CA2492644A1 - Formes polymorphes de nateglinide - Google Patents

Formes polymorphes de nateglinide Download PDF

Info

Publication number
CA2492644A1
CA2492644A1 CA002492644A CA2492644A CA2492644A1 CA 2492644 A1 CA2492644 A1 CA 2492644A1 CA 002492644 A CA002492644 A CA 002492644A CA 2492644 A CA2492644 A CA 2492644A CA 2492644 A1 CA2492644 A1 CA 2492644A1
Authority
CA
Canada
Prior art keywords
nateglinide
crystalline form
crystalline
preparing
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002492644A
Other languages
English (en)
Inventor
Ronit Yahalomi
Evgeny Shapiro
Ben-Zion Dolitzky
Igal Gozlan
Boaz Gome
Shlomit Wizel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/614,266 external-priority patent/US6861553B2/en
Application filed by Individual filed Critical Individual
Publication of CA2492644A1 publication Critical patent/CA2492644A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne des formes cristallines de nateglinide, les formes marquées A, C, D, F, G, I, J, K, L, M, N, O, P, Q, T, U, V, Y, .alpha., .beta., ?, ?, e, S, ? et O, des procédés permettant leur préparation et des procédés de préparation d'autres formes cristallines de nateglinide. L'invention concerne également leurs formulations pharmaceutiques et procédés d'administration.
CA002492644A 2002-07-18 2003-07-18 Formes polymorphes de nateglinide Abandoned CA2492644A1 (fr)

Applications Claiming Priority (21)

Application Number Priority Date Filing Date Title
US39690402P 2002-07-18 2002-07-18
US60/396,904 2002-07-18
US41362202P 2002-09-25 2002-09-25
US60/413,622 2002-09-25
US41419902P 2002-09-26 2002-09-26
US60/414,199 2002-09-26
US42375002P 2002-11-05 2002-11-05
US60/423,750 2002-11-05
US43209302P 2002-12-10 2002-12-10
US60/432,093 2002-12-10
US43296202P 2002-12-12 2002-12-12
US60/432,962 2002-12-12
US44210903P 2003-01-23 2003-01-23
US60/442,109 2003-01-23
US44979103P 2003-02-24 2003-02-24
US60/449,791 2003-02-24
US47901603P 2003-06-16 2003-06-16
US60/479,016 2003-06-16
US10/614,266 2003-07-03
US10/614,266 US6861553B2 (en) 2002-07-03 2003-07-03 Process for preparing nateglinide and intermediates thereof
PCT/US2003/022375 WO2004009532A1 (fr) 2002-07-18 2003-07-18 Formes polymorphes de nateglinide

Publications (1)

Publication Number Publication Date
CA2492644A1 true CA2492644A1 (fr) 2004-01-29

Family

ID=30773824

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002492644A Abandoned CA2492644A1 (fr) 2002-07-18 2003-07-18 Formes polymorphes de nateglinide

Country Status (6)

Country Link
EP (1) EP1467964A1 (fr)
JP (1) JP2006511614A (fr)
AU (1) AU2003253971A1 (fr)
CA (1) CA2492644A1 (fr)
IL (1) IL166308A0 (fr)
WO (1) WO2004009532A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7534913B2 (en) * 2002-07-18 2009-05-19 Teva Pharmaceutica Industries Ltd. Crystalline form of nateglinide
HU227073B1 (hu) * 2003-07-10 2010-06-28 Richter Gedeon Nyrt Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenil-alanin (nateglinid) és kristálymódosulatainak elõállítására, valamint a G-kristálymódosulata
US20060004102A1 (en) * 2004-05-07 2006-01-05 Shlomit Wizel Polymorphic forms of nateglinide
JP2009516655A (ja) * 2005-11-22 2009-04-23 テバ ファーマシューティカル インダストリーズ リミティド シナカルセット塩酸塩の結晶形フォーム（Ｆｏｒｍ）、およびそれらの調製方法
MA39033A1 (fr) 2013-11-15 2017-11-30 Akebia Therapeutics Inc Formes solides d'acide {[5-(3-chlorophényl)-3-hydroxypyridine-2-carbonyl] amino}acétique, compositions et leurs utilisations
CN109369443A (zh) * 2018-11-05 2019-02-22 扬子江药业集团江苏海慈生物药业有限公司 一种新的那格列奈h晶型的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6354321A (ja) * 1985-03-27 1988-03-08 Ajinomoto Co Inc 血糖降下剤
US5463116A (en) * 1991-07-30 1995-10-31 Ajinomoto Co., Inc. Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them
JP4114200B2 (ja) * 2000-10-18 2008-07-09 味の素株式会社 ナテグリニド結晶の製造方法
CA2426745C (fr) * 2000-10-24 2009-09-15 Ajinomoto Co., Inc. Procede de production de cristaux de nateglinide a forme b
WO2003022251A1 (fr) * 2001-09-12 2003-03-20 Alembic Limited Nouvelle forme de cristal stable de n-(trans-4-isopropylcyclohexyl carbonyl)-d-phenylalanine et procede de preparation correspondant
EP2261202A1 (fr) * 2002-04-15 2010-12-15 Ajinomoto Co., Inc. Nouveau crystals des nateglinide

Also Published As

Publication number Publication date
EP1467964A1 (fr) 2004-10-20
IL166308A0 (en) 2006-01-15
JP2006511614A (ja) 2006-04-06
AU2003253971A1 (en) 2004-02-09
WO2004009532A1 (fr) 2004-01-29

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued