CA2524394C - Nouvelles benzodiazepines, compositions de celles-ci et leurs utilisations - Google Patents

Nouvelles benzodiazepines, compositions de celles-ci et leurs utilisations Download PDF

Info

Publication number
CA2524394C
CA2524394C CA2524394A CA2524394A CA2524394C CA 2524394 C CA2524394 C CA 2524394C CA 2524394 A CA2524394 A CA 2524394A CA 2524394 A CA2524394 A CA 2524394A CA 2524394 C CA2524394 C CA 2524394C
Authority
CA
Canada
Prior art keywords
compound
alkyl
cell
cells
disorder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2524394A
Other languages
English (en)
Other versions
CA2524394A1 (fr
Inventor
Gary D. Glick
Anthony W. Opipari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan
Original Assignee
University of Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/427,212 external-priority patent/US7144880B2/en
Priority claimed from US10/634,114 external-priority patent/US20040176358A1/en
Priority claimed from US10/795,535 external-priority patent/US7276348B2/en
Application filed by University of Michigan filed Critical University of Michigan
Publication of CA2524394A1 publication Critical patent/CA2524394A1/fr
Application granted granted Critical
Publication of CA2524394C publication Critical patent/CA2524394C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5076—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving cell organelles, e.g. Golgi complex, endoplasmic reticulum
    • G01N33/5079—Mitochondria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2510/00—Detection of programmed cell death, i.e. apoptosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
CA2524394A 2003-05-01 2004-04-30 Nouvelles benzodiazepines, compositions de celles-ci et leurs utilisations Expired - Fee Related CA2524394C (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US10/427,211 2003-05-01
US10/427,212 US7144880B2 (en) 1999-04-30 2003-05-01 Compositions relating to novel compounds and targets thereof
US10/427,211 US7572788B2 (en) 1999-04-30 2003-05-01 Compositions and methods relating to novel compounds and targets thereof
US10/427,212 2003-05-01
US10/634,114 2003-08-04
US10/634,114 US20040176358A1 (en) 1999-04-30 2003-08-04 Compositions and methods relating to novel compounds and targets thereof
US10/795,535 2004-03-08
US10/795,535 US7276348B2 (en) 1999-04-30 2004-03-08 Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof
PCT/US2004/013455 WO2005004988A2 (fr) 2003-05-01 2004-04-30 Compositions et procedes de recherche de nouveaux composes et leurs cibles

Publications (2)

Publication Number Publication Date
CA2524394A1 CA2524394A1 (fr) 2005-01-20
CA2524394C true CA2524394C (fr) 2011-07-12

Family

ID=34069318

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2524394A Expired - Fee Related CA2524394C (fr) 2003-05-01 2004-04-30 Nouvelles benzodiazepines, compositions de celles-ci et leurs utilisations

Country Status (6)

Country Link
EP (1) EP1622684A4 (fr)
JP (1) JP2007500212A (fr)
AU (1) AU2004255153B2 (fr)
CA (1) CA2524394C (fr)
MX (1) MXPA05011741A (fr)
WO (1) WO2005004988A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8759340B2 (en) 2007-11-06 2014-06-24 The Regents Of The University Of Michigan Benzodiazepinone compounds useful in the treatment of skin conditions
US8791104B2 (en) 2005-11-01 2014-07-29 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones with therapeutic properties
US8809323B2 (en) 1999-04-30 2014-08-19 The Regents Of The University Of Michigan Therapeutic applications of pro-apoptotic benzodiazepines
US9126978B2 (en) 2009-11-17 2015-09-08 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060025388A1 (en) 1999-04-30 2006-02-02 Glick Gary D Compositions and methods relating to novel compounds and targets thereof
US20050113460A1 (en) * 1999-04-30 2005-05-26 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US7144880B2 (en) 1999-04-30 2006-12-05 Regents Of The University Of Michigan Compositions relating to novel compounds and targets thereof
US7276348B2 (en) 1999-04-30 2007-10-02 Regents Of The University Of Michigan Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof
US7713973B2 (en) 2004-10-15 2010-05-11 Takeda Pharmaceutical Company Limited Kinase inhibitors
AU2006203946B2 (en) 2005-01-03 2009-07-23 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US20070043033A1 (en) 2005-06-01 2007-02-22 The Regents Of The University Of Michigan Unsolvated benzodiazepine compositions and methods
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
US7759338B2 (en) 2006-04-27 2010-07-20 The Regents Of The University Of Michigan Soluble 1,4 benzodiazepine compounds and stable salts thereof
AU2007258468B2 (en) 2006-06-09 2011-09-22 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
SG175609A1 (en) 2006-10-09 2011-11-28 Takeda Pharmaceutical Kinase inhibitors
MX2009009645A (es) * 2007-03-09 2009-11-19 Univ Michigan Composiciones y metodos relacionados con nuevos compuestos y objetivos de los mismos.
WO2009036175A2 (fr) 2007-09-14 2009-03-19 The Regents Of The University Of Michigan Inhibiteur de f1f0-atpase et procédés associés
US8598150B1 (en) 2008-04-02 2013-12-03 Jonathan R. Brestoff Composition and method for affecting obesity and related conditions
US8987245B2 (en) 2008-04-02 2015-03-24 Jonathan R. Brestoff Parker Composition and method for affecting obesity and related conditions
JP5567573B2 (ja) 2008-09-11 2014-08-06 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン アリールグアニジンｆ１ｆ０−ａｔｐアーゼ阻害剤およびそれと関連する方法
US8604023B2 (en) 2009-04-17 2013-12-10 The Regents Of The University Of Michigan 1,4-benzodiazepinone compounds and their use in treating cancer
JP2013505258A (ja) 2009-09-18 2013-02-14 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン ベンゾジアゼピノン化合物およびそれを使用する治療方法
WO2011062766A2 (fr) 2009-11-17 2011-05-26 The Regents Of The University Of Michigan 1,4-benzodiazépine-2,5-diones et composés apparentés présentant des propriétés thérapeutiques

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524832B1 (en) * 1994-02-04 2003-02-25 Arch Development Corporation DNA damaging agents in combination with tyrosine kinase inhibitors
EP1143946B1 (fr) * 1999-04-30 2004-01-28 The Regents Of The University Of Michigan Applications therapeutiques de benzodiazepines pro-apoptotiques
US20030119029A1 (en) * 1999-04-30 2003-06-26 Regents Of The University Of Michigan Compositions and methods relating to novel benzodiazepine compounds and targets thereof
CA2457405A1 (fr) * 2001-08-15 2003-02-27 The Regents Of The University Of Michigan Compositions et methodes relatives a des benzodiazepines

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8809323B2 (en) 1999-04-30 2014-08-19 The Regents Of The University Of Michigan Therapeutic applications of pro-apoptotic benzodiazepines
US8791104B2 (en) 2005-11-01 2014-07-29 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones with therapeutic properties
US8759340B2 (en) 2007-11-06 2014-06-24 The Regents Of The University Of Michigan Benzodiazepinone compounds useful in the treatment of skin conditions
US9126978B2 (en) 2009-11-17 2015-09-08 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties

Also Published As

Publication number Publication date
EP1622684A2 (fr) 2006-02-08
MXPA05011741A (es) 2006-05-12
JP2007500212A (ja) 2007-01-11
AU2004255153A1 (en) 2005-01-20
AU2004255153B2 (en) 2007-11-22
WO2005004988A3 (fr) 2006-02-23
WO2005004988A2 (fr) 2005-01-20
EP1622684A4 (fr) 2007-07-25
CA2524394A1 (fr) 2005-01-20

Similar Documents

Publication Publication Date Title
US7276348B2 (en) Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof
US8722667B2 (en) Compositions and methods for inhibiting the proliferation of cells
CA2524394C (fr) Nouvelles benzodiazepines, compositions de celles-ci et leurs utilisations
US7683046B2 (en) Benzodiazepine compositions for treating epidermal hyperplasia and related disorders
AU2005323519B2 (en) Methods and compositions for treating diseases and conditions associated with mitochondrial function
US7638624B2 (en) Compositions and methods relating to novel benzodiazepine compounds and derivatives
US20050113460A1 (en) Compositions and methods relating to novel compounds and targets thereof
US20040176358A1 (en) Compositions and methods relating to novel compounds and targets thereof
US20120077805A1 (en) Unsolvated benzodiazepine compositions and methods
AU2008200867A1 (en) Compositions and methods relating to novel compounds and targets thereof
JP2012107022A (ja) 新規化合物およびその標的に関する組成物および方法

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20170501