CA2523134A1 - Pyridyl substituted ketolide antibiotics - Google Patents

Pyridyl substituted ketolide antibiotics Download PDF

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Publication number
CA2523134A1
CA2523134A1 CA002523134A CA2523134A CA2523134A1 CA 2523134 A1 CA2523134 A1 CA 2523134A1 CA 002523134 A CA002523134 A CA 002523134A CA 2523134 A CA2523134 A CA 2523134A CA 2523134 A1 CA2523134 A1 CA 2523134A1
Authority
CA
Canada
Prior art keywords
substituted
alkyl
hydrogen
compound
previously defined
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002523134A
Other languages
English (en)
French (fr)
Inventor
Matthew Burger
Georgia Carroll
Daniel Chu
Xiaodong Lin
Jacob Plattner
Alice Rico
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2523134A1 publication Critical patent/CA2523134A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CA002523134A 2003-04-25 2004-04-23 Pyridyl substituted ketolide antibiotics Abandoned CA2523134A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46529403P 2003-04-25 2003-04-25
US60/465,294 2003-04-25
PCT/US2004/012645 WO2004096822A2 (en) 2003-04-25 2004-04-23 Pyridyl substituted ketolide antibiotics

Publications (1)

Publication Number Publication Date
CA2523134A1 true CA2523134A1 (en) 2004-11-11

Family

ID=33418219

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002523134A Abandoned CA2523134A1 (en) 2003-04-25 2004-04-23 Pyridyl substituted ketolide antibiotics

Country Status (5)

Country Link
US (1) US7332476B2 (enExample)
EP (1) EP1618119A2 (enExample)
JP (1) JP2006524702A (enExample)
CA (1) CA2523134A1 (enExample)
WO (1) WO2004096822A2 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1638549A4 (en) 2003-03-10 2011-06-15 Optimer Pharmaceuticals Inc NEW ANTIBACTERIAL AGENTS
WO2004096823A2 (en) * 2003-04-25 2004-11-11 Chiron Corporation Novel ketolide derivatives
EP1794171A2 (en) * 2004-07-28 2007-06-13 Ranbaxy Laboratories, Ltd. Ketolide derivatives as antibacterial agents
ES2638427T3 (es) 2005-08-24 2017-10-20 Melinta Therapeutics, Inc. Compuestos de triazol y procedimientos de preparación y uso del mismo
CA2703475A1 (en) 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
EP2358379B1 (en) 2008-10-24 2015-12-16 Cempra Pharmaceuticals, Inc. Biodefenses using triazole-containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
ES2608285T3 (es) 2009-09-10 2017-04-07 Cempra Pharmaceuticals, Inc. Procedimientos para el tratamiento de paludismo, tuberculosis y enfermedades por MAC
KR101945324B1 (ko) 2010-05-20 2019-02-07 셈프라 파마슈티컬스, 인크. 매크로라이드들 및 케톨라이드들과 이의 중간체들을 제조하는 공정들
US9815863B2 (en) 2010-09-10 2017-11-14 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
EP2658855A2 (en) 2010-12-31 2013-11-06 Acies Bio d.o.o. Novel polyketide compounds and methods of making same
JP5718488B2 (ja) * 2011-03-01 2015-05-13 ウォックハート リミテッド ケトライド中間体の調製方法
KR20140139083A (ko) 2012-03-27 2014-12-04 셈프라 파마슈티컬스, 인크. 마크롤라이드계 항생제를 투여하기 위한 비경구 제제
RU2015138796A (ru) 2013-03-14 2017-04-19 Семпра Фармасьютикалс, Инк. Способы и составы для лечения респираторных заболеваний
JP6675973B2 (ja) 2013-03-15 2020-04-08 センプラ ファーマシューティカルズ，インコーポレイテッド マクロライド抗菌薬を調製するための集束的な方法
CA3035195A1 (en) * 2016-08-29 2018-03-08 Michael J. Soth Inhibitors of dual leucine zipper (dlk) kinase for the treatment of disease
WO2018067663A2 (en) * 2016-10-04 2018-04-12 Biopharmati Sa Ketolides having antibacterial activity
JP7128816B2 (ja) 2016-12-08 2022-08-31 ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム 疾患の治療のための二重ロイシンジッパー（ｄｌｋ）キナーゼのビシクロ［１．１．１］ペンタン阻害剤
US11560366B2 (en) 2019-10-21 2023-01-24 Board Of Regents, The University Of Texas System Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857641A (en) 1987-08-14 1989-08-15 Pfizer Inc. C.12 modified erythromycin A derivatives
US6063561A (en) 1991-01-17 2000-05-16 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
FR2718450B1 (fr) 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
JP2000509712A (ja) 1996-05-07 2000-08-02 アボツト・ラボラトリーズ ６―ｏ―置換エリスロマイシン及びその製造方法
US5750510A (en) 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
UA51730C2 (uk) 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
CA2272620A1 (en) 1996-11-27 1998-06-04 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
WO1998042720A1 (fr) 1997-03-24 1998-10-01 Taisho Pharmaceutical Co., Ltd. Derives d'erythromycine a
EP1404693A2 (en) 2001-07-03 2004-04-07 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
WO2004096823A2 (en) * 2003-04-25 2004-11-11 Chiron Corporation Novel ketolide derivatives

Also Published As

Publication number Publication date
WO2004096822A2 (en) 2004-11-11
WO2004096822A3 (en) 2004-12-16
JP2006524702A (ja) 2006-11-02
US7332476B2 (en) 2008-02-19
US20050009764A1 (en) 2005-01-13
EP1618119A2 (en) 2006-01-25

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