CA2512346A1 - Imino acid derivatives for use as inhibitors of matrix metalloproteinases - Google Patents
Imino acid derivatives for use as inhibitors of matrix metalloproteinases Download PDFInfo
- Publication number
- CA2512346A1 CA2512346A1 CA002512346A CA2512346A CA2512346A1 CA 2512346 A1 CA2512346 A1 CA 2512346A1 CA 002512346 A CA002512346 A CA 002512346A CA 2512346 A CA2512346 A CA 2512346A CA 2512346 A1 CA2512346 A1 CA 2512346A1
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- Prior art keywords
- heteroaryl
- substituted
- ring
- independently
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10300015.1 | 2003-01-03 | ||
| DE10300015A DE10300015A1 (de) | 2003-01-03 | 2003-01-03 | Iminosäurederivate als Inhibitoren von Matrix-Metallproteinasen |
| PCT/EP2003/014611 WO2004060874A1 (de) | 2003-01-03 | 2003-12-19 | Iminosäurederivate als inhibitoren von matrix-metalloproteinasen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2512346A1 true CA2512346A1 (en) | 2004-07-22 |
Family
ID=32519590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002512346A Abandoned CA2512346A1 (en) | 2003-01-03 | 2003-12-19 | Imino acid derivatives for use as inhibitors of matrix metalloproteinases |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20050004166A1 (https=) |
| EP (1) | EP1585728B1 (https=) |
| JP (1) | JP4764009B2 (https=) |
| AT (1) | ATE458721T1 (https=) |
| AU (1) | AU2003300535B2 (https=) |
| BR (1) | BR0317894A (https=) |
| CA (1) | CA2512346A1 (https=) |
| DE (2) | DE10300015A1 (https=) |
| DK (1) | DK1585728T3 (https=) |
| ES (1) | ES2341612T3 (https=) |
| IL (1) | IL169496A0 (https=) |
| MX (1) | MXPA05006054A (https=) |
| PT (1) | PT1585728E (https=) |
| WO (1) | WO2004060874A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10344936A1 (de) * | 2003-09-27 | 2005-04-21 | Aventis Pharma Gmbh | Bicyclische Iminosäurederivate als Inhibitoren von Matrix-Metalloproteinasen |
| DE102005015040A1 (de) * | 2005-03-31 | 2006-10-05 | Sanofi-Aventis Deutschland Gmbh | Substituierte Tetrahydroisochinoline als MMP-Inhibitoren, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| JP2009505962A (ja) * | 2005-07-29 | 2009-02-12 | バイエル・ヘルスケア・エルエルシー | 肥満を治療するためのビフェニルアミノ酸誘導体の製造および使用 |
| ES2549187T3 (es) | 2008-07-14 | 2015-10-23 | Novartis Ag | Inhibidores selectivos de MMP-12 y MMP-13 basados en ácido hidroxámico |
| RU2646752C2 (ru) * | 2016-02-25 | 2018-03-07 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" | Ингибиторы цинк-зависимых металлопротеиназ (ММП-2 и ММП-9) в ряду бензоиламино(фенилсульфонил)-замещенных циклических аминокислот как потенциальные лекарственные средства, препятствующие постинфарктному ремоделированию левого желудочка сердца |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5455258A (en) | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| IT1264447B1 (it) | 1993-05-14 | 1996-09-23 | Ist Naz Stud Cura Dei Tumori | Espressione di oncogeni derivati da ntrki in cellule di feocromocitoma pc12 ed utilizzo di questo sistema come screening di sostanze di |
| US5863949A (en) | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
| KR100266467B1 (ko) * | 1995-09-27 | 2000-10-02 | 우에노 도시오 | 설폰아미드 유도체 |
| RU2164914C2 (ru) * | 1995-11-13 | 2001-04-10 | Хехст Акциенгезелльшафт | ЦИКЛИЧЕСКИЕ И ГЕТЕРОЦИКЛИЧЕСКИЕ N-ЗАМЕЩЕННЫЕ α-ИМИНОГИДРОКСАМОВЫЕ И КАРБОНОВЫЕ КИСЛОТЫ |
| WO2000058304A1 (en) * | 1999-03-26 | 2000-10-05 | Shionogi & Co., Ltd. | Heterocyclic sulfonamide derivatives |
| AR027943A1 (es) * | 2000-02-25 | 2003-04-16 | Wyeth Corp | Acidos orto-sulfonamido aril hidroxamicos como inhibidores de metaloproteinasa de matriz y preparacion de los mismos |
| US6855708B2 (en) | 2001-03-20 | 2005-02-15 | Merck & Co., Inc. | N-arylsulfonyl aza-bicyclic derivatives as potent cell adhesion inhibitors |
-
2003
- 2003-01-03 DE DE10300015A patent/DE10300015A1/de not_active Withdrawn
- 2003-12-19 DK DK03814463.0T patent/DK1585728T3/da active
- 2003-12-19 JP JP2004564205A patent/JP4764009B2/ja not_active Expired - Fee Related
- 2003-12-19 AT AT03814463T patent/ATE458721T1/de not_active IP Right Cessation
- 2003-12-19 MX MXPA05006054A patent/MXPA05006054A/es active IP Right Grant
- 2003-12-19 CA CA002512346A patent/CA2512346A1/en not_active Abandoned
- 2003-12-19 WO PCT/EP2003/014611 patent/WO2004060874A1/de not_active Ceased
- 2003-12-19 EP EP03814463A patent/EP1585728B1/de not_active Expired - Lifetime
- 2003-12-19 BR BR0317894-3A patent/BR0317894A/pt not_active IP Right Cessation
- 2003-12-19 PT PT03814463T patent/PT1585728E/pt unknown
- 2003-12-19 DE DE50312458T patent/DE50312458D1/de not_active Expired - Lifetime
- 2003-12-19 ES ES03814463T patent/ES2341612T3/es not_active Expired - Lifetime
- 2003-12-19 AU AU2003300535A patent/AU2003300535B2/en not_active Ceased
-
2004
- 2004-01-05 US US10/751,600 patent/US20050004166A1/en not_active Abandoned
-
2005
- 2005-06-30 IL IL169496A patent/IL169496A0/en unknown
-
2006
- 2006-04-18 US US11/405,834 patent/US7772270B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP4764009B2 (ja) | 2011-08-31 |
| US20060252752A1 (en) | 2006-11-09 |
| US20050004166A1 (en) | 2005-01-06 |
| MXPA05006054A (es) | 2005-08-16 |
| AU2003300535A1 (en) | 2004-07-29 |
| PT1585728E (pt) | 2010-04-20 |
| BR0317894A (pt) | 2005-12-06 |
| ES2341612T3 (es) | 2010-06-23 |
| EP1585728A1 (de) | 2005-10-19 |
| IL169496A0 (en) | 2007-07-04 |
| US7772270B2 (en) | 2010-08-10 |
| WO2004060874A1 (de) | 2004-07-22 |
| ATE458721T1 (de) | 2010-03-15 |
| EP1585728B1 (de) | 2010-02-24 |
| AU2003300535B2 (en) | 2009-12-17 |
| DK1585728T3 (da) | 2010-06-14 |
| DE10300015A1 (de) | 2004-07-15 |
| DE50312458D1 (de) | 2010-04-08 |
| JP2006517912A (ja) | 2006-08-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |