CA2532667A1 - Semi-solid formulations for the oral administration of taxoids - Google Patents
Semi-solid formulations for the oral administration of taxoids Download PDFInfo
- Publication number
- CA2532667A1 CA2532667A1 CA002532667A CA2532667A CA2532667A1 CA 2532667 A1 CA2532667 A1 CA 2532667A1 CA 002532667 A CA002532667 A CA 002532667A CA 2532667 A CA2532667 A CA 2532667A CA 2532667 A1 CA2532667 A1 CA 2532667A1
- Authority
- CA
- Canada
- Prior art keywords
- taxoid
- semi
- formulations
- formulation
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 150000003839 salts Chemical class 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000012439 solid excipient Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 230000007332 vesicle formation Effects 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03291795A EP1498120A1 (en) | 2003-07-18 | 2003-07-18 | Semi-solid formulations for the oral administration of taxoids |
| EP03291795.7 | 2003-07-18 | ||
| PCT/EP2004/008551 WO2005013968A1 (en) | 2003-07-18 | 2004-07-15 | Semi-solid formulations for the oral administration of taxoids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2532667A1 true CA2532667A1 (en) | 2005-02-17 |
Family
ID=33462258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002532667A Abandoned CA2532667A1 (en) | 2003-07-18 | 2004-07-15 | Semi-solid formulations for the oral administration of taxoids |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20050070496A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP1498120A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5116306B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101143341B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1826110B (cg-RX-API-DMAC7.html) |
| AR (1) | AR045996A1 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE388701T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2004262496B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0412759A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2532667A1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE602004012413T2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1648440T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2303642T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL173110A (cg-RX-API-DMAC7.html) |
| IN (1) | IN229997B (cg-RX-API-DMAC7.html) |
| MX (1) | MX260260B (cg-RX-API-DMAC7.html) |
| MY (1) | MY137965A (cg-RX-API-DMAC7.html) |
| PT (1) | PT1648440E (cg-RX-API-DMAC7.html) |
| TW (1) | TWI342774B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005013968A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1498143A1 (en) * | 2003-07-18 | 2005-01-19 | Aventis Pharma S.A. | Self-emulsifying and self-microemulsifying formulations for the oral administration of taxoids |
| US20080045589A1 (en) * | 2006-05-26 | 2008-02-21 | Susan Kelley | Drug Combinations with Substituted Diaryl Ureas for the Treatment of Cancer |
| FR2922107B1 (fr) * | 2007-10-10 | 2010-02-26 | Aventis Pharma Sa | Nouvelles compositions a base de taxoides |
| FR2924024B1 (fr) | 2007-11-27 | 2012-08-17 | Centre Nat Rech Scient | Nanoparticules d'actifs therapeutiques de faible solubilite aqueuse |
| FR2931152B1 (fr) * | 2008-05-16 | 2010-07-30 | Centre Nat Rech Scient | Nouveau systeme de transfert d'acide nucleique |
| WO2011051894A1 (en) | 2009-10-29 | 2011-05-05 | Aventis Pharma S.A. | Novel antitumoral use of cabazitaxel |
| AU2011248449B2 (en) | 2010-05-03 | 2016-09-15 | Teikoku Pharma Usa, Inc. | Non-aqueous taxane pro-emulsion formulations and methods of making and using the same |
| JO3685B1 (ar) | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
| CN103980232A (zh) * | 2014-06-05 | 2014-08-13 | 北京诺普德医药科技有限公司 | 10-乙酰基多西紫杉醇及其用途 |
| KR101542364B1 (ko) * | 2014-10-31 | 2015-08-07 | 대화제약 주식회사 | 탁산을 포함하는 경구 투여용 약학 조성물 |
| CN113698369A (zh) * | 2021-08-31 | 2021-11-26 | 无锡紫杉药业有限公司 | 一种除去卡巴他赛中特定单杂的方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3406497A1 (de) * | 1984-02-23 | 1985-09-05 | Mueller Bernhard Willi Werner | Hochdisperse pharmazeutische mehrkomponentensysteme und verfahren zu ihrer herstellung |
| US5272171A (en) * | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
| JP3208517B2 (ja) * | 1992-07-01 | 2001-09-17 | ブリストル−マイヤーズ スクイブ カンパニー | ７，８−シクロプロパタキサン類 |
| US5254580A (en) * | 1993-01-19 | 1993-10-19 | Bristol-Myers Squibb Company | 7,8-cyclopropataxanes |
| US5294637A (en) * | 1992-07-01 | 1994-03-15 | Bristol-Myers Squibb Company | Fluoro taxols |
| US5478854A (en) * | 1992-10-01 | 1995-12-26 | Bristol-Myers Squibb Company | Deoxy taxols |
| US5973160A (en) * | 1992-12-23 | 1999-10-26 | Poss; Michael A. | Methods for the preparation of novel sidechain-bearing taxanes |
| US5646176A (en) * | 1992-12-24 | 1997-07-08 | Bristol-Myers Squibb Company | Phosphonooxymethyl ethers of taxane derivatives |
| US6054136A (en) * | 1993-09-30 | 2000-04-25 | Gattefosse S.A. | Orally administrable composition capable of providing enhanced bioavailability when ingested |
| US6458373B1 (en) * | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
| IL131217A0 (en) * | 1998-03-10 | 2001-01-28 | Napro Biotherapeutics Inc | Novel methods and compositions for delivery of taxanes |
| WO1999049848A1 (en) * | 1998-04-01 | 1999-10-07 | Rtp Pharma Inc. | Anticancer compositions |
| MXPA01011981A (es) * | 1999-05-24 | 2003-09-04 | Sonus Pharma Inc | Vehiculo de emulsion para farmacos poco solubles. |
| US6136846A (en) * | 1999-10-25 | 2000-10-24 | Supergen, Inc. | Formulation for paclitaxel |
| JP2004520398A (ja) * | 2001-01-18 | 2004-07-08 | ファルマシア・アンド・アップジョン・カンパニー | 経口生物学的利用能が改善されたパクリタキセルの化学療法マイクロエマルジョン組成物 |
| WO2003045357A1 (en) * | 2001-11-27 | 2003-06-05 | Transform Pharmaceuticals, Inc. | Oral pharmaceutical formulations comprising paclitaxel, derivatives and methods of administration thereof |
| RS52904A (sr) * | 2001-12-20 | 2006-12-15 | Bristol-Myers Squib Company | Farmaceutske smeše oralno aktivnih derivata taksana koje imaju povećanu bioraspoloživost |
| WO2003074027A2 (en) * | 2002-03-01 | 2003-09-12 | Novagali Pharma Sa | Self emulsifying drug delivery systems for poorly soluble drugs |
| KR20090072980A (ko) * | 2007-12-28 | 2009-07-02 | 서울옵토디바이스주식회사 | 발광 다이오드 및 그 제조방법 |
-
2003
- 2003-07-18 EP EP03291795A patent/EP1498120A1/en not_active Ceased
-
2004
- 2004-07-15 KR KR1020067001136A patent/KR101143341B1/ko not_active Expired - Fee Related
- 2004-07-15 AU AU2004262496A patent/AU2004262496B2/en not_active Ceased
- 2004-07-15 IN IN198CH2006 patent/IN229997B/en unknown
- 2004-07-15 ES ES04741331T patent/ES2303642T3/es not_active Expired - Lifetime
- 2004-07-15 JP JP2006519899A patent/JP5116306B2/ja not_active Expired - Fee Related
- 2004-07-15 WO PCT/EP2004/008551 patent/WO2005013968A1/en not_active Ceased
- 2004-07-15 PT PT04741331T patent/PT1648440E/pt unknown
- 2004-07-15 DE DE602004012413T patent/DE602004012413T2/de not_active Expired - Lifetime
- 2004-07-15 AT AT04741331T patent/ATE388701T1/de not_active IP Right Cessation
- 2004-07-15 CA CA002532667A patent/CA2532667A1/en not_active Abandoned
- 2004-07-15 DK DK04741331T patent/DK1648440T3/da active
- 2004-07-15 CN CN2004800207228A patent/CN1826110B/zh not_active Expired - Fee Related
- 2004-07-15 BR BRPI0412759-5A patent/BRPI0412759A/pt not_active IP Right Cessation
- 2004-07-15 AR ARP040102493A patent/AR045996A1/es not_active Application Discontinuation
- 2004-07-15 MX MXPA06000636 patent/MX260260B/es active IP Right Grant
- 2004-07-15 EP EP04741331A patent/EP1648440B1/en not_active Expired - Lifetime
- 2004-07-16 MY MYPI20042868A patent/MY137965A/en unknown
- 2004-07-16 TW TW093121233A patent/TWI342774B/zh not_active IP Right Cessation
- 2004-07-19 US US10/894,163 patent/US20050070496A1/en not_active Abandoned
-
2006
- 2006-01-12 IL IL173110A patent/IL173110A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004262496B2 (en) | 2009-02-05 |
| AR045996A1 (es) | 2005-11-23 |
| MY137965A (en) | 2009-04-30 |
| MX260260B (es) | 2008-09-04 |
| CN1826110A (zh) | 2006-08-30 |
| HK1091743A1 (zh) | 2007-01-26 |
| AU2004262496A1 (en) | 2005-02-17 |
| BRPI0412759A (pt) | 2006-09-26 |
| IN2006CH00198A (cg-RX-API-DMAC7.html) | 2007-06-08 |
| DK1648440T3 (da) | 2008-07-14 |
| EP1648440A1 (en) | 2006-04-26 |
| ES2303642T3 (es) | 2008-08-16 |
| DE602004012413D1 (de) | 2008-04-24 |
| WO2005013968A1 (en) | 2005-02-17 |
| CN1826110B (zh) | 2010-05-12 |
| KR101143341B1 (ko) | 2012-05-24 |
| JP2009513558A (ja) | 2009-04-02 |
| MXPA06000636A (es) | 2006-04-19 |
| JP5116306B2 (ja) | 2013-01-09 |
| ATE388701T1 (de) | 2008-03-15 |
| EP1648440B1 (en) | 2008-03-12 |
| IL173110A (en) | 2011-04-28 |
| EP1498120A1 (en) | 2005-01-19 |
| IN229997B (cg-RX-API-DMAC7.html) | 2009-03-27 |
| PT1648440E (pt) | 2008-06-24 |
| TW200517104A (en) | 2005-06-01 |
| US20050070496A1 (en) | 2005-03-31 |
| TWI342774B (en) | 2011-06-01 |
| IL173110A0 (en) | 2006-06-11 |
| DE602004012413T2 (de) | 2009-03-12 |
| KR20060037370A (ko) | 2006-05-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20150715 |