CA2530460A1 - Procede de traitement du syndrome coronarien aigu - Google Patents
Procede de traitement du syndrome coronarien aigu Download PDFInfo
- Publication number
- CA2530460A1 CA2530460A1 CA002530460A CA2530460A CA2530460A1 CA 2530460 A1 CA2530460 A1 CA 2530460A1 CA 002530460 A CA002530460 A CA 002530460A CA 2530460 A CA2530460 A CA 2530460A CA 2530460 A1 CA2530460 A1 CA 2530460A1
- Authority
- CA
- Canada
- Prior art keywords
- therapeutic agent
- group
- formulation
- encapsulated
- bisphosphonate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000004476 Acute Coronary Syndrome Diseases 0.000 title claims abstract 8
- 238000000034 method Methods 0.000 title abstract 3
- 239000003814 drug Substances 0.000 claims abstract 25
- 229940124597 therapeutic agent Drugs 0.000 claims abstract 25
- 239000000203 mixture Substances 0.000 claims abstract 16
- 238000009472 formulation Methods 0.000 claims abstract 15
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 9
- 210000001539 phagocyte Anatomy 0.000 claims abstract 6
- 206010000891 acute myocardial infarction Diseases 0.000 claims abstract 5
- 230000007423 decrease Effects 0.000 claims abstract 4
- 206010002388 Angina unstable Diseases 0.000 claims abstract 3
- 208000007814 Unstable Angina Diseases 0.000 claims abstract 3
- 230000000694 effects Effects 0.000 claims abstract 3
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims abstract 3
- 210000002540 macrophage Anatomy 0.000 claims abstract 3
- 210000001616 monocyte Anatomy 0.000 claims abstract 3
- 229940122361 Bisphosphonate Drugs 0.000 claims 8
- 150000004663 bisphosphonates Chemical group 0.000 claims 8
- 125000005843 halogen group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 230000003834 intracellular effect Effects 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 claims 3
- DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 claims 3
- DKJJVAGXPKPDRL-UHFFFAOYSA-N Tiludronic acid Chemical compound OP(O)(=O)C(P(O)(O)=O)SC1=CC=C(Cl)C=C1 DKJJVAGXPKPDRL-UHFFFAOYSA-N 0.000 claims 3
- 229940062527 alendronate Drugs 0.000 claims 3
- ACSIXWWBWUQEHA-UHFFFAOYSA-N clodronic acid Chemical compound OP(O)(=O)C(Cl)(Cl)P(O)(O)=O ACSIXWWBWUQEHA-UHFFFAOYSA-N 0.000 claims 3
- 229960002286 clodronic acid Drugs 0.000 claims 3
- 239000000084 colloidal system Substances 0.000 claims 3
- 229940009626 etidronate Drugs 0.000 claims 3
- 239000002502 liposome Substances 0.000 claims 3
- 239000011859 microparticle Substances 0.000 claims 3
- 239000004005 microsphere Substances 0.000 claims 3
- 239000002105 nanoparticle Substances 0.000 claims 3
- 239000002077 nanosphere Substances 0.000 claims 3
- WRUUGTRCQOWXEG-UHFFFAOYSA-N pamidronate Chemical compound NCCC(O)(P(O)(O)=O)P(O)(O)=O WRUUGTRCQOWXEG-UHFFFAOYSA-N 0.000 claims 3
- 229940046231 pamidronate Drugs 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 229940019375 tiludronate Drugs 0.000 claims 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- -1 chlorosubstituted phenyl Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 150000003512 tertiary amines Chemical class 0.000 claims 2
- 239000000824 cytostatic agent Substances 0.000 claims 1
- 230000001085 cytostatic effect Effects 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/607,623 | 2003-06-27 | ||
US10/607,623 US10517883B2 (en) | 2003-06-27 | 2003-06-27 | Method of treating acute myocardial infarction |
US10/871,488 US9498488B2 (en) | 2003-06-27 | 2004-06-18 | Method of treating acute coronary syndromes |
US10/871,488 | 2004-06-18 | ||
PCT/US2004/020487 WO2005002545A1 (fr) | 2003-06-27 | 2004-06-24 | Procede de traitement du syndrome coronarien aigu |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2530460A1 true CA2530460A1 (fr) | 2005-01-13 |
CA2530460C CA2530460C (fr) | 2012-08-14 |
Family
ID=33568009
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2530460A Expired - Fee Related CA2530460C (fr) | 2003-06-27 | 2004-06-24 | Procede de traitement du syndrome coronarien aigu |
Country Status (4)
Country | Link |
---|---|
JP (1) | JP4621202B2 (fr) |
AU (1) | AU2004253527B2 (fr) |
CA (1) | CA2530460C (fr) |
WO (1) | WO2005002545A1 (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060051407A1 (en) * | 2003-06-27 | 2006-03-09 | Yoram Richter | Method of treating ischemia-reperfusion injury |
US10517883B2 (en) | 2003-06-27 | 2019-12-31 | Zuli Holdings Ltd. | Method of treating acute myocardial infarction |
JP4992091B2 (ja) * | 2005-02-17 | 2012-08-08 | ハダシット メディカル リサーチ サービシーズ アンド デベロップメント リミテッド | 子宮内膜症を治療するためのビスホスホネート |
EP2279726A3 (fr) * | 2005-05-26 | 2012-06-20 | Biorest Ltd. | Compositions et méthodes d'utilisation desdites compositions dans l'administration d'agents dans un organe cible protégé par une barrière sanguine |
ES2537216T3 (es) * | 2009-09-01 | 2015-06-03 | Duke University | Composiciones de bisfosfonato y métodos para tratar la insuficiencia cardíaca |
JP6261512B2 (ja) | 2011-11-16 | 2018-01-17 | デューク ユニバーシティ | 心機能障害を治療及び/又は低減するためのビスホスホネート組成物並びに方法 |
US9993427B2 (en) | 2013-03-14 | 2018-06-12 | Biorest Ltd. | Liposome formulation and manufacture |
CN106456775A (zh) * | 2014-05-16 | 2017-02-22 | 生物休眠有限公司 | 双膦酸盐作为hiv/aids辅助治疗的用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6139871A (en) * | 1995-07-26 | 2000-10-31 | The University Of British Columbia | Liposome compositions and methods for the treatment of atherosclerosis |
AU7525296A (en) * | 1995-11-01 | 1997-05-22 | Chiron Corporation | Treatment of a cardiovascular indication by delivery of therapeutics to the pericardial space |
DE19637890A1 (de) * | 1996-09-17 | 1998-03-19 | Max Planck Gesellschaft | Biphosphonat-Liposomen |
IL125336A0 (en) * | 1998-07-14 | 1999-03-12 | Yissum Res Dev Co | Compositions for inhibition and treatment of restinosis |
CN1635910A (zh) * | 2001-05-02 | 2005-07-06 | 普渡研究基金会 | 巨噬细胞介导的疾病的治疗和诊断 |
-
2004
- 2004-06-24 AU AU2004253527A patent/AU2004253527B2/en not_active Ceased
- 2004-06-24 WO PCT/US2004/020487 patent/WO2005002545A1/fr active Application Filing
- 2004-06-24 CA CA2530460A patent/CA2530460C/fr not_active Expired - Fee Related
- 2004-06-24 JP JP2006517683A patent/JP4621202B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2530460C (fr) | 2012-08-14 |
JP4621202B2 (ja) | 2011-01-26 |
WO2005002545A8 (fr) | 2006-02-16 |
AU2004253527A1 (en) | 2005-01-13 |
JP2007524632A (ja) | 2007-08-30 |
AU2004253527B2 (en) | 2010-04-08 |
WO2005002545A1 (fr) | 2005-01-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20200831 |