CA2499863A1 - Intermediaires utilises dans la preparation d'acides amines bicycliques fusionnes a action therapeutique - Google Patents

Intermediaires utilises dans la preparation d'acides amines bicycliques fusionnes a action therapeutique Download PDF

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Publication number
CA2499863A1
CA2499863A1 CA002499863A CA2499863A CA2499863A1 CA 2499863 A1 CA2499863 A1 CA 2499863A1 CA 002499863 A CA002499863 A CA 002499863A CA 2499863 A CA2499863 A CA 2499863A CA 2499863 A1 CA2499863 A1 CA 2499863A1
Authority
CA
Canada
Prior art keywords
pain
formula
compound
carboxylic acid
protecting group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002499863A
Other languages
English (en)
Inventor
Iain Robert Gladwell
Alan John Pettman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2499863A1 publication Critical patent/CA2499863A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/608—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a ring other than a six-membered aromatic ring in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
    • C07C53/136—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings containing condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/26—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/20—All rings being cycloaliphatic the ring system containing seven carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention présente des composés correspondant à la formule (I) dans laquelle R représente H ou un groupe protecteur à base d'acide carboxylique, qui sont des intermédiaires dans la préparation d'acides aminés bicycliques fusionnés à action thérapeutique.
CA002499863A 2002-10-04 2003-09-22 Intermediaires utilises dans la preparation d'acides amines bicycliques fusionnes a action therapeutique Abandoned CA2499863A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0223070.4 2002-10-04
GBGB0223070.4A GB0223070D0 (en) 2002-10-04 2002-10-04 Intermediates in the preparation of therapeutic fused bicyclic amino acids
PCT/IB2003/004179 WO2004031115A1 (fr) 2002-10-04 2003-09-22 Intermediaires utilises dans la preparation d'acides amines bicycliques fusionnes a action therapeutique

Publications (1)

Publication Number Publication Date
CA2499863A1 true CA2499863A1 (fr) 2004-04-15

Family

ID=9945336

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002499863A Abandoned CA2499863A1 (fr) 2002-10-04 2003-09-22 Intermediaires utilises dans la preparation d'acides amines bicycliques fusionnes a action therapeutique

Country Status (8)

Country Link
EP (1) EP1551789A1 (fr)
JP (1) JP2006501296A (fr)
AU (1) AU2003263487A1 (fr)
BR (1) BR0315046A (fr)
CA (1) CA2499863A1 (fr)
GB (1) GB0223070D0 (fr)
MX (1) MXPA05003638A (fr)
WO (1) WO2004031115A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110818550A (zh) * 2019-11-25 2020-02-21 东华理工大学 一种选择性酶促水解反应制备右旋异丁苯丙酸的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2444053C (fr) * 2001-04-19 2008-06-17 Warner-Lambert Company Llc Acides amnines bicycliques ou tricycliques fondus

Also Published As

Publication number Publication date
MXPA05003638A (es) 2005-06-03
BR0315046A (pt) 2005-08-16
AU2003263487A1 (en) 2004-04-23
JP2006501296A (ja) 2006-01-12
EP1551789A1 (fr) 2005-07-13
GB0223070D0 (en) 2002-11-13
WO2004031115A1 (fr) 2004-04-15

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US7018818B2 (en) Intermediates in the preparation of therapeutic fused bicyclic amino acids

Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead