CA2523134A1 - Pyridyl substituted ketolide antibiotics - Google Patents

Pyridyl substituted ketolide antibiotics Download PDF

Info

Publication number
CA2523134A1
CA2523134A1 CA002523134A CA2523134A CA2523134A1 CA 2523134 A1 CA2523134 A1 CA 2523134A1 CA 002523134 A CA002523134 A CA 002523134A CA 2523134 A CA2523134 A CA 2523134A CA 2523134 A1 CA2523134 A1 CA 2523134A1
Authority
CA
Canada
Prior art keywords
substituted
alkyl
hydrogen
compound
previously defined
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002523134A
Other languages
English (en)
French (fr)
Inventor
Matthew Burger
Georgia Carroll
Daniel Chu
Xiaodong Lin
Jacob Plattner
Alice Rico
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2523134A1 publication Critical patent/CA2523134A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CA002523134A 2003-04-25 2004-04-23 Pyridyl substituted ketolide antibiotics Abandoned CA2523134A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46529403P 2003-04-25 2003-04-25
US60/465,294 2003-04-25
PCT/US2004/012645 WO2004096822A2 (en) 2003-04-25 2004-04-23 Pyridyl substituted ketolide antibiotics

Publications (1)

Publication Number Publication Date
CA2523134A1 true CA2523134A1 (en) 2004-11-11

Family

ID=33418219

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002523134A Abandoned CA2523134A1 (en) 2003-04-25 2004-04-23 Pyridyl substituted ketolide antibiotics

Country Status (5)

Country Link
US (1) US7332476B2 (enExample)
EP (1) EP1618119A2 (enExample)
JP (1) JP2006524702A (enExample)
CA (1) CA2523134A1 (enExample)
WO (1) WO2004096822A2 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7601695B2 (en) 2003-03-10 2009-10-13 Optimer Pharmaceuticals, Inc. Antibacterial agents
EP1618120A2 (en) * 2003-04-25 2006-01-25 Chiron Corporation Novel ketolide derivatives
WO2006080954A1 (en) * 2004-07-28 2006-08-03 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
EP1928893A2 (en) 2005-08-24 2008-06-11 Rib-X Pharmaceuticals, Inc. Triazole compounds and methods of making and using the same
AU2008316830B2 (en) * 2007-10-25 2016-03-17 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
CN107854477A (zh) 2008-10-24 2018-03-30 森普拉制药公司 使用含三唑的大环内酯治疗抗性疾病的方法
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US9480679B2 (en) 2009-09-10 2016-11-01 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
BR112012029586A2 (pt) 2010-05-20 2016-08-02 Cempra Pharmaceuticals Inc processos para preparar macrolídeos e cetolídeos e intermediários dos mesmos
KR20130120458A (ko) 2010-09-10 2013-11-04 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
WO2012089349A2 (en) 2010-12-31 2012-07-05 Acies Bio D.O.O. Novel polyketide compounds and methods of making same
CN103619849B (zh) * 2011-03-01 2016-05-25 沃克哈特有限公司 酮内酯中间体的制备方法
WO2013148891A1 (en) 2012-03-27 2013-10-03 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
WO2014152326A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
AU2014233240B2 (en) 2013-03-15 2018-08-09 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
MX2019002444A (es) * 2016-08-29 2019-09-02 Univ Texas Inhibidores de cinasa de cremallera de leucina dual (dlk) para el tratamiento de enfermedades.
WO2018067663A2 (en) * 2016-10-04 2018-04-12 Biopharmati Sa Ketolides having antibacterial activity
CA3045947A1 (en) 2016-12-08 2018-06-14 Michael J. Soth Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (dlk) kinase for the treatment of disease
US11560366B2 (en) 2019-10-21 2023-01-24 Board Of Regents, The University Of Texas System Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857641A (en) 1987-08-14 1989-08-15 Pfizer Inc. C.12 modified erythromycin A derivatives
US6063561A (en) 1991-01-17 2000-05-16 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
FR2718450B1 (fr) 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5750510A (en) 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
EP0918783A1 (en) 1996-05-07 1999-06-02 Abbott Laboratories 6-o-substituted erythromycins and method for making them
UA51730C2 (uk) 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
US6191118B1 (en) 1996-11-27 2001-02-20 Taisho Pharmaceutical Co., Ltd. Erythromycin A derivatives
AU6421398A (en) 1997-03-24 1998-10-20 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
WO2003004509A2 (en) * 2001-07-03 2003-01-16 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
EP1618120A2 (en) * 2003-04-25 2006-01-25 Chiron Corporation Novel ketolide derivatives

Also Published As

Publication number Publication date
EP1618119A2 (en) 2006-01-25
JP2006524702A (ja) 2006-11-02
US20050009764A1 (en) 2005-01-13
WO2004096822A3 (en) 2004-12-16
WO2004096822A2 (en) 2004-11-11
US7332476B2 (en) 2008-02-19

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead