CA2512399A1 - Antagonistes du recepteur de f11 (f11r) en tant qu'agents therapeutiques - Google Patents
Antagonistes du recepteur de f11 (f11r) en tant qu'agents therapeutiques Download PDFInfo
- Publication number
- CA2512399A1 CA2512399A1 CA002512399A CA2512399A CA2512399A1 CA 2512399 A1 CA2512399 A1 CA 2512399A1 CA 002512399 A CA002512399 A CA 002512399A CA 2512399 A CA2512399 A CA 2512399A CA 2512399 A1 CA2512399 A1 CA 2512399A1
- Authority
- CA
- Canada
- Prior art keywords
- seq
- peptide
- peptides
- antagonist
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La présente invention concerne une molécule d'adhésion cellulaire (CAM), désignée en tant que récepteur de F11 (F11R), qui fait partie de la superfamille de l'immunoglobuline localisée à la surface des plaquettes humaines, et a pour rôle de promouvoir l'agrégation des plaquettes, la sécrétion, l'étalement des plaquettes et l'adhésion cellulaire. L'invention a également pour objet de l'ADNc de F11R cloné, de l'ADNc de F11R pleine longueur et des séquences d'acides aminés, ainsi que des antagonistes de F11R et des procédés pour prévenir et traiter la thrombose, l'infarctus du myocarde, l'accident vasculaire cérébral et autres troubles cliniques liés à la formation de thrombus.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43866903P | 2003-01-03 | 2003-01-03 | |
US60/438,669 | 2003-01-03 | ||
PCT/US2003/039890 WO2004063327A2 (fr) | 2003-01-03 | 2003-12-16 | Antagonistes du recepteur de f11 (f11r) en tant qu'agents therapeutiques |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2512399A1 true CA2512399A1 (fr) | 2004-07-29 |
Family
ID=32713364
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002512399A Abandoned CA2512399A1 (fr) | 2003-01-03 | 2003-12-16 | Antagonistes du recepteur de f11 (f11r) en tant qu'agents therapeutiques |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1581551A4 (fr) |
JP (1) | JP2006516255A (fr) |
AU (1) | AU2003297124A1 (fr) |
CA (1) | CA2512399A1 (fr) |
WO (1) | WO2004063327A2 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050265992A1 (en) | 2003-01-03 | 2005-12-01 | The Research Foundation Of State University Of New York | F11 receptor (F11R) antagonists as therapeutic agents |
US8557957B2 (en) | 2003-01-03 | 2013-10-15 | Elizabeth Kornecki | Methods of treating disorders by administration of F11 receptor antagonists |
US20220339248A1 (en) * | 2019-06-19 | 2022-10-27 | The Research Foundation For The State University Of New York | Methods for treating neointimal hyperlasia using f11r/jam-a inhibitors |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5665701A (en) * | 1994-11-17 | 1997-09-09 | The Research Foundation Of State University Of New York | Platelet membrane glycoprotein F11 and polypeptide fragments thereof |
US6358707B1 (en) * | 1997-07-10 | 2002-03-19 | Smithkline Beecham Corporation | Human F11 antigen: a novel cell surface receptor involved in platelet aggregation |
US6699688B1 (en) * | 1998-09-16 | 2004-03-02 | The Research Foundation Of The State University Of New York | Human platelet F11 receptor |
-
2003
- 2003-12-16 JP JP2004566554A patent/JP2006516255A/ja active Pending
- 2003-12-16 CA CA002512399A patent/CA2512399A1/fr not_active Abandoned
- 2003-12-16 AU AU2003297124A patent/AU2003297124A1/en not_active Abandoned
- 2003-12-16 EP EP03815213A patent/EP1581551A4/fr not_active Withdrawn
- 2003-12-16 WO PCT/US2003/039890 patent/WO2004063327A2/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
EP1581551A4 (fr) | 2007-12-12 |
WO2004063327A3 (fr) | 2005-04-21 |
AU2003297124A1 (en) | 2004-08-10 |
WO2004063327A2 (fr) | 2004-07-29 |
EP1581551A2 (fr) | 2005-10-05 |
JP2006516255A (ja) | 2006-06-29 |
AU2003297124A8 (en) | 2004-08-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued |
Effective date: 20150616 |
|
FZDE | Discontinued |
Effective date: 20150616 |