CA2522595A1 - Compositions useful as inhibitors of protein kinases - Google Patents

Info

Publication number

CA2522595A1

CA2522595A1 CA002522595A CA2522595A CA2522595A1 CA 2522595 A1 CA2522595 A1 CA 2522595A1 CA 002522595 A CA002522595 A CA 002522595A CA 2522595 A CA2522595 A CA 2522595A CA 2522595 A1 CA2522595 A1 CA 2522595A1

Authority

CA

Canada

Prior art keywords

compound according

optionally substituted

chromen

compounds

phenyl

Prior art date

2003-04-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
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• 239000003112 inhibitor Substances 0.000 title abstract description 37
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• 108010014905 Glycogen Synthase Kinase 3 Proteins 0.000 claims description 75
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• 108010046882 ZAP-70 Protein-Tyrosine Kinase Proteins 0.000 claims description 49
• 230000000694 effects Effects 0.000 claims description 46
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 45
• 102100025387 Tyrosine-protein kinase JAK3 Human genes 0.000 claims description 36
• FSPQCTGGIANIJZ-UHFFFAOYSA-N 2-[[(3,4-dimethoxyphenyl)-oxomethyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(=O)NC1=C(C(N)=O)C(CCCC2)=C2S1 FSPQCTGGIANIJZ-UHFFFAOYSA-N 0.000 claims description 34
• 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 claims description 34
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• OQOXFJOITKRWEI-UHFFFAOYSA-N 1-[4-[5,7-dihydroxy-4-hydroxyimino-2-(4-hydroxyphenyl)chromen-6-yl]oxyphenyl]ethanone Chemical compound C1=CC(C(=O)C)=CC=C1OC1=C(O)C=C(OC(=CC2=NO)C=3C=CC(O)=CC=3)C2=C1O OQOXFJOITKRWEI-UHFFFAOYSA-N 0.000 claims description 2
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