CA2497132A1 - Method of diagnosing ovarian endometriosis - Google Patents
Method of diagnosing ovarian endometriosis Download PDFInfo
- Publication number
- CA2497132A1 CA2497132A1 CA002497132A CA2497132A CA2497132A1 CA 2497132 A1 CA2497132 A1 CA 2497132A1 CA 002497132 A CA002497132 A CA 002497132A CA 2497132 A CA2497132 A CA 2497132A CA 2497132 A1 CA2497132 A1 CA 2497132A1
- Authority
- CA
- Canada
- Prior art keywords
- oex
- gene
- ovarian endometriosis
- expression
- endometriosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 201000002595 endometriosis of ovary Diseases 0.000 title claims abstract description 214
- 208000030747 ovarian endometriosis Diseases 0.000 title claims abstract description 214
- 238000000034 method Methods 0.000 title claims abstract description 158
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 467
- 150000001875 compounds Chemical class 0.000 claims abstract description 121
- 238000012216 screening Methods 0.000 claims abstract description 43
- 230000014509 gene expression Effects 0.000 claims description 234
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 164
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 150
- 210000004027 cell Anatomy 0.000 claims description 147
- 229920001184 polypeptide Polymers 0.000 claims description 144
- 102000004169 proteins and genes Human genes 0.000 claims description 141
- 238000012360 testing method Methods 0.000 claims description 84
- 208000031513 cyst Diseases 0.000 claims description 73
- 230000001105 regulatory effect Effects 0.000 claims description 71
- 230000002357 endometrial effect Effects 0.000 claims description 59
- 150000007523 nucleic acids Chemical group 0.000 claims description 58
- 239000000203 mixture Substances 0.000 claims description 56
- 108020004414 DNA Proteins 0.000 claims description 46
- 230000027455 binding Effects 0.000 claims description 46
- 102000039446 nucleic acids Human genes 0.000 claims description 44
- 108020004707 nucleic acids Proteins 0.000 claims description 44
- 239000012472 biological sample Substances 0.000 claims description 41
- 230000004071 biological effect Effects 0.000 claims description 39
- 230000000694 effects Effects 0.000 claims description 34
- 239000002773 nucleotide Substances 0.000 claims description 31
- 125000003729 nucleotide group Chemical group 0.000 claims description 31
- 239000012634 fragment Substances 0.000 claims description 29
- 230000007423 decrease Effects 0.000 claims description 28
- 239000000523 sample Substances 0.000 claims description 28
- 108020004459 Small interfering RNA Proteins 0.000 claims description 26
- 210000002919 epithelial cell Anatomy 0.000 claims description 26
- 206010011732 Cyst Diseases 0.000 claims description 24
- 239000004055 small Interfering RNA Substances 0.000 claims description 21
- 238000001514 detection method Methods 0.000 claims description 20
- 108700008625 Reporter Genes Proteins 0.000 claims description 17
- 239000000074 antisense oligonucleotide Substances 0.000 claims description 17
- 238000012230 antisense oligonucleotides Methods 0.000 claims description 17
- 229960005486 vaccine Drugs 0.000 claims description 17
- 108020004999 messenger RNA Proteins 0.000 claims description 14
- 102000040430 polynucleotide Human genes 0.000 claims description 13
- 108091033319 polynucleotide Proteins 0.000 claims description 13
- 239000002157 polynucleotide Substances 0.000 claims description 13
- 239000013598 vector Substances 0.000 claims description 12
- 230000002401 inhibitory effect Effects 0.000 claims description 11
- 230000002103 transcriptional effect Effects 0.000 claims description 10
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 9
- 239000003153 chemical reaction reagent Substances 0.000 claims description 9
- 230000000295 complement effect Effects 0.000 claims description 9
- 238000009396 hybridization Methods 0.000 claims description 9
- 108091034117 Oligonucleotide Proteins 0.000 claims description 8
- 230000000692 anti-sense effect Effects 0.000 claims description 7
- 108091026890 Coding region Proteins 0.000 claims description 2
- 235000018102 proteins Nutrition 0.000 description 136
- 201000009273 Endometriosis Diseases 0.000 description 66
- 206010028980 Neoplasm Diseases 0.000 description 59
- 102000055046 tissue-factor-pathway inhibitor 2 Human genes 0.000 description 58
- 108010016054 tissue-factor-pathway inhibitor 2 Proteins 0.000 description 58
- 101710126866 Intelectin Proteins 0.000 description 53
- 230000003248 secreting effect Effects 0.000 description 43
- 210000001519 tissue Anatomy 0.000 description 42
- 239000012071 phase Substances 0.000 description 41
- 201000011510 cancer Diseases 0.000 description 39
- 241000282414 Homo sapiens Species 0.000 description 38
- 238000003757 reverse transcription PCR Methods 0.000 description 38
- 239000002299 complementary DNA Substances 0.000 description 34
- 238000011282 treatment Methods 0.000 description 29
- 239000000047 product Substances 0.000 description 27
- 108090000994 Catalytic RNA Proteins 0.000 description 26
- 102000053642 Catalytic RNA Human genes 0.000 description 26
- 230000002611 ovarian Effects 0.000 description 26
- 108091092562 ribozyme Proteins 0.000 description 26
- 230000027758 ovulation cycle Effects 0.000 description 25
- 230000035752 proliferative phase Effects 0.000 description 23
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 22
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 22
- 210000000612 antigen-presenting cell Anatomy 0.000 description 20
- 230000000875 corresponding effect Effects 0.000 description 18
- 208000024891 symptom Diseases 0.000 description 18
- 150000001413 amino acids Chemical class 0.000 description 17
- 210000005168 endometrial cell Anatomy 0.000 description 17
- 238000010186 staining Methods 0.000 description 17
- 239000004480 active ingredient Substances 0.000 description 15
- 239000000427 antigen Substances 0.000 description 15
- 108091007433 antigens Proteins 0.000 description 15
- 102000036639 antigens Human genes 0.000 description 15
- 210000004443 dendritic cell Anatomy 0.000 description 15
- 201000010099 disease Diseases 0.000 description 15
- 230000001939 inductive effect Effects 0.000 description 15
- 239000003814 drug Substances 0.000 description 14
- 238000009472 formulation Methods 0.000 description 14
- 108020000948 Antisense Oligonucleotides Proteins 0.000 description 13
- 230000005809 anti-tumor immunity Effects 0.000 description 13
- 239000003795 chemical substances by application Substances 0.000 description 13
- 230000006698 induction Effects 0.000 description 13
- 230000001225 therapeutic effect Effects 0.000 description 13
- 210000001744 T-lymphocyte Anatomy 0.000 description 12
- 230000012010 growth Effects 0.000 description 11
- 239000000463 material Substances 0.000 description 11
- 239000000843 powder Substances 0.000 description 11
- 230000002265 prevention Effects 0.000 description 11
- 108700018351 Major Histocompatibility Complex Proteins 0.000 description 10
- 238000004458 analytical method Methods 0.000 description 10
- 239000003550 marker Substances 0.000 description 10
- 238000002493 microarray Methods 0.000 description 10
- 239000003826 tablet Substances 0.000 description 10
- 210000004881 tumor cell Anatomy 0.000 description 10
- 101150112014 Gapdh gene Proteins 0.000 description 9
- 235000001014 amino acid Nutrition 0.000 description 9
- 238000011161 development Methods 0.000 description 9
- 230000018109 developmental process Effects 0.000 description 9
- 239000003112 inhibitor Substances 0.000 description 9
- 208000000509 infertility Diseases 0.000 description 8
- 230000036512 infertility Effects 0.000 description 8
- 231100000535 infertility Toxicity 0.000 description 8
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 8
- 238000004393 prognosis Methods 0.000 description 8
- 238000002560 therapeutic procedure Methods 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 102100026327 Oviduct-specific glycoprotein Human genes 0.000 description 7
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 7
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 7
- 238000003556 assay Methods 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 7
- 230000001413 cellular effect Effects 0.000 description 7
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 7
- 238000003745 diagnosis Methods 0.000 description 7
- 208000035475 disorder Diseases 0.000 description 7
- 229940079593 drug Drugs 0.000 description 7
- 230000009545 invasion Effects 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 6
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 6
- 208000005171 Dysmenorrhea Diseases 0.000 description 6
- 206010013935 Dysmenorrhoea Diseases 0.000 description 6
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 6
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 6
- 101001121378 Homo sapiens Oviduct-specific glycoprotein Proteins 0.000 description 6
- 238000000636 Northern blotting Methods 0.000 description 6
- 241000283973 Oryctolagus cuniculus Species 0.000 description 6
- 208000000450 Pelvic Pain Diseases 0.000 description 6
- 230000003321 amplification Effects 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 210000004556 brain Anatomy 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 239000013604 expression vector Substances 0.000 description 6
- 239000000284 extract Substances 0.000 description 6
- 102000037865 fusion proteins Human genes 0.000 description 6
- 108020001507 fusion proteins Proteins 0.000 description 6
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 6
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 6
- 238000003125 immunofluorescent labeling Methods 0.000 description 6
- 230000001965 increasing effect Effects 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 238000002347 injection Methods 0.000 description 6
- 238000010208 microarray analysis Methods 0.000 description 6
- 238000003199 nucleic acid amplification method Methods 0.000 description 6
- 210000002826 placenta Anatomy 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 230000002062 proliferating effect Effects 0.000 description 6
- 230000004044 response Effects 0.000 description 6
- 230000002441 reversible effect Effects 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 238000004659 sterilization and disinfection Methods 0.000 description 6
- 239000000758 substrate Substances 0.000 description 6
- 238000001262 western blot Methods 0.000 description 6
- 208000005623 Carcinogenesis Diseases 0.000 description 5
- -1 D-galactofuranosyl residues Chemical group 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 5
- 102100036241 HLA class II histocompatibility antigen, DQ beta 1 chain Human genes 0.000 description 5
- 108010065026 HLA-DQB1 antigen Proteins 0.000 description 5
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 description 5
- 101000894525 Homo sapiens Transforming growth factor-beta-induced protein ig-h3 Proteins 0.000 description 5
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 108010029485 Protein Isoforms Proteins 0.000 description 5
- 102000001708 Protein Isoforms Human genes 0.000 description 5
- 102100021398 Transforming growth factor-beta-induced protein ig-h3 Human genes 0.000 description 5
- 230000004913 activation Effects 0.000 description 5
- 238000007792 addition Methods 0.000 description 5
- 239000002246 antineoplastic agent Substances 0.000 description 5
- 238000013459 approach Methods 0.000 description 5
- 230000036952 cancer formation Effects 0.000 description 5
- 239000002775 capsule Substances 0.000 description 5
- 231100000504 carcinogenesis Toxicity 0.000 description 5
- 229940088598 enzyme Drugs 0.000 description 5
- 210000002744 extracellular matrix Anatomy 0.000 description 5
- 238000003364 immunohistochemistry Methods 0.000 description 5
- 238000009169 immunotherapy Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 230000007246 mechanism Effects 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 230000004048 modification Effects 0.000 description 5
- 238000012986 modification Methods 0.000 description 5
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 229940124597 therapeutic agent Drugs 0.000 description 5
- 230000014616 translation Effects 0.000 description 5
- 102100037513 40S ribosomal protein S23 Human genes 0.000 description 4
- 102100022278 Arachidonate 5-lipoxygenase-activating protein Human genes 0.000 description 4
- 102100034799 CCAAT/enhancer-binding protein delta Human genes 0.000 description 4
- 102100036360 Cadherin-3 Human genes 0.000 description 4
- 201000009030 Carcinoma Diseases 0.000 description 4
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 description 4
- 108020004635 Complementary DNA Proteins 0.000 description 4
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 4
- 208000004483 Dyspareunia Diseases 0.000 description 4
- 102100040505 HLA class II histocompatibility antigen, DR alpha chain Human genes 0.000 description 4
- 108010067802 HLA-DR alpha-Chains Proteins 0.000 description 4
- 101001097953 Homo sapiens 40S ribosomal protein S23 Proteins 0.000 description 4
- 101000755875 Homo sapiens Arachidonate 5-lipoxygenase-activating protein Proteins 0.000 description 4
- 101000945965 Homo sapiens CCAAT/enhancer-binding protein delta Proteins 0.000 description 4
- 101000762242 Homo sapiens Cadherin-15 Proteins 0.000 description 4
- 101000714553 Homo sapiens Cadherin-3 Proteins 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 4
- 241000124008 Mammalia Species 0.000 description 4
- 108700020796 Oncogene Proteins 0.000 description 4
- 229910019142 PO4 Inorganic materials 0.000 description 4
- 241000700159 Rattus Species 0.000 description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
- 239000000556 agonist Substances 0.000 description 4
- 230000004075 alteration Effects 0.000 description 4
- 239000011324 bead Substances 0.000 description 4
- 230000004663 cell proliferation Effects 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 230000001684 chronic effect Effects 0.000 description 4
- 238000007796 conventional method Methods 0.000 description 4
- 238000012258 culturing Methods 0.000 description 4
- 210000000805 cytoplasm Anatomy 0.000 description 4
- 230000003247 decreasing effect Effects 0.000 description 4
- 230000001419 dependent effect Effects 0.000 description 4
- 230000003828 downregulation Effects 0.000 description 4
- 210000002889 endothelial cell Anatomy 0.000 description 4
- 239000003623 enhancer Substances 0.000 description 4
- 229940011871 estrogen Drugs 0.000 description 4
- 239000000262 estrogen Substances 0.000 description 4
- 230000002349 favourable effect Effects 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 210000004907 gland Anatomy 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 230000028993 immune response Effects 0.000 description 4
- 210000000987 immune system Anatomy 0.000 description 4
- 238000011532 immunohistochemical staining Methods 0.000 description 4
- 238000001114 immunoprecipitation Methods 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 238000002372 labelling Methods 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 238000012423 maintenance Methods 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 210000004379 membrane Anatomy 0.000 description 4
- 230000002175 menstrual effect Effects 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 239000010452 phosphate Substances 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- 230000035755 proliferation Effects 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 210000000813 small intestine Anatomy 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 230000004936 stimulating effect Effects 0.000 description 4
- 210000002536 stromal cell Anatomy 0.000 description 4
- 238000010396 two-hybrid screening Methods 0.000 description 4
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 3
- 108090001008 Avidin Proteins 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 3
- 108091006146 Channels Proteins 0.000 description 3
- 102000016917 Complement C1 Human genes 0.000 description 3
- 102000004127 Cytokines Human genes 0.000 description 3
- 108090000695 Cytokines Proteins 0.000 description 3
- 108700039887 Essential Genes Proteins 0.000 description 3
- 102100038644 Four and a half LIM domains protein 2 Human genes 0.000 description 3
- 208000032612 Glial tumor Diseases 0.000 description 3
- 206010018338 Glioma Diseases 0.000 description 3
- 102100036242 HLA class II histocompatibility antigen, DQ alpha 2 chain Human genes 0.000 description 3
- 108010086786 HLA-DQA1 antigen Proteins 0.000 description 3
- 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 description 3
- 101001031714 Homo sapiens Four and a half LIM domains protein 2 Proteins 0.000 description 3
- 101000612875 Homo sapiens Testis-specific Y-encoded-like protein 1 Proteins 0.000 description 3
- 108060003951 Immunoglobulin Proteins 0.000 description 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 3
- 108090001090 Lectins Proteins 0.000 description 3
- 102000004856 Lectins Human genes 0.000 description 3
- 108020002230 Pancreatic Ribonuclease Proteins 0.000 description 3
- 102000005891 Pancreatic ribonuclease Human genes 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 102100025670 Protein S100-A13 Human genes 0.000 description 3
- 101710110946 Protein S100-A13 Proteins 0.000 description 3
- 102000000625 Secreted frizzled-related protein 4 Human genes 0.000 description 3
- 108050008088 Secreted frizzled-related protein 4 Proteins 0.000 description 3
- 229920002684 Sepharose Polymers 0.000 description 3
- 102100040953 Testis-specific Y-encoded-like protein 1 Human genes 0.000 description 3
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 3
- 102100031358 Urokinase-type plasminogen activator Human genes 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 238000001042 affinity chromatography Methods 0.000 description 3
- 239000005557 antagonist Substances 0.000 description 3
- 230000006907 apoptotic process Effects 0.000 description 3
- 210000003719 b-lymphocyte Anatomy 0.000 description 3
- 229960002685 biotin Drugs 0.000 description 3
- 235000020958 biotin Nutrition 0.000 description 3
- 239000011616 biotin Substances 0.000 description 3
- 239000013592 cell lysate Substances 0.000 description 3
- 238000010367 cloning Methods 0.000 description 3
- 210000001072 colon Anatomy 0.000 description 3
- 239000003636 conditioned culture medium Substances 0.000 description 3
- 238000012217 deletion Methods 0.000 description 3
- 230000037430 deletion Effects 0.000 description 3
- 210000004696 endometrium Anatomy 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000012091 fetal bovine serum Substances 0.000 description 3
- 239000012894 fetal calf serum Substances 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 210000002216 heart Anatomy 0.000 description 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
- 230000001900 immune effect Effects 0.000 description 3
- 102000018358 immunoglobulin Human genes 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 239000002523 lectin Substances 0.000 description 3
- 230000003902 lesion Effects 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 239000000314 lubricant Substances 0.000 description 3
- 230000003211 malignant effect Effects 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 238000012775 microarray technology Methods 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 230000035772 mutation Effects 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 210000001672 ovary Anatomy 0.000 description 3
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 230000000750 progressive effect Effects 0.000 description 3
- 238000002271 resection Methods 0.000 description 3
- 210000002460 smooth muscle Anatomy 0.000 description 3
- 230000001629 suppression Effects 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 239000000375 suspending agent Substances 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 238000013518 transcription Methods 0.000 description 3
- 230000035897 transcription Effects 0.000 description 3
- 238000013519 translation Methods 0.000 description 3
- 230000003827 upregulation Effects 0.000 description 3
- 210000004291 uterus Anatomy 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 210000005253 yeast cell Anatomy 0.000 description 3
- 102100026726 40S ribosomal protein S11 Human genes 0.000 description 2
- 102100035916 60S ribosomal protein L11 Human genes 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 2
- 102000052030 Aldehyde Dehydrogenase 1 Family Human genes 0.000 description 2
- 101710196131 Aldehyde dehydrogenase 1 Proteins 0.000 description 2
- 102100021986 Apoptosis-stimulating of p53 protein 2 Human genes 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 2
- 208000026310 Breast neoplasm Diseases 0.000 description 2
- 102100025250 C-X-C motif chemokine 14 Human genes 0.000 description 2
- 102100037084 C4b-binding protein alpha chain Human genes 0.000 description 2
- 101710186200 CCAAT/enhancer-binding protein Proteins 0.000 description 2
- 108010009992 CD163 antigen Proteins 0.000 description 2
- 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 description 2
- 102100029758 Cadherin-4 Human genes 0.000 description 2
- 102100021849 Calretinin Human genes 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 102000014914 Carrier Proteins Human genes 0.000 description 2
- 241000282693 Cercopithecidae Species 0.000 description 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 2
- 108010028774 Complement C1 Proteins 0.000 description 2
- 108010078044 Complement C1r Proteins 0.000 description 2
- 108090000955 Complement C2 Proteins 0.000 description 2
- 102000004381 Complement C2 Human genes 0.000 description 2
- 108010028780 Complement C3 Proteins 0.000 description 2
- 102000016918 Complement C3 Human genes 0.000 description 2
- 102100034622 Complement factor B Human genes 0.000 description 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 description 2
- 102100036871 Cyclin-J Human genes 0.000 description 2
- 230000004544 DNA amplification Effects 0.000 description 2
- 102100024425 Dihydropyrimidinase-related protein 3 Human genes 0.000 description 2
- 101150029707 ERBB2 gene Proteins 0.000 description 2
- 108010009900 Endothelial Protein C Receptor Proteins 0.000 description 2
- 102000009839 Endothelial Protein C Receptor Human genes 0.000 description 2
- 241000282326 Felis catus Species 0.000 description 2
- 108010088842 Fibrinolysin Proteins 0.000 description 2
- 102100024185 G1/S-specific cyclin-D2 Human genes 0.000 description 2
- 102100039556 Galectin-4 Human genes 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- BPDVTFBJZNBHEU-HGNGGELXSA-N Glu-Ala-His Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](C(O)=O)CC1=CN=CN1 BPDVTFBJZNBHEU-HGNGGELXSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 description 2
- 102100031150 Growth arrest and DNA damage-inducible protein GADD45 alpha Human genes 0.000 description 2
- 102100031153 Growth arrest and DNA damage-inducible protein GADD45 beta Human genes 0.000 description 2
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 description 2
- 102100028966 HLA class I histocompatibility antigen, alpha chain F Human genes 0.000 description 2
- 102100029966 HLA class II histocompatibility antigen, DP alpha 1 chain Human genes 0.000 description 2
- 102100040485 HLA class II histocompatibility antigen, DRB1 beta chain Human genes 0.000 description 2
- 108010013476 HLA-A24 Antigen Proteins 0.000 description 2
- 108010093061 HLA-DPA1 antigen Proteins 0.000 description 2
- 108010039343 HLA-DRB1 Chains Proteins 0.000 description 2
- 102100025255 Haptoglobin Human genes 0.000 description 2
- 108050005077 Haptoglobin Proteins 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 101001119215 Homo sapiens 40S ribosomal protein S11 Proteins 0.000 description 2
- 101000752711 Homo sapiens Apoptosis-stimulating of p53 protein 2 Proteins 0.000 description 2
- 101000858068 Homo sapiens C-X-C motif chemokine 14 Proteins 0.000 description 2
- 101000710032 Homo sapiens Complement factor B Proteins 0.000 description 2
- 101000713131 Homo sapiens Cyclin-J Proteins 0.000 description 2
- 101001053501 Homo sapiens Dihydropyrimidinase-related protein 3 Proteins 0.000 description 2
- 101000980741 Homo sapiens G1/S-specific cyclin-D2 Proteins 0.000 description 2
- 101000608765 Homo sapiens Galectin-4 Proteins 0.000 description 2
- 101001066158 Homo sapiens Growth arrest and DNA damage-inducible protein GADD45 alpha Proteins 0.000 description 2
- 101001066164 Homo sapiens Growth arrest and DNA damage-inducible protein GADD45 beta Proteins 0.000 description 2
- 101000986080 Homo sapiens HLA class I histocompatibility antigen, alpha chain F Proteins 0.000 description 2
- 101000961145 Homo sapiens Immunoglobulin heavy constant gamma 3 Proteins 0.000 description 2
- 101000990912 Homo sapiens Matrilysin Proteins 0.000 description 2
- 101000636209 Homo sapiens Matrix-remodeling-associated protein 5 Proteins 0.000 description 2
- 101001128456 Homo sapiens Myosin regulatory light polypeptide 9 Proteins 0.000 description 2
- 101000988394 Homo sapiens PDZ and LIM domain protein 5 Proteins 0.000 description 2
- 101001105683 Homo sapiens Pre-mRNA-processing-splicing factor 8 Proteins 0.000 description 2
- 101000611643 Homo sapiens Protein phosphatase 1 regulatory subunit 15A Proteins 0.000 description 2
- 101000667595 Homo sapiens Ribonuclease pancreatic Proteins 0.000 description 2
- 101001041393 Homo sapiens Serine protease HTRA1 Proteins 0.000 description 2
- 101000711846 Homo sapiens Transcription factor SOX-9 Proteins 0.000 description 2
- 101000714762 Homo sapiens Transmembrane protein 176A Proteins 0.000 description 2
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 2
- 102100039348 Immunoglobulin heavy constant gamma 3 Human genes 0.000 description 2
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 102100032241 Lactotransferrin Human genes 0.000 description 2
- 240000007472 Leucaena leucocephala Species 0.000 description 2
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 2
- 108060001084 Luciferase Proteins 0.000 description 2
- 102100030417 Matrilysin Human genes 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 2
- 101100518501 Mus musculus Spp1 gene Proteins 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 206010029260 Neuroblastoma Diseases 0.000 description 2
- 239000000020 Nitrocellulose Substances 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 206010033128 Ovarian cancer Diseases 0.000 description 2
- 238000012408 PCR amplification Methods 0.000 description 2
- 102100029181 PDZ and LIM domain protein 5 Human genes 0.000 description 2
- 108091000080 Phosphotransferase Proteins 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 102100021231 Pre-mRNA-processing-splicing factor 8 Human genes 0.000 description 2
- 102000001253 Protein Kinase Human genes 0.000 description 2
- 102100040714 Protein phosphatase 1 regulatory subunit 15A Human genes 0.000 description 2
- 102100028965 Proteoglycan 4 Human genes 0.000 description 2
- 102100039120 Retinoblastoma-like protein 1 Human genes 0.000 description 2
- 102100022941 Retinol-binding protein 1 Human genes 0.000 description 2
- 102100039832 Ribonuclease pancreatic Human genes 0.000 description 2
- 108010000605 Ribosomal Proteins Proteins 0.000 description 2
- 102000002278 Ribosomal Proteins Human genes 0.000 description 2
- 102100025831 Scavenger receptor cysteine-rich type 1 protein M130 Human genes 0.000 description 2
- 108091058545 Secretory proteins Proteins 0.000 description 2
- 102000040739 Secretory proteins Human genes 0.000 description 2
- 102000012479 Serine Proteases Human genes 0.000 description 2
- 108010022999 Serine Proteases Proteins 0.000 description 2
- 102100021119 Serine protease HTRA1 Human genes 0.000 description 2
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 description 2
- 102100024519 Src-like-adapter Human genes 0.000 description 2
- 108091081024 Start codon Proteins 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 102100034204 Transcription factor SOX-9 Human genes 0.000 description 2
- 102100036380 Transmembrane protein 176A Human genes 0.000 description 2
- 108010078814 Tumor Suppressor Protein p53 Proteins 0.000 description 2
- 102100020695 Ubiquitin-conjugating enzyme E2 N Human genes 0.000 description 2
- 108010020277 WD repeat containing planar cell polarity effector Proteins 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 125000000539 amino acid group Chemical group 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 229940041181 antineoplastic drug Drugs 0.000 description 2
- 210000003567 ascitic fluid Anatomy 0.000 description 2
- 230000006472 autoimmune response Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 108010056708 bcr-abl Fusion Proteins Proteins 0.000 description 2
- 102000004441 bcr-abl Fusion Proteins Human genes 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 108091008324 binding proteins Proteins 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 210000004413 cardiac myocyte Anatomy 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 101150055766 cat gene Proteins 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 230000022131 cell cycle Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 208000009060 clear cell adenocarcinoma Diseases 0.000 description 2
- 230000001332 colony forming effect Effects 0.000 description 2
- 238000004590 computer program Methods 0.000 description 2
- 238000009799 cystectomy Methods 0.000 description 2
- 229960003067 cystine Drugs 0.000 description 2
- 231100000433 cytotoxic Toxicity 0.000 description 2
- 230000001472 cytotoxic effect Effects 0.000 description 2
- 230000003013 cytotoxicity Effects 0.000 description 2
- 231100000135 cytotoxicity Toxicity 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000002405 diagnostic procedure Methods 0.000 description 2
- 230000009274 differential gene expression Effects 0.000 description 2
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 2
- 235000021186 dishes Nutrition 0.000 description 2
- 239000002270 dispersing agent Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000009977 dual effect Effects 0.000 description 2
- 238000001378 electrochemiluminescence detection Methods 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 description 2
- 229940035638 gonadotropin-releasing hormone Drugs 0.000 description 2
- 229960000789 guanidine hydrochloride Drugs 0.000 description 2
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 2
- 238000001794 hormone therapy Methods 0.000 description 2
- 210000002865 immune cell Anatomy 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 description 2
- 108010084553 jacalin Proteins 0.000 description 2
- 108010028309 kalinin Proteins 0.000 description 2
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 150000002617 leukotrienes Chemical class 0.000 description 2
- 229940040145 liniment Drugs 0.000 description 2
- 239000000865 liniment Substances 0.000 description 2
- 239000002502 liposome Substances 0.000 description 2
- 210000002540 macrophage Anatomy 0.000 description 2
- 210000001161 mammalian embryo Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 210000003593 megakaryocyte Anatomy 0.000 description 2
- 230000009401 metastasis Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 108010046778 molybdenum cofactor Proteins 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 229920001220 nitrocellulos Polymers 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 208000025661 ovarian cyst Diseases 0.000 description 2
- 230000002018 overexpression Effects 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 102000020233 phosphotransferase Human genes 0.000 description 2
- 239000013612 plasmid Substances 0.000 description 2
- 229940012957 plasmin Drugs 0.000 description 2
- 229920002401 polyacrylamide Polymers 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- 108060006633 protein kinase Proteins 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 108010014186 ras Proteins Proteins 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000001850 reproductive effect Effects 0.000 description 2
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 210000002027 skeletal muscle Anatomy 0.000 description 2
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 230000004960 subcellular localization Effects 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 230000001131 transforming effect Effects 0.000 description 2
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 2
- 238000002255 vaccination Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- DWAKNKKXGALPNW-BYPYZUCNSA-M (S)-1-pyrroline-5-carboxylate Chemical compound [O-]C(=O)[C@@H]1CCC=N1 DWAKNKKXGALPNW-BYPYZUCNSA-M 0.000 description 1
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 1
- 101150072531 10 gene Proteins 0.000 description 1
- YTOPFCCWCSOHFV-UHFFFAOYSA-N 2,6-dimethyl-4-tridecylmorpholine Chemical compound CCCCCCCCCCCCCN1CC(C)OC(C)C1 YTOPFCCWCSOHFV-UHFFFAOYSA-N 0.000 description 1
- HVAUUPRFYPCOCA-AREMUKBSSA-N 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP([O-])(=O)OCC[N+](C)(C)C HVAUUPRFYPCOCA-AREMUKBSSA-N 0.000 description 1
- 102100030799 28S ribosomal protein S2, mitochondrial Human genes 0.000 description 1
- SATHPVQTSSUFFW-UHFFFAOYSA-N 4-[6-[(3,5-dihydroxy-4-methoxyoxan-2-yl)oxymethyl]-3,5-dihydroxy-4-methoxyoxan-2-yl]oxy-2-(hydroxymethyl)-6-methyloxane-3,5-diol Chemical compound OC1C(OC)C(O)COC1OCC1C(O)C(OC)C(O)C(OC2C(C(CO)OC(C)C2O)O)O1 SATHPVQTSSUFFW-UHFFFAOYSA-N 0.000 description 1
- LKDMKWNDBAVNQZ-UHFFFAOYSA-N 4-[[1-[[1-[2-[[1-(4-nitroanilino)-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid Chemical compound OC(=O)CCC(=O)NC(C)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(C(=O)NC=1C=CC(=CC=1)[N+]([O-])=O)CC1=CC=CC=C1 LKDMKWNDBAVNQZ-UHFFFAOYSA-N 0.000 description 1
- 102100036610 AN1-type zinc finger protein 5 Human genes 0.000 description 1
- 102100023388 ATP-dependent RNA helicase DHX15 Human genes 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 101710093498 Actin, gamma Proteins 0.000 description 1
- 102100022454 Actin, gamma-enteric smooth muscle Human genes 0.000 description 1
- 102100023989 Actin-related protein 2 Human genes 0.000 description 1
- 108090000963 Actin-related protein 2 Proteins 0.000 description 1
- 102100038820 Actin-related protein 2/3 complex subunit 1B Human genes 0.000 description 1
- 102000003741 Actin-related protein 3 Human genes 0.000 description 1
- 108090000104 Actin-related protein 3 Proteins 0.000 description 1
- 108010085238 Actins Proteins 0.000 description 1
- 102000007469 Actins Human genes 0.000 description 1
- 102100034542 Acyl-CoA (8-3)-desaturase Human genes 0.000 description 1
- 102100035886 Adenine DNA glycosylase Human genes 0.000 description 1
- 101710186708 Agglutinin Proteins 0.000 description 1
- 102100040069 Aldehyde dehydrogenase 1A1 Human genes 0.000 description 1
- 102100039075 Aldehyde dehydrogenase family 1 member A3 Human genes 0.000 description 1
- 101710150756 Aldehyde dehydrogenase, mitochondrial Proteins 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 102100034112 Alkyldihydroxyacetonephosphate synthase, peroxisomal Human genes 0.000 description 1
- 108700028369 Alleles Proteins 0.000 description 1
- 102100040743 Alpha-crystallin B chain Human genes 0.000 description 1
- 241000428352 Amma Species 0.000 description 1
- 102000052589 Anaphase-Promoting Complex-Cyclosome Apc4 Subunit Human genes 0.000 description 1
- 229920000189 Arabinogalactan Polymers 0.000 description 1
- 239000001904 Arabinogalactan Substances 0.000 description 1
- YZXBAPSDXZZRGB-DOFZRALJSA-M Arachidonate Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC([O-])=O YZXBAPSDXZZRGB-DOFZRALJSA-M 0.000 description 1
- 102100030356 Arginase-2, mitochondrial Human genes 0.000 description 1
- 208000002109 Argyria Diseases 0.000 description 1
- 244000025352 Artocarpus heterophyllus Species 0.000 description 1
- 235000008725 Artocarpus heterophyllus Nutrition 0.000 description 1
- 206010003445 Ascites Diseases 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 102100022716 Atypical chemokine receptor 3 Human genes 0.000 description 1
- 102100027954 BAG family molecular chaperone regulator 3 Human genes 0.000 description 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 102100023658 Beta-chimaerin Human genes 0.000 description 1
- 101710125089 Bindin Proteins 0.000 description 1
- 102100036848 C-C motif chemokine 20 Human genes 0.000 description 1
- 102100031102 C-C motif chemokine 4 Human genes 0.000 description 1
- 102000000905 Cadherin Human genes 0.000 description 1
- 108050007957 Cadherin Proteins 0.000 description 1
- 108010028326 Calbindin 2 Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 102000005701 Calcium-Binding Proteins Human genes 0.000 description 1
- 108010045403 Calcium-Binding Proteins Proteins 0.000 description 1
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 102100033040 Carbonic anhydrase 12 Human genes 0.000 description 1
- 102100032378 Carboxypeptidase E Human genes 0.000 description 1
- 108010058255 Carboxypeptidase H Proteins 0.000 description 1
- 102100025975 Cathepsin G Human genes 0.000 description 1
- 108090000617 Cathepsin G Proteins 0.000 description 1
- 102100035888 Caveolin-1 Human genes 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 108010021988 Cellular Retinol-Binding Proteins Proteins 0.000 description 1
- 102100038731 Chitinase-3-like protein 2 Human genes 0.000 description 1
- 102000009016 Cholera Toxin Human genes 0.000 description 1
- 108010049048 Cholera Toxin Proteins 0.000 description 1
- 108090000317 Chymotrypsin Proteins 0.000 description 1
- 102100035595 Cohesin subunit SA-2 Human genes 0.000 description 1
- 241001550206 Colla Species 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 108010028778 Complement C4 Proteins 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 description 1
- 235000019750 Crude protein Nutrition 0.000 description 1
- 102100028908 Cullin-3 Human genes 0.000 description 1
- 102000005889 Cysteine-Rich Protein 61 Human genes 0.000 description 1
- 108010019961 Cysteine-Rich Protein 61 Proteins 0.000 description 1
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 description 1
- 102000003849 Cytochrome P450 Human genes 0.000 description 1
- 102100029368 Cytochrome P450 2C18 Human genes 0.000 description 1
- NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 description 1
- 239000012623 DNA damaging agent Substances 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 108010073542 Delta-5 Fatty Acid Desaturase Proteins 0.000 description 1
- 201000008163 Dentatorubral pallidoluysian atrophy Diseases 0.000 description 1
- 108010008532 Deoxyribonuclease I Proteins 0.000 description 1
- 102100030012 Deoxyribonuclease-1 Human genes 0.000 description 1
- 102100022874 Dexamethasone-induced Ras-related protein 1 Human genes 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 239000004338 Dichlorodifluoromethane Substances 0.000 description 1
- 102100028572 Disabled homolog 2 Human genes 0.000 description 1
- 102100029721 DnaJ homolog subfamily B member 1 Human genes 0.000 description 1
- 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 1
- 101000968267 Drosophila melanogaster Protein dachsous Proteins 0.000 description 1
- 102100023275 Dual specificity mitogen-activated protein kinase kinase 3 Human genes 0.000 description 1
- 102100023965 Dynein light chain Tctex-type 3 Human genes 0.000 description 1
- 102100032249 Dystonin Human genes 0.000 description 1
- 102100025189 E3 ubiquitin-protein ligase RBBP6 Human genes 0.000 description 1
- 102100035079 ETS-related transcription factor Elf-3 Human genes 0.000 description 1
- 239000006145 Eagle's minimal essential medium Substances 0.000 description 1
- 208000005431 Endometrioid Carcinoma Diseases 0.000 description 1
- 102100031780 Endonuclease Human genes 0.000 description 1
- 108010042407 Endonucleases Proteins 0.000 description 1
- 102000035210 Epididymal Secretory Proteins Human genes 0.000 description 1
- 108010006450 Epididymal Secretory Proteins Proteins 0.000 description 1
- 102100039603 Epithelial splicing regulatory protein 2 Human genes 0.000 description 1
- 241000283074 Equus asinus Species 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- 108010054265 Factor VIIa Proteins 0.000 description 1
- 108010071289 Factor XIII Proteins 0.000 description 1
- 108010080805 Factor XIa Proteins 0.000 description 1
- 102100037362 Fibronectin Human genes 0.000 description 1
- 241000195522 Fucales Species 0.000 description 1
- 108091006027 G proteins Proteins 0.000 description 1
- 102100033506 G-rich sequence factor 1 Human genes 0.000 description 1
- 102000030782 GTP binding Human genes 0.000 description 1
- 108091000058 GTP-Binding Proteins 0.000 description 1
- 102100040510 Galectin-3-binding protein Human genes 0.000 description 1
- 206010061178 Genital haemorrhage Diseases 0.000 description 1
- 102100033053 Glutathione peroxidase 3 Human genes 0.000 description 1
- 102000005720 Glutathione transferase Human genes 0.000 description 1
- 108010070675 Glutathione transferase Proteins 0.000 description 1
- 102100023903 Glycerol kinase Human genes 0.000 description 1
- 102100039329 Glycerol kinase 2 Human genes 0.000 description 1
- 108700016170 Glycerol kinases Proteins 0.000 description 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 1
- 102100029492 Glycogen phosphorylase, muscle form Human genes 0.000 description 1
- 102100021184 Golgi membrane protein 1 Human genes 0.000 description 1
- 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 description 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 1
- 108091027874 Group I catalytic intron Proteins 0.000 description 1
- 108091029499 Group II intron Proteins 0.000 description 1
- 101150009006 HIS3 gene Proteins 0.000 description 1
- 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 description 1
- 102100030595 HLA class II histocompatibility antigen gamma chain Human genes 0.000 description 1
- 108010088729 HLA-A*02:01 antigen Proteins 0.000 description 1
- 108010042283 HSP40 Heat-Shock Proteins Proteins 0.000 description 1
- 206010060781 Haemorrhagic ovarian cyst Diseases 0.000 description 1
- 102100040352 Heat shock 70 kDa protein 1A Human genes 0.000 description 1
- 102100031624 Heat shock protein 105 kDa Human genes 0.000 description 1
- 102100031962 Heme-binding protein 1 Human genes 0.000 description 1
- 102100021519 Hemoglobin subunit beta Human genes 0.000 description 1
- 102100039894 Hemoglobin subunit delta Human genes 0.000 description 1
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 description 1
- 102100021866 Hepatocyte growth factor Human genes 0.000 description 1
- 108010068250 Herpes Simplex Virus Protein Vmw65 Proteins 0.000 description 1
- 102000006479 Heterogeneous-Nuclear Ribonucleoproteins Human genes 0.000 description 1
- 108010019372 Heterogeneous-Nuclear Ribonucleoproteins Proteins 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 102100029009 High mobility group protein HMG-I/HMG-Y Human genes 0.000 description 1
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 description 1
- 102100037487 Histone H1.0 Human genes 0.000 description 1
- 102100022846 Histone acetyltransferase KAT2B Human genes 0.000 description 1
- 102100021453 Histone deacetylase 5 Human genes 0.000 description 1
- 102100038719 Histone deacetylase 7 Human genes 0.000 description 1
- 102100022373 Homeobox protein DLX-5 Human genes 0.000 description 1
- 101000636137 Homo sapiens 28S ribosomal protein S2, mitochondrial Proteins 0.000 description 1
- 101001073740 Homo sapiens 60S ribosomal protein L11 Proteins 0.000 description 1
- 101000782077 Homo sapiens AN1-type zinc finger protein 5 Proteins 0.000 description 1
- 101000907886 Homo sapiens ATP-dependent RNA helicase DHX15 Proteins 0.000 description 1
- 101000678433 Homo sapiens Actin, gamma-enteric smooth muscle Proteins 0.000 description 1
- 101000809459 Homo sapiens Actin-related protein 2/3 complex subunit 1B Proteins 0.000 description 1
- 101001000351 Homo sapiens Adenine DNA glycosylase Proteins 0.000 description 1
- 101000959046 Homo sapiens Aldehyde dehydrogenase family 1 member A3 Proteins 0.000 description 1
- 101000799143 Homo sapiens Alkyldihydroxyacetonephosphate synthase, peroxisomal Proteins 0.000 description 1
- 101000797282 Homo sapiens Alpha-actinin-4 Proteins 0.000 description 1
- 101000891982 Homo sapiens Alpha-crystallin B chain Proteins 0.000 description 1
- 101000694718 Homo sapiens Amine oxidase [flavin-containing] A Proteins 0.000 description 1
- 101000792835 Homo sapiens Arginase-2, mitochondrial Proteins 0.000 description 1
- 101000678890 Homo sapiens Atypical chemokine receptor 3 Proteins 0.000 description 1
- 101000697871 Homo sapiens BAG family molecular chaperone regulator 3 Proteins 0.000 description 1
- 101000906924 Homo sapiens Beta-chimaerin Proteins 0.000 description 1
- 101000713099 Homo sapiens C-C motif chemokine 20 Proteins 0.000 description 1
- 101000777471 Homo sapiens C-C motif chemokine 4 Proteins 0.000 description 1
- 101000740685 Homo sapiens C4b-binding protein alpha chain Proteins 0.000 description 1
- 101000898072 Homo sapiens Calretinin Proteins 0.000 description 1
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 description 1
- 101000898449 Homo sapiens Cathepsin B Proteins 0.000 description 1
- 101000715467 Homo sapiens Caveolin-1 Proteins 0.000 description 1
- 101000883325 Homo sapiens Chitinase-3-like protein 2 Proteins 0.000 description 1
- 101000642968 Homo sapiens Cohesin subunit SA-2 Proteins 0.000 description 1
- 101000916238 Homo sapiens Cullin-3 Proteins 0.000 description 1
- 101000919360 Homo sapiens Cytochrome P450 2C18 Proteins 0.000 description 1
- 101000620808 Homo sapiens Dexamethasone-induced Ras-related protein 1 Proteins 0.000 description 1
- 101000915391 Homo sapiens Disabled homolog 2 Proteins 0.000 description 1
- 101000931227 Homo sapiens DnaJ homolog subfamily A member 1 Proteins 0.000 description 1
- 101000866018 Homo sapiens DnaJ homolog subfamily B member 1 Proteins 0.000 description 1
- 101001115394 Homo sapiens Dual specificity mitogen-activated protein kinase kinase 3 Proteins 0.000 description 1
- 101000881127 Homo sapiens Dual specificity protein phosphatase 10 Proteins 0.000 description 1
- 101000904012 Homo sapiens Dynein light chain Tctex-type 3 Proteins 0.000 description 1
- 101001016186 Homo sapiens Dystonin Proteins 0.000 description 1
- 101001077300 Homo sapiens E3 ubiquitin-protein ligase RBBP6 Proteins 0.000 description 1
- 101000877379 Homo sapiens ETS-related transcription factor Elf-3 Proteins 0.000 description 1
- 101001066265 Homo sapiens Endothelial transcription factor GATA-2 Proteins 0.000 description 1
- 101000814080 Homo sapiens Epithelial splicing regulatory protein 2 Proteins 0.000 description 1
- 101001027128 Homo sapiens Fibronectin Proteins 0.000 description 1
- 101000870806 Homo sapiens G-rich sequence factor 1 Proteins 0.000 description 1
- 101000967904 Homo sapiens Galectin-3-binding protein Proteins 0.000 description 1
- 101000871067 Homo sapiens Glutathione peroxidase 3 Proteins 0.000 description 1
- 101000888011 Homo sapiens Glycerol kinase 2 Proteins 0.000 description 1
- 101000700475 Homo sapiens Glycogen phosphorylase, muscle form Proteins 0.000 description 1
- 101001040742 Homo sapiens Golgi membrane protein 1 Proteins 0.000 description 1
- 101000746367 Homo sapiens Granulocyte colony-stimulating factor Proteins 0.000 description 1
- 101001082627 Homo sapiens HLA class II histocompatibility antigen gamma chain Proteins 0.000 description 1
- 101001037759 Homo sapiens Heat shock 70 kDa protein 1A Proteins 0.000 description 1
- 101000866478 Homo sapiens Heat shock protein 105 kDa Proteins 0.000 description 1
- 101000843842 Homo sapiens Heme-binding protein 1 Proteins 0.000 description 1
- 101000899111 Homo sapiens Hemoglobin subunit beta Proteins 0.000 description 1
- 101001035503 Homo sapiens Hemoglobin subunit delta Proteins 0.000 description 1
- 101000986380 Homo sapiens High mobility group protein HMG-I/HMG-Y Proteins 0.000 description 1
- 101001026554 Homo sapiens Histone H1.0 Proteins 0.000 description 1
- 101001047006 Homo sapiens Histone acetyltransferase KAT2B Proteins 0.000 description 1
- 101000899255 Homo sapiens Histone deacetylase 5 Proteins 0.000 description 1
- 101001032113 Homo sapiens Histone deacetylase 7 Proteins 0.000 description 1
- 101000901627 Homo sapiens Homeobox protein DLX-5 Proteins 0.000 description 1
- 101001003310 Homo sapiens Immediate early response gene 5 protein Proteins 0.000 description 1
- 101001044094 Homo sapiens Inositol monophosphatase 2 Proteins 0.000 description 1
- 101000999377 Homo sapiens Interferon-related developmental regulator 1 Proteins 0.000 description 1
- 101001081606 Homo sapiens Islet cell autoantigen 1 Proteins 0.000 description 1
- 101001050320 Homo sapiens Junctional adhesion molecule B Proteins 0.000 description 1
- 101001139130 Homo sapiens Krueppel-like factor 5 Proteins 0.000 description 1
- 101001051313 Homo sapiens Laminin subunit beta-3 Proteins 0.000 description 1
- 101000740227 Homo sapiens Lathosterol oxidase Proteins 0.000 description 1
- 101000780205 Homo sapiens Long-chain-fatty-acid-CoA ligase 5 Proteins 0.000 description 1
- 101000798109 Homo sapiens Melanotransferrin Proteins 0.000 description 1
- 101000967073 Homo sapiens Metal regulatory transcription factor 1 Proteins 0.000 description 1
- 101001027945 Homo sapiens Metallothionein-1E Proteins 0.000 description 1
- 101000958791 Homo sapiens Mitotic-spindle organizing protein 1 Proteins 0.000 description 1
- 101001030211 Homo sapiens Myc proto-oncogene protein Proteins 0.000 description 1
- 101001030197 Homo sapiens Myelin transcription factor 1 Proteins 0.000 description 1
- 101000818546 Homo sapiens N-formyl peptide receptor 2 Proteins 0.000 description 1
- 101000602237 Homo sapiens Neuroblastoma suppressor of tumorigenicity 1 Proteins 0.000 description 1
- 101001023833 Homo sapiens Neutrophil gelatinase-associated lipocalin Proteins 0.000 description 1
- 101000597417 Homo sapiens Nuclear RNA export factor 1 Proteins 0.000 description 1
- 101000744394 Homo sapiens Oxidized purine nucleoside triphosphate hydrolase Proteins 0.000 description 1
- 101000574223 Homo sapiens Palmitoyl-protein thioesterase 1 Proteins 0.000 description 1
- 101000854777 Homo sapiens Pantetheinase Proteins 0.000 description 1
- 101001096050 Homo sapiens Perilipin-2 Proteins 0.000 description 1
- 101000660828 Homo sapiens Phenylalanine-tRNA ligase beta subunit Proteins 0.000 description 1
- 101001096169 Homo sapiens Phosphatidylserine decarboxylase proenzyme, mitochondrial Proteins 0.000 description 1
- 101001097889 Homo sapiens Platelet-activating factor acetylhydrolase Proteins 0.000 description 1
- 101001026214 Homo sapiens Potassium voltage-gated channel subfamily A member 5 Proteins 0.000 description 1
- 101001077420 Homo sapiens Potassium voltage-gated channel subfamily H member 7 Proteins 0.000 description 1
- 101000952113 Homo sapiens Probable ATP-dependent RNA helicase DDX5 Proteins 0.000 description 1
- 101000979748 Homo sapiens Protein NDRG1 Proteins 0.000 description 1
- 101000739146 Homo sapiens Protein SFI1 homolog Proteins 0.000 description 1
- 101000757232 Homo sapiens Protein arginine N-methyltransferase 2 Proteins 0.000 description 1
- 101000893493 Homo sapiens Protein flightless-1 homolog Proteins 0.000 description 1
- 101001123332 Homo sapiens Proteoglycan 4 Proteins 0.000 description 1
- 101000609336 Homo sapiens Pyrroline-5-carboxylate reductase 2 Proteins 0.000 description 1
- 101000926083 Homo sapiens Rab GDP dissociation inhibitor beta Proteins 0.000 description 1
- 101000636109 Homo sapiens Ras suppressor protein 1 Proteins 0.000 description 1
- 101000744331 Homo sapiens Retinoblastoma-like protein 1 Proteins 0.000 description 1
- 101000756373 Homo sapiens Retinol-binding protein 1 Proteins 0.000 description 1
- 101000665882 Homo sapiens Retinol-binding protein 4 Proteins 0.000 description 1
- 101000692943 Homo sapiens Ribonuclease K6 Proteins 0.000 description 1
- 101000654335 Homo sapiens Secernin-1 Proteins 0.000 description 1
- 101000628575 Homo sapiens Serine/threonine-protein kinase 19 Proteins 0.000 description 1
- 101000869480 Homo sapiens Serum amyloid A-1 protein Proteins 0.000 description 1
- 101000701440 Homo sapiens Stanniocalcin-1 Proteins 0.000 description 1
- 101000625818 Homo sapiens TBC1 domain family member 2B Proteins 0.000 description 1
- 101000800047 Homo sapiens Testican-2 Proteins 0.000 description 1
- 101000845189 Homo sapiens Testis-specific Y-encoded protein 1 Proteins 0.000 description 1
- 101000835083 Homo sapiens Tissue factor pathway inhibitor 2 Proteins 0.000 description 1
- 101000662809 Homo sapiens Trafficking protein particle complex subunit 4 Proteins 0.000 description 1
- 101000801701 Homo sapiens Tropomyosin alpha-1 chain Proteins 0.000 description 1
- 101000987017 Homo sapiens Tumor protein p53-inducible protein 11 Proteins 0.000 description 1
- 101000840051 Homo sapiens Ubiquitin-60S ribosomal protein L40 Proteins 0.000 description 1
- 101000644684 Homo sapiens Ubiquitin-conjugating enzyme E2 N Proteins 0.000 description 1
- 101000807820 Homo sapiens V-type proton ATPase subunit S1 Proteins 0.000 description 1
- 101000743353 Homo sapiens Vacuolar protein sorting-associated protein 11 homolog Proteins 0.000 description 1
- 101000666856 Homo sapiens Vasoactive intestinal polypeptide receptor 1 Proteins 0.000 description 1
- 101000954157 Homo sapiens Vasopressin V1a receptor Proteins 0.000 description 1
- 101000931048 Homo sapiens Zinc finger protein DPF3 Proteins 0.000 description 1
- 101710146024 Horcolin Proteins 0.000 description 1
- 208000033830 Hot Flashes Diseases 0.000 description 1
- 206010060800 Hot flush Diseases 0.000 description 1
- 108010013958 Ikaros Transcription Factor Proteins 0.000 description 1
- 102000017182 Ikaros Transcription Factor Human genes 0.000 description 1
- 102100020688 Immediate early response gene 5 protein Human genes 0.000 description 1
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 description 1
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 description 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
- 102100021608 Inositol monophosphatase 2 Human genes 0.000 description 1
- 102100036527 Interferon-related developmental regulator 1 Human genes 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 108090000978 Interleukin-4 Proteins 0.000 description 1
- 108010002586 Interleukin-7 Proteins 0.000 description 1
- 102100027640 Islet cell autoantigen 1 Human genes 0.000 description 1
- 102100023430 Junctional adhesion molecule B Human genes 0.000 description 1
- 102100025656 Keratin, type II cytoskeletal 6A Human genes 0.000 description 1
- 108010070557 Keratin-6 Proteins 0.000 description 1
- 102100020680 Krueppel-like factor 5 Human genes 0.000 description 1
- 108010003718 LDL-Receptor Related Protein-Associated Protein Proteins 0.000 description 1
- 102100024629 Laminin subunit beta-3 Human genes 0.000 description 1
- 241001523179 Lasia <small-headed fly> Species 0.000 description 1
- 102100037199 Lathosterol oxidase Human genes 0.000 description 1
- 108091026898 Leader sequence (mRNA) Proteins 0.000 description 1
- 101710189395 Lectin Proteins 0.000 description 1
- 108010006444 Leucine-Rich Repeat Proteins Proteins 0.000 description 1
- 102000003960 Ligases Human genes 0.000 description 1
- 108090000364 Ligases Proteins 0.000 description 1
- 102100034318 Long-chain-fatty-acid-CoA ligase 5 Human genes 0.000 description 1
- 102100026238 Lymphotoxin-alpha Human genes 0.000 description 1
- 102100037611 Lysophospholipase Human genes 0.000 description 1
- 241000294754 Macroptilium atropurpureum Species 0.000 description 1
- 102100026475 Malate dehydrogenase, cytoplasmic Human genes 0.000 description 1
- 101710175625 Maltose/maltodextrin-binding periplasmic protein Proteins 0.000 description 1
- 101710179758 Mannose-specific lectin Proteins 0.000 description 1
- 101710150763 Mannose-specific lectin 1 Proteins 0.000 description 1
- 101710150745 Mannose-specific lectin 2 Proteins 0.000 description 1
- 238000000585 Mann–Whitney U test Methods 0.000 description 1
- 102000004318 Matrilysin Human genes 0.000 description 1
- 108090000855 Matrilysin Proteins 0.000 description 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 description 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 description 1
- 208000017657 Menopausal disease Diseases 0.000 description 1
- 102100040514 Metal regulatory transcription factor 1 Human genes 0.000 description 1
- 102100037510 Metallothionein-1E Human genes 0.000 description 1
- 102100038336 Mitotic-spindle organizing protein 1 Human genes 0.000 description 1
- HDAJUGGARUFROU-JSUDGWJLSA-L MoO2-molybdopterin cofactor Chemical compound O([C@H]1NC=2N=C(NC(=O)C=2N[C@H]11)N)[C@H](COP(O)(O)=O)C2=C1S[Mo](=O)(=O)S2 HDAJUGGARUFROU-JSUDGWJLSA-L 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- 101100523827 Mus musculus Rbpjl gene Proteins 0.000 description 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 1
- 102100030330 Myosin regulatory light chain 12B Human genes 0.000 description 1
- 101710092698 Myosin regulatory light chain 2 Proteins 0.000 description 1
- 102100031787 Myosin regulatory light polypeptide 9 Human genes 0.000 description 1
- 102000055056 N-Myc Proto-Oncogene Human genes 0.000 description 1
- 108700026495 N-Myc Proto-Oncogene Proteins 0.000 description 1
- 102100021126 N-formyl peptide receptor 2 Human genes 0.000 description 1
- 108010018525 NFATC Transcription Factors Proteins 0.000 description 1
- 102000002673 NFATC Transcription Factors Human genes 0.000 description 1
- 206010029113 Neovascularisation Diseases 0.000 description 1
- 102100037142 Neuroblastoma suppressor of tumorigenicity 1 Human genes 0.000 description 1
- 102000012106 Neutral Amino Acid Transport Systems Human genes 0.000 description 1
- 108010036505 Neutral Amino Acid Transport Systems Proteins 0.000 description 1
- 102100035405 Neutrophil gelatinase-associated lipocalin Human genes 0.000 description 1
- 241000187654 Nocardia Species 0.000 description 1
- 102100035402 Nuclear RNA export factor 1 Human genes 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 108090000816 Oviductin Proteins 0.000 description 1
- 241000283903 Ovis aries Species 0.000 description 1
- 102100039792 Oxidized purine nucleoside triphosphate hydrolase Human genes 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 102000005327 Palmitoyl protein thioesterase Human genes 0.000 description 1
- 108020002591 Palmitoyl protein thioesterase Proteins 0.000 description 1
- 102100025824 Palmitoyl-protein thioesterase 1 Human genes 0.000 description 1
- 241000282579 Pan Species 0.000 description 1
- 102100020749 Pantetheinase Human genes 0.000 description 1
- 108090000526 Papain Proteins 0.000 description 1
- 241000282520 Papio Species 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 108010067902 Peptide Library Proteins 0.000 description 1
- 102100037896 Perilipin-2 Human genes 0.000 description 1
- 108010004478 Phenylalanine-tRNA Ligase Proteins 0.000 description 1
- 102100035312 Phenylalanine-tRNA ligase beta subunit Human genes 0.000 description 1
- 102100029354 Phenylalanine-tRNA ligase, mitochondrial Human genes 0.000 description 1
- 108010058864 Phospholipases A2 Proteins 0.000 description 1
- 102100039421 Phytanoyl-CoA dioxygenase, peroxisomal Human genes 0.000 description 1
- 108090000113 Plasma Kallikrein Proteins 0.000 description 1
- 102100034869 Plasma kallikrein Human genes 0.000 description 1
- 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 description 1
- 102100039418 Plasminogen activator inhibitor 1 Human genes 0.000 description 1
- 108010003541 Platelet Activating Factor Proteins 0.000 description 1
- 102100037518 Platelet-activating factor acetylhydrolase Human genes 0.000 description 1
- 102100030477 Plectin Human genes 0.000 description 1
- 108010054050 Plectin Proteins 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 102100037445 Potassium voltage-gated channel subfamily A member 5 Human genes 0.000 description 1
- 102100025133 Potassium voltage-gated channel subfamily H member 7 Human genes 0.000 description 1
- 102100037434 Probable ATP-dependent RNA helicase DDX5 Human genes 0.000 description 1
- 101710136733 Proline-rich protein Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 101800004937 Protein C Proteins 0.000 description 1
- 102000017975 Protein C Human genes 0.000 description 1
- 102000055027 Protein Methyltransferases Human genes 0.000 description 1
- 108700040121 Protein Methyltransferases Proteins 0.000 description 1
- 102100024980 Protein NDRG1 Human genes 0.000 description 1
- 102100037271 Protein SFI1 homolog Human genes 0.000 description 1
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 102100022988 Protein arginine N-methyltransferase 2 Human genes 0.000 description 1
- 102100040923 Protein flightless-1 homolog Human genes 0.000 description 1
- 101710127913 Proteoglycan 4 Proteins 0.000 description 1
- 108700020978 Proto-Oncogene Proteins 0.000 description 1
- 102000052575 Proto-Oncogene Human genes 0.000 description 1
- 102100039450 Pyrroline-5-carboxylate reductase 2 Human genes 0.000 description 1
- 108010086890 R-cadherin Proteins 0.000 description 1
- 108091034057 RNA (poly(A)) Proteins 0.000 description 1
- 108090000944 RNA Helicases Proteins 0.000 description 1
- 102000004409 RNA Helicases Human genes 0.000 description 1
- 108020005067 RNA Splice Sites Proteins 0.000 description 1
- 238000010240 RT-PCR analysis Methods 0.000 description 1
- 102100034328 Rab GDP dissociation inhibitor beta Human genes 0.000 description 1
- 102100030800 Ras suppressor protein 1 Human genes 0.000 description 1
- 102100030814 Regulator of G-protein signaling 9 Human genes 0.000 description 1
- 108010023377 Retinoblastoma Binding Proteins Proteins 0.000 description 1
- 102000011260 Retinoblastoma Binding Proteins Human genes 0.000 description 1
- 108050002592 Retinoblastoma-like protein 1 Proteins 0.000 description 1
- 102100038246 Retinol-binding protein 4 Human genes 0.000 description 1
- 102100026386 Ribonuclease K6 Human genes 0.000 description 1
- 102000004167 Ribonuclease P Human genes 0.000 description 1
- 108090000621 Ribonuclease P Proteins 0.000 description 1
- 108091006311 SLC3A1 Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 101800001700 Saposin-D Proteins 0.000 description 1
- 102100030053 Secreted frizzled-related protein 3 Human genes 0.000 description 1
- 108091081021 Sense strand Proteins 0.000 description 1
- 101710187074 Serine proteinase inhibitor Proteins 0.000 description 1
- 102100026757 Serine/threonine-protein kinase 19 Human genes 0.000 description 1
- 102100032277 Serum amyloid A-1 protein Human genes 0.000 description 1
- 102100022056 Serum response factor Human genes 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000251131 Sphyrna Species 0.000 description 1
- 102100030511 Stanniocalcin-1 Human genes 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 102000014169 Steroid 21-Hydroxylase Human genes 0.000 description 1
- 108010011732 Steroid 21-Hydroxylase Proteins 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 230000024932 T cell mediated immunity Effects 0.000 description 1
- 102100024766 TBC1 domain family member 2B Human genes 0.000 description 1
- 102000018679 Tacrolimus Binding Proteins Human genes 0.000 description 1
- 108010027179 Tacrolimus Binding Proteins Proteins 0.000 description 1
- 102100036221 Tax1-binding protein 3 Human genes 0.000 description 1
- 101710193790 Tax1-binding protein 3 Proteins 0.000 description 1
- 244000247617 Teramnus labialis var. labialis Species 0.000 description 1
- 102100031283 Testis-specific Y-encoded protein 1 Human genes 0.000 description 1
- 108091036066 Three prime untranslated region Proteins 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 108010000499 Thromboplastin Proteins 0.000 description 1
- 102000002262 Thromboplastin Human genes 0.000 description 1
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 1
- 102400000336 Thyrotropin-releasing hormone Human genes 0.000 description 1
- 101800004623 Thyrotropin-releasing hormone Proteins 0.000 description 1
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 description 1
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 description 1
- 102100040526 Tissue alpha-L-fucosidase Human genes 0.000 description 1
- 101710141373 Tissue alpha-L-fucosidase Proteins 0.000 description 1
- 102100030951 Tissue factor pathway inhibitor Human genes 0.000 description 1
- 101710120037 Toxin CcdB Proteins 0.000 description 1
- 102100037496 Trafficking protein particle complex subunit 4 Human genes 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 239000013504 Triton X-100 Substances 0.000 description 1
- 229920004890 Triton X-100 Polymers 0.000 description 1
- 102100033632 Tropomyosin alpha-1 chain Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 102100027873 Tumor protein p53-inducible protein 11 Human genes 0.000 description 1
- 102000006837 U5 Small Nuclear Ribonucleoprotein Human genes 0.000 description 1
- 108010086857 U5 Small Nuclear Ribonucleoprotein Proteins 0.000 description 1
- 102100028462 Ubiquitin-60S ribosomal protein L40 Human genes 0.000 description 1
- 101710192923 Ubiquitin-conjugating enzyme E2 N Proteins 0.000 description 1
- 108091023045 Untranslated Region Proteins 0.000 description 1
- 102100038309 Vacuolar protein sorting-associated protein 11 homolog Human genes 0.000 description 1
- 102100037187 Vasopressin V1a receptor Human genes 0.000 description 1
- 102100022748 Wilms tumor protein Human genes 0.000 description 1
- 101710185494 Zinc finger protein Proteins 0.000 description 1
- 102100023597 Zinc finger protein 816 Human genes 0.000 description 1
- 102100036296 Zinc finger protein DPF3 Human genes 0.000 description 1
- HMNZFMSWFCAGGW-XPWSMXQVSA-N [3-[hydroxy(2-hydroxyethoxy)phosphoryl]oxy-2-[(e)-octadec-9-enoyl]oxypropyl] (e)-octadec-9-enoate Chemical compound CCCCCCCC\C=C\CCCCCCCC(=O)OCC(COP(O)(=O)OCCO)OC(=O)CCCCCCC\C=C\CCCCCCCC HMNZFMSWFCAGGW-XPWSMXQVSA-N 0.000 description 1
- 238000012084 abdominal surgery Methods 0.000 description 1
- 230000001594 aberrant effect Effects 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 208000009956 adenocarcinoma Diseases 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000001919 adrenal effect Effects 0.000 description 1
- 239000000910 agglutinin Substances 0.000 description 1
- 125000005600 alkyl phosphonate group Chemical group 0.000 description 1
- 229940037003 alum Drugs 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 229940030486 androgens Drugs 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 230000002491 angiogenic effect Effects 0.000 description 1
- 230000001740 anti-invasion Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000005975 antitumor immune response Effects 0.000 description 1
- 230000001640 apoptogenic effect Effects 0.000 description 1
- 235000019312 arabinogalactan Nutrition 0.000 description 1
- 229940114078 arachidonate Drugs 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 238000002820 assay format Methods 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 210000000270 basal cell Anatomy 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 210000004323 caveolae Anatomy 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 239000002458 cell surface marker Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 230000035572 chemosensitivity Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000002759 chromosomal effect Effects 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 229960002376 chymotrypsin Drugs 0.000 description 1
- 229940105784 coagulation factor xiii Drugs 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 229940000425 combination drug Drugs 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 208000035196 congenital hypomyelinating 2 neuropathy Diseases 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 230000006552 constitutive activation Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 230000016396 cytokine production Effects 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 239000002254 cytotoxic agent Substances 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000005115 demineralization Methods 0.000 description 1
- 230000002328 demineralizing effect Effects 0.000 description 1
- 230000002074 deregulated effect Effects 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000000104 diagnostic biomarker Substances 0.000 description 1
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 1
- 235000019404 dichlorodifluoromethane Nutrition 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000001177 diphosphate Substances 0.000 description 1
- 235000011180 diphosphates Nutrition 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 239000008157 edible vegetable oil Substances 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 201000003908 endometrial adenocarcinoma Diseases 0.000 description 1
- 201000003914 endometrial carcinoma Diseases 0.000 description 1
- 208000028730 endometrioid adenocarcinoma Diseases 0.000 description 1
- 208000029382 endometrium adenocarcinoma Diseases 0.000 description 1
- 230000003511 endothelial effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 210000003979 eosinophil Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000010195 expression analysis Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229940012414 factor viia Drugs 0.000 description 1
- 230000006126 farnesylation Effects 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 150000008195 galaktosides Chemical class 0.000 description 1
- 238000003633 gene expression assay Methods 0.000 description 1
- 102000034356 gene-regulatory proteins Human genes 0.000 description 1
- 108091006104 gene-regulatory proteins Proteins 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 230000008303 genetic mechanism Effects 0.000 description 1
- 239000003862 glucocorticoid Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 1
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 229940029575 guanosine Drugs 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 229940125697 hormonal agent Drugs 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 102000053563 human MYC Human genes 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 229960002411 imatinib Drugs 0.000 description 1
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 238000012744 immunostaining Methods 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 230000001024 immunotherapeutic effect Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 239000003701 inert diluent Substances 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 210000002570 interstitial cell Anatomy 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 108010028930 invariant chain Proteins 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000007951 isotonicity adjuster Substances 0.000 description 1
- 101150066555 lacZ gene Proteins 0.000 description 1
- 108700010824 lambda-like proteins Proteins 0.000 description 1
- 238000002357 laparoscopic surgery Methods 0.000 description 1
- 210000004901 leucine-rich repeat Anatomy 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 150000004668 long chain fatty acids Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 239000012139 lysis buffer Substances 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 238000012737 microarray-based gene expression Methods 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 239000003226 mitogen Substances 0.000 description 1
- 238000002715 modification method Methods 0.000 description 1
- 239000007932 molded tablet Substances 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000012120 mounting media Substances 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 238000012243 multiplex automated genomic engineering Methods 0.000 description 1
- QCQYVCMYGCHVMR-AAZUGDAUSA-N n-[(2r,3r,4s,5r)-4,5,6-trihydroxy-1-oxo-3-[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexan-2-yl]acetamide Chemical compound CC(=O)N[C@@H](C=O)[C@H]([C@@H](O)[C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O QCQYVCMYGCHVMR-AAZUGDAUSA-N 0.000 description 1
- 229940100662 nasal drops Drugs 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 230000031942 natural killer cell mediated cytotoxicity Effects 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 230000009826 neoplastic cell growth Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000002687 nonaqueous vehicle Substances 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 230000002246 oncogenic effect Effects 0.000 description 1
- 238000010397 one-hybrid screening Methods 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 201000003707 ovarian clear cell carcinoma Diseases 0.000 description 1
- 210000003101 oviduct Anatomy 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 235000010603 pastilles Nutrition 0.000 description 1
- 230000008289 pathophysiological mechanism Effects 0.000 description 1
- 230000007310 pathophysiology Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 210000003200 peritoneal cavity Anatomy 0.000 description 1
- 230000008823 permeabilization Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- PTMHPRAIXMAOOB-UHFFFAOYSA-N phosphoramidic acid Chemical compound NP(O)(O)=O PTMHPRAIXMAOOB-UHFFFAOYSA-N 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000003169 placental effect Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920000729 poly(L-lysine) polymer Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002384 proinvasive effect Effects 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 229960000856 protein c Drugs 0.000 description 1
- 230000004853 protein function Effects 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 230000012743 protein tagging Effects 0.000 description 1
- 230000025220 protein targeting to vacuole Effects 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 235000020095 red wine Nutrition 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 108010064950 regulator of g-protein signaling 9 Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- 108010008790 ribosomal phosphoprotein P1 Proteins 0.000 description 1
- 108090000930 ribosomal protein S11 Proteins 0.000 description 1
- 102000004413 ribosomal protein S11 Human genes 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000003118 sandwich ELISA Methods 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000003001 serine protease inhibitor Substances 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000007447 staining method Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 108091029536 tRNA precursor Proteins 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 229960000187 tissue plasminogen activator Drugs 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000005809 transesterification reaction Methods 0.000 description 1
- 239000012096 transfection reagent Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000014621 translational initiation Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 229960000575 trastuzumab Drugs 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 210000002993 trophoblast Anatomy 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 238000003160 two-hybrid assay Methods 0.000 description 1
- 238000007039 two-step reaction Methods 0.000 description 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 description 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 description 1
- 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 230000009452 underexpressoin Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- WQAJKOXBERTWBK-UHFFFAOYSA-N verdine Natural products CC1CNC2C(C1)OC3(CCC4C5CCC6(O)CC(O)CC(O)C6(C)C5C(=O)C4=C3C)C2C WQAJKOXBERTWBK-UHFFFAOYSA-N 0.000 description 1
- 108700026220 vif Genes Proteins 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/36—Gynecology or obstetrics
- G01N2800/364—Endometriosis, i.e. non-malignant disorder in which functioning endometrial tissue is present outside the uterine cavity
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Endocrinology (AREA)
- Food Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40736502P | 2002-08-30 | 2002-08-30 | |
| US60/407,365 | 2002-08-30 | ||
| US45092003P | 2003-02-28 | 2003-02-28 | |
| US60/450,920 | 2003-02-28 | ||
| PCT/JP2003/010257 WO2004024952A1 (en) | 2002-08-30 | 2003-08-12 | Method of diagnosing ovarian endometriosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2497132A1 true CA2497132A1 (en) | 2004-03-25 |
Family
ID=31997699
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002497132A Abandoned CA2497132A1 (en) | 2002-08-30 | 2003-08-12 | Method of diagnosing ovarian endometriosis |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1537243B1 (https=) |
| JP (2) | JP4401295B2 (https=) |
| AT (1) | ATE397098T1 (https=) |
| AU (1) | AU2003253440A1 (https=) |
| CA (1) | CA2497132A1 (https=) |
| DE (1) | DE60321356D1 (https=) |
| WO (1) | WO2004024952A1 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8932993B1 (en) | 2007-06-11 | 2015-01-13 | Juneau Biosciences, LLC. | Method of testing for endometriosis and treatment therefor |
| US9434991B2 (en) | 2013-03-07 | 2016-09-06 | Juneau Biosciences, LLC. | Method of testing for endometriosis and treatment therefor |
| US11287425B2 (en) | 2009-04-22 | 2022-03-29 | Juneau Biosciences, Llc | Genetic markers associated with endometriosis and use thereof |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4603548B2 (ja) * | 2003-09-24 | 2010-12-22 | オンコセラピー・サイエンス株式会社 | Ｔｆｐｉ−２タンパク質を用いた卵巣子宮内膜症の診断法 |
| JP2008537474A (ja) * | 2005-02-18 | 2008-09-18 | アメリカ合衆国 | 血液リンパ球における子宮内膜症に関する分子診断マーカーの同定 |
| EP2065707A1 (en) | 2007-11-28 | 2009-06-03 | Laboratorios S.A.L.V.A.T., S.A. | Detection of endometrial secretion markers for assesment of endometriosis |
| ES2534437T3 (es) | 2008-06-30 | 2015-04-22 | Oncotherapy Science, Inc. | Anticuerpos anti-CDH3 marcados con etiqueta de radioisótopo y usos de los mismos |
| TW201008574A (en) | 2008-08-19 | 2010-03-01 | Oncotherapy Science Inc | INHBB epitope peptides and vaccines containing the same |
| JP5526378B2 (ja) * | 2009-03-05 | 2014-06-18 | 国立大学法人山口大学 | 子宮頸癌の検出方法 |
| WO2011080796A1 (en) | 2009-12-28 | 2011-07-07 | Oncotherapy Science, Inc. | Anti-cdh3 antibodies and uses thereof |
| JP5224308B2 (ja) * | 2010-02-22 | 2013-07-03 | 公立大学法人横浜市立大学 | 卵巣明細胞腺癌に特異的に発現しているタンパク質とその応用 |
| DE102012002929A1 (de) | 2012-02-14 | 2013-08-14 | Jürgen Lewald | Minimalinvasives Verfahren für die Diagnose und die Therapieverlaufskontrolle der Endometriose |
| SG11201700303UA (en) * | 2014-07-17 | 2017-02-27 | Celmatix Inc | Methods and systems for assessing infertility and related pathologies |
| JP6535357B2 (ja) * | 2017-02-06 | 2019-06-26 | 国立研究開発法人農業・食品産業技術総合研究機構 | 非アルコール性脂肪肝治療用組成物、非アルコール性脂肪肝の治療剤の候補物質のスクリーニング方法及びｄｎａチップ |
| CN112470002A (zh) * | 2018-04-20 | 2021-03-09 | 德克萨斯大学体系董事会 | 用于治疗子宫内膜异位症的组合物和方法 |
| CN110408695A (zh) * | 2019-04-05 | 2019-11-05 | 辽宁省肿瘤医院 | 子宫内膜异位症恶变相关卵巢癌诊断或预后标志物及应用 |
| WO2020218465A1 (ja) * | 2019-04-26 | 2020-10-29 | 中外製薬株式会社 | 子宮内膜症の診断方法、病態モニタリング方法及びキット |
| JP2021175394A (ja) * | 2020-04-24 | 2021-11-04 | 花王株式会社 | 月経周期マーカー |
| WO2024223379A1 (en) * | 2023-04-27 | 2024-10-31 | Scailyte Ag | Biomarkers for the diagnosis of diseases or disorders of the female reproductive tract |
| CN119769990B (zh) * | 2024-12-26 | 2025-09-09 | 大连医科大学附属第二医院 | 子宫内膜异位症的检测系统和治疗剂 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0828003A3 (en) * | 1996-09-06 | 2003-01-15 | SmithKline Beecham plc | Human serine protease |
| GB9806104D0 (en) * | 1998-03-20 | 1998-05-20 | Smithkline Beecham Biolog | Novel compounds |
| WO1999052942A2 (en) * | 1998-04-15 | 1999-10-21 | Genset | Genomic sequence of the 5-lipoxygenase-activating protein (flap), polymorphic markers thereof and methods for detection of asthma |
| AU3395900A (en) * | 1999-03-12 | 2000-10-04 | Human Genome Sciences, Inc. | Human lung cancer associated gene sequences and polypeptides |
| AU2001266787A1 (en) * | 2000-06-07 | 2002-01-08 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
| WO2002000939A2 (en) * | 2000-06-28 | 2002-01-03 | Diadexus, Inc. | Method of diagnosing, monitoring, staging, imaging and treating colon cancer |
| DE10048633A1 (de) * | 2000-09-25 | 2002-04-18 | Schering Ag | Methode zur in vitro Diagnostik von Endometriose |
| EP1202065A1 (en) * | 2000-10-25 | 2002-05-02 | Aventis Pharma S.A. | Net, a transcription factor of the TCF family, as regulator of angiogenic expression. |
-
2003
- 2003-08-12 AU AU2003253440A patent/AU2003253440A1/en not_active Abandoned
- 2003-08-12 DE DE60321356T patent/DE60321356D1/de not_active Expired - Lifetime
- 2003-08-12 AT AT03795220T patent/ATE397098T1/de not_active IP Right Cessation
- 2003-08-12 EP EP03795220A patent/EP1537243B1/en not_active Expired - Lifetime
- 2003-08-12 CA CA002497132A patent/CA2497132A1/en not_active Abandoned
- 2003-08-12 WO PCT/JP2003/010257 patent/WO2004024952A1/en not_active Ceased
- 2003-08-12 JP JP2004535871A patent/JP4401295B2/ja not_active Expired - Fee Related
-
2009
- 2009-07-31 JP JP2009178542A patent/JP4942052B2/ja not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8932993B1 (en) | 2007-06-11 | 2015-01-13 | Juneau Biosciences, LLC. | Method of testing for endometriosis and treatment therefor |
| US9840738B2 (en) | 2007-06-11 | 2017-12-12 | Juneau Biosciences, Llc | Method of testing for endometriosis and treatment therefor |
| US11287425B2 (en) | 2009-04-22 | 2022-03-29 | Juneau Biosciences, Llc | Genetic markers associated with endometriosis and use thereof |
| US9434991B2 (en) | 2013-03-07 | 2016-09-06 | Juneau Biosciences, LLC. | Method of testing for endometriosis and treatment therefor |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE397098T1 (de) | 2008-06-15 |
| WO2004024952A1 (en) | 2004-03-25 |
| AU2003253440A8 (en) | 2004-04-30 |
| JP2010029189A (ja) | 2010-02-12 |
| JP4942052B2 (ja) | 2012-05-30 |
| EP1537243A1 (en) | 2005-06-08 |
| JP2005537027A (ja) | 2005-12-08 |
| AU2003253440A1 (en) | 2004-04-30 |
| JP4401295B2 (ja) | 2010-01-20 |
| EP1537243B1 (en) | 2008-05-28 |
| DE60321356D1 (de) | 2008-07-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4942052B2 (ja) | 卵巣子宮内膜症の診断法 | |
| US20050214836A1 (en) | Method of diagnosing ovarian endometriosis | |
| US20070092519A1 (en) | Method for diagnosing chronic myeloid leukemia | |
| US20060194199A1 (en) | Method for diagnosing testicular seminomas | |
| US20050259483A1 (en) | Genes and polypeptides relating to prostate cancers | |
| US8029981B2 (en) | Hypoxia-inducible protein 2 (HIG2), a diagnostic marker for clear cell renal cell carcinoma | |
| US11531023B2 (en) | Biomarker for diagnosing overactive bladder disease and screening method of therapeutic agents using the same | |
| TW200418988A (en) | Method for diagnosing prostate cancer | |
| US20060204960A1 (en) | Method for diagnosing diffuse-type gastric cancers | |
| JP2006500945A (ja) | 結腸直腸癌の転移を治療または予防する方法 | |
| KR20080005193A (ko) | 유방암 관련 ｚｎｆｎ３ａ１ 유전자 | |
| EP1932926A2 (en) | Method of diagnosing ovarian endometriosis | |
| US20080063640A1 (en) | Pin-Prc Transition Genes | |
| EP1907859B1 (en) | Genes and polypeptides relating to prostate cancers | |
| KR102942974B1 (ko) | HER2 양성 유방암의 전이 예후 예측용 Copine1 유전자 마커 및 이의 용도 | |
| EP2064341A2 (en) | Prostate cancer related gene styk1 | |
| CN101273145A (zh) | 癌症相关基因rasgef1a | |
| HK1115193B (en) | Colon cancer related gene tom34 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |