CA2496634A1 - Modulateurs de l'activite des recepteurs de surface des cellules il-1 et de tnf-alpha - Google Patents

Modulateurs de l'activite des recepteurs de surface des cellules il-1 et de tnf-alpha Download PDF

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Publication number
CA2496634A1
CA2496634A1 CA002496634A CA2496634A CA2496634A1 CA 2496634 A1 CA2496634 A1 CA 2496634A1 CA 002496634 A CA002496634 A CA 002496634A CA 2496634 A CA2496634 A CA 2496634A CA 2496634 A1 CA2496634 A1 CA 2496634A1
Authority
CA
Canada
Prior art keywords
receptor
tnf
oligopeptide
activity
activation domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002496634A
Other languages
English (en)
Inventor
Lennart Olsson
Tatjana Naranda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Receptron
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Receptron filed Critical Receptron
Publication of CA2496634A1 publication Critical patent/CA2496634A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne des méthodes et des réactifs qui permettent de moduler l'activité de récepteurs de surface des cellules. La modulation de l'activité des récepteurs se produit lorsque des composés bioactifs exogènes sont mis en contact avec le domaine d'activation des récepteurs. La modulation peut être une augmentation de l'activité des récepteurs ou une diminution de l'activité des récepteurs induite par les ligands. Cette invention se rapporte également à des méthodes d'identification et de criblage de composés bioactifs.
CA002496634A 2002-08-29 2003-08-28 Modulateurs de l'activite des recepteurs de surface des cellules il-1 et de tnf-alpha Abandoned CA2496634A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40739602P 2002-08-29 2002-08-29
US60/407,396 2002-08-29
PCT/US2003/027381 WO2004020608A2 (fr) 2002-08-29 2003-08-28 Modulateurs de l'activite des recepteurs de surface des cellules il-1 et de tnf-alpha

Publications (1)

Publication Number Publication Date
CA2496634A1 true CA2496634A1 (fr) 2004-03-11

Family

ID=31978475

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002496634A Abandoned CA2496634A1 (fr) 2002-08-29 2003-08-28 Modulateurs de l'activite des recepteurs de surface des cellules il-1 et de tnf-alpha

Country Status (3)

Country Link
AU (1) AU2003263044A1 (fr)
CA (1) CA2496634A1 (fr)
WO (1) WO2004020608A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9028822B2 (en) 2002-06-28 2015-05-12 Domantis Limited Antagonists against TNFR1 and methods of use therefor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346390B1 (en) * 1996-03-08 2002-02-12 Receptron, Inc. Receptor derived peptides involved in modulation of response to ligand binding

Also Published As

Publication number Publication date
AU2003263044A8 (en) 2004-03-19
AU2003263044A1 (en) 2004-03-19
WO2004020608A2 (fr) 2004-03-11
WO2004020608A3 (fr) 2005-08-04

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Legal Events

Date Code Title Description
FZDE Discontinued