CA2507573A1 - Nucleic acid labeling compounds - Google Patents

Nucleic acid labeling compounds Download PDF

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Publication number
CA2507573A1
CA2507573A1 CA002507573A CA2507573A CA2507573A1 CA 2507573 A1 CA2507573 A1 CA 2507573A1 CA 002507573 A CA002507573 A CA 002507573A CA 2507573 A CA2507573 A CA 2507573A CA 2507573 A1 CA2507573 A1 CA 2507573A1
Authority
CA
Canada
Prior art keywords
alkyl
nucleic acid
compound
group
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002507573A
Other languages
English (en)
French (fr)
Inventor
Glenn Mcgall
Anthony D. Barone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Affymetrix Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/314,012 external-priority patent/US6864059B2/en
Application filed by Individual filed Critical Individual
Publication of CA2507573A1 publication Critical patent/CA2507573A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
    • A61K47/557—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells the modifying agent being biotin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
CA002507573A 2002-12-05 2003-12-05 Nucleic acid labeling compounds Abandoned CA2507573A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10/314,012 2002-12-05
US10/314,012 US6864059B2 (en) 1996-01-23 2002-12-05 Biotin containing C-glycoside nucleic acid labeling compounds
US10/641,677 US7282327B2 (en) 1996-01-23 2003-08-15 Nucleic acid labeling compounds
US10/641,677 2003-08-15
PCT/US2003/038652 WO2004052907A1 (en) 2002-12-05 2003-12-05 Nucleic acid labeling compounds

Publications (1)

Publication Number Publication Date
CA2507573A1 true CA2507573A1 (en) 2004-06-24

Family

ID=32511018

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002507573A Abandoned CA2507573A1 (en) 2002-12-05 2003-12-05 Nucleic acid labeling compounds

Country Status (5)

Country Link
US (1) US7282327B2 (US20040101892A1-20040527-C00092.png)
EP (1) EP1575972A1 (US20040101892A1-20040527-C00092.png)
JP (1) JP2006515863A (US20040101892A1-20040527-C00092.png)
CA (1) CA2507573A1 (US20040101892A1-20040527-C00092.png)
WO (1) WO2004052907A1 (US20040101892A1-20040527-C00092.png)

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CA2777741A1 (en) 2009-10-16 2011-04-21 Rib-X Pharmaceuticals, Inc. Antimicrobial compounds and methods of making and using the same
US9206216B2 (en) 2010-04-21 2015-12-08 Pierce Biotechnology, Inc. Modified nucleotides methods and kits
US8536323B2 (en) * 2010-04-21 2013-09-17 Pierce Biotechnology, Inc. Modified nucleotides
JP2013046586A (ja) * 2011-08-29 2013-03-07 Tosoh Corp ２−（４−アミノスチリル）ベンゾチアゾリウム塩を化学結合で結合したオリゴヌクレオチド誘導体、その製造方法およびそれをオリゴヌクレオチドプローブとして用いる核酸の検出方法
WO2015035421A1 (en) 2013-09-09 2015-03-12 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
KR20160070066A (ko) 2013-09-09 2016-06-17 멜린타 테라퓨틱스, 인크. 항균 화합물, 및 이의 제조 방법 및 이용 방법
MX2017011616A (es) 2015-03-11 2018-04-11 Melinta Therapeutics Inc Compuestos antimicrobianos y métodos para hacerlos y usarlos.
CN114292281B (zh) * 2021-12-22 2023-10-24 东南大学 一种用于实现细胞内脂滴动态成像的小分子荧光探针及其制备方法和应用
WO2023131254A1 (zh) * 2022-01-06 2023-07-13 上海吉量医药工程有限公司 N1位修饰假尿嘧啶核苷及其在mRNA合成中的应用

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Also Published As

Publication number Publication date
JP2006515863A (ja) 2006-06-08
US7282327B2 (en) 2007-10-16
EP1575972A1 (en) 2005-09-21
US20040101892A1 (en) 2004-05-27
WO2004052907A1 (en) 2004-06-24

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Legal Events

Date Code Title Description
FZDE Discontinued