DE10300015A1 - Iminosäurederivate als Inhibitoren von Matrix-Metallproteinasen - Google Patents
Iminosäurederivate als Inhibitoren von Matrix-Metallproteinasen Download PDFInfo
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- DE10300015A1 DE10300015A1 DE10300015A DE10300015A DE10300015A1 DE 10300015 A1 DE10300015 A1 DE 10300015A1 DE 10300015 A DE10300015 A DE 10300015A DE 10300015 A DE10300015 A DE 10300015A DE 10300015 A1 DE10300015 A1 DE 10300015A1
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- heteroaryl
- alkyl
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- independently
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Classifications
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C—CHEMISTRY; METALLURGY
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Indole Compounds (AREA)
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10300015A DE10300015A1 (de) | 2003-01-03 | 2003-01-03 | Iminosäurederivate als Inhibitoren von Matrix-Metallproteinasen |
| CA002512346A CA2512346A1 (en) | 2003-01-03 | 2003-12-19 | Imino acid derivatives for use as inhibitors of matrix metalloproteinases |
| DE50312458T DE50312458D1 (de) | 2003-01-03 | 2003-12-19 | Iminosäurederivate als inhibitoren von matrix-metalloproteinasen |
| ES03814463T ES2341612T3 (es) | 2003-01-03 | 2003-12-19 | Derivados de iminoacidos en calidad de inhibidores de metaloproteinasas matriciales. |
| PT03814463T PT1585728E (pt) | 2003-01-03 | 2003-12-19 | Derivados de iminoácidos como inibidores de metaloproteinases matriciais |
| EP03814463A EP1585728B1 (de) | 2003-01-03 | 2003-12-19 | Iminosäurederivate als inhibitoren von matrix-metalloproteinasen |
| AU2003300535A AU2003300535B2 (en) | 2003-01-03 | 2003-12-19 | Imino acid derivatives for use as inhibitors of matrix metalloproteinases |
| PCT/EP2003/014611 WO2004060874A1 (de) | 2003-01-03 | 2003-12-19 | Iminosäurederivate als inhibitoren von matrix-metalloproteinasen |
| JP2004564205A JP4764009B2 (ja) | 2003-01-03 | 2003-12-19 | マトリックスメタロプロテイナーゼ阻害剤として使用するためのイミノ酸誘導体 |
| BR0317894-3A BR0317894A (pt) | 2003-01-03 | 2003-12-19 | Derivados de ácido imino como inibidores de matriz de metaloproteinase |
| DK03814463.0T DK1585728T3 (da) | 2003-01-03 | 2003-12-19 | Iminosyrederivater som inhibitorer af matrix-metalloproteinaser |
| AT03814463T ATE458721T1 (de) | 2003-01-03 | 2003-12-19 | Iminosäurederivate als inhibitoren von matrix- metalloproteinasen |
| MXPA05006054A MXPA05006054A (es) | 2003-01-03 | 2003-12-19 | Derivados iminoacidos para el uso como inhibidores de metaloproteinasas matriciales. |
| US10/751,600 US20050004166A1 (en) | 2003-01-03 | 2004-01-05 | Imino acid derivatives as inhibitors of matrix metalloproteinases |
| IL169496A IL169496A0 (en) | 2003-01-03 | 2005-06-30 | Imino acid derivatives for use as inhibitors of matrix metalloproteinases |
| US11/405,834 US7772270B2 (en) | 2003-01-03 | 2006-04-18 | Imino acid derivatives as inhibitors of matrix metalloproteinases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10300015A DE10300015A1 (de) | 2003-01-03 | 2003-01-03 | Iminosäurederivate als Inhibitoren von Matrix-Metallproteinasen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10300015A1 true DE10300015A1 (de) | 2004-07-15 |
Family
ID=32519590
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10300015A Withdrawn DE10300015A1 (de) | 2003-01-03 | 2003-01-03 | Iminosäurederivate als Inhibitoren von Matrix-Metallproteinasen |
| DE50312458T Expired - Lifetime DE50312458D1 (de) | 2003-01-03 | 2003-12-19 | Iminosäurederivate als inhibitoren von matrix-metalloproteinasen |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE50312458T Expired - Lifetime DE50312458D1 (de) | 2003-01-03 | 2003-12-19 | Iminosäurederivate als inhibitoren von matrix-metalloproteinasen |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20050004166A1 (https=) |
| EP (1) | EP1585728B1 (https=) |
| JP (1) | JP4764009B2 (https=) |
| AT (1) | ATE458721T1 (https=) |
| AU (1) | AU2003300535B2 (https=) |
| BR (1) | BR0317894A (https=) |
| CA (1) | CA2512346A1 (https=) |
| DE (2) | DE10300015A1 (https=) |
| DK (1) | DK1585728T3 (https=) |
| ES (1) | ES2341612T3 (https=) |
| IL (1) | IL169496A0 (https=) |
| MX (1) | MXPA05006054A (https=) |
| PT (1) | PT1585728E (https=) |
| WO (1) | WO2004060874A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005015040A1 (de) * | 2005-03-31 | 2006-10-05 | Sanofi-Aventis Deutschland Gmbh | Substituierte Tetrahydroisochinoline als MMP-Inhibitoren, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10344936A1 (de) * | 2003-09-27 | 2005-04-21 | Aventis Pharma Gmbh | Bicyclische Iminosäurederivate als Inhibitoren von Matrix-Metalloproteinasen |
| JP2009505962A (ja) * | 2005-07-29 | 2009-02-12 | バイエル・ヘルスケア・エルエルシー | 肥満を治療するためのビフェニルアミノ酸誘導体の製造および使用 |
| ES2549187T3 (es) | 2008-07-14 | 2015-10-23 | Novartis Ag | Inhibidores selectivos de MMP-12 y MMP-13 basados en ácido hidroxámico |
| RU2646752C2 (ru) * | 2016-02-25 | 2018-03-07 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" | Ингибиторы цинк-зависимых металлопротеиназ (ММП-2 и ММП-9) в ряду бензоиламино(фенилсульфонил)-замещенных циклических аминокислот как потенциальные лекарственные средства, препятствующие постинфарктному ремоделированию левого желудочка сердца |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5455258A (en) | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| IT1264447B1 (it) | 1993-05-14 | 1996-09-23 | Ist Naz Stud Cura Dei Tumori | Espressione di oncogeni derivati da ntrki in cellule di feocromocitoma pc12 ed utilizzo di questo sistema come screening di sostanze di |
| US5863949A (en) | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
| KR100266467B1 (ko) * | 1995-09-27 | 2000-10-02 | 우에노 도시오 | 설폰아미드 유도체 |
| RU2164914C2 (ru) * | 1995-11-13 | 2001-04-10 | Хехст Акциенгезелльшафт | ЦИКЛИЧЕСКИЕ И ГЕТЕРОЦИКЛИЧЕСКИЕ N-ЗАМЕЩЕННЫЕ α-ИМИНОГИДРОКСАМОВЫЕ И КАРБОНОВЫЕ КИСЛОТЫ |
| WO2000058304A1 (en) * | 1999-03-26 | 2000-10-05 | Shionogi & Co., Ltd. | Heterocyclic sulfonamide derivatives |
| AR027943A1 (es) * | 2000-02-25 | 2003-04-16 | Wyeth Corp | Acidos orto-sulfonamido aril hidroxamicos como inhibidores de metaloproteinasa de matriz y preparacion de los mismos |
| US6855708B2 (en) | 2001-03-20 | 2005-02-15 | Merck & Co., Inc. | N-arylsulfonyl aza-bicyclic derivatives as potent cell adhesion inhibitors |
-
2003
- 2003-01-03 DE DE10300015A patent/DE10300015A1/de not_active Withdrawn
- 2003-12-19 DK DK03814463.0T patent/DK1585728T3/da active
- 2003-12-19 JP JP2004564205A patent/JP4764009B2/ja not_active Expired - Fee Related
- 2003-12-19 AT AT03814463T patent/ATE458721T1/de not_active IP Right Cessation
- 2003-12-19 MX MXPA05006054A patent/MXPA05006054A/es active IP Right Grant
- 2003-12-19 CA CA002512346A patent/CA2512346A1/en not_active Abandoned
- 2003-12-19 WO PCT/EP2003/014611 patent/WO2004060874A1/de not_active Ceased
- 2003-12-19 EP EP03814463A patent/EP1585728B1/de not_active Expired - Lifetime
- 2003-12-19 BR BR0317894-3A patent/BR0317894A/pt not_active IP Right Cessation
- 2003-12-19 PT PT03814463T patent/PT1585728E/pt unknown
- 2003-12-19 DE DE50312458T patent/DE50312458D1/de not_active Expired - Lifetime
- 2003-12-19 ES ES03814463T patent/ES2341612T3/es not_active Expired - Lifetime
- 2003-12-19 AU AU2003300535A patent/AU2003300535B2/en not_active Ceased
-
2004
- 2004-01-05 US US10/751,600 patent/US20050004166A1/en not_active Abandoned
-
2005
- 2005-06-30 IL IL169496A patent/IL169496A0/en unknown
-
2006
- 2006-04-18 US US11/405,834 patent/US7772270B2/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005015040A1 (de) * | 2005-03-31 | 2006-10-05 | Sanofi-Aventis Deutschland Gmbh | Substituierte Tetrahydroisochinoline als MMP-Inhibitoren, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
Also Published As
| Publication number | Publication date |
|---|---|
| JP4764009B2 (ja) | 2011-08-31 |
| CA2512346A1 (en) | 2004-07-22 |
| US20060252752A1 (en) | 2006-11-09 |
| US20050004166A1 (en) | 2005-01-06 |
| MXPA05006054A (es) | 2005-08-16 |
| AU2003300535A1 (en) | 2004-07-29 |
| PT1585728E (pt) | 2010-04-20 |
| BR0317894A (pt) | 2005-12-06 |
| ES2341612T3 (es) | 2010-06-23 |
| EP1585728A1 (de) | 2005-10-19 |
| IL169496A0 (en) | 2007-07-04 |
| US7772270B2 (en) | 2010-08-10 |
| WO2004060874A1 (de) | 2004-07-22 |
| ATE458721T1 (de) | 2010-03-15 |
| EP1585728B1 (de) | 2010-02-24 |
| AU2003300535B2 (en) | 2009-12-17 |
| DK1585728T3 (da) | 2010-06-14 |
| DE50312458D1 (de) | 2010-04-08 |
| JP2006517912A (ja) | 2006-08-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8127 | New person/name/address of the applicant |
Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, 65929 FRANKFURT, |
|
| 8141 | Disposal/no request for examination |