9475914B2 (en) * 2010-01-08 2016-10-25 University Of Tasmania Porous polymer monoliths, processes for preparation and use thereof
JP5819943B2 (ja) * 2010-05-07 2015-11-24 ユーティ—バテル エルエルシー 表面からサンプルを抽出するためのシステムおよび方法
JP2011242159A (ja) * 2010-05-14 2011-12-01 Yokohama City Univ 電気泳動で分離されたタンパク質を膜フィルターに転写し質量分析する方法
US8486703B2 (en) 2010-09-30 2013-07-16 Ut-Battelle, Llc Surface sampling concentration and reaction probe
US8519330B2 (en) 2010-10-01 2013-08-27 Ut-Battelle, Llc Systems and methods for laser assisted sample transfer to solution for chemical analysis
US8637813B2 (en) 2010-10-01 2014-01-28 Ut-Battelle, Llc System and method for laser assisted sample transfer to solution for chemical analysis
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
EP2699907A1 (en) 2011-04-19 2014-02-26 Porex Corporation Cards for sample storage and delivery comprising sintered porous plastic
WO2013006904A1 (en) 2011-07-12 2013-01-17 University Of Tasmania Use of porous polymer materials for storage of biological samples
EP3511423B2 (en) 2012-10-17 2024-05-29 Spatial Transcriptomics AB Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
LT3013984T (lt) 2013-06-25 2023-06-12 Prognosys Biosciences, Inc. Biologinių taikinių erdvinių modelių mėginyje nustatymo būdai
JP2016534839A (ja) 2013-09-16 2016-11-10 ジョンソン・アンド・ジョンソン・イノベーション・エルエルシーＪｏｈｎｓｏｎ ＆ Ｊｏｈｎｓｏｎ Ｉｎｎｏｖａｔｉｏｎ ＬＬＣ 境界層分離を組み込む、マイクロ流体器官補助装置
US10540536B2 (en) 2014-08-01 2020-01-21 Katholieke Universiteit Leuven, K.U.Leuven R&D System for interpretation of image patterns in terms of anatomical or curated patterns
DE202014010921U1 (de) * 2014-10-06 2017-01-18 Bruker Daltonik Gmbh MALDI-Träger mit magnetisch gehaltener Federstahlplatte
WO2016117541A1 (ja) * 2015-01-22 2016-07-28 株式会社村田製作所 空隙配置構造体およびその製造方法
FR3033409B1 (fr) * 2015-03-03 2017-04-14 Nicolas Ugolin Electrodot : procede d'analyse d'echantillons biologiques en matrice de spots fixes par l'action d'un courant electrique conjuguee a une difference de pression
CN120425026A (zh) 2015-04-10 2025-08-05 十程基因技术瑞典公司 生物样本的空间区别、多重核酸分析
JP6105182B1 (ja) 2015-09-03 2017-03-29 浜松ホトニクス株式会社 表面支援レーザ脱離イオン化法、質量分析方法、及び質量分析装置
CN106796198B (zh) * 2015-09-03 2020-06-30 浜松光子学株式会社 试样支撑体和试样支撑体的制造方法
JP6883585B2 (ja) * 2015-09-24 2021-06-09 ゼーン ベアード， 稀な細胞および無細胞分子の質量タグ分析
WO2017074934A1 (en) * 2015-10-28 2017-05-04 Wafergen, Inc. Single cell capture with capture chips
EP3442062A4 (en) * 2016-04-08 2019-12-18 Idemitsu Kosan Co., Ltd. BINDING AGENT FOR ELECTROCHEMICAL ELEMENT
FR3065652B1 (fr) * 2017-04-27 2021-07-23 Biomerieux Sa Plaque d'analyse maldi-tof a support papier et son utilisation
WO2019155741A1 (ja) * 2018-02-09 2019-08-15 浜松ホトニクス株式会社 試料支持体
WO2019155759A1 (ja) * 2018-02-09 2019-08-15 浜松ホトニクス株式会社 試料支持体、試料のイオン化方法、及び質量分析方法
WO2020112879A1 (en) * 2018-11-30 2020-06-04 Perkinelmer Health Sciences, Inc. Biological sample preparation using electric fields
CN113767176A (zh) 2018-12-10 2021-12-07 10X基因组学有限公司 成像系统硬件
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
JP7227823B2 (ja) * 2019-03-29 2023-02-22 浜松ホトニクス株式会社 試料支持体
KR102095784B1 (ko) * 2019-04-26 2020-04-01 한국과학기술연구원 다수표본 마이크로어레이 및 이차이온질량분석기를 이용한 법과학 증거물 감식방법 및 장치
US12157124B2 (en) 2019-11-06 2024-12-03 10X Genomics, Inc. Imaging system hardware
US12110541B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Methods for preparing high-resolution spatial arrays
US11768175B1 (en) * 2020-03-04 2023-09-26 10X Genomics, Inc. Electrophoretic methods for spatial analysis
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
EP4421186B1 (en) 2020-06-08 2025-08-13 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
AU2021288090A1 (en) 2020-06-10 2023-01-19 10X Genomics, Inc. Fluid delivery methods
ES2993269T3 (en) 2020-09-18 2024-12-26 10X Genomics Inc Sample handling apparatus and image registration methods
AU2021409136A1 (en) 2020-12-21 2023-06-29 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
ES3030033T3 (en) 2021-06-03 2025-06-26 10X Genomics Inc Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis
CN117501092A (zh) * 2021-08-02 2024-02-02 豪夫迈·罗氏有限公司 多孔板亲脂性测定
EP4305195A2 (en) 2021-12-01 2024-01-17 10X Genomics, Inc. Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis
WO2023122033A1 (en) 2021-12-20 2023-06-29 10X Genomics, Inc. Self-test for pathology/histology slide imaging device

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3271198A (en) * 1959-12-30 1966-09-06 Ibm Electrolytic semiconductor photocell
US5810989A (en) * 1997-09-04 1998-09-22 Motorola, Inc. Photoelectric synthesis of DNA or protein probe arrays
US6167910B1 (en) * 1998-01-20 2001-01-02 Caliper Technologies Corp. Multi-layer microfluidic devices
US6494614B1 (en) * 1998-07-27 2002-12-17 Battelle Memorial Institute Laminated microchannel devices, mixing units and method of making same
AU766334B2 (en) 1999-01-28 2003-10-16 Universite De Geneve Method and kit for identifying or characterising polypeptides
US20020122747A1 (en) * 2000-09-19 2002-09-05 Mingqi Zhao Integrated microdevices for conducting chemical operations
AU2001296809A1 (en) 2000-10-10 2002-04-22 Biotrove, Inc. Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof
CA2434699A1 (en) * 2001-01-17 2002-10-17 Randall W. Nelson An integrated high throughput system for the analysis of biomolecules
US6919046B2 (en) * 2001-06-07 2005-07-19 Nanostream, Inc. Microfluidic analytical devices and methods
GB0120131D0 (en) 2001-08-17 2001-10-10 Micromass Ltd Maldi target plate
GB0122200D0 (en) 2001-09-14 2001-10-31 James Peter Concentration of protein and/or peptide samples
US7166441B2 (en) * 2002-03-12 2007-01-23 Perseptive Biosystems Inc. Method and apparatus for the identification and quantification of biomolecules
US7030373B2 (en) * 2003-12-19 2006-04-18 Applera Corporation MALDI plate construction with grid

Also Published As

Publication number Publication date
US20100133098A1 (en) 2010-06-03
EP1676292A2 (en) 2006-07-05
US20050116161A1 (en) 2005-06-02
JP2007508552A (ja) 2007-04-05
WO2005036132A2 (en) 2005-04-21
WO2005036132A3 (en) 2006-03-02
US7534338B2 (en) 2009-05-19
EP1676292A4 (en) 2009-01-07

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