CA2536383A1 - Composes de nicotinamide utiles en tant qu'inhibiteurs de pde4 - Google Patents

Info

Publication number

CA2536383A1

CA2536383A1 CA002536383A CA2536383A CA2536383A1 CA 2536383 A1 CA2536383 A1 CA 2536383A1 CA 002536383 A CA002536383 A CA 002536383A CA 2536383 A CA2536383 A CA 2536383A CA 2536383 A1 CA2536383 A1 CA 2536383A1

Authority

CA

Canada

Prior art keywords

fluoro

hydroxy

dihydro

thiophen

syn

Prior art date

2003-07-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
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• 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 title description 16
• 239000002587 phosphodiesterase IV inhibitor Substances 0.000 title description 16
• 238000000034 method Methods 0.000 claims abstract description 26
• 150000001875 compounds Chemical class 0.000 claims description 71
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• 150000003839 salts Chemical class 0.000 claims description 46
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 41
• 230000008506 pathogenesis Effects 0.000 claims description 34
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• 238000011282 treatment Methods 0.000 claims description 30
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 24
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• 201000009267 bronchiectasis Diseases 0.000 claims description 19
• 208000035475 disorder Diseases 0.000 claims description 18
• RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Chemical group C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 18
• 239000012453 solvate Substances 0.000 claims description 18
• 230000000694 effects Effects 0.000 claims description 17
• 125000001424 substituent group Chemical group 0.000 claims description 17
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• 208000024780 Urticaria Diseases 0.000 claims description 16
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 16
• 101100296720 Dictyostelium discoideum Pde4 gene Proteins 0.000 claims description 15
• 101100082610 Plasmodium falciparum (isolate 3D7) PDEdelta gene Proteins 0.000 claims description 15
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• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 14
• 239000003112 inhibitor Substances 0.000 claims description 13
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• SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical group N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims description 12
• 230000001154 acute effect Effects 0.000 claims description 12
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• LJWRCRYKRWVNNS-UHFFFAOYSA-N N-(4-aminocyclohexyl)-2-(2,3-dihydro-1-benzothiophen-6-yloxy)-5-fluoropyridine-3-carboxamide Chemical compound C1CC(N)CCC1NC(=O)C1=CC(F)=CN=C1OC1=CC=C(CCS2)C2=C1 LJWRCRYKRWVNNS-UHFFFAOYSA-N 0.000 claims description 9
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• JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical group N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 claims description 8
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• UTCSSFWDNNEEBH-UHFFFAOYSA-N imidazo[1,2-a]pyridine Chemical group C1=CC=CC2=NC=CN21 UTCSSFWDNNEEBH-UHFFFAOYSA-N 0.000 claims description 7
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• SLLFVLKNXABYGI-UHFFFAOYSA-N 1,2,3-benzoxadiazole Chemical compound C1=CC=C2ON=NC2=C1 SLLFVLKNXABYGI-UHFFFAOYSA-N 0.000 claims description 4
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• KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical group N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims description 4
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