CA2536906A1 - Compositions for treating pathologies that necessitate suppression of gastric acid secretion - Google Patents
Compositions for treating pathologies that necessitate suppression of gastric acid secretion Download PDFInfo
- Publication number
- CA2536906A1 CA2536906A1 CA002536906A CA2536906A CA2536906A1 CA 2536906 A1 CA2536906 A1 CA 2536906A1 CA 002536906 A CA002536906 A CA 002536906A CA 2536906 A CA2536906 A CA 2536906A CA 2536906 A1 CA2536906 A1 CA 2536906A1
- Authority
- CA
- Canada
- Prior art keywords
- beads
- gastric
- ppi
- oral composition
- coated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 104
- 230000027119 gastric acid secretion Effects 0.000 title claims abstract description 51
- 230000001629 suppression Effects 0.000 title claims description 14
- 230000007170 pathology Effects 0.000 title claims description 10
- ANRIQLNBZQLTFV-DZUOILHNSA-N pentagastrin Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1[C]2C=CC=CC2=NC=1)NC(=O)CCNC(=O)OC(C)(C)C)CCSC)C(N)=O)C1=CC=CC=C1 ANRIQLNBZQLTFV-DZUOILHNSA-N 0.000 claims abstract description 310
- 108010079943 Pentagastrin Proteins 0.000 claims abstract description 298
- 229960000444 pentagastrin Drugs 0.000 claims abstract description 298
- 230000002496 gastric effect Effects 0.000 claims abstract description 75
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 69
- 210000002784 stomach Anatomy 0.000 claims abstract description 69
- 239000012530 fluid Substances 0.000 claims abstract description 44
- 210000001711 oxyntic cell Anatomy 0.000 claims abstract description 43
- 229940126409 proton pump inhibitor Drugs 0.000 claims abstract description 13
- 239000000612 proton pump inhibitor Substances 0.000 claims abstract description 12
- 239000003112 inhibitor Substances 0.000 claims abstract description 9
- 230000002427 irreversible effect Effects 0.000 claims abstract description 6
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 143
- 239000011324 bead Substances 0.000 claims description 96
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 70
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 claims description 63
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- UIIMBOGNXHQVGW-UHFFFAOYSA-M sodium bicarbonate Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 42
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- 230000036962 time dependent Effects 0.000 claims description 19
- MJIHNNLFOKEZEW-UHFFFAOYSA-N lansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-UHFFFAOYSA-N 0.000 claims description 18
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 18
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- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 10
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- YREYEVIYCVEVJK-UHFFFAOYSA-N rabeprazole Chemical compound COCCCOC1=CC=NC(CS(=O)C=2NC3=CC=CC=C3N=2)=C1C YREYEVIYCVEVJK-UHFFFAOYSA-N 0.000 claims description 7
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 5
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 5
- PPQREHKVAOVYBT-UHFFFAOYSA-H aluminium carbonate Inorganic materials [Al+3].[Al+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O PPQREHKVAOVYBT-UHFFFAOYSA-H 0.000 claims description 5
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 5
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- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims description 4
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- 208000000718 duodenal ulcer Diseases 0.000 claims description 4
- 201000006549 dyspepsia Diseases 0.000 claims description 4
- 125000005448 ethoxyethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims description 4
- 239000011777 magnesium Substances 0.000 claims description 4
- 229910052749 magnesium Inorganic materials 0.000 claims description 4
- 229940091250 magnesium supplement Drugs 0.000 claims description 4
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims description 4
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims description 4
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 4
- 238000004321 preservation Methods 0.000 claims description 4
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 4
- PSIREIZGKQBEEO-UHFFFAOYSA-N 2-(1h-benzimidazol-2-ylsulfinylmethyl)-n-methyl-n-(2-methylpropyl)aniline Chemical compound CC(C)CN(C)C1=CC=CC=C1CS(=O)C1=NC2=CC=CC=C2N1 PSIREIZGKQBEEO-UHFFFAOYSA-N 0.000 claims description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 3
- 208000007882 Gastritis Diseases 0.000 claims description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 3
- 229910019142 PO4 Inorganic materials 0.000 claims description 3
- IQPSEEYGBUAQFF-UHFFFAOYSA-N Pantoprazole Chemical compound COC1=CC=NC(CS(=O)C=2NC3=CC=C(OC(F)F)C=C3N=2)=C1OC IQPSEEYGBUAQFF-UHFFFAOYSA-N 0.000 claims description 3
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- 235000010210 aluminium Nutrition 0.000 claims description 3
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- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 3
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- OVGXLJDWSLQDRT-UHFFFAOYSA-L magnesium lactate Chemical compound [Mg+2].CC(O)C([O-])=O.CC(O)C([O-])=O OVGXLJDWSLQDRT-UHFFFAOYSA-L 0.000 claims description 3
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- LJCZNYWLQZZIOS-UHFFFAOYSA-N 2,2,2-trichlorethoxycarbonyl chloride Chemical compound ClC(=O)OCC(Cl)(Cl)Cl LJCZNYWLQZZIOS-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- General Health & Medical Sciences (AREA)
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- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49793003P | 2003-08-27 | 2003-08-27 | |
| US60/497,930 | 2003-08-27 | ||
| US54431804P | 2004-02-17 | 2004-02-17 | |
| US60/544,318 | 2004-02-17 | ||
| PCT/IB2004/002745 WO2005020879A2 (en) | 2003-08-27 | 2004-08-25 | Compositions for treating pathologies that necessitate suppression of gastric acid secretion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2536906A1 true CA2536906A1 (en) | 2005-03-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002536906A Abandoned CA2536906A1 (en) | 2003-08-27 | 2004-08-25 | Compositions for treating pathologies that necessitate suppression of gastric acid secretion |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1658089A4 (ru) |
| JP (1) | JP2007503427A (ru) |
| KR (1) | KR20060083198A (ru) |
| AU (1) | AU2004268446A1 (ru) |
| CA (1) | CA2536906A1 (ru) |
| IL (1) | IL173944A0 (ru) |
| RU (1) | RU2006109357A (ru) |
| WO (1) | WO2005020879A2 (ru) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007506730A (ja) * | 2003-09-24 | 2007-03-22 | ベクタ・リミテッド | ペンタガストリンを含む胃酸分泌刺激用経口組成物 |
| US7803817B2 (en) | 2005-05-11 | 2010-09-28 | Vecta, Ltd. | Composition and methods for inhibiting gastric acid secretion |
| US7981908B2 (en) | 2005-05-11 | 2011-07-19 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
| SG184754A1 (en) * | 2005-12-28 | 2012-10-30 | Takeda Pharmaceutical | Controlled release solid preparation |
| MY151470A (en) * | 2005-12-28 | 2014-05-30 | Takeda Pharmaceutical | Controlled release solid preparation |
| CA2658804A1 (en) | 2006-07-25 | 2008-01-31 | Vecta Ltd. | Compositions and methods for inhibiting gastric acid secretion using derivatives of small dicarboxylic acids in combination with ppi |
| JP2010534721A (ja) * | 2007-07-27 | 2010-11-11 | ディポメド，インコーポレイティド | パルス型胃滞留性製剤 |
| EP4311542A1 (en) * | 2022-07-27 | 2024-01-31 | Roquette Freres | Floating tab-in-tab dosage forms |
| CN116585283A (zh) * | 2023-05-26 | 2023-08-15 | 桂林华信制药有限公司 | 兰索拉唑肠溶胶囊及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL77186A0 (en) * | 1985-11-29 | 1986-04-29 | Touitou Elka | Pharmaceutical insulin composition |
| US4997950A (en) * | 1989-04-20 | 1991-03-05 | Richard Finbar Murphy | Novel C-terminal gastrin antagonists |
| JP3181062B2 (ja) * | 1991-01-31 | 2001-07-03 | 帝國製薬株式会社 | 下部消化管崩壊経口製剤 |
| PT1130978E (pt) * | 1998-11-17 | 2005-03-31 | Hickory Specialities Inc | Metodo para cobrir um produto alimentar com colagenio |
| AU5060499A (en) * | 1999-08-04 | 2001-03-05 | Ranbaxy Laboratories Limited | Hydrodynamically balanced oral drug delivery system |
| IL152289A0 (en) * | 2002-10-14 | 2003-05-29 | Vectabiotics Ltd | Method and composition for inhibiting h.pylori infection in a mammalian tissue |
-
2004
- 2004-08-25 WO PCT/IB2004/002745 patent/WO2005020879A2/en not_active Application Discontinuation
- 2004-08-25 JP JP2006524456A patent/JP2007503427A/ja active Pending
- 2004-08-25 RU RU2006109357/15A patent/RU2006109357A/ru unknown
- 2004-08-25 CA CA002536906A patent/CA2536906A1/en not_active Abandoned
- 2004-08-25 AU AU2004268446A patent/AU2004268446A1/en not_active Abandoned
- 2004-08-25 EP EP04769171A patent/EP1658089A4/en not_active Withdrawn
- 2004-08-25 KR KR1020067003852A patent/KR20060083198A/ko not_active Application Discontinuation
-
2006
- 2006-02-26 IL IL173944A patent/IL173944A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2006109357A (ru) | 2007-10-10 |
| EP1658089A4 (en) | 2007-03-14 |
| JP2007503427A (ja) | 2007-02-22 |
| KR20060083198A (ko) | 2006-07-20 |
| WO2005020879A3 (en) | 2005-05-19 |
| IL173944A0 (en) | 2006-07-05 |
| AU2004268446A1 (en) | 2005-03-10 |
| EP1658089A2 (en) | 2006-05-24 |
| WO2005020879A2 (en) | 2005-03-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |