CA2532668A1 - Emulsifying systems containing azetidine derivatives - Google Patents
Emulsifying systems containing azetidine derivatives Download PDFInfo
- Publication number
- CA2532668A1 CA2532668A1 CA002532668A CA2532668A CA2532668A1 CA 2532668 A1 CA2532668 A1 CA 2532668A1 CA 002532668 A CA002532668 A CA 002532668A CA 2532668 A CA2532668 A CA 2532668A CA 2532668 A1 CA2532668 A1 CA 2532668A1
- Authority
- CA
- Canada
- Prior art keywords
- composition
- azetidine
- active ingredient
- azetidine derivative
- potentiating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000001539 azetidines Chemical class 0.000 title claims abstract description 43
- 230000001804 emulsifying effect Effects 0.000 title abstract description 9
- 239000000203 mixture Substances 0.000 claims abstract description 96
- 238000009472 formulation Methods 0.000 claims abstract description 43
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 33
- 239000004480 active ingredient Substances 0.000 claims description 20
- 230000000694 effects Effects 0.000 claims description 20
- 230000003389 potentiating effect Effects 0.000 claims description 14
- 239000008389 polyethoxylated castor oil Substances 0.000 claims description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- 239000007787 solid Substances 0.000 claims description 9
- 150000003904 phospholipids Chemical class 0.000 claims description 8
- 239000000654 additive Substances 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- UNAANXDKBXWMLN-UHFFFAOYSA-N sibutramine Chemical compound C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UNAANXDKBXWMLN-UHFFFAOYSA-N 0.000 claims description 6
- 229960004425 sibutramine Drugs 0.000 claims description 6
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims description 5
- 210000004556 brain Anatomy 0.000 claims description 4
- 230000015883 synaptic transmission, dopaminergic Effects 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 3
- 229910052736 halogen Inorganic materials 0.000 claims description 3
- 150000002367 halogens Chemical group 0.000 claims description 3
- 125000001072 heteroaryl group Chemical group 0.000 claims description 3
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- 238000004519 manufacturing process Methods 0.000 claims description 3
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- 239000003381 stabilizer Substances 0.000 claims description 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 2
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- 230000000996 additive effect Effects 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
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Classifications
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Neurosurgery (AREA)
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- Psychiatry (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03291797A EP1498123A1 (en) | 2003-07-18 | 2003-07-18 | Emulsifying systems containing azetidine derivatives |
| EP03291797.3 | 2003-07-18 | ||
| PCT/EP2004/008552 WO2005013972A1 (en) | 2003-07-18 | 2004-07-08 | Emulsifying systems containing azetidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2532668A1 true CA2532668A1 (en) | 2005-02-17 |
Family
ID=33462260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002532668A Abandoned CA2532668A1 (en) | 2003-07-18 | 2004-07-08 | Emulsifying systems containing azetidine derivatives |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US20050037062A1 (sr) |
| EP (2) | EP1498123A1 (sr) |
| JP (1) | JP2009513559A (sr) |
| KR (1) | KR20060040690A (sr) |
| CN (1) | CN1822830A (sr) |
| AR (1) | AR045912A1 (sr) |
| AU (1) | AU2004262497A1 (sr) |
| BR (1) | BRPI0412239A (sr) |
| CA (1) | CA2532668A1 (sr) |
| CR (1) | CR8178A (sr) |
| EC (1) | ECSP066291A (sr) |
| GT (1) | GT200400134A (sr) |
| HR (1) | HRP20060021A2 (sr) |
| IL (1) | IL173113A0 (sr) |
| MA (1) | MA27921A1 (sr) |
| MX (1) | MXPA06000478A (sr) |
| MY (1) | MY142076A (sr) |
| NO (1) | NO20060510L (sr) |
| NZ (1) | NZ544707A (sr) |
| OA (1) | OA13190A (sr) |
| PA (1) | PA8606601A1 (sr) |
| PE (1) | PE20050699A1 (sr) |
| RS (1) | RS20050971A (sr) |
| RU (1) | RU2348615C2 (sr) |
| SG (1) | SG144140A1 (sr) |
| TN (1) | TNSN06012A1 (sr) |
| TW (1) | TW200522946A (sr) |
| UA (1) | UA82539C2 (sr) |
| UY (1) | UY28422A1 (sr) |
| WO (1) | WO2005013972A1 (sr) |
| ZA (1) | ZA200600489B (sr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1498122A1 (en) * | 2003-07-18 | 2005-01-19 | Aventis Pharma S.A. | Semi-solid systems containing azetidine derivatives |
| CN101346128B (zh) * | 2005-10-25 | 2013-10-02 | 雅培制药有限公司 | 包含低水溶解度药物的配方及其使用方法 |
| CN102159143A (zh) * | 2006-09-29 | 2011-08-17 | 普拉罗美德公司 | 碎石术期间预防结石和结石碎片后退的方法 |
| US8536208B2 (en) * | 2007-08-21 | 2013-09-17 | Basilea Pharmaceutica Ag | Antifungal composition |
| FR2923719B1 (fr) * | 2007-11-15 | 2009-11-20 | Sanofi Aventis | Compositions pharmaceutiques a base de derives d'azetidine |
| IT1394400B1 (it) * | 2009-02-25 | 2012-06-15 | Neuroscienze Pharmaness S C Ar L | Composizioni farmaceutiche |
| AU2016245984B2 (en) * | 2015-04-10 | 2021-03-25 | Bioresponse, L.L.C. | Self-emulsifying formulations of DIM-related indoles |
| CN106551902B (zh) * | 2015-09-17 | 2020-07-03 | 阿赖耶识（上海）生物技术有限公司 | 一种高稳定的非囊泡型纳米颗粒及其在治疗微生物感染中的应用 |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| CN110913906A (zh) | 2017-05-02 | 2020-03-24 | 默沙东公司 | 抗lag3抗体的制剂和抗lag3抗体与抗pd-1抗体的共制剂 |
| EP4351515A1 (en) * | 2021-06-11 | 2024-04-17 | Universidade Da Beira Interior | Self-emulsifying composition, production methods and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9405304D0 (en) * | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
| JP2740153B2 (ja) * | 1995-03-07 | 1998-04-15 | エフ・ホフマン−ラ ロシユ アーゲー | 混合ミセル |
| US6355631B1 (en) * | 2000-03-03 | 2002-03-12 | Aventis Pharma S.A. | Pharmaceutical compositions containing azetidine derivatives, novel azetidine derivatives and their preparation |
| FR2814678B1 (fr) * | 2000-10-04 | 2002-12-20 | Aventis Pharma Sa | Association d'un antagoniste du recepteur cb1 et de sibutramine, les compositions pharmaceutiques les contenant et leur utilisation pour la traitement de l'obesite |
| FR2829027A1 (fr) * | 2001-08-29 | 2003-03-07 | Aventis Pharma Sa | Association avec un antagoniste du recepteur cb1, les compositions pharmaceutiques les contenant et leur utilisation pour le traitement de la maladie de parkinson |
| FR2833842B1 (fr) * | 2001-12-21 | 2004-02-13 | Aventis Pharma Sa | Compositions pharmaceutiques a base de derives d'azetidine |
-
2003
- 2003-07-18 EP EP03291797A patent/EP1498123A1/en not_active Withdrawn
-
2004
- 2004-07-01 PE PE2004000633A patent/PE20050699A1/es not_active Application Discontinuation
- 2004-07-08 CA CA002532668A patent/CA2532668A1/en not_active Abandoned
- 2004-07-08 BR BRPI0412239-9A patent/BRPI0412239A/pt not_active IP Right Cessation
- 2004-07-08 OA OA1200600017A patent/OA13190A/en unknown
- 2004-07-08 KR KR1020067001146A patent/KR20060040690A/ko not_active Application Discontinuation
- 2004-07-08 SG SG200804302-8A patent/SG144140A1/en unknown
- 2004-07-08 AU AU2004262497A patent/AU2004262497A1/en not_active Abandoned
- 2004-07-08 MX MXPA06000478A patent/MXPA06000478A/es not_active Application Discontinuation
- 2004-07-08 WO PCT/EP2004/008552 patent/WO2005013972A1/en active Application Filing
- 2004-07-08 CN CNA2004800206437A patent/CN1822830A/zh active Pending
- 2004-07-08 EP EP04741332A patent/EP1648441A1/en not_active Withdrawn
- 2004-07-08 JP JP2006519900A patent/JP2009513559A/ja active Pending
- 2004-07-08 RU RU2006105000/04A patent/RU2348615C2/ru not_active IP Right Cessation
- 2004-07-08 NZ NZ544707A patent/NZ544707A/en unknown
- 2004-07-08 RS YUP-2005/0971A patent/RS20050971A/sr unknown
- 2004-07-13 US US10/889,729 patent/US20050037062A1/en not_active Abandoned
- 2004-07-14 PA PA20048606601A patent/PA8606601A1/es unknown
- 2004-07-15 AR ARP040102494A patent/AR045912A1/es not_active Application Discontinuation
- 2004-07-16 UY UY28422A patent/UY28422A1/es unknown
- 2004-07-16 MY MYPI20042870A patent/MY142076A/en unknown
- 2004-07-16 TW TW093121230A patent/TW200522946A/zh unknown
- 2004-07-16 GT GT200400134A patent/GT200400134A/es unknown
- 2004-08-07 UA UAA200601706A patent/UA82539C2/uk unknown
-
2006
- 2006-01-06 CR CR8178A patent/CR8178A/es not_active Application Discontinuation
- 2006-01-12 IL IL173113A patent/IL173113A0/en unknown
- 2006-01-16 MA MA28725A patent/MA27921A1/fr unknown
- 2006-01-17 EC EC2006006291A patent/ECSP066291A/es unknown
- 2006-01-17 HR HR20060021A patent/HRP20060021A2/hr not_active Application Discontinuation
- 2006-01-17 TN TNP2006000012A patent/TNSN06012A1/en unknown
- 2006-01-17 ZA ZA200600489A patent/ZA200600489B/xx unknown
- 2006-01-31 NO NO20060510A patent/NO20060510L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TNSN06012A1 (en) | 2007-10-03 |
| CN1822830A (zh) | 2006-08-23 |
| RU2006105000A (ru) | 2006-07-10 |
| OA13190A (en) | 2006-12-13 |
| TW200522946A (en) | 2005-07-16 |
| BRPI0412239A (pt) | 2006-09-12 |
| ECSP066291A (es) | 2006-07-28 |
| UY28422A1 (es) | 2005-02-28 |
| AU2004262497A2 (en) | 2005-02-17 |
| SG144140A1 (en) | 2008-07-29 |
| AR045912A1 (es) | 2005-11-16 |
| GT200400134A (es) | 2005-02-22 |
| CR8178A (es) | 2007-12-04 |
| NO20060510L (no) | 2006-01-31 |
| MA27921A1 (fr) | 2006-06-01 |
| MY142076A (en) | 2010-08-30 |
| RU2348615C2 (ru) | 2009-03-10 |
| HRP20060021A2 (en) | 2006-02-28 |
| EP1498123A1 (en) | 2005-01-19 |
| NZ544707A (en) | 2009-01-31 |
| JP2009513559A (ja) | 2009-04-02 |
| KR20060040690A (ko) | 2006-05-10 |
| UA82539C2 (en) | 2008-04-25 |
| AU2004262497A1 (en) | 2005-02-17 |
| PA8606601A1 (es) | 2005-03-03 |
| EP1648441A1 (en) | 2006-04-26 |
| IL173113A0 (en) | 2006-06-11 |
| MXPA06000478A (es) | 2006-04-05 |
| PE20050699A1 (es) | 2005-09-15 |
| ZA200600489B (en) | 2007-04-25 |
| US20050037062A1 (en) | 2005-02-17 |
| RS20050971A (en) | 2008-06-05 |
| WO2005013972A1 (en) | 2005-02-17 |
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