CA2511683A1 - Methode de synthese efficace de 3-aryloxy-3-arylpropylamines et de leurs stereoisomeres optiques - Google Patents

Methode de synthese efficace de 3-aryloxy-3-arylpropylamines et de leurs stereoisomeres optiques Download PDF

Info

Publication number
CA2511683A1
CA2511683A1 CA 2511683 CA2511683A CA2511683A1 CA 2511683 A1 CA2511683 A1 CA 2511683A1 CA 2511683 CA2511683 CA 2511683 CA 2511683 A CA2511683 A CA 2511683A CA 2511683 A1 CA2511683 A1 CA 2511683A1
Authority
CA
Canada
Prior art keywords
process according
methyl
pharmaceutically acceptable
phenylpropylamine
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2511683
Other languages
English (en)
Other versions
CA2511683C (fr
Inventor
Zhi-Xian Wang
Mohammed Abdul Raheem
Gamini Weeratunga
Bhaskar Reddy Guntoori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apotex Pharmachem Inc
Original Assignee
Apotex Pharmachem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apotex Pharmachem Inc filed Critical Apotex Pharmachem Inc
Priority to CA 2511683 priority Critical patent/CA2511683C/fr
Priority to PCT/CA2006/001051 priority patent/WO2007006132A1/fr
Publication of CA2511683A1 publication Critical patent/CA2511683A1/fr
Application granted granted Critical
Publication of CA2511683C publication Critical patent/CA2511683C/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA 2511683 2005-07-08 2005-07-08 Methode de synthese efficace de 3-aryloxy-3-arylpropylamines et de leurs stereoisomeres optiques Expired - Fee Related CA2511683C (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA 2511683 CA2511683C (fr) 2005-07-08 2005-07-08 Methode de synthese efficace de 3-aryloxy-3-arylpropylamines et de leurs stereoisomeres optiques
PCT/CA2006/001051 WO2007006132A1 (fr) 2005-07-08 2006-06-27 Procédé efficace pour la préparation de 3-aryloxy-3- arylpropylamines et de leurs stéréoisomères optiques

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA 2511683 CA2511683C (fr) 2005-07-08 2005-07-08 Methode de synthese efficace de 3-aryloxy-3-arylpropylamines et de leurs stereoisomeres optiques

Publications (2)

Publication Number Publication Date
CA2511683A1 true CA2511683A1 (fr) 2007-01-08
CA2511683C CA2511683C (fr) 2013-09-10

Family

ID=37625887

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2511683 Expired - Fee Related CA2511683C (fr) 2005-07-08 2005-07-08 Methode de synthese efficace de 3-aryloxy-3-arylpropylamines et de leurs stereoisomeres optiques

Country Status (2)

Country Link
CA (1) CA2511683C (fr)
WO (1) WO2007006132A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2060559A1 (fr) * 2007-11-19 2009-05-20 Cadila Pharmaceuticals Limited Procédé pour la préparation de 3-hyxdroxy-3-arylpropylamines énantiomériquement pures et leurs stéréoisomères optiques

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8101642B2 (en) 2008-06-05 2012-01-24 Sk Biopharmaceuticals Co., Ltd. 3-substituted propanamine compounds
CN102026988B (zh) * 2008-06-05 2013-07-03 爱思开生物制药株式会社 3-取代的丙胺化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL181604B1 (pl) * 1996-04-24 2001-08-31 Przed Farmaceutyczne Jelfa Sa Sposób wytwarzania fluoksetyny
ES2120368B1 (es) * 1996-06-14 1999-07-01 Almirall Prodesfarma Sa Procedimiento de obtencion de n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina y sus sales farmaceuticamente aceptables.
WO2000037425A1 (fr) * 1998-12-21 2000-06-29 Siegfried Cms Ag Procede de production de fluoxetine
AU1724201A (en) * 1999-12-17 2001-06-25 Ranbaxy Laboratories Limited Process for the preparation of fluoxetine hydrochloride
GB0112122D0 (en) * 2001-05-18 2001-07-11 Lilly Co Eli Heteroaryloxy 3-substituted propanamines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2060559A1 (fr) * 2007-11-19 2009-05-20 Cadila Pharmaceuticals Limited Procédé pour la préparation de 3-hyxdroxy-3-arylpropylamines énantiomériquement pures et leurs stéréoisomères optiques

Also Published As

Publication number Publication date
CA2511683C (fr) 2013-09-10
WO2007006132A1 (fr) 2007-01-18

Similar Documents

Publication Publication Date Title
US7538232B2 (en) Process for the asymmetric synthesis of duloxetine
US7709662B2 (en) Method of manufacturing (S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine hydrochloride (duloxetine)
CA2561866A1 (fr) Resolution optique et recyclage de la tomoxetine
AU744895B2 (en) Process to make chiral compounds
US7928250B2 (en) Process for making duloxetine and related compounds
CA2748595C (fr) Procede de preparation de chlorhydrate de cinacalcet
US8729308B2 (en) Process for the preparation of tapentadol and intermediates thereof
EP1828110B1 (fr) Procede de preparation de la tamsulosine et d'intermediaires de la tamsulosine
CA2511683C (fr) Methode de synthese efficace de 3-aryloxy-3-arylpropylamines et de leurs stereoisomeres optiques
US8420846B2 (en) Process for producing (S)-3-[(1-dimethylamino)ethyl] phenyl-N-ethyl-N-methyl-carbamate via novel intermediates
US7485754B2 (en) Efficient method for preparing 3-aryloxy-3-arylpropylamines and their optical stereoisomers
US8299305B2 (en) Method for preparing atomoxetine
EP2619174A1 (fr) Procédé de préparation de dérivés de l-phényl-3-diméthylaminopropane
WO2008062473A1 (fr) Procédé de préparation de chlorhydrate d'atomoxétine
KR100458983B1 (ko) 광학적으로 활성인 세린 유도체의 제조방법
JP4045722B2 (ja) アミン化合物、中間体、製造法および光学分割剤
WO2007009405A1 (fr) Procede d'elaboration d'hydrochlorure de (r)-n-methyl-3-(2-methylphenoxy)-3-phenylpropylamine (atomoxetine)
KR101644016B1 (ko) 중간체로서 광학 활성 3-아미노-1-페닐프로판올 유도체의 제조방법 및 상기 중간체를 이용한 광학 활성 약학적 산물의 제조방법
WO2008026227A2 (fr) Procédé de préparation de chlorhydrate d'atomoxétine
US6677485B2 (en) Process for the preparation of fluoxetine hydrochloride
EP2125772B1 (fr) Procédé de préparation de duloxétine et nouveaux intermédiaires clés pour une utilisation dans celui-ci.
WO2014024205A1 (fr) Procédé pour préparer la (s)-(+)-n,n-diméthyl-3-(naphtalén-1-yloxy)-1-phénylpropan-1-amine ou son sel et intermédiaire de celle-ci
WO2010010412A2 (fr) Procédé de préparation de dérivés de n-méthyl-aryloxy-propanamine
HU205055B (en) Process for racemization of (halogen phenyl) alkyl amines

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20190708